monitorization of response to treatment with imatinib of a rectal gist

... and oxidative capacity in cancer cells Cancer Res 2004, 64:985-993 35 Tomiyama A, Serizawa S, Tachibana K, Sakurada K, Samejima H, Kuchino Y, Kitanaka C: Critical role for mitochondrial oxidative ... mechanism of 5-FU mediated cell death Flow cytometric analysis of plasma membrane exposure of phosphatidylserine (detected using an annexin VFITC assay) was used as an index of apoptotic (annexinpositive) ... observed that treatment of cells with 3BrP or IA was associated Sánchez-Aragó and Cuezva Journal of Translational Medicine 2011, 9:19 http://www.translational-medicine.com/content/9/1/19 IA C 100...

Ngày tải lên: 18/06/2014, 19:20

... and oxidative capacity in cancer cells Cancer Res 2004, 64:985-993 35 Tomiyama A, Serizawa S, Tachibana K, Sakurada K, Samejima H, Kuchino Y, Kitanaka C: Critical role for mitochondrial oxidative ... mechanism of 5-FU mediated cell death Flow cytometric analysis of plasma membrane exposure of phosphatidylserine (detected using an annexin VFITC assay) was used as an index of apoptotic (annexinpositive) ... observed that treatment of cells with 3BrP or IA was associated Sánchez-Aragó and Cuezva Journal of Translational Medicine 2011, 9:19 http://www.translational-medicine.com/content/9/1/19 IA C 100...

Ngày tải lên: 20/06/2014, 03:20

... broad IBS has historically been viewed as a diagnosis of symptom-based rather than as a primary diagnosis However, for a variety of reasons, the diagnosis of IBS is not an easy task compared with ... that IBS patients with bloating have impaired intestinal handling of gas loads (Caldarella et al, 2002; Serra et al, 2001) Gas transit is tuned by a series of reflexes acting at various sites of ... demonstrated that a dystonic response of the abdominal wall to intraabdominal volume increments in patients with bloating compared with healthy subjects (Azpiroz &Malagelada, 2005) Moreover, Tremolaterra...

Ngày tải lên: 26/09/2015, 10:05

... Table Hematologic parameters at baseline, following change to imatib and return to imatinib therapy Laboratory value January 2007 Imatinib 400 mg/day March 2007 Imatib 400 mg/day July 2007 Imatinib ... the patient resumed imatinib at a daily dose of 600 mg per day In July 2007, after approximately two months of therapy with imatinib, laboratory values revealed a return to a full hematologic and ... had been achieved with a %BCR-ABL/ABL International Scale (IS) score of about 0.01 compared to an initial value of This status had been maintained for approximately three years In January 2007,...

Ngày tải lên: 11/08/2014, 17:21

... experiments, participated in analysis and interpretation of data, and helped to write the paper TvdPK participated in analysis and interpretation of data and analysis tools TC, DB, and BD participated ... weeks of treatment, clinical response was assessed using the European League Against Rheumatism (EULAR) response criteria [15,16] Table 1: Characteristics of patients at baseline Array analysis ... and four months after start of therapy in EULAR good responder patients and EULAR poor responder patients Abbreviations AMC: Academic Medical Center; ANOVA: analysis of variance; DAS28: disease...

Ngày tải lên: 12/08/2014, 11:22

... well as adalimumab were widely available (Figure 1) The number of biologic-naïve patients starting adalimumab was too limited to allow meaningful analysis, and patients treated with adalimumab ... intervals Any withdrawal from treatment was registered prospectively and classified by the treating physician as withdrawal caused by adverse events (AEs), lack of response/ treatment failure, ... for categorical variables Values are reported as the mean ± standard deviation except where stated otherwise Adherence to therapy data was estimated according to Kaplan-Meier and further analysed...

