mutagenesis the outcome of faulty replication of dna

THE MECHANISMS OF DNA REPLICATION pot

Ngày tải lên : 30/03/2014, 00:20

... strand to the outside surface of the complex and retaining the other within the central channel of the hexamer Although the molecular details 13 14 The Mechanisms of DNA Replication of this process ... coordinate the actions of the molecular machines that are elongating eukaryotic DNA replication forks Phases of DNA replication The replication of DNA during the Synthesis (S) Phase of the cell is generally ... uninterrupted DNA chains The removal of all the primers, filling of the subsequent gaps, and the final ligation of the products represent the completion of S-phase Model systems for elongation of DNA replication...

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Toward Improving the Outcome of Pregnancy III pot

Ngày tải lên : 05/03/2014, 13:20

... patients: positioning them, their newborns and their families at Toward Improving the Outcome of Pregnancy III the center of their care and making them an integral part of their health care decisionmaking ... together with the father or other identified partner, and others, family of the patient-baby In this aspect of perinatal care, the parents of the baby define the family and how they wish to be ... with the allocation of resources and the regionalization of subspecialty care Toward Improving the Outcome of Pregnancy, Recommendations for the Regional 10 marchofdimes.com Development of Maternal...

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Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx

Ngày tải lên : 07/03/2014, 21:20

... found a set of DIDO1 homologues in the context of DNA binding and chromatin regulation These homologues include members of the CpG binding protein (CGBP) family of proteins that bind DNA at unmethylated ... long isoform (Figs and S2) It is the second domain of the elongation factor, TFSII [15], that stimulates RNA polymerase II to transcribe through regions of DNA The structure of domain III of this ... in the tree (Fig 1), the branch of the FEBS Journal 272 (2005) 3505–3511 ª 2005 FEBS A M Rojas et al fungal sequences is clearly distant from the other branches, which was indeed predicted The...

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Báo cáo khoa học: End-damage-speciﬁc proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair docx

Ngày tải lên : 23/03/2014, 11:20

... identification of these lesions as a strand break, verification of the nature of the 3¢ end, and identification of a satisfactory pathway for repair The XRCC1 component of the XRCC1 DNA ligase IIIa ... require specific proteins for ‘cleaning’ the ends and preparing them for DNA repair, the time and mechanism of entry of these proteins and other BER partners into the repair process is unknown This ... incubation for the times indicated, proteins involved in repair are cross-linked to the DNA and to each other by the addition of formaldehyde The beads are subsequently washed before reversal of the cross-links,...

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Báo cáo Y học: Thermodynamics and kinetics of the cleavage of DNA catalyzed by bleomycin A5 A microcalorimetric study pdf

Ngày tải lên : 24/03/2014, 04:21

... m Thermodynamics of the binding of ADM and (1,10-phenanthroline)-copper to DNA Fig A comparison of the UV and visible spectrum of BLM-A5 after the cleavage of calf thymus DNA by a mixture of ... cleaving potential of the remaining molecules The impact of self-inactivation of activated BLM on the thermodynamics of DNA binding is more complex As the structural identities of the BLM degradation ... model for the binding of small molecules to DNA Understanding the thermodynamics of the binding of small molecules to DNA is of practical interest, because many small molecules that bind to DNA are...

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Báo cáo khoa học: Effect of monovalent cations and G-quadruplex structures on the outcome of intramolecular homologous recombination doc

Ngày tải lên : 29/03/2014, 23:20

... either on the 3¢-side of the G-quadruplex DNA structure or in the template strand; in the latter case, the slippage would produce the observed deletions This model explains the generation of ... 1A As the lacZ gene is situated between the two copies of the MsH43 inserts, the recombination that takes place after pairing of the MsH43 homologous sequences leads to the excision of the lacZ ... unequal, then the EcoRI fragment containing the minisatellite showed size variations (asterisks in Fig 2A) In the case of the p80.1, the digestion with EcoRI of the original plasmid yielded four DNA...

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Báo cáo khoa học: Murine serum nucleases – contrasting effects of plasmin and heparin on the activities of DNase1 and DNase1-like 3 (DNase1l3) doc

Ngày tải lên : 30/03/2014, 02:20

... characteristics of recombinant rat DNase1-like (rrDNase1l3; DNase c, DNase Y, LS-DNase, nhDNase) [7,8] DNase1l3 belongs to the DNase1 nuclease family, which consists of DNase1 and three further DNase1-like ... kDa) from the zymograms of DNase1 and DNase1l3 By comparing the properties of rmDNase1 and rmDNase1l3 in the hydrolysis of pDNA and chromatin with those of serum collected from WT and DNase1 KO ... nucleolytic activity of both nucleases varied in the presence of either Mg2+ or Mn2+ ions Thus, the pH optimum of rmDNase1 Establishing DPZ for the detection of rmDNase1 and rmDNase1l3 In previous...

