multiple myeloma waldenström s macroglobulinemia and benign monoclonal gammopathy characteristics of the b cell clone immunoregulatory cell populations and clinical implications
Báo cáo y học: " Ageing, autoimmunity and arthritis: Senescence of the B cell compartment — implications for humoral immunity" pptx
Ngày tải lên :
09/08/2014, 01:23
... pro -B and < /b> pre -B cells harvested from aged as compared with young mice, and < /b> this may result in the < /b> increased apoptosis observed in these cell populations [15,20] The < /b> possibility also exists that ... in autoantibodies, distinguish mouse strains with increased numbers of < /b> MZ, B1 , and < /b> memory B cell subsets, and < /b> not surprisingly aged mice [12,39–41] Finally, stable B cell expansions with clonal ... gradual loss of < /b> naïve follicular B cells, but not of < /b> MZ or B1 B cells Recent studies conducted in our laboratory also suggest that reduced influx of < /b> B cells from the < /b> BM drives the < /b> selection of < /b> antigen-experienced...
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báo cáo khoa học: "Epigenetic modifications as key regulators of Waldenstrom’s Macroglobulinemia biology" pot
Ngày tải lên :
10/08/2014, 22:21
... cells present with increased level of < /b> miRNA155, together with increased expression of < /b> HDACs and < /b> reduced expression of < /b> HATs, leading WM clone expansion and < /b> tumor progression (BMSCs: bone marrow stromal ... control cells [14] Similarly, miRNA-155 modulated cell cycle progression in WM cells, as demonstrated by an increased % of < /b> cells in G1-phase, together with a decreased % of < /b> cells in S-< /b> phase These ... in WM patients included tumor suppressors, cell cycle inhibitors, cytokine signaling suppressors and < /b> tyrosine phosphatases Conversely, predicted target genes for the < /b> decreased miRNAs in WM included...
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báo cáo khoa học: "Spontaneous splenic rupture in Waldenstrom’s macroglobulinemia: a case report" doc
Ngày tải lên :
11/08/2014, 02:21
... of < /b> both clinical features and < /b> a myriad of < /b> cellular parameters In the < /b> absence of < /b> specific disease markers (such as in WM), this combination of < /b> factors is important in attaining a ‘pattern of < /b> best-fit’ ... features of < /b> WM are that of < /b> a diffuse infiltration of < /b> the < /b> bone marrow by small lymphocytes, plasma cells and < /b> plasmacytoid cells Splenic architecture, when available, demonstrates a lymphoplasmacytic ... lymphoma [3] Despite this Figure Low-power magnification of < /b> the < /b> splenic tissue This slide displays significant distortion and < /b> diffuse infiltration of < /b> the < /b> splenic parenchyma by lymphoid cells Of < /b> particular...
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Protecting Children''''s Health In A Changing Environment - Report Of The Fifth Ministerial Conference On Environment And Health.pdf potx
Ngày tải lên :
22/03/2014, 16:22
... outweigh the < /b> costs of < /b> dealing with them Constant surveillance is essential to monitor communicable diseases and < /b> the < /b> movements of < /b> vectors that result in the < /b> new geographical spread of < /b> the < /b> diseases they ... conditions and < /b> disasters Despite the < /b> progress achieved so far, addressing major preventable determinants and < /b> diseases, such as obesity, respiratory and < /b> cardiovascular diseases, remains a major challenge ... Health and < /b> involving the < /b> Federal Office of < /b> Sports, Health Promotion Switzerland, representatives of < /b> the < /b> cantons and < /b> industry, and < /b> an alliance of < /b> NGOs and < /b> numerous other actors All of < /b> these were also...
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PUBLIC ACCOUNTS AND ESTIMATES COMMITTEE Financial Audit of the Victorian Auditor-General''''s Office Tender brief March 2010_part1 pptx
Ngày tải lên :
19/06/2014, 15:20
... financial statements and < /b> the < /b> expression of < /b> independent professional opinions on these statements, attesting to their fair presentation in line with professional reporting standards and < /b> processes The < /b> ... year Submissions Submissions should: • address all the < /b> above selection criteria; • include details of < /b> key proposed personnel; • detail a fixed price total professional service fees (exclusive of < /b> ... fit with the < /b> Chair of < /b> the < /b> Committee and/< /b> or the < /b> Audit Sub-Committee of < /b> the < /b> Committee; • evaluate the < /b> progress, adequacy and < /b> effectiveness of < /b> measures implemented by VAGO to address issues and < /b> recommendations...