Ngày tải lên: 09/08/2014, 08:23

... MK, and CS analyzed and interpreted the patient data regarding the hematological disease MvBB analyzed and interpreted the patient data regarding the hematological disease and contributed to the ... publication of this case report and any accompanying images A copy of the written consent is available for review by the Editor-in-Chief of this journal Page of Buet D, Raslova H, Geay JF, Jarrier P, Lazar ... Computed tomography revealed a large hematoma in the left gluteal region One day after the onset of symptoms surgery became necessary because of increasing swelling accompanied by a drop of the...

Ngày tải lên: 10/08/2014, 23:21

... Journal of Medical Case Reports 2007, 1:166 regimen, panic attacks continued and his overall state deteriorated eventually leading to hospitalization to a youth inpatient ward Treatment was changed ... understood phenomenon Patients often describe feelings of hopelessness and despair that may develop after starting treatment with an antidepressant [12] that may lead to suicidality The classical action ... for treatment of children 2003 Akiskal HS, Benazzi F: Does the FDA proposed list of possible correlates of suicidality associated with antidepressants apply to an adult private practice population?...

Ngày tải lên: 11/08/2014, 10:23

... hypoxia and reoxygenation The alkaline sedimentation profiles of HeLa and CCRF cells after hypoxia and reoxygenation already revealed [4] that hypoxic incubation caused significant accumulation of ... reoxygenated cells The mainly nuclear localization of PCNA is due to the fixation procedure Acetone fixation leads to cell shrinkage and loss of membranes Therefore cytosolic PCNA is not as prominent as ... acetone/methanol and total DNA was stained with bisbenzimide Subsequently cells were photographed and counted The percentage of mitotic cells was calculated as indicated mitotic index also exhibits a double-peaked...

Ngày tải lên: 21/02/2014, 00:20

... osseointegration of greater than 15% among groups with a power greater than 80% and an alpha of 0.05, assuming a standard deviation of up to 11% Results from four quadrants were averaged to obtain the ... Joint Surg Am 2003, 85 -A: 885-889 49 Herrera A, Canales V, Anderson J, Garcia-Araujo C, Murcia-Mazon A, Tonino AJ: Seven to 10 years followup of an anatomic hip prosthesis: an international study ... implant surfaces P = plasma-sprayed titanium (mean Ra = 27 microns); PHA = plasma-sprayed titanium with plasma-sprayed hydroxyapatite coating (mean Ra = 17 microns); CHA = chemical-textured titanium...

Ngày tải lên: 20/06/2014, 04:20

... contributed to conception and design of the study, acquisition of data, analysis of data and interpretation of data, drafted the manuscript, and has given final approval of the version to be published ... baseline At month mean total FIS score had decreased in the treatment- naïve, pre-treated, and total groups At month 12, compared to baseline, mean total FIS score had decreased in the treatment- naïve ... Results Fatigue and depression Baseline and discontinuation data Table shows FIS values in treatment- naïve, pre-treated and total patient groups at baseline, month and month 12, and changes from baseline...

Ngày tải lên: 20/06/2014, 15:20

... Sanofi-Synthelabo and AstraZeneca to attend several conferences References Soares JC: Recent advances in the treatment of bipolar mania, depression, mixed states and rapid cycling International ... now Until today, only olanzapine has received official approval as monotherapy for the maintenance phase of bipolar illness Our data suggest that further research is necessary to investigate the ... tests and EEG Case The patient is a 31 years old unmarried bipolar I female At the age of 20 she manifested a manic episode with auditory hallucinations, about month duration Five more manic episodes...

Ngày tải lên: 08/08/2014, 20:23

... hypothalamicpituitary-adrenal axis (HPA) function A central laboratory was used for all cortisol measurements Statistical analysis Assuming a common standard deviation of 450 ml, a sample size of ... population overall was 45.1 years, with a higher proportion of females More than half of the patients (57%) had at least a 10-year history of asthma and lung function was similar across all treatment ... ERS and the AAAAI; and has participated in clinical research studies sponsored by AstraZeneca, GlaxoSmithKline, Merck Sharpe and Dohme, and Novartis JL is also editor of Respiratory Research and...

