most common paraneoplastic syndrome in small cell lung cancer

Ngày tải lên: 10/08/2014, 23:22

... following scoring, as previously described [14]: 0 = negative or faint staining in <10% of tumor cells; 1 = weak staining in >10% of cancer cells; 2 = moderate staining; 3 = strong staining. A ... domain. Clin Transl Oncol 2010, 12:75-80. 9. Gazdar AF: Activating and resistance mutations of EGFR in non -small- cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors. Oncogene ... of detecting EGFR mutations in lung cancer patients. Methods: EGFR mutation status was analyzed by DNA assays, and compared with IHC results in five non -small- cell lung cancer (NSCLC) cell lines...

Ngày tải lên: 18/06/2014, 16:20

... DNA in blood circulation may act as a risk marker of lung cancer in Taiwan. Cancer 2003, 97:1558-1563. 11. Klein F, Amin Kotb WF, Petersen I: Incidence of human papilloma virus in lung cancer. Lung ... in lung tumor cells but not in the adjacent noninvolved lung tissue [9]. HPV 16/18 have been detected in t he blood of women with cervical infection suggesting that HPV 16/18 can infect the lung ... varia- tions. In the United States, HPVs DNA is found in about 20-25% of lung cancers [8]. The most common strains found are HPV 16 and HPV 18, the same strains that are commonly found in cervical cancer. ...

Ngày tải lên: 18/06/2014, 16:20

... being exploited in cancer, attempting to modulate their expression, rein- troducing microRNAs lost in cancer, or inhibiting onco- genic microRNAs by using anti-micro oligonucleotides [38]. In ... Al-Saad S, Al-Shibli K, et al: Inverse prognostic impact of angiogenic marker expression in tumor cells versus stromal cells in non small cell lung cancer. Clin Cancer Res 2007, 13:6649-57. 24. ... lymphocyte infiltration in non -small cell lung cancer. Clin Cancer Res 2008, 14:5220-7. 30. Andersen S, Eilertsen M, Donnem T, et al: Diverging prognostic impacts of hypoxic markers according to...

Ngày tải lên: 18/06/2014, 16:20

... gefitinib in non -small cell lung cancer cell lines. Mol Cancer Res. 2006; 4(8): 521-8. 102. Taguchi F, Solomon B, Gregorc V, et al. Mass spectrometry to classify non -small- cell lung cancer ... expression in non -small cell lung cancer Is correlated with survival. Clin Cancer Res. 2001; 7(7): 1850-5. 93. Cappuzzo F, Gregorc V, Rossi E, et al. Gefitinib in pretreated non -small- cell lung cancer ... ifosfamide in patients with advanced non -small- cell lung cancer previously treated with platinum-containing chemotherapy regimens. The TAX 320 Non -Small Cell Lung Cancer Study Group. J Clin Oncol....

Ngày tải lên: 08/08/2014, 17:20

... Access Pathological complete response induced by first-line chemotherapy with single agent docetaxel in a patient with advanced non small cell lung cancer Ferdinando Riccardi 1* , Giuseppe Di Lorenzo 1 , ... Scagliarini 1 , Florinda Scognamiglio 1 , Marilena Di Napoli 1 , Giacomo Carteni’ 1 Abstract Background: Defining the optimal treatment for patients with inoperable non small cell lung cancer ... discourage to continue treatment. Introduction In non -small cell lung cancer (NSCLC), mediastinal lymphnode involvement comprises a wide spectrum of severity. In fact, while 9% of patients with...

Ngày tải lên: 09/08/2014, 03:21

... versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non -small- cell lung cancer. J Clin Oncol 1999, 17:2692-2699. 3. Komaki ... radiochemotherapy with vinorelbine plus cisplatin or carboplatin in patients with locally advanced non -small- cell lung cancer (NSCLC) and an increased risk of treatment complications: Preliminary results. ... chemotherapy and IMRT [21]. More clinical evidence on using IMRT in treating lung cancer is needed. We started using IMRT to treat lung cancer in 2005, and we evaluated clinical and dosimetric factors...

Ngày tải lên: 09/08/2014, 08:23

... indicated in these patients, though prospective clinical studies are needed. Keywords: Stereotactic Body Rad iotherapy, Oligometastases, Non -Small Cell Lung Cancer Background Non -small cell lung ... from NSCLC to any organ(s), including brain, bone, liver,orlungwereincludedin this study. Only patients with biopsy-proven NSCLC were included. Those with prior curative-intent treat- ment of metastatic ... control rates of 60-90% have been reported for metastatic tumors involving spine, lung, and liver [16-20]. In this study, patients with initial stage IV NSCLC treated with aggressive local therapy...

Ngày tải lên: 09/08/2014, 09:20

... I non -small cell lung cancer. Radiother Oncol 2007, 85:429-434. 39. Sinha B, McGarry RC: Stereotactic body radiotherapy for bilat- eral primary lung cancers: the Indiana university experience. Int ... using tumour based image guided posi- tion verification and correction [31]. In addition, small delineation uncertainties will exist. Thus, a minimum of 3 mm ITV to PTV margin is required in ... motion into account. However, similar to the reasoning given for the ITV to PTV margin, a minimum margin of 3 mm should be used for the incorporation of the other uncertainties. Organs at risk definition Dose...

