multifactorial etiology of gastric cancer

... Post HOC Scheffe, p > 0.05) GC, gastric cancer; EGC, early gastric cancer; AGC, advanced gastric cancer Page of 11 (page number not for citation purposes) Journal of Translational Medicine 2009, ... (cut-off value of 5.5 ng/ml), and 71% and 67% (cut-off value of ng/ml) The sensitivity and specificity of serum CEA levels for the diagnosis of high-risk lesions was 39% and 76% (cut-off value of ... of our study [20,21] However, the sensitivity and specificity of serum HMGB1 was about 71% and 67% (cut-off value of ng/ml) for the detection of cancer (EGC), and 70% and 64% (cut-off value of...

Ngày tải lên: 18/06/2014, 15:20

... the interface of tumor nest and stroma is the main location of infiltrating macrophages in gastric cancer, and phagocytosis of cancer cells by macrophage, indicating the coexistence of M1 and M2 ... observable step of cancer progression Cancer invasion occurs in a particular context of tissue microenvironment which is under constant evolution largely due to the interactions of cancer cells ... of cancer molecules, while the clinical studies focused on the “spatial evolution” of cancer tissues The underlying theory behind these studies is to focus on cancer itself A major drawback of...

Ngày tải lên: 18/06/2014, 16:20

... evaluation of HIPEC In recent years, increasing number of animal models of PC have been intensively studied, including nude mouse model of gastric cancer PC constructed by implanting human gastric cancer ... by the Animal Welfare Committee of the Center Construction of rabbit model of VX2 gastric carcinoma with PC Rabbit VX2 carcinoma was used to establish gastric cancer with PC in this study The ... animal model of PC from gastric cancer for experimental studies to test extensive CRS and HIPEC In our previous study [19], we have established a stable rabbit model of gastric cancer with PC...

Ngày tải lên: 18/06/2014, 19:20

... augments anti -cancer immunity in a mouse model of gastric cancer Journal of Translational Medicine 2011 9:140 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient ... increase of Tregs does not necessarily affect the anticancer effect of the treatment It remains to be determined whether late appearance of Tregs actually has an impact on the therapeutic efficacy of ... four mimicry epitopes for gastric cancer Cancer Biol Ther 2005, 4:308-312 25 Nockel J, van den Engel NK, Winter H, Hatz RA, Zimmermann W, Kammerer R: Characterization of gastric adenocarcinoma cell...

Ngày tải lên: 18/06/2014, 22:20

... evaluation of HIPEC In recent years, increasing number of animal models of PC have been intensively studied, including nude mouse model of gastric cancer PC constructed by implanting human gastric cancer ... by the Animal Welfare Committee of the Center Construction of rabbit model of VX2 gastric carcinoma with PC Rabbit VX2 carcinoma was used to establish gastric cancer with PC in this study The ... animal model of PC from gastric cancer for experimental studies to test extensive CRS and HIPEC In our previous study [19], we have established a stable rabbit model of gastric cancer with PC...

Ngày tải lên: 20/06/2014, 03:20

... imaging findings of gastric wall invasion included case of T1, of T2 (Figure 7), and 11 of T3 (Figure 8) Pathologic results of resected specimens included cases of pT1, of pT2, and 12 of pT3 Differentiation ... layers of the gastric wall and also MRI of gastric carcinoma could enable accurate diagnosis of location, gross appearance, degree of gastric wall invasion of the tumors and delineation of regional ... stage of gastric cancer Gastric Cancer 8: 29-34 Botet JF, Lightdale CJ, Zauber AG, Gerdes H, Winawer SJ, Urmacher C & Brennan MF (1991) Preoperative staging of gastric carcinoma: comparison of endoscopic...

Ngày tải lên: 28/06/2014, 05:20

... irradiation sensitizer in gastric cancer therapy Guidelines of the NCCN on gastric cancer Figure Quantification of mRNA expression of different genes Analysis of mRNA expression of COX-2, VEGF and EGFR ... and EGFR genes in gastric cancer cells, which was mainly due to the decrease in expression of NF-B via inhibited b-ARs Discussion Gastric cancer is one of the major causes of cancer mortalities ... patients with a high risk of recurrence in gastric cancer Investigation of the specific mechanisms of NF-B activation by radiation is currently a rapidly expanding field of research It has been...