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báo cáo hóa học:" A MIF haplotype is associated with the outcome of patients with severe sepsis: a case control study" pdf

Ngày tải lên : 18/06/2014, 15:20

... about the functional relevance of the -173 promoter SNP [16], whereas Baugh and co workers detected the -794 microsatellite and reported about the influence of the number of CATT repeats on the ... preconditions the power of the presented results for the -173 G/C SNP and the -794 (CATT)n microsatellite was 98% and 87%, respectively The linkage disequilibrium of the two loci was assessed with the ... between the two groups (Table 2) The allele CATT8 was neither detectable in the patients' group nor in either of the control groups The genotype distribution and allele frequencies for the -173...

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Báo cáo khoa học: "Effect of a feedback control by early secondary xylem formation on the outcome of competition between leafy shoots in apple (Malus x domestica Borkh.)" ppt

Ngày tải lên : 09/08/2014, 02:21

... from the presence of a third bud and from the direction of this deviation Fig displays the distribution of the degrees of dominance in selected subpopulations where deviation infringes upon the ... Considering the relative elongations of both shoots together with the relative width of new xylem formed below the shoots in the bearing axis, it clearly appears (Fig 3) that, in the last group, ... dominance of this latter; whereas bud near bud favors the occurrence of a fork (Jebari and Crabbe, 1984; Crabbe, 1985) This is, however, further complicated by the frequent helical deviation of the...

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Báo cáo khoa học: "Comparison of RBE values of high- LET a-particles for the induction of DNA-DSBs, chromosome aberrations and cell reproductive death" potx

Ngày tải lên : 09/08/2014, 09:20

... problem The RBE value of 14.6 for cell reproductive death is similar to values in the range of to 15 published for many other lines of cultured cells [45] The RBE of derived for the induction of DNA- DSB ... Page of that many of these aberrations are either repaired or not cause complete impairment of the cell reproductive capacity The number of fragments is higher than that of colour junctions as the ... characteristics of the minority of DSB which yield biological damage are still subject of studies [22] Furthermore the strong dependence of frequencies of chromosome aberrations and cell inactivation on the...

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Báo cáo y học: " Bronchoalveoloar lavage fluid cytokines and chemokines as markers and predictors for the outcome of interstitial lung disease in systemic sclerosis patients" pps

Ngày tải lên : 09/08/2014, 14:22

... numbers Further studies are needed to address this question Major limitations of the study are the fact that the majority of patients received immunosuppressive therapies at the time of BAL Therefore, ... [38] In another study, anti-CD3 therapy also diminished bleomycininduced fibrosis [39] Therefore, T-cell therapy could provide a useful target for further therapies Because most of the fibroblast ... Zoetermeer, The Netherlands) Furthermore, for the evaluation of fibrotic skin changes, the modified Rodnan Skin Score (mRSS) was used [12] Pulmonary fibrosis was defined by evidence of fibrosis...

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Báo cáo y học: "Factors affecting the outcome of surgically treated non-iatrogenic traumatic cervical esophageal perforation: 28 years experience at a single center" docx

Ngày tải lên : 10/08/2014, 09:22

... repair of the perforation site and drainage offers the highest probability of survival Clinical outcome of these patients is influenced primarily by a delay in diagnosis and the presence of associated ... results, at a rate of 10-25% [8] Of our patients, 60% underwent esophagograms; of these, 16.6% of the results were false negatives Computed tomographic findings suggestive of esophageal perforation ... 70% of our patients The presence of cervical emphysema is suggestive of a perforated esophagus and warrants further diagnostic study with contrast esophagography The esophagogram is considered the...

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Báo cáo y học: " Factors predicting the outcome of customised foot orthoses in patients with rheumatoid arthritis: a prospective cohort stud" pps

Ngày tải lên : 10/08/2014, 21:24

... baseline (before the start of the intervention) and at final follow up (directly after the end of the intervention period) The intervention period consisted of one or more appointments with the podiatrist ... the maximum possible sum of the item scores and then multiplied by 100 The scores range from to 100; the higher the score the more pain, disability and activity restriction respectively For the ... calculate the subscale scores and the total score the item scores were summed, divided by the maximum possible sum of the item scores and then multiplied by 100 The scores range from to 100; the higher...

