mtor pathway targeted therapy of non clear cell renal cell carcinoma
báo cáo khoa học: "Recent advances of novel targeted therapy in non-small cell lung cancer" pot
Ngày tải lên :
10/08/2014, 22:20
... and extracellular-signal regulated kinase kinase), ERK1 and ERK2 (extracellular-signal regulated kinase and 2) pathway leading to cell growth, the mTOR (mammalian target of rapamycin) pathway ... induction of apoptosis in cell lines with mutant EGFR [22] The combination of chemotherapy and TKI in some cases may cause a G1 arrest of growth that blocks the subsequent effects of chemotherapy ... with adenocarcinoma, and lifetime nonsmokers Also, the response rate was higher when 10 percent or more of tumor cells expressed EGFR The presence of EGFR gene mutations was not predictive of a survival...
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Báo cáo khoa học: "Glycogen-rich clear cell carcinoma of the breast" pps
Ngày tải lên :
09/08/2014, 07:21
... Figure cinoma of the kidney Clear- cell carcinoma of the breast, resembling clear- cell carClear -cell carcinoma of the breast, resembling clear- cell carcinoma of the kidney The lobular arrangement ... Mackenzie DH: Clear- cell carcinoma of the lung J Pathol Bact 1964, 87:25-27 Seo I, Tomich CE, Hull MT, Warfel KA: Clear cell carcinoma of the larynx: a variant of mucoepidermoid carcinoma Ann ... the benign clear cell (sugar) tumor, which contains abundant glycogen [10,11] and the clear carcinoma, which contains abundant mucin [12] Clear cell carcinoma of the larynx, a variant of mucoepidermoid...
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Báo cáo khoa học: " Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma" ppsx
Ngày tải lên :
09/08/2014, 10:20
... SAS/mp53 cells At a dose of Gy, the Figure BNCT Suppression of the colony formation of oral SCC cells by Suppression of the colony formation of oral SCC cells by BNCT SAS/neo and SAS/mp53 cells ... Suppression of the proliferation of oral SCC cells by BNCT To determine the effect of BNCT on the proliferation of cells, SAS/neo and SAS/mp53 cells were treated with BNCT at a dose of Gy After ... proliferation of oral SCC cells by BNCT Suppression of the proliferation of oral SCC cells by BNCT SAS/neo and SAS/mp53 cells were treated with BNCT, and cell viability was measured by the MTT assay The cell...
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Báo cáo khoa học: " Evalution of surface-based deformable image registration for adaptive radiotherapy of non-small cell lung cancer (NSCLC)" pptx
Ngày tải lên :
09/08/2014, 10:20
... during radiotherapy and radiochemotherapy will be required for further analysis of this important aspect of adaptive radiotherapy KB developed in-house software for voxel-based analysis of CT image ... the end of radiochemotherapy Comparison of CTplan and CTFU was performed for quantification of anatomical changes during the treatment Regarding the shape of the GTV, best visual results of the ... radiotherapy was combined with chemotherapy of cisplatin and oral vinorelbine; five additional patients were treated with the same radiotherapy and chemotherapy protocol Simultaneous chemotherapy...
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Báo cáo y học: "proteomic characterization of non-small cell lung cancer in a comprehensive translational thoracic oncology database" docx
Ngày tải lên :
10/08/2014, 09:22
... on the histological features of the tumor: small cell and non- small cell lung cancer NSCLC is the more common of the two sub-types of lung cancer, constituting 85% of cases [5,6] Furthermore, ... (4) Non- Specified 321 (24) (6) n/a Race Histology Adenocarcinoma 603 (46) 58 (55) 51 (66) Large Cell Carcinoma 75 (6) 18 (17) 15 (19) Squamous Cell Carcinoma 338 (26) 15 (14) 11 (14) NSCLC Non- Specified ... histology: adenocarcinoma (AC), squamous cell carcinoma (SqCC), and large cell carcinoma (LCC) To study the relationship between protein expression and survival in non- small cell lung cancer,...
