mri and novel contrast agents for molecular imaging

... genetically engineered forms (i.e., sfv, minibody, diabody, domaindeleted) that are under evaluation for imaging and therapeutic applications The valency and molecular weight of these mAb forms have been ... is a good candidate for imaging Studies are continuing with the panitumumab F(ab’)2 to further evaluate the role of panitumumab F(ab’) in radiological imaging, SPECT and PET, and also for its potential ... Authors’ contributions KJW performed the in vitro and in vivo studies KEB and KG carried out radiolabelings TN performed PET imaging and analysis MWB synthesized the chelate and participated in the...

Ngày tải lên: 21/06/2014, 02:20

... tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results Blood 2006, ... patients taking imatinib compared with 6.3 months for T315I mutations, 10.8 months for M351T mutations, 2.9 months for A-loop mutations and 8.7 months for other mutations [22] Additionally, of the ... Magistroni V, Andreoni F, Scapozza L, Formelli F, Gambacorti-Passerini C: In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imat- Page of (page number not for citation...

Ngày tải lên: 10/08/2014, 22:20

... http://www.comparative-hepatology.com/content/8/1/3 and feasible method for storage for further molecular analysis, and is in agreement with the findings of others for yeast, human renal and uterine myometrial tissues ... taken for medical and research purposes, are processed for histopathology including immunohistochemistry and RNA and protein isolation Since these diverse intentions require different fixation and ... contributions GH performed the biopsies and wrote the first draft of this manuscript JIJ performed the IHC and co-wrote the first draft of this manuscript BB and BAS did the molecular analysis...

Ngày tải lên: 13/08/2014, 13:20

... protein; and the iProLINK tool [55,56], which performs automated extraction of annotations for given protein names and provides information related to the organisms in which proteins are found and ... certain applications in bioinformatics [18] Although these tools are useful for many tasks, it is timeconsuming to use them for efficient searches and article selection, and such functions must be ... such as genes, proteins and drugs automatically and unambiguously within free text, over 50 information-extraction and text-mining tools have recently been implemented, and two community-wide...

Ngày tải lên: 14/08/2014, 14:21

... symmetric in shape and therefore they are not good candidates of second harmonic generation (SHG) The coupled dipole model was used to design and optimize a gold nano-helix for SHG For a given excitation ... Therefore external contrast agents like fluorescent dyes or nanoparticles are necessary These contrast agents should be small enough to be able to target cells The optical signature from these contrast ... signature from these contrast agents should be strong and it should allow for long term monitoring of the samples Hence there is a need for better contrast agent for nonlinear optical microscopy...

Ngày tải lên: 09/09/2015, 18:50

... backbones for a 1D molecular electronic material Backbones for 2D and 3D molecular electronics are similar to 1D’s HS HS HS SH n (a) SH n (b) SH (c) Scheme 1.1 Representative structures for 1D molecular ... excitation wavelength of 233 nm for 9, 237 nm for 10, 282 nm for 11 and 279 nm for 12, respectively They all have weak PL and emit light in the blue-violet (370-420 nm) region UV and PL data show that ... known for organic materials For example, in the liquid state, the refractive index at room temperature at the sodium D line (589 nm) nD is 1.43 for octane and tetradecane, 1.49 for toluene and...

Ngày tải lên: 16/10/2015, 15:38

... amount of the diagnostic agents loaded, vibrating sample magnetometer and superconducting quantum interference device for magnetization and magnetic resonance imaging (MRI) for contrast efficiency ... improved contrast effect for both in vitro and ex vivo MR images Therefore these nanoparticles could become a potential contrast agent for MRI QDs loaded poly(D, L-lactide-co-glicolide) (PLGA) and ... potential fluorescent probe for cellular and biomolecular imaging VII List of Tables Table TR and TE for r2 and r2* relaxivity measurements 31 Table Properties of IOs and IOs loaded PLGA-mPEG...

