mouse the model organism of choice
Báo cáo y học: "GWASs and the age of human as the model organism for autoimmune genetic research" doc
Ngày tải lên :
09/08/2014, 20:21
... remains: what is the most appropriate scientific approach to understand function of risk alleles discovered in human genetics research? Is the mouse the most appropriate model organism, or these genetic ... critical, as the region of LD surrounding the associated SNP often contains more than one gene (although often there is one likely candidate gene from the known biology) A region of LD includes ... levels of risk to SLE There is an approximately twofold increase in the level of risk between carriers of the highest and lowest risk haplotypes Second, candidate genes from a region of LD can...
- 7
- 407
- 0
The joint effects of choice assortment and regulatory focus on choice behavior
Ngày tải lên :
16/10/2015, 15:38
... making the correct choice from the assortment and their level of preference for making a choice from the assortment will decrease with increase in size of the assortment However, the confidence of ... confidence of the promotion focused consumers about the correctness of their choice decision This increased confidence level of the promotion focused consumers on the correctness of their choice decision ... making the correct choice from the assortment increases, this increased confidence level of the prevention focused consumers on the correctness of their choice decision with the increase in size of...
- 108
- 233
- 0
báo cáo hóa học: " Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson''''s disease" pptx
Ngày tải lên :
19/06/2014, 22:20
... as the sum of the distance measured (in centimeters) across the 30-min recording period Vertical activity is quantified as the sum of the number of vertical photobeam interruptions across the ... relative to the Nissl-stained sections (Fig 1C &1D or Fig 2C &2D) of the same mouse brain The Pearson correlation matrix shows the graphic representation of pooled data values for the number of TH- ... the HT mouse performance was between that of the WT and the KO mice The sensitivity of this assay may be suboptimal due to a ceiling effect from the maximum trial length of 150 seconds, the ability...
- 16
- 468
- 0
Báo cáo y học: "The role of Qa-2, the functional homolog of HLA-G, in a Behcet''''s disease-like mouse model induced by the herpes virus simplex" pptx
Ngày tải lên :
11/08/2014, 03:20
... response, but rather to down-regulation of Qa-2 In addition, the present results showed that the injection of Qa-2 Figure The frequency of NK cells in BD and BDN mice The frequency of NK cells was ... Lee et al., The role of Qa-2, the functional homolog of HLA-G, in a Behcet's disease-like mouse model induced by the herpes virus simplex Journal of Inflammation 2010, 7:31 Page 12 of 12 ... the design of the study and discussion of data analysis SS conceived of the study, participated in its design and coordination, and helped draft the manuscript All authors read and approved the...
- 12
- 287
- 0
Anti inflammatory effects of inhibitors of the NF kb pathway in the mouse asthma model
Ngày tải lên :
11/09/2015, 16:03
... promote the synthesis and secretion of numerous proteins into the extracellular matrix The thickening of the subepithelia basement membrane has also been shown to be related to the infiltration of ... al., 2007) Epithelium serves as the main barrier for the airways; abnormal barrier function of the epithelium has been linked to high incidences of asthma, suggesting the role of epithelium dysfunction ... inhibition, but there might be other mechanisms for this drug The major limitation of theophylline is its narrow therapeutic index Therefore, theophylline is now considered as the second-line therapy...
- 206
- 266
- 0
Patterns of hippocampal neuronal loss and axon reorganisation of the dentate gyrus in the mouse pilocarpine model of temporal lobe epilepsy
Ngày tải lên :
11/09/2015, 16:04
... diameter of 3–5μm located at the end of the collaterals) with the proximal dendrites of mossy cells, the basal dendrites of the DG basket cells, and other unidentified neurons (Ribak et al., 1985) The ... exist in these hypotheses of epilepsy on the role of the dentate gyrus in epileptogenesis Due to variations of neuropathological changes, each of them has its limitations, such as neglection of differently ... distinctive feature of the HIPP cells is the distant distribution and copious innervation of their axon plexus, extending to about 35% of the whole septotemporal length of DG Many of the HIPP cells...
