molecular techniques to study the blood brain barrier
Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain
Ngày tải lên :
26/11/2015, 22:48
... 1.1 BLOOD BRAIN BARRIER 1.1.1 History and Anatomy of the Blood Brain Barrier 1.1.2 Functions of the Blood Brain Barrier 1.1.3 Clinical Significance of the Blood Brain Barrier 1.2 METHODS TO OVERCOME ... Functions of the Blood Brain Barrier The main function of the blood brain barrier is to protect the brain The BBB serves as an impermeable wall to prevent the entry of agents from outside of the brain ... isolate the central nervous systems from toxic chemicals in the blood 1.1.1 History and Anatomy of Blood Brain Barrier It was in the late 19th century that the concept of blood- brain barrier arose The...
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the blood – brain barrier
Ngày tải lên :
11/04/2014, 10:34
... enough to reach the bottom of the bottle so that the last few drops of fixative can flow into the system The outer end of the glass connector tube is connected to tubing, which is connected to a ... around the tissue to form a four-sided pyramid, with the tissue at the top of the pyramid c The block face is usually rectangular with the top and bottom edges parallel to one another to obtain a ribbon ... 2.2.3 Mitochondria Most of the mitochondria in cerebral endothelium are located in the vicinity of the nucleus, but occasional mitochondria occur throughout the cytoplasm and these tend to be parallel...
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báo cáo hóa học: " Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF" potx
Ngày tải lên :
19/06/2014, 22:20
... mainly localized to the luminal membrane of BMECs Therefore, enhanced invasion of HIV-1 into the brain may be mediated by BMEC-derived cytokines secreted into blood or by blood- borne cytokines Consistent ... BMECs to release IL-6 and GM-CSF into the blood; (3) IL-6 and GM-CSF act at the luminal surface of the BMECs to enhance the transcellular transport of HIV-1 across the BBB In our previous study, ... blood- brain barrier to various sized molecules Am J Physiology 1985, 248:H712-H718 Chou S, Dix RD: Viral infections and the blood- brain barrier In Implications of the Blood- Brain Barrier and...
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Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt
Ngày tải lên :
13/08/2014, 15:21
... in the ICU This phenomenon is thought to represent a consequence of inflammation-mediated dysfunction of the blood- brain barrier (BBB), thus allowing neurotoxic mediators to extravasate from the ... the BBB maintains the cerebral micro-environment by tightly regulating the passage of molecules into and out of the brain to protect the brain from microorganisms and neurotoxic substances During ... cells, relaying into the brain inflammatory response and jeopardising the functional integrity of the BBB [55-57] In the present study, we found that, during experimental sepsis, the antibody-mediated...
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Application of biologically active micelles in drug delivery across the blood brain barrier
Ngày tải lên :
11/09/2015, 09:10
... system (CNS) is to overcome the barrier preventing the drugs moving into the brain parenchyma The blood brain barrier (BBB) lies between the blood flow and the brain parenchyma The BBB prohibits ... entering from the blood to brain, including CNS drugs The limited penetration of drugs through the BBB into the brain parenchyma is the rule, not the exception In the treatment of brain infection ... bloodstream to the brain parenchyma or spinal cord (Pardridge, 1997; Rubin and Staddon, 1999), due to the existence of the blood brain barrier (BBB) or the blood cerebral spinal fluid barrier (BCSFB)...
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A study on techniques to improve the 1st year english majors' speaking skill at HPU
Ngày tải lên :
14/12/2013, 16:45
... includes the rationale to the study It also includes the aims of the study, the research questions, the scope of the study Next the design of the study is also presented Part II, The study consists ... INTRODUCTION The current study begins with this introductory part, which describes the rationale to the study and presents the aims of the study It also discusses the scope of the study, the method of the ... like the skilful conductor of an orchestra, giving each of the performers a chance to participate and monitoring their performance to see that it is satisfactory 5.3 The role of the teacher at the...
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báo cáo hóa học:" Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells" docx
Ngày tải lên :
18/06/2014, 15:20
... tumor-free brain regions (Additional file 5) We suspect that rhodamine B labeled Gd-G5 and Gd-G8 dendrimers are toxic to the BBTB in addition to the otherwise healthy blood- brain barrier This toxicity ... other charged nanoparticles [66-69] across the barrier may be from direct charge induced damage to endothelial cells of the barrier and disruption of the barrier Our proposed mechanism for the ... hampered due to ineffective drug delivery across the blood- brain tumor barrier (BBTB), in addition to the inability to simultaneously image drug permeation through tumor tissue [1-3] The current...