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Báo cáo y học: "Study of the outcome of suicide attempts: characteristics of hospitalization in a psychiatric ward group, critical care center group, and nonhospitalized group" pdf

Ngày tải lên : 11/08/2014, 17:20

... listed as one of the important items of evaluation in judging the outcome of suicide attempts at the scene of the emergency [36] Some foreign studies report that men of 45-years of age or over ... studies on the outcomes of suicide attempts, including completed suicides, the ratio of men is highest in the “completed suicide” group, then in the hospitalized group, and lowest in the outpatient ... means, the presence of depressive disorder was often recognized among patients over 50 years of age [19] It was also reported in the outcome survey of suicide attempters noted above that the age of...

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Báo cáo khoa học: "Ethnic and geographical differences in HLA associations with the outcome of hepatitis C virus infection" pot

Ngày tải lên : 12/08/2014, 04:21

... Discussion The current study investigated the associations of HLAclass I and -class II alleles to the outcome of early HCV infection in a Midwestern American population Similar to other two studies of ... are associated with the outcome of HCV infection The majority of such studies have been focused on the associations between HLAclass II alleles and HCV infection In addition, the reported associations ... One study of a Northeastern American population in Baltimore showed that HLA-DQB1*03 is protective in African Americans but not in Caucasians [18] The results of another study of Northeastern...

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Báo cáo y học: " Impact of nosocomial pneumonia on the outcome of mechanically-ventilated patient pps

Ngày tải lên : 12/08/2014, 18:20

... aureus 0% (0/1) At the time of suspicion of pneumonia 33 of the 82 patients (40%) were on antibiotics The duration of prior antibiotic therapy (within 10 days before the diagnosis of pneumonia) was ... was then advanced next to the orifice of the sampling area in order to visualize the entrance to the radiographically abnormal bronchial sub-segment The diagnosis of pneumonia was based on: The ... However, the stepwise logistic regression analysis identified only three of these (MOF, SAPS > and ARDS) as significant predictors of outcome (Table 3) Within the group of patients with NP, the stepwise...

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Báo cáo y học: "The outcome of extubation failure in a community hospital intensive care unit: a cohort study" pot

Ngày tải lên : 12/08/2014, 20:20

... patients; of these the gastrointestinal and vascular services were more common in the failed extubation group Study cases were reintubated a median of 24 hours after extubation Outcomes of respiratory ... Effect of failed extubation on the outcome of mechanical ventilation Chest 1997, 112:186-192 Rady MY, Ryan T: Perioperative predictors of extubation failure and the effect on clinical outcome ... divided by the institutional charge/cost ratio during the time period of review (1.21): hospital costs per day = (total hospital charges/total hospital length of stay)/1.21 Other outcome data...

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Báo cáo y học: "The outcome of patients presenting to the emergency department" pps

Ngày tải lên : 13/08/2014, 01:20

... from the ED Conclusion The emerging role of the ED in severe sepsis and septic shock is a much needed and evolving part of the landscape of critical care medicine [18] Although the merits of EGDT ... the EGDT patients The authors mention timely administration of antibiotics, central venous pressures of 10.8 ± 4.7 mmHg, and use of vasopressor agents in 70% of the patients as an indicator of ... intervention in the ED Although this comparison is respected, these retrospective data transmit other signals The early use of vasopressors is not necessarily a sign of an aggressive level of care;...

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Báo cáo y học: "Improvements in the outcome of children with meningococcal disease" pptx

Ngày tải lên : 13/08/2014, 08:20

... returning to the central PICU, then they may not contribute to published PICU mortality figures True population based studies of MCD mortality are of crucial importance; a study of this kind ... reduce mortality in the UK have been designed to raise awareness at every step of the patient journey Public awareness had been raised with the help of charities such as the Meningitis Research ... J, Maconochie I, Winrow A, Coen PG, Booy R: The role of healthcare delivery in the outcome of meningococcal disease in children: case-control study of fatal and non-fatal cases BMJ 2005, 330:1475...

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Báo cáo y học: "Are serum cytokines early predictors for the outcome of burn patients with inhalation injuries who do not survive" pot

Ngày tải lên : 13/08/2014, 11:22

... transform the logit using Prob[YG9group] = 1/[1 + ExpBurned].) To assess the goodness -of- fit for the regression, the likelihood ratio test statistic and the mean, standard error of the mean, ... correspond to standard error of the mean *P < 0.05 increased The coefficient for IL-7 was positive, indicating that the risk of mortality increased as the levels of IL-7 decreased The means, standard ... enrolled in the study Permission for conducting the study was obtained from the Institutional Review Board of the University of Texas Medical Branch, Galveston, Texas, USA Before the study, for...

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