Ngày tải lên: 09/08/2014, 09:22

... Jeremic B: Report from the international atomic energy agency (IAEA) consultants' meeting on elective nodal irradiation in lung cancer: non -small cell lung cancer (NSCLC). Int J Radiat Oncol Biol ... irradiation be omittd in Stage III non -small cell lung cancer? An analysis of recur- rences in a phase II study of induction chemotherapy and involved-field radiotherapy. Int J Radiat Oncol Biol ... MK, Macapinlac H, Komaki R, Cox JD: Intrathoracic patterns of fail- ure for non -small- cell lung cancer with position-emission tomography/computed tomography defined target delinea- tion. Int J Radiat...

Ngày tải lên: 09/08/2014, 09:22

... suggesting long-lasting learning experiences in clinical trials. As the need for immediate monitoring was described by Schaake-Koning et al. [9] from a quality control study in the EORTC lung cancer ... least 1 cm margin around the clinical target volume (CTV); and interfraction interval of 6 hours or longer. Dose constraints were defined in regards to the spinal cord and the lung. The QA assessment ... at the beginning of this trial. Dose constraints were defined in regard to the dose to the spinal cord and the lung. The dose to the spinal cord was kept at ≤ 36 Gy. A posterior spinal shield...

Ngày tải lên: 09/08/2014, 09:22

... purposes) Background Worldwide and in Europe lung cancer is the most com- mon cause of cancer related-death with an increasing inci- dence each year. The majority of patients has Non -Small Cell Lung Cancer (NSCLC) ... versus sequential thoracic radiotherapy in combination with mito- mycin, vindesine, and cisplatin in unresectable stage III non- small- cell lung cancer. J Clin Oncol 1999, 17:2692-2699. 19. Martel ... GD, Bartelink H: Feasibility of escalating daily doses of cisplatin in combination with accelerated radi- otherapy in non -small cell lung cancer. Eur J Cancer 1996, 32A:1314-1319. 7. Uitterhoeve...

Ngày tải lên: 09/08/2014, 10:21

... cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non -small- cell lung cancer: Four-Arm Cooperative Study in Japan. ... Miyaoka E: The Japanese Joint Committee of Lung Cancer Registry. Prognosis of 6644 resected non -small cell lung cancers in Japan: a Japanese lung cancer registry study. Lung Cancer 2005, 50:227-34. 11. ... R, Postmus PE, Rusch V, Sobin L: International Association for the Study of Lung Cancer International Staging Committee; Participating Institutions. The IASLC Lung Cancer Staging Project: proposals...

Ngày tải lên: 10/08/2014, 09:22

... new cases of lung cancer are diagnosed each year [1]. About 85% of lung cancer are non -small cell lung cancer (NSCLC), including adenocarcinoma, squamous cell, and large cell carcinoma [2], and ... Clinical Bioinformatics 2011, 1:6 http://www.jclinbioinformatics.com/content/1/1/6 Page 6 of 6 REVIE W Open Access RNA interference against polo-like kinase-1 in advanced non -small cell lung cancers Eri ... trials of RNAi therapies against cancers are ongoing. In this article, we discuss the most recent findings concerning the administration of siRNA against polo- like kinase-1 (PLK-1) to liver metastatic...

Ngày tải lên: 10/08/2014, 09:22

... staining compares the relative intensity of staining of onecoreofaTMAtothatofacontrolcoreonthe same slide. A score of 1 indicates faint staining, 2 indi- cates medium intensity staining, and 3 indicates ... entered into the database. Patients with non -small cell lung cancer comprise the majority of cases annotated within the database. Other cancers contained in the database include small cell lung cancer, mesothelioma, ... the histological features of the tumor: small cell and non -small cell lung cancer. NSCLC is the more common of the two sub-types of lung cancer, constituting 85% of cases [5,6]. Further- more,...

Ngày tải lên: 10/08/2014, 09:22

... actually included in the com- bined small cell lung carcinomas according to WHO more recent classification [11,13]. Thus it seems more logical to offer surgery in mixed or combined small cell tumors. 3. ... Norstein J: Small cell lung cancer in Norway Should more patients have been offered surgical therapy? Eur j Cardi- othorac Surg 2004, 26:782-786. 18. Leo F, Pastorino U: Surgery in small cell lung ... Aam- dal S, Norwegian Lung Cancer Study Group: Cisplatin and etopos- side regimenis superior to cyclophosphamide, epirubicin and vincristine regimen in small cell lung cancer: results from a randomized...

Ngày tải lên: 10/08/2014, 10:20

Ngày tải lên: 10/08/2014, 10:20

Ngày tải lên: 10/08/2014, 10:21

Ngày tải lên: 10/08/2014, 10:21

Ngày tải lên: 10/08/2014, 10:21