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Báo cáo y học: "Effect of magnesium sulfate administration on blood–brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study" ppt
Ngày tải lên :
12/08/2014, 20:20
... the peritoneum was opened and the prepared clot was injected into the peritoneal cavity directly from the syringe Sham-operated rats had a sterile clot injected into their peritoneal cavity To ... shown to pass from the circulation into the brain parenchyma in a similar manner to that seen in portosystemic encephalopathy However, there is no evidence in the literature to suggest that this ... brain site it interacts with the endothelial cells forming the BBB and inhibits their activation [4,24,25] To our knowledge, the present data are the first to show the positive effects of magnesium...
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Báo cáo khoa học: "Techniques to incorporate the benefits of a Hierarchy in a modified hidden Markov model" pptx
Ngày tải lên :
08/03/2014, 02:21
... been calculated, the system then need only to use the top-level of the hierarchy tree to estimate the probability sequences This means the model will now become a linear HMM for the final Viterbi ... groups The system uses the clause information to construct the hierarchical structure of text chunks, where the clauses represent the phrases within the sentence The clauses can be embedded in other ... (2001) to rewrite the bracketing rule by calculating the dependency of each possible phrase The outcome of this restructuring is to reduce the complexity of the hierarchical structure and reduce the...
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The aim of the research is to study the factors affecting the lifetime of pulsed plasma thruster
Ngày tải lên :
15/03/2014, 23:15
... but also to the total number of packets arriving at a given location (such as our skin) • Total Energy depends on many factors including the intensity of sunlight • The UV Index rates the total ... http://www.mhhe.com/physsci/astronomy/arny/instructor/graphics/ch03/0305.html The Sun’s Radiation Spectrum Most of the sun’s radiation is UV, Vis & IR : • ~ 43% is in the visible range • ~ 49% is in the near infrared range • ~ 7% is in the ... so they don’t use sunscreen with inorganic ingredients • Of the people who use them, most apply too little to get full protection Source: http://www.4girls.gov/body/sunscreen.jpg 34 Why Do They...
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Báo cáo khoa học: The use of recombinant protein and RNA interference approaches to study the reproductive functions of a gonad-stimulating hormone from the shrimp Metapenaeus ensis ppt
Ngày tải lên :
16/03/2014, 05:20
... in the hepatopancreas serves as an extraovarian source for the final synthesis of vitellin The newly made vitellogenin is expected to be secreted rapidly into the hemolymph and transported to the ... levels of the gene or protein The expression level was normalized with either the rRNA (for the northern blot) or hemocyanin (for the western blot) Either simple t-test or anova was used to perform ... indicating that both the hepatopancreas and ovary are the targets of MeMIH-B This result will provide the basis for identifying and characterizing the receptor for the neuropeptide Furthermore, rMeMIH-B...
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Báo cáo khoa học: Combined use of selective inhibitors and fluorogenic substrates to study the specificity of somatic wild-type angiotensin-converting enzyme docx
Ngày tải lên :
16/03/2014, 13:20
... G(d,p) basis set To preserve the structure of the protein during the relaxation of the complexes, harmonic restraints were applied to the atomic position of several sets of atoms The harmonic constants ... to 100, and 0.5 kcalÆ ˚ mol)1ÆA)2 for the ions and their chelating residues, the ˚ atoms of the protein situated at a distance greater than A 1780 of the inhibitor, and the backbone and Cb atoms ... same approach, as the potency and selectivity of the RXP inhibitors did not appear to vary to any great extent toward these ACE enzymes Such studies are relevant in the light of the differences...
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Image denoising techniques to improve the performance on optical character recognition.
Ngày tải lên :
12/04/2014, 15:39
... image The documentary image has top The first top will express characters, the other will express the background The best threshold is the threshold that the difference between two areas of the ... Picture The matrix describing the histogram value of the image pixels For example, an image with the histogram value of the image pixel as above, if the size of the scanning window is 3*3, the value ... transparence level of the lens, the dust in the surface of the documents…Thanks to the association of the factors, we will get the images which was collected from making noise elements Therefore, we...
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báo cáo hóa học:" Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors" ppt
Ngày tải lên :
18/06/2014, 15:20
... over 600 to 700 minutes We compared the permeability of the BTB of RG-2 gliomas grown within the brain, the orthotopic site, to that of the BTB of RG-2 gliomas grown outside the brain in the temporalis ... ectopic site, the permeability of the BTB of the breast cancer tumor growing in the brain is lower than the BTB of the original tumor in breast tissue, the orthotopic site[5] The brain tissue ... in the right anterior brain, which was the orthotopic site, and the left temporalis muscle, which was the ectopic site The change in blood and tumor tissue Gd concentration, