multi marker analyses for case control data

... anorexia data set (5 controls per case) , the anorexia data set with or randomly selected controls per case, and the anorexia data with no controls or only randomly-selected control per case combined ... 0.77 = 23%) for a current study with one control per case to almost no reduction (1 - 0.97 = 3%) for a current study with five controls per case For a fixed number of controls per case in the ... Study Design for Epidemiological studies 1.2 Ideas for re-using existing data 1.3 Re-using existing case- control data 1.4 Re-using existing nested case- control data ...

Ngày tải lên: 12/10/2015, 17:36

... study period were used as control subjects The original study design was to match three controls for each of the 75 RA cases for age, sex and visit date Controls were matched for age at diagnosis ... order to control for shifts in practice and diagnostic patterns Using these criteria, we were able to identify 130 controls, therefore some cases had one control and others had two controls After ... diagnoses for the patient throughout his/her lifetime) for each control We are confident that symptoms or clinical manifestations of RA would have been recorded in the patients' charts The diagnosis for...

Ngày tải lên: 09/08/2014, 06:23

... Kruskal-Wallis tests Double data entry was performed, which were then compared, validated and subsequently corrected Data entry was performed concurrently with data collection, and the database was managed ... questionnaires, after patients had signed the informed consent forms Additional information was obtained from medical records Figure Algorithm for selection of patients for the study of factors associated ... before the onset of cough A study case was defined as a patient who presented a delay in initiating treatment and a control as a patient who did not present a delay in initiating treatment For...

Ngày tải lên: 06/03/2014, 04:20

... protocol for shifting between execution models presents an intriguing future avenue of research THE CASE FOR NONDETERMINISM Before making the case for disallowing nondeterministic behavior in database ... concurrency across multiple threads Middleware solutions such as that implemented by xkoto (recently acquired by Teradata) and Tashkent-API [8] attempt to perform replication over multiple database systems ... protocols for replicated databates SIGMOD Rec., 28(2):97–108, 1999 [8] S Elnikety, S Dropsho, and F Pedone Tashkent: uniting durability with transaction ordering for high-performance scalable database...

Ngày tải lên: 30/03/2014, 13:20

... managerial capacity for TB control at all levels within the health system This had a direct effect on program performance, particularly on all aspects of TB case management, TB case notification, ... Educational Handbook for Health Personnel WHO Offset Publication no.35: World Health Organization, Geneva; 1998 Training for Better TB Control: Human Resource Development for TB Control - a Strategic ... district and provincial level; (ii) availability of trained staff for TB control for hospitals; and (iii) the development of a TB component for the curricula in basic training institutions The key activities...

Ngày tải lên: 18/06/2014, 17:20

... position for 20 before blood collection Blood samples for PAI-1 antigen and vonWillebrand factor antigen (vWF) were kept on crushed ice until centrifugation Samples were centrifuged at 2500 × g for ... ultrasound is a more sensitive method for the detection of polycystic ovaries In the TVUS data used for statistical analysis were the mean of observed values for the left and right ovaries Page ... standard deviation (SD) for all parameters Variables with a skewed distribution (waist circumference, insulin, HOMA IR , PAI-1) were logarithmically transformed before analyses, to improve the...

Ngày tải lên: 20/06/2014, 07:20

... a bootstrap procedure [5] Statistical analyses were performed with SPSS for Windows, version 12.0.1 (SPSS, Chicago, IL, USA) Bootstrap analyses were performed using the software package S-plus ... in the controls than in the cases because insufficient numbers of controls could be found for some of the more senior patients Concomitant use of PPIs was significantly higher in the controls ... higher in the controls than in the cases (cases 14 (13.5%) and controls 77 (27.1%); p = 0.005) Use of selective COX-2 inhibitors was comparable (cases 17 (16.4%) and controls 50 (17.6%); p = 0.77)...