- 162
- 596
- 0
The effects of bilirubin in the dextran sulfate sodium (DSS) mouse colitis model
Ngày tải lên :
28/01/2016, 10:25
... compared to other animal models of colitis, the DSS-induced colitis model has some advantages Only changing the concentration of administration of DSS and cycle in rats and other strains of mice, ... enzymes, are the major source of heme for bile pigment synthesis (Schmid R et al., 1975) The catabolism of heme occurs in the cells of the reticulo-endothelial system both liver and spleen From the body ... presence of DSS in the epithelial cells of the proximal renal tubules after days of DSS treatment is an indication of the excretion process of absorbed DSS In this study, we showed that the severity...
- 74
- 487
- 0
Application of house’s model for translation quality assessment in assessing the english version of the vietnam’s law on investment no. 59/2005/qh11
Ngày tải lên :
07/11/2012, 14:36
... 247), or for the discovery of ‘mismatches’ between the TT and the ST on the same three levels 2.1.2 Operation of the model A key concept in the operation of House’s model is the context of situation ... Translation of legal documents 24 CHAPTER APPLICATION OF HOUSE’S MODEL FOR TRANSLATION QUALITY ASSESSMENT 2.1 Presentation of the model 27 27 2.1.1 An overview of the model 27 2.1.2 Operation of the model ... statement of function of the ST is made, including the ideational and interpersonal component of that function A similar profile and statement of function is made of the TT The TT profile is compared...
- 86
- 896
- 5
The simple economics of easter island a ricardo malthus model of renewable resource use
Ngày tải lên :
13/12/2013, 11:36
... Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited without ... permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited without ... permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited without...
- 20
- 378
- 0
Tài liệu The OSI Model: Understanding the Seven Layers of Computer Networks ppt
Ngày tải lên :
24/01/2014, 09:20
... Protocols, or rules, can their work in either hardware or software or, as with most protocol stacks, in a combination of the two The nature of these stacks is that the lower layers their work in hardware ... standards for this layer Note: The Physical Layer of the OSI model is only part of a LAN (Local Area Network) Layer – The Data Link Layer Layer of the OSI model provides the following functions: • ... vendor supports them The main benefits of the OSI model include the following: • Helps users understand the big picture of networking • Helps users understand how hardware and software elements...
- 11
- 542
- 0
Tài liệu Báo cáo khoa học: Minor capsid proteins of mouse polyomavirus are inducers of apoptosis when produced individually but are only moderate contributors to cell death during the late phase of viral infection ppt
Ngày tải lên :
16/02/2014, 09:20
... as a control of sample loadings Discussion In the present work, the cytotoxic properties of the minor structural proteins (VP2 and VP3) of the MPyV were studied in the absence of other virus components ... levels of apoptotic markers during the late stages of MPyV infection However, comparison of the levels of apoptotic markers and cytotoxicity during the replication of wt MPyV, and replication of the ... (described by Rainey-Barger et al [14]) The addition of EGFP sequences to either the N-terminus or the C-terminus of the minor proteins improved the efficiency of transfection ⁄ expression markedly...
- 14
- 539
- 0
Tài liệu Báo cáo khoa học: "Enhanced word decomposition by calibrating the decision threshold of probabilistic models and using a model ensemble" pdf
Ngày tải lên :
20/02/2014, 04:20
... unsupervised algorithms The purpose of this paper is an analysis of the underlying probabilistic models and the types of errors committed by each one Furthermore, it is investigated how the decision threshold ... say that our models describe the process of word generation from the left to the right by alternately using two dice, the first for deciding whether to place a morpheme boundary in the current ... boundaries than in the opposite direction with a net increase of 0.0819 of correct boundaries which led to the increased recall Since the deduction of precision is less than the increase of recall, a...
- 9
- 557
- 0
Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc
Ngày tải lên :
21/02/2014, 03:20
... CCAAT box at 324 bp upstream of the major transcription start site The presence of a CCAAT box and the absence of a TATA box seem to be one of the characteristics of the mouse integrin a3 gene We ... previously reported the structures of the mouse a3 integrin subunit gene including the exon/intron organization and the alternative exon usage for the generation of variants of the a3 subunits (a3A ... (where A/C is the transcription start site) The role of the sequence containing CCT is unknown but it might play a role in the initiation of transcription The active promoter region of the mouse integrin...