Ngày tải lên: 09/08/2014, 09:20

... the SPSS software package (SPSS Inc, Chicago, USA) A value of P < 0.05 was considered significant Results Down-regulation of COX-2 inhibited the growth and tumorigenecity of gastric cancer cells ... might inhibit the malignant growth of SGC7901 cells in vivo Down-regulation of COX-2 inhibited angiogenesis of gastric cancer cells As shown in Figure 3, the number of endothelial cells within the ... (right) Yao et al Journal of Experimental & Clinical Cancer Research 2011, 30:13 http://www.jeccr.com/content/30/1/13 Page of of COX-2 was frequently found in gastric cancer, in which COX-2 expression...

Ngày tải lên: 10/08/2014, 10:21

... retention in cancer cells The results of FCM showed that down-regulation of miR- Figure Effects of a miR-27a on expression of cyclin D1, P-gp, p21 and p27 in gastric cancer cells The mRNA level of the ... time results of MTT assay and soft agar assay revealed that down-regulation of miR-27a inhibited cell growth of gastric cancer cells in vitro, which was consistent with the data of nude mice ... of miR-27a might inhibit the growth of MKN45 cells in vitro and in vivo Down-regulation of miR-27a might reverse drug resistance of gastric cancer cells As shown in Table 1, the IC50 values of...

Ngày tải lên: 10/08/2014, 10:21

... Yamamoto H: Participation of c-met in the progression of human gastric cancers: anti-c-met oligonucleotides inhibit proliferation or invasiveness of gastric cancer cells Cancer Gene Ther 1996, 3:393-404 ... promotes apoptosis of gastric cancer cells Journal of Experimental & Clinical Cancer Research 2011 30:67 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online ... therapeutic target for this type of cancer [3] The aim of this study was to evaluate the effects of recombinant immunotoxin anti-c-Met/PE38KDEL on proliferation and apoptosis of GC cells and explore the...

Ngày tải lên: 10/08/2014, 10:21

... or kill early gastric cancer cells is very key for early diagnosis and therapy of patients with gastric cancer Up to date, looking for biomarkers closely associated with gastric cancer is still ... associated with early gastric cancer were identified [5,6], no one gene can be confirmed to be specific biomarker of gastric cancer Therefore, in order to recognize early gastric cancer cells, we ... target for most gastric cancer, if as-prepared nanoprobes may recognize 64% patients with early gastric cancer, it will be very useful for diagnosis and therapy of clinical gastric cancer patients...

Ngày tải lên: 11/08/2014, 00:23

... karyotyping of seventeen gastric cancer cell lines 7.1 Gastric cancer spectral karyotypes 7.2 148 Recurrent patterns of translocations Multimodality whole genome characterization of gastric cancer ... Table of contents Contents TITLE PAGE i ACKNOWLEDGEMENTS ii TABLE OF CONTENT iv SUMMARY vii LIST OF TABLES xi LIST OF FIGURES xiii LIST OF ABBREVIATIONS xx REVIEW OF THE LITERATURE Gastric cancer ... in surgery: gastric cancer Curr Probl Surg 43, 566-670 (2006) 22 Japanese Gastric Cancer Association Japanese Classification of Gastric Carcinoma - 2nd English Edition - Gastric Cancer 1, 10-24...

Ngày tải lên: 14/09/2015, 08:38

... the cancer biology through systematic analysis of whole genomes and transcriptomes 1.2 Gastric Cancer Gastric cancer is a leading cause of cancer mortality worldwide, surpassed only by lung cancer ... treatment of gastric cancer is that very few of the currently utilized classification schemes are strong predictors of clinical behavior Traditional classifications of gastric cancer on the basis of ... members of Asia-Pacific Gastric Cancer Genomics Consortium (Prof Hiroyuki Aburatani, University of Tokyo, Japan; Prof David Bowtell, Peter MacCallum Cancer Centre, Australia; Assoc Prof Suet...