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báo cáo khoa học: " Upregulation of microRNA-451 increases cisplatin sensitivity of non-small cell lung cancer cell line (A549)" pot
Ngày tải lên :
10/08/2014, 10:21
... percentage of apoptotic cells was calculated as the number of apoptotic cells per number of total cells × 100% The mock or stably transfected A549 cells were seeded into 96-well plates (6.0 × 103 cells/well) ... upregulation of miR-451 expression in A549/miR-451 cells (Figure 2B) Page of 11 Upregulation of miR-451 inhibits growth and enhances apoptosis of NSCLC cell line (A549) To analyze the effect of miR-451 ... enhancement in A549 cells Upregulation of miR-451 expression inactivates the Akt signaling pathway of A549 cells It has been reported that activation of the Akt signaling pathway can regulate...
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Báo cáo sinh học: "Silencing the epidermal growth factor receptor gene with RNAi may be developed as a potential therapy for non small cell lung cancer" pot
Ngày tải lên :
14/08/2014, 19:22
... time of transfection Lipofectamine 2000 was diluted in serum-free DMEM and mixed with dsRNA at a 1:2 ratio (4 µl of 20 µmol/L of siRNA formulated with µl of Lipofectamine 2000) The formulation of ... and SPC-A1 cells At a multiplicity of infection (MOI) of 10 and 72 hours after transduction, RNAi-mediated gene silencing of EGFR was apparent About 75% of A549 and 80% of SPC-A1 cells became ... 2002, 32:S3-9 Hansen HH: Treatment of advanced non- small cell lung cancer BMJ 2002, 325:452-453 Cridelli C: Targeted therapies in the treatment of non small cell lung cancer: Curr Opin Oncol 2004,...
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Báo cáo khoa học: "Use of serum squamous cell carcinoma antigen for follow-up monitoring of cervical cancer patients who were treated by concurrent chemoradiotherapy" pot
Ngày tải lên :
09/08/2014, 09:20
... operable squamous cell carcinoma of the cervix Eur J Cancer 2002, 38:1987-1991 Ngan HY, Chan SY, Wong LC, Choy DT, Ma HK: Serum squamous cell carcinoma antigen in the monitoring of radiotherapy treatment ... evidence of relapse Similarly, 10 of our patients had only once instance of elevated serum SCC-Ag, with normalization at subsequent follow-ups None of these 10 patients had any evidence of disease ... Hoshina M, Mochizuki M: Tumor-associated antigen, TA-4, in the monitoring of the effects of therapy for squamous cell carcinoma of the uterine cervix Serial determinations and tissue localization Cancer...
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báo cáo khoa học: "Antisense oligodeoxynucleotides targeting ATM strengthen apoptosis of laryngeal squamous cell carcinoma grown in nude mice" docx
Ngày tải lên :
10/08/2014, 10:21
... molecules of the phosphate backbone with sulfur Transfection of ODNs in Hep-2 cells Hep-2 cells at a density of × 105 cells/ml were plated in 6 -cell plates for overnight incubation Cells were ... inhibition of DNA-Dsb rejoining and radiosensitization of human non- small cell lung cancer (NSCLC) cell line [18] Leonard CE’s study showed that the Paclitaxel could enhance the radiosensitivity of squamous ... apoptotic index (AI) was calculated as the percentage of positive staining cells, namely AI = number of apoptotic cells × 100/total number of nucleated cells Statistics Results were expressed as mean...
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báo cáo khoa học: "Different patterns of NF-B and Notch1 signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma" ppt
Ngày tải lên :
10/08/2014, 10:21
... histoscore = (1 × percentage of weakly positive tumor cells) + (2 × percentage of moderately positive tumor cells) + (3 × percentage of intensely positive tumor cells) The histoscore was determined ... primary antibody Assessment of immunohistochemical staining Nuclear staining of NF-B and cytoplasmic staining of Notch1 and VEGF-C were scored in this study The intensity of NF-B, Notch1, podoplanin, ... a scale of 0-3 as follows: 0, negative; 1, light; 2, moderate; and 3, intense The percentage of positive tumor cells at each intensity level was presented as a ratio of the percentage of surface...