Ngày tải lên: 26/11/2015, 22:40

... CELLULAR AND MOLECULAR IMAGING 1.1 EMERGENCE OF CELLULAR AND MOLECULAR IMAGING 1.2 CELLULAR AND MOLECULAR IMAGING MODALITIES 1.2.1 Biomarkers 1.2.2 Molecular Imaging Probes ... Optical imaging provides very high spatial and temporal resolution for genomic and proteomic studies, PET and SPECT enables functional imaging while MRI and US contribute the horsepower for in-vivo ... the source of contrast in MR imaging and is the reason for its superiority in in-vivo visualization of soft tissue (109-111) In molecular and cellular imaging, the use of MR contrast agents exploits...

Ngày tải lên: 11/09/2015, 10:01

... used ligand in molecular imaging as it outperforms other agents in the ability to form complexes with a large number of transition and lanthanide metal ions with high thermodynamic stability and ... resonance imaging [Gd(Ⅲ), Eu(Ⅲ)], nuclear imaging[ 111In(Ⅲ), 68Ga(Ⅲ), 64/67 Cu(Ⅱ)], and therapeutic radiopharmaceuticals [90Y(Ⅲ), 177 Lu(Ⅲ)] Low molecular- weight contrast agents for MRI, such ... may yield improved contrast and low detection limit x Chapter Chapter 1.1 Introduction Introduction Metal Complex for MRI or PET Molecular imaging is one of the most exciting and rapidly growing...

Ngày tải lên: 16/10/2015, 11:57

... is set to 1.0 for the purpose of local contrast preservation and is set to -1.0 for the purpose of local contrast enhancement Therefore, expression (10), referred to as the general form of SDRCLCE ... local contrast preservation based on the concept of local contrast range transform Although this method performs well for enhancement of LDR images, the image enhancement procedure is transformed ... Michelson or Weber contrast formula [20] In this article, the Weber contrast formula is utilized to derive the condition of local image contrast preservation Let I in (x, y) and I avg (x, y),...

Ngày tải lên: 20/06/2014, 22:20

... is set to 1.0 for the purpose of local contrast preservation and is set to -1.0 for the purpose of local contrast enhancement Therefore, expression (10), referred to as the general form of SDRCLCE ... local contrast preservation based on the concept of local contrast range transform Although this method performs well for enhancement of LDR images, the image enhancement procedure is transformed ... Michelson or Weber contrast formula [20] In this article, the Weber contrast formula is utilized to derive the condition of local image contrast preservation Let I in (x, y) and I avg (x, y),...

Ngày tải lên: 21/06/2014, 00:20

... the increase both in relaxivity and in specificity Therefore, studies on molecular contrast agents special for liver with relatively longer metabolic time and stable contrast effect in liver tissue ... obtain the nanocomplexes as contrast agent for molecular MRI The formulation was tested for physical parameters such as particle size, zeta potential, image contrast effect, and the stability in human ... relaxivity and specificity The carriers including proteins [3], dendrimers [4, 5], linear polymers [6, 7], and micelles [8] have been proposed and evaluated as molecular MRI contrast agents DTPA...

Ngày tải lên: 22/06/2014, 00:20

... homogeneity and Corresponding Author, Professor, Department of Statistics Biotechnology - Molecular Studies and Novel Applications for Improved Quality of Human Life uniformly distributed, and then ... vinelandii and Azomonas agilis, but the problems of segregation and mutant stability remained, despite their nitrogen-fixation 16 Biotechnology - Molecular Studies and Novel Applications for Improved ... 200 rpm Experiments were performed in triplicate For A vinelandii, almost no ammonium accumulation was 20 Biotechnology - Molecular Studies and Novel Applications for Improved Quality of Human...

Ngày tải lên: 28/06/2014, 15:20

... for hSGLT1 and 10 µM for hSGLT2, while thioglycoside VII showed IC50 values of 15 µM for hSGLT1 and 88 µM for hSGLT2 These data confirm the strong inhibitory effects of thioglycoside I and VII on ... µM for hSGLT1 and from 10 µM to 88 µM for hSGLT2 The values obtained by the thioglycosides were similar to those obtained with phlorizin, which were equivalent to 42 µM and 28 µM for hSGLT1 and ... [(A460/A580)/(I460/I580)], where A and I represent the readings after or before addition each thioglucoside, respectively For I, the readings Int J Med Sci 2007, from 2-5 sec were averaged; and for A, readings...