Ngày tải lên: 15/09/2015, 17:09

... ratio: is the effect of a variable (e.g., treatment) on the risk of an event (e.g., survival); it is considered an estimate of relative risk References Sugano K Gastric cancer: pathogenesis, ... esophagogastric cancer J Clin Oncol 2002; 20:1996-2004 Cunningham D, Starling N, Rao S, et al Upper Gastrointestinal Clinical Studies Group of the National Cancer Research Institute of the United ... study of irinotecan plus S-1 (IRIS) versus S-1 alone as first-line treatment for advanced gastric cancer (GC0301/TOP-002) ASCO Gastrointestinal Symposium 2008; (a5) 12 Arkenau HT Gastric cancer...

Ngày tải lên: 06/03/2014, 02:21

... activation of P-gp in PrPC-transfected gastric cancer cells, inhibition of which would reverse gastric cancer MDR, partly by decreasing the transcriptional activation of P-gp This model of a PrPC/PI3K/P-gp ... Co-expression of PrP and Akt in gastric cancer (A) Serial sections of gastric cancer tissue were stained with antibodies against PrPC (3F4, Sigma) or p-Akt (Thr 308; Cell Signaling Technology) (a) Gastric ... this process Table IC50 values (lgÆmL)1) for anticancer drugs for gastric cancer cells Survival rates of gastric cancer cells treated with anticancer drugs were evaluated by the MTT assay as described...

Ngày tải lên: 07/03/2014, 03:20

... Deprivation is a risk factor for development of squamous cancer of the oesophagus and for gastric cancer Tobacco smoking increases the risk of squamous cancer of the oesophagus approximately nine fold ... Oesophageal and gastric cancers occur mainly in people over 55 years of age Male sex is a risk factor for squamous cancer of the oesophagus and for oesophagogastric junction cancer Deprivation ... and with a risk of oesophagogastric junction cancer The presence of Helicobacter pylori infection is associated with a two to threefold increase in the risk of developing gastric cancer B A test...

Ngày tải lên: 15/03/2014, 01:20

... enhanced risk of oesophageal adenocarcinoma and with a risk of oesophagogastric junction cancer. 11,12 There is no association of high BMI with gastric cancer or with squamous cancer of the oesophagus ... appear to offer a means of reducing gastric cancer risk, it did not reduce the frequency of gastric cancer development in one study conducted in a Chinese population with a very high gastric cancer ... oesophageal cancer (males: 4% to 10%; females: 7% to 13%) and gastric cancer (males: 6% to 13%; females: 9% to 18%) it remains low  Management of oesophageal and gastric cancer 1.2 Scottish audit of Gastric...

Ngày tải lên: 28/03/2014, 23:20

... expression of a chosen sample by which the expression profile of each sample of interest is adjusted: this approach enables the investigator to compare the expression profile of the samples of interest ... aimed to profiling the peripheral blood of 70 patents affected with gastric adenocarcinoma by using qrtPCR We tested four biomarkers, two of the presence, ad two of the aggressiveness of the tumor, ... expression levels of (as human gastric text for details)four genes of interest in real GenePCR: see cancer cells the measured by quantitativeN87 Gene expression levels of the four genes of interest...

Ngày tải lên: 18/06/2014, 15:20

... the effect of CKBM-A01 (a combined recipe of the above mentioned Chinese herbs and yeast) on the growth of human gastric cancer using a unique subcutaneous implantation model of gastric cancer tissue ... Adjunct Professor of University of Toronto and is Honorary or Visiting Professor of over ten universities Int J Med Sci 2004 1(3): 137-145 142 Chi-Hin Cho, PhD, is Chair Professor of Pharmacology ... induction of apoptosis and inhibition of proliferation of gastric cancer cells However, further clinical trials in humans are needed to examine the pharmacokinetics and the therapeutic action of CKBM...

Ngày tải lên: 08/08/2014, 18:20