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Báo cáo khoa học: "Delayed diagnosis of oral squamous cell carcinoma: a case series" pdf
Ngày tải lên :
10/08/2014, 23:21
... histological examination of the biopsy specimen was a well-differentiated squamous cell carcinoma at the grade level On the basis of the clinical, radiological and histological evaluations of the lesion, ... 30 days of diagnosis to achieve improved outcomes [14] The results of a survey of North American radiation oncologists showed a consensus that delays in initiating radiation therapy of approximately ... stage, aggressive therapy, including surgery, radiotherapy and, if needed, chemotherapy may be used to treat patients with the worst prognoses [15] Conclusion In terms of quality of life, survival...
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báo cáo khoa học:" Distant metastases of a squamous cell carcinoma of the tongue in peripheral skeletal muscles and adjacent soft tissues" doc
Ngày tải lên :
12/08/2014, 01:22
... nutritional status of the patient were clearly reduced with a body mass index (BMI) of 15.6 kg/m2 (body weight of 40 kg and height of 1.60 m) The medical examination revealed the presence of bilateral ... they were clearly of metastasis in the right vastustissue window: Soft tissue Contrast enhanced CT, soft medialis/intermedius muscles Figure Contrast enhanced CT, soft tissue window: Soft tissue ... midhand and in the bones of the foot [5] As to our knowledge, no case has been reported up to date on the manifestation of distant metastases of a SCC in the soft tissue of the extremities In summary,...
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Báo cáo khoa học: "Clinical Analysis of stereotactic body radiation therapy using extracranial gamma knife for patients with mainly bulky inoperable early stage non-small cell lung carcinoma" pot
Ngày tải lên :
09/08/2014, 09:20
... stereotactic body radiation therapy in non- small cell lung cancer Journal of Thoracic Oncology: Official Publication of the International Association for the Study of Lung Cancer 2007, 13 van ... mortality of the patients with chemotherapy was 3.659 times higher than that of the patients without chemotherapy (p = 0.042) In these 13 patients receiving chemotherapy, the number of cases with ... Dosimetric evaluation of heterogeneity corrections for RTOG 0236: stereotactic body radiotherapy of inoperable stage I-II non- small -cell lung cancer International Journal of Radiation Oncology,...
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Báo cáo khoa học: " Absence of toxicity with hypofractionated 3-dimensional radiation therapy for inoperable, early stage non-small cell lung cancer" pot
Ngày tải lên :
09/08/2014, 10:21
... I non- small cell lung cancer Int J Radiat Oncon Biol Phys 2002, 52:1047-57 Qiao X, Tullgren O, Lax I, Sirzen F, Lewensohn R: The role of radiation therapy in treatment of stage I non- small cell ... Radiation therapy alone in early stage non- small cell lung cancer Semin Surg Oncol 2003, 21:91-97 Sibley GS: Radiation therapy for patients with medically inoperable Stage I non small cell lung carcinoma: ... symptom of distant metastases The optimal accelerated regimen of conformal 3-dimensional hypofractionated radiation therapy (3DHRT) for this group of patients is yet to be defined Hypofractionation...
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báo cáo hóa học:" Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences" doc
Ngày tải lên :
18/06/2014, 15:20
... Determination of the level of RNA products of the H19 gene The PCR reactions were carried out in 25 μl volumes in the presence of ng/μl of each of the forward and the reverse primers using 0.05 units/μl of ... RNA isolated from cells of ascites fluid of different patients determined by RT-PCR or by ISH Figure The level of H19 transcript in RNA isolated from cells of ascites fluid of different patients ... thirds of the cells and (+3) more than two thirds of cells (I-indicates the intensity of the signal, Q-indicates the quantity of signal) Some samples could not be analyzed due to lack of material...