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PUBLIC ACCOUNTS AND ESTIMATES COMMITTEE Financial Audit of the Victorian Auditor-General''''s Office Tender brief March 2010_part2 pdf
Ngày tải lên :
19/06/2014, 15:20
... (including the < /b> persons specified in Item of < /b> Schedule 1, any Replacement Staff and < /b> any Additional Staff); and < /b> the < /b> acts and < /b> omissions of < /b> such persons are deemed to be the < /b> acts and < /b> omissions of < /b> the < /b> Service ... or statutory body or authority; (ii) a person includes the < /b> person s < /b> legal personal representatives, successors, assigns and < /b> persons substituted by novation; (iii) any legislation includes subordinate ... substantially the < /b> same contents prior to the < /b> commencement of < /b> the < /b> provision of < /b> the < /b> Services ‘Price Schedule’ means the < /b> schedule of < /b> Fees payable by the < /b> Purchaser to the < /b> Service Provider for the < /b> provision of...
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PUBLIC ACCOUNTS AND ESTIMATES COMMITTEE Financial Audit of the Victorian Auditor-General''''s Office Tender brief March 2010_part3 pptx
Ngày tải lên :
19/06/2014, 15:20
... for the < /b> Service Provider for reasonable access to the < /b> premises at such times as may be reasonably necessary to enable the < /b> Service Provider to provide the < /b> Services 27.2 Obligations When the < /b> Service ... though they were the < /b> actions of < /b> the < /b> Service Provider itself Access and < /b> Safety 27.1 Access to premises If the < /b> Service Provider requires access to the < /b> premises of < /b> the < /b> Auditee in connection with the < /b> ... all such transitional assistance as may be reasonably necessary or requested by the < /b> Purchaser to facilitate the < /b> smooth transition of < /b> any relevant information, knowledge, systems or assets from the...
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PUBLIC ACCOUNTS AND ESTIMATES COMMITTEE Financial Audit of the Victorian Auditor-General''''s Office Tender brief March 2010_part4 ppt
Ngày tải lên :
19/06/2014, 15:20
... party Severability Any provision of < /b> this Agreement which is invalid or unenforceable is to be read down, if possible, so as to be valid and < /b> enforceable, and,< /b> if that is not possible, the < /b> provision ... Understanding (a) This Agreement, together with its Schedules and < /b> Annexures contains the < /b> entire understanding between the < /b> parties as to the < /b> subject matter of < /b> this Agreement (b) Except as otherwise provided ... www.adultpdf.com Public Accounts and < /b> Estimates Committee – Financial Audit Schedule Professional services and < /b> price schedule Services required by the < /b> Purchaser s < /b> Representative to be provided by the < /b> Service...
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PUBLIC ACCOUNTS AND ESTIMATES COMMITTEE Financial Audit of the Victorian Auditor-General''''s Office Tender brief March 2010_part5 doc
Ngày tải lên :
19/06/2014, 15:20
... commensurate with the < /b> breach or the < /b> offence on which the < /b> Adverse Assessment is based and < /b> can be reasonably expected to prevent such breach or offence from recurring; or (b) whether the < /b> Purchaser is ... any other rights or remedies of < /b> the < /b> Service Provider under this Agreement or otherwise at Law 2.12 In this paragraph 2: Adverse Assessment means an assessment by the < /b> Purchaser pursuant to the < /b> ... opinion of < /b> the < /b> Service Provider is relevant to the < /b> Adverse Assessment, including the < /b> Service Provider s < /b> grounds for any objection to the < /b> Adverse Assessment; any existing or planned remedial measures...
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Báo cáo toán học: "On a theorem of Erd˝s, Rubin, and Taylor on o choosability of complete bipartite graphs" pptx
Ngày tải lên :
07/08/2014, 06:23
... every ei is an r-subset of < /b> V For every i = 1, , k and < /b> j = 1, , |E|, assign wi,j the < /b> list L(wi,j ) = ej Assume that G has a coloring f from the < /b> lists Note that no color v is present on every ... Srinivasan, Improved bounds and < /b> algorithms for hypergraph two-coloring, Random Structures and < /b> Algorithms, 16 ( 2000), 4–32 [10] J Spencer, Coloring n-sets red and < /b> blue, J Comb.Theory Ser A, 30 ... combinatorics (2002), #N9 Assume that G has a coloring f from the < /b> lists Since G is a complete k-partite graph, every color v is used on at most one part Then f produces a k-coloring gf of < /b> V as...