Ngày tải lên: 26/10/2012, 10:04

... 1247 Coalition for Affordable Housing and the Environment 483 Coalition for Affordable Housing and the Environment 1160 Coalition for Auto Insurance Competition 365 Coalition for Natural Health ... REPRESENTED ORGANIZATIONS AND THEIR LEGISLATIVE AGENTS BY REGISTRATION NUMBER FOR THE THIRD QUARTER 2002 CLIENT ORGANIZATION NAME AGENT REGISTRATION NUMBER Forbes Inc 360 Ford Motor Co 1187 Foster ... Cendant Corp 551 Cendant Corp 1224 Center for Energy & Economic Development The 1077 Center for Family Guidance 868 Center for International Education 1244 Center for Non-Profit Corp Inc 682 Central...

Ngày tải lên: 16/02/2014, 10:20

... of microtubules and intermediary filaments, as well as keratin and 15 We also looked for genes involved in cell adhesion and migration and found integrin alpha 3, integrin beta and intercellular ... hematoxylin-eosin stains and confirmed by immunohistochemical staining looking for pan-cytokeratin, cytokeratin and 7, chromogranin A, synaptophysin and tissue-transcripion-factor1 For validation of ... vs NT and SCLC vs NT was 2.2, 2.1 and 3.2-fold, respectively); collagen, type I, alpha (overexpression in AC vs NT, SCC vs NT and SCLC vs NT was 7.98, 3.24 and 2.4-fold, respectively) and mesoderm...

Ngày tải lên: 18/06/2014, 15:20

... implementation of a stand alone H.264 q-pel MC on FPGA has shown speeds between 95.9 fps for HD1080p frames, 229 fps for HD 720p and between 2502 and 12623 fps for CIF and QCIF formats Keywords: ... has been used A stand alone H.264 q-pel MC block has achieved speeds between 95.9 fps for HD1080p frames, 229 fps for HD 720p and between 2502 and 1262 fps for CIF and QCIF formats These results ... image formats, the framerate is considerably higher: between 12623 fps for QCIF and 2502 fps for CIF format The bandwidth toward the memory is visibly improved by an optimal data arrangement and...

Ngày tải lên: 18/06/2014, 22:20

... experimentations and drafted the manuscript GT performed the statistical analysis MG carried out the plasmid and viral construction MP designed the molecular construction SB and MP conceived of, designed and ... used for all cloning steps, and introduced into A tumefaciens C58 MP90 by electroporation Transformed A tumefaciens colonies were plated and cultivated at 28°C on LB medium containing kanamycin and ... sequenced Phenotypic effect of mutations The IR-, AC1- and AC3-mutants, and one of the AV1mutants were tested For each mutant, virus accumulation and its effect on the total dry weight of the infected...

Ngày tải lên: 20/06/2014, 01:20

... implementation of a stand alone H.264 q-pel MC on FPGA has shown speeds between 95.9 fps for HD1080p frames, 229 fps for HD 720p and between 2502 and 12623 fps for CIF and QCIF formats Keywords: ... has been used A stand alone H.264 q-pel MC block has achieved speeds between 95.9 fps for HD1080p frames, 229 fps for HD 720p and between 2502 and 1262 fps for CIF and QCIF formats These results ... image formats, the framerate is considerably higher: between 12623 fps for QCIF and 2502 fps for CIF format The bandwidth toward the memory is visibly improved by an optimal data arrangement and...

Ngày tải lên: 20/06/2014, 04:20

... been used A stand alone H.264 q-pel MC block has achieved speeds between 95.9 fps Page of 12 for HD1080p frames, 229 fps for HD 720p and between 2502 and 1262 fps for CIF and QCIF formats These ... Agency for Innovation by Science and Technology in Flanders (Agentschap voor Innovatie door Wetenschap en Technologie in Vlaanderen) for funding the Vampire project and Alcatel Lucent-Bell (ALU) for ... proposed implementation is able to perform H.264 q-pel MC at speeds between 229.9 fps HD720p and 95.5 fps for 1080p frames and between 12623 and 2187.7 fps for QCIF and CIF, respectively The proposed...

Ngày tải lên: 20/06/2014, 21:20