- 9
- 562
- 0
Báo cáo " PRELIMINARY ASSESSMENT AND SIMULATION OF THE WATER QUALITY OF CAU RIVER, BAC NINH PROVINCE BY MATHEMATICAL MODEL " pptx
Ngày tải lên :
05/03/2014, 10:20
... standard of Vietnam (TCVN 5942/95/B) [4, 9] The two reasons for this situation are the discharges of cattle waste into channels then to river and the uses of fertilizer The concentrations of DO, ... decrease toward the downstream This proves quite good self-purification ability of Cau River 3.2 Modeling water quality of Cau River by QUAL2E The Enhanced Stream Water Quality Model (QUAL2E) ... finite-difference solution of the advective-dispersive mass transport and reaction equations The model is intended for using as a water quality planning tool [5] The modeling procedure included:...
- 5
- 433
- 0
Báo cáo khoa học: Investigating the role of the invariant carboxylate residues E552 and E1197 in the catalytic activity of Abcb1a (mouse Mdr3) docx
Ngày tải lên :
07/03/2014, 06:20
... cleavage of the c-phosphate does occur in the NBD with the mutation at the IC [36,38,39] Moreover, these and other studies suggest that the IC residues are involved in the formation of the NBD ... activates the attacking water molecule that cleaves the terminal phosphate of bound ATP In the latter model, the IC is part of a catalytic dyad, along with the histidine residue of the H-loop, ... sequence contacts the c-phosphate of the bound nucleotide across the dimer [15] and the aromatic residue of the A-loop Abcb1a catalytic mechanism stacks against the adenine moiety of bound nucleotide...
- 13
- 458
- 0
Báo cáo khoa học: Two short protein domains are responsible for the nuclear localization of the mouse spermine oxidase l isoform pdf
Ngày tải lên :
07/03/2014, 17:20
... SMOs Molecular modeling of the 3D structure of the mSMOl isoform was thus carried out in order to test the hypothesis that the 277–307 region and the protein domain encoded by the exon VIa could ... mammalian-specific function of SMO (e.g nuclear targeting of the mSMOl isoform) Inspection of the mSMOl modelled structure (Fig 2) indicates that both regions are located on the tip of the FAD-binding domain, ... targeting to the nucleus Fig Stereo representation of the modelled 3D structure of the mouse spermine oxidase catalytically active splice variant, mSMOl The molecular surface of the protein is...
- 8
- 413
- 0
Báo cáo khoa học: The influence of cold shock proteins on transcription and translation studied in cell-free model systems pdf
Ngày tải lên :
07/03/2014, 21:20
... from the data of [17] b 4694 Note that the values obtained not critically depend on the other free parameters of the model, a property of the used function On the other hand, this means that the ... Inuence of CSPs on transcription and translation R Hofweber et al In detail, the CSP of the hyperthermophilic organism T maritima has no signicant effect up to a concentration of Ê 100 lm, then the ... in the Experimental procedures; 10 lL of the reaction volume were subjected to SDS PAGE The difference in expression level of the two versions of H-Ras is shown in Fig The synthetic sequence of...
- 12
- 487
- 0
Báo cáo khoa học: "Techniques to incorporate the benefits of a Hierarchy in a modified hidden Markov model" pptx
Ngày tải lên :
08/03/2014, 02:21
... rewrite the bracketing rule by calculating the dependency of each possible phrase The outcome of this restructuring is to reduce the complexity of the hierarchical structure and reduce the number of ... This is modelled by making them share the same sub-models Using a HHMM allows for the merging of repeated parts of the structure, which results in fewer states needing to be identified—one of the ... of the sentence, and the right hand side shows the transformed structure The model s hierarchy is reduced by one level, where the state P ∗ has become a sub-state of state S instead of N ∗ The...
- 8
- 528
- 0
Báo cáo " MODEL OF CONDUCTIVITY FOR PEROVSKITES BASED ON THE SCALING PROPERTY OF GRAIN BOUNDARY " ppt
Ngày tải lên :
14/03/2014, 13:20
... temperature-independent part of the boundary resistivity whereas the ρ1 to the temperature-dependent part The problem was not, however, the determination of n, D or D but their physical foundation The procedures ... the ratio lG = LS /LA of the linear extents LS , determined on the basis of the grain domain perimeter G − length (in unit of image size) and LA , determined on the basis of the grain domain area ... moment there is no way to prove that D really corresponds to the true boundary resistivity For the purpose of the first approximation, we must adopt the asumption that the D, estimated by the procedure...
- 8
- 324
- 0