Ngày tải lên: 09/08/2014, 01:22

... performed using Students' t-tests and Mann-Whitney U-tests for continuous variables and Pearson's Chi-square tests for dichotomic variables Page of (page number not for citation purposes) The dataset ... factors for CVD was done for two reasons Firstly, because these risk factors could be overor under-represented in certain DMARD groups and, therefore, falsely influence the cardiovascular risk for ... quantities (for example, 30 mg for MTX and 3,000 mg for SSZ) we calculated the percentage of the maximum dosages allowed by the Dutch and European medication agencies to be prescribed For example,...

Ngày tải lên: 09/08/2014, 08:22

... five were DCIS For invasive tumors, four tumors were T1 and two tumors were T2 Axillary lymph nodes were positive for two, negative for two, and unknown for two tumors The case- control analysis ... occurring after HL as compared to primary BC, we conducted a case- control analysis for patients with invasive tumors We excluded from our case- control analysis all women with ductal carcinoma in-situ ... Fourteen patients also had CT, eleven for primary disease and three for relapse For primary disease, five patients received doxorubicin, Table 1: Age distribution for Hodgkin's lymphoma, breast cancer...

Ngày tải lên: 09/08/2014, 09:22

... lower for the controls than for the cases because insufficient numbers of controls could be found for some of the extremely elderly cases Statistical results In univariate analysis, cases and controls ... the cases resulted in a significant change in the univariate analyses for use of oral glucose-lowering drugs (cases 6.3%; controls 5.3%; p = 0.74) and for use of low molecular mass heparin (cases ... (8 cases (47%); 19 controls (38%); p = 0.51), non-selective NSAIDs (3 cases (18%); 10 controls Page of (page number not for citation purposes) In six patients no diagnostic procedure was performed...

Ngày tải lên: 09/08/2014, 10:20

... the cases and controls, 71% and 72%, respectively, are female; the mean age was 51 ± 13 years in cases and 54 ± 12 in controls Information about RF and anti-CCP antibody status was available for ... analysis SNP id Case/ control rs729749 Case CC 0.69 (256) CT 0.26 (95) TT 0.05 (18) Control CC 0.57 (141) CT 0.40 (98) TT 0.04 (9) Case AA 0.81 (244) AG 0.15 (46) GG 0.03 (10) Control AA 0.78 ... to obtain HWE P values for the case and control groups separately, each dataset was uploaded separately Single marker analysis Contingency tables were created for each SNP using the JMP 5.0 software...

Ngày tải lên: 09/08/2014, 10:21

... a bootstrap procedure [5] Statistical analyses were performed with SPSS for Windows, version 12.0.1 (SPSS, Chicago, IL, USA) Bootstrap analyses were performed using the software package S-plus ... in the controls than in the cases because insufficient numbers of controls could be found for some of the more senior patients Concomitant use of PPIs was significantly higher in the controls ... higher in the controls than in the cases (cases 14 (13.5%) and controls 77 (27.1%); p = 0.005) Use of selective COX-2 inhibitors was comparable (cases 17 (16.4%) and controls 50 (17.6%); p = 0.77)...

Ngày tải lên: 09/08/2014, 13:22

... non-parametric data Categorical data was compared by means of chi-squared or Fishers Exact tests Statistical analysis of data was performed using Prism for Mac (GraphPad Inc, California, USA) Patients ... responsible for conceiving and developing the study protocol; JZ & NB performed all EVH cases; KC, FM, BHK & NB conducted telephone interviews and collated data; BHK & JBB reviewed data and performed ... opted for a case- control study from a single surgeon in order to minimise the number of confounding factors introduced by different surgical techniques or management While the case and control...