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Báo cáo y học: "No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary Sjögren''''s syndrome" pptx
Ngày tải lên :
09/08/2014, 07:20
... pSS The < /b> bar represents the < /b> standard error BAFF = B- cell- activating factor; pSS, primary Sjögren 's < /b> syndrome Discussion level in 95 patients with pSS Association between BAFF -871 T/C polymorphism ... monocytes We therefore investigated the < /b> association between BAFF -871 T/C polymorphism and < /b> BAFF expression, and < /b> focused first on the < /b> correlation between BAFF polymorphism and < /b> serum level as assessed ... patients without antiSSA/SSB autoantibodies, in whom disease is usually less systemic Moreover, we previously reported that BAFF level was not associated with systemic features in pSS [8] Likewise,...
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báo cáo khoa học: "Unusual histological findings after partial pancreaticoduodenectomy including benign multicystic mesothelioma, adenomyoma of the ampulla of Vater, and undifferentiated carcinoma, sarcomatoid variant: a case series" pdf
Ngày tải lên :
11/08/2014, 02:22
... hyperplastic mesenchymal tissue which consisted of < /b> muscle fibers, fibroblasts and < /b> myofibroblasts (Figure 4A and < /b> 4B) Figure Histologic findings and < /b> immunohistochemical staining for smooth muscle actin ... diagnosis was benign < /b> multicystic mesothelioma Case Case presentations Case An 86-year-old Caucasian woman was admitted with nausea and < /b> abdominal pain Abdominal and < /b> endoscopic ultrasound, as well as ... resection and < /b> end-to-end anastomosis of < /b> the < /b> SMV The < /b> postoperative course was uneventful Ten months later, the < /b> patient had no signs of < /b> recurrence A gross 2.5 cm tumor of < /b> the < /b> head of < /b> the < /b> pancreas...
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examining and integrating transaction cost economics and resource-based view explanations of the firm’s boundary choices
Ngày tải lên :
02/11/2014, 00:34
... this section analyses transactions with the < /b> combinations of < /b> extreme (high/low) levels of < /b> asset specificity across the < /b> two stages, as indicated in Figure The < /b> analysis draws on the < /b> necessary and < /b> sufficient ... levels of < /b> specificities across the < /b> stages per se Further, given symmetrical appropriable losses, firms may also be able to avoid contracting costs, and < /b> negligible market transaction costs will be ... concerns discussed with organizing low asset specific transactions across homogenous exchange partners in the < /b> market apply to SHS transactions as well It follows that only a subset of < /b> SHS transactions...
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Developing the competitive strategy for thien hoa’s supermarket system on a retail market of the electronic and electrical appliances in Hochiminh city
Ngày tải lên :
26/03/2015, 10:55
... formation of < /b> specialized B2 B sales channels – channel sales to the < /b> enterprises Characteristic of < /b> this sales channel is the < /b> number of < /b> customers buying less, but high volume and < /b> turnover - The < /b> business ... applying this strategy is not only our business have access to cheap resources So, other competitors can fully copy of < /b> the < /b> business strategy The < /b> important thing is whether the < /b> business has the < /b> ability ... uses the < /b> inputs by the < /b> analysis in the < /b> first stage and < /b> the < /b> combined results of < /b> the < /b> analysis in the < /b> second stage to determine the < /b> strategic objective of < /b> the < /b> likely alternative The < /b> attractiveness...
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Oil for freedom in brunei state policies and women¿s strategies in brunei a case study of the women¿s business council
Ngày tải lên :
16/10/2015, 15:35
... inability of < /b> the < /b> government to ensure these women to have successful businesses thus questions whether the < /b> Brunei as a welfare-state is as capable as it used to be in appeasing the < /b> demands of < /b> ... provides access to wider opportunities, advice on common business issues, and < /b> unites common business interests,"42 The < /b> WBC has the < /b> mandate to forge a strategic network amongst women s < /b> businesses in ... pressing need to have a national body that served the < /b> interest of < /b> local Malay Muslim businesswomen and < /b> to establish networks amongst female business owners The < /b> WBC was established with the < /b> aim of...