Ngày tải lên: 12/08/2014, 14:20

... increased in the blood The vasoconstrictor TXB2 (a metabolite of thromboxane A2 ) also increased, and its concentration was always higher than that of the vasodilator 6-keto-PGF1α (metabolite of ... varying responses to INO Besides, a limitation may include the intravariability and intervariability of the animal lung injury model On the contrary, most parameters of the inflammatory mediators ... for analysis Effect of endotoxin Endotoxin exposure caused an increase in the MPAP and the pulmonary vascular resistance, whereas the cardiac output remained unaltered There was a mean decrease...

Ngày tải lên: 13/08/2014, 11:23

... central mechanism that can be specifically targeted for the treatment of cancer Caspases are a family of proteins that play an important role as effectors of apoptosis The caspases are a group of ... using absorbance at 595nm wavelength using an automated ELISA reader Cell death was calculated as: Mean of triplicate OD values of cells incubated with the drug Mean of triplicate OD values of cells ... One caspase can activate another caspase leading to the formation of a caspase cascade that amplifies the death signal In a typical cell undergoing apoptosis two distinct mechanisms have been...

Ngày tải lên: 16/09/2015, 17:11

... 1.5 mL of normal growth medium Cells were cotransfected with a ␤- galactosidase-containing plasmid (p-cytomegalovirus-␤ galactosidase) at a ratio of 3.5 ␮g of pCDNA3-Bax:0.5 ␮g of p-cytomegalovirus-␤-galactosidase ... receptor (data not shown), and inhibition of caspase activation had no effect on the mitochondrial translocation of Bax In addition, the relative lack of caspase activation and absence of downstream ... cleavage provide additional evidence in favor of a mechanism for signaling Bax to the mitochondria that is either parallel to or independent of death receptor and/or caspase activation A similar...

Ngày tải lên: 16/09/2015, 17:11

... function of activation of the apoptotic death pathway as evidenced by the significant increase in caspase activity, cleavage of the caspase-3 substrate PARP, and appearance of the sub-G1 fraction ... photoproduct of MC540, triggered mitochondrial generation of H2O2 that was responsible for the release of cytochrome c and downstream activation of the caspase cascade (21) Similar to the data obtained with ... the addition of RSV and C2 resulted in a decrease of intracellular O2Ϫ (data not shown) and restored death signaling in response to C2 (Fig 5D) To gain additional insight into the death-inhibitory...

Ngày tải lên: 16/09/2015, 17:11

... of a patients with a giant GIST of the duodenum After neoadjuvant imatinib therapy was initiated, a dramatic tumor regression led to an upper gastrointestinal bleeding and an emergency laparotomy ... Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors: a European Organisation for Research and Treatment of Cancer-Italian ... therapy prior to surgery had a duodenal GIST [8] It thus remains unclear, if the high safety of imatinib can be transferred to patients with GISTs at rare tumor localizations Alternatively primary...

Ngày tải lên: 09/08/2014, 03:21

... survival data we also analyzed the animals' clinical status We found that imatinib treatment in both early and late treatment arms also attenuated radiationrelated clinical adverse effects such as ... Importantly to us, imatinib treatment starting weeks Figure (a) Kaplan-Meier analysis of mouse survival following thoracic irradiation and imatinib treatment (a) Kaplan-Meier analysis of mouse ... irradiation and imatinib treatments were calculated with the Kaplan-Meier method and compared using the log-rank test Other quantitative data are given as mean values ± SD or as indicated For analysis...

Ngày tải lên: 09/08/2014, 10:20

... initiation, promotion, progression and metastasis [28,29] In more than 50% of all cancers, an aberrant activation of nuclear factor kappa-light-chainenhancer of activated B cells and/or signal transducer ... Vitale A, Zanus G, Donach M, Farina M, Zovato S, Pastorelli D: Pegylated liposomal doxorubicin and gemcitabine in patients with advanced hepatocellular carcinoma: results of a phase study Cancer 2011, ... a partial response and 11 patients had stable disease based on RECIST criteria Our patient participated in a phase II study of AMT in patients with various solid tumors Pivotal clinical data on...

Ngày tải lên: 10/08/2014, 23:20