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Báo cáo hóa học: " Fowlpox virus recombinants expressing HPV-16 E6 and E7 oncogenes for the therapy of cervical carcinoma elicit humoral and cell-mediated responses in rabbits" pot
Ngày tải lên :
18/06/2014, 16:20
... Tumour cell growth and regression Rabbits were injected i.d with a single dose of non- syngeneic VX2T tumour rabbit cells (107 cells in 200 μl of PBS-), containing the complete genome of CRPV ... (5'-GCA-TGA-CTC-AAA-AAA-CTT-AGCAAT-TCT-G-3') The target cells were confluent monolayers of SV40immortalised rabbit autologous skin cells (106 cells/5-cm Petri dish) infected with 10 PFU /cell of the FPE6 or FPE7 recombinants ... syngeneic Ag-specific SV40-immortalized target cells, and either expanded CTLs or fresh peripheral blood mononuclear cells (PBMCs) as effector cells Methods Cells Specific-pathogen-free primary chick...
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Báo cáo hóa học: " Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences" potx
Ngày tải lên :
18/06/2014, 16:20
... negligible in all of the cell lines All experiments were done in triplicates and the results expressed as mean and standard error In vitro targeted therapy The cells were cotransfected with μg of the LucSV40 ... bladder carcinoma cells were trypsinized to a single cell suspension and resuspended in PBS × 106 T24P cells or HT-1376 cells (in 150 μl volume) were subcutaneously injected into the back of female ... highly active in a variety of human cancers In this study we present an approach for targeted therapy of bladder carcinoma by driving the DTA expression under the control of IGF2-P4 and H19 regulatory...
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Báo cáo hóa học: " Detection of EGFR mutations with mutation-specific antibodies in stage IV non-small-cell lung cancer" pdf
Ngày tải lên :
18/06/2014, 16:20
... and small cell neuroendocrine carcinomas, squamous cell carcinoma and 69 adenocarcinomas, of which 55 showed a single pattern and 14 presented mixed aspects We further evaluated the adenocarcinoma ... smoker 45 58 Adenocarcinoma 69 88.4 Large -cell carcinoma Squamous cell carcinoma 7.1 1.4 Others 4.3 Glandular 36 52.2 Solid 20 29 Papillary 8.7 Sex Race Caucasian Smoker Histology Adenocarcinoma subtype ... Katherine Crosby (Cell Signaling Technology, Inc.) We received five slides of the H1975 cell line and five of the H1650 cell line with 4-μm sections for IHC analysis from the Cell Signaling Technology...
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Báo cáo hóa học: "Prognostic Impact of MiR-155 in Non-Small Cell Lung Cancer Evaluated by in Situ Hybridization" pot
Ngày tải lên :
18/06/2014, 16:20
... cell carcinoma; LCC, large -cell carcinoma; BAC, bronchioalveolar carcinoma Donnem et al Journal of Translational Medicine 2011, 9:6 http://www.translational-medicine.com/content/9/1/6 Page of ... the majority of patients were male (75%) The NSCLC tumors comprised 191 squamous cell carcinomas (SCCs), 95 adenocarcinomas (ACs), 31 large cell carcinomas and 18 bronchioloalveolar carcinomas ... most cores there was a mixture of stromal cells and tumor cells By morphological criteria only tumor cells were scored staining intensity Page of All samples were anonymized and independently scored...
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Báo cáo sinh học: "Comparisons of three polyethyleneimine-derived nanoparticles as a gene therapy delivery system for renal cell carcinoma" doc
Ngày tải lên :
18/06/2014, 19:20
... Hiraoka M: A tumorspecific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas Cancer Sci 2005, 5:288-294 31 Sudimack J, Lee RJ: Targeted drug delivery via ... methods [20], the renal cancer cell line, phagocytic cells and endothelial cells were used to detect the toxicity of three modified PEI-derived materials in vitro The OS-RC-2 cells were seeded ... half of cells were alive with 200 μg/ml 2-kD PEI treatment, while 60% cells had viability even exposed to more than 200 μg/ml of FAPEAs or HPEI Generally, for OS-RC-2 cells, the cytotoxicity of...
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