Ngày tải lên: 10/08/2014, 09:22

... veno-venous ECLS for poisoning-related refractory hypoxemia, such as in Rona et al Journal of Medical Case Reports 2011, 5:231 http://www.jmedicalcasereports.com/content/5/1/231 cases of hydrocarbon, ... poisoning Consent Written informed consent was obtained from the patient for publication of this case report and any accompanying images A copy of the written consent is available for review by the Editor-in-Chief ... this article as: Rona et al.: Extra-corporeal life support for near-fatal multi- drug intoxication: a case report Journal of Medical Case Reports 2011 5:231 ...

Ngày tải lên: 10/08/2014, 23:21

... collected for cases only Information regarding the relationship to the deceased was collected for all informants The median number of days from death to informant interview was days for the cases: ... team For 129 subjects (66%) information was collected directly from the controls themselves Third party informants were interviewed for 65 controls (34%) Description of informants Of the 194 informants ... information (number of records inspected 53/194 for the cases and 38/194 for the controls) Statistical analyses The intended sample size was 200 cases and 200 controls This would have provided 85% power...

Ngày tải lên: 11/08/2014, 17:20

... among cases and controls Exposed Not exposed No indication Exposure Gender Controls/ cases n % n % n % Sitting Female Controls 261 86.2 28 9.2 14 4.6 Cases 367 83.8 60 13.7 11 2.5 Male Controls ... (separately for men and women) In the next step, to form the final model, constant items were transformed into categorical variables for better representation A further reason for the transformation ... 34 12.7 2.2 Cases 239 79.4 53 17.6 3.0 Female Controls 240 79.2 49 16.2 14 4.6 Cases 363 82.9 64 14.6 11 2.5 Male Controls 226 84.4 36 13.4 2.2 Cases 249 82.7 43 14.3 3.0 Female Controls 249...

Ngày tải lên: 12/08/2014, 12:20

... Criteria for case recruitment were: (a) firm clinical diagnosis of stable COPD, (b) airflow obstruction as indicated by a post-bronchodilator ratio of forced expiratory volume in one second over forced ... and FEV1 (before and after bronchodilator), and of single breath diffusing capacity of the lung for carbon monoxide (DLCO) Spirometry, and DLCO measurements were performed in conformity with ... preceding the study entry By study design, the controls were recruited to match the COPD patients on age and gender All the controls were current or former smokers with a smoking history ≥20 pack-years...

Ngày tải lên: 12/08/2014, 13:22

... volume * p < 0.05 for comparison of SScPAH+ with SScPAH-; † p < 0.05 for comparison of SScPAH+ with control. ‡ p < 0.05 for comparison of SScPAH- with control Page of (page number not for citation ... pulmonary function testing to form a control group for TLCO, Dm and Vc measurements Pulmonary function Static and dynamic lung volumes Forced expiratory flow in s (FEV1), forced vital capacity (FVC), ... of data, helped drafting the manuscript JWLP acquisition of data, interpreted the data AVN designed the manuscript, analysis and interpretation of data, draft of manuscript MDS analysed the data, ...

Ngày tải lên: 12/08/2014, 14:20

... use noisy data because we want to test the performance of the algorithms confronting noises, which is usually the case for real microarray data Another reason for the usage of noisy data is, we ... CBR classifier, each class contains one case- base For a testing case, we retrieve similar cases from each casebase, and combine the results of all the case- bases to provide a classification label ... retrieve 0.3|ω| cases from a case- base which contains |ω| cases The other two parameters, θ h and a, are data- dependent Therefore we adopted cross-validation to choose them After the whole data were...

Ngày tải lên: 12/08/2014, 17:20

... every 72 hours Available online http://ccforum.com/content/10/2/R45 Table Baseline characteristics for the overall population and for controls and cases with AT level below 70% Characteristic ... supplementation during the intervention period, and differed significantly from that of controls (95 ± 20% for cases, 55 ± 12% for controls; p = 0.001) During the intervention period, the median dose of AT ... adjusted for the severity of illness, mortality for patients treated with AT did not differ significantly from that calculated in control patients (the riskadjusted mortality rate was 1.1 for cases...

Ngày tải lên: 12/08/2014, 23:22