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Báo cáo y học: "980 nm diode lasers in oral and facial practice: current state of the science and art"
Ngày tải lên :
26/10/2012, 09:48
... scars caused by naive operators who have been persuaded by unprofessional salespeople that "these intelligent machines" can replace "the < /b> brain and < /b> hand, skill and < /b> experience" of < /b> the < /b> specialist ... lasers are indicated as a supplement to chemical sclerosis [26,27] On the < /b> basis of < /b> the < /b> results obtained in the < /b> treatment of < /b> benign < /b> facial pigmented and < /b> vascular lesions, while recognising the < /b> physical ... expensive in terms of < /b> maintenance and < /b> running costs Also Q-switched Nd:YAG and < /b> ruby sources appear to be interesting [23-25] Angiectases of < /b> the < /b> lower limbs, where the < /b> skin is thick, are deeper and...
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Báo cáo y học: "Incidence of Ocular Zoonoses referred to the Inflammatory and Autoimmune Ocular Diseases Service of the University of Parma - Italy"
Ngày tải lên :
03/11/2012, 11:11
... [1] The < /b> only case of < /b> Lyme disease affected a 31 year-old farmer and < /b> his ocular manifestations are described in the < /b> specific section Figure 1: Geographical location of < /b> the < /b> province of < /b> Parma (Italy) ... (Italy) References Mora P, Vecchi M, Barbera L, Toscani M, Orsoni JG Use of < /b> systemic cyclosporin A in a case of < /b> severe Toxocara uveitis J Infect 2006; 52:159-161 http://www.medsci.org ... Med Sci 2009, 119 this case the < /b> patient had a panuveitis, which recovered only after a combination of < /b> medical treatment and < /b> surgery, with a final visual acuity of < /b> 40% in the < /b> affected eye [1] The...
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Radioactive waste in the Barents and Kara Seas - Russian implementation of the global dumping regime
Ngày tải lên :
01/11/2013, 09:20
... is only one of < /b> the < /b> substances dealt with by this Convention, it has been the < /b> single most politicised issue The < /b> main decision-making body is the < /b> Consultative Meeting of < /b> the < /b> Parties, usually held ... directed the < /b> establishment of < /b> several closed nuclear laboratories in secluded cities.58 As of < /b> 1990, there were more than 100 such ‘secret cities’, some with tens of < /b> thousands of < /b> inhabitants, omitted ... for the < /b> removal of < /b> spent fuel from nuclear reactors in the < /b> naval bases;53 those rules were stillborn, however, because physical access to the < /b> bases is up to the < /b> military to decide The < /b> Northern...
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Tài liệu Decision Analysis and Risk Management: Two Sides of the Same Coin pdf
Ngày tải lên :
10/12/2013, 17:15
... identified in step This involves a comparison of < /b> the < /b> pros and < /b> cons, costs and < /b> benefits of < /b> each alternative based on criteria, and < /b> standards established by the < /b> person doing the < /b> analysis Roller blades are ... uncertainties have been considered in the < /b> pre-decision analysis Decision analysis is the < /b> process of < /b> dissecting the < /b> inputs to a decision It clarifies the < /b> degree of < /b> understanding of < /b> issues involved and < /b> ... possible future events) therefore begins by ensuring that an organization s < /b> decisions are of < /b> the < /b> highest possible quality given the < /b> constraints of < /b> time and < /b> resources Quality Decisions and < /b> Risk...
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Tài liệu Deteriorating Access to Women’s Health Services in Texas: Potential Effects of the Women’s Health Program Affiliate Rule doc
Ngày tải lên :
13/02/2014, 06:20
... as the < /b> number of < /b> WHP patients who can continue to be served climbs, the < /b> state s < /b> budget losses grow larger These are estimates based on some basic assumptions; the < /b> actual outcomes may differ based ... further assume that the < /b> 90% federal matching rate is no longer available to the < /b> WHP and < /b> the < /b> state must bear all the < /b> costs Based on these assumptions, we estimate the < /b> program impacts and < /b> costs and < /b> savings ... affiliate has a billing address in Dallas County, but some of < /b> its sites are in other adjacent counties and < /b> some of < /b> the < /b> patients served may be residents of < /b> other counties The < /b> list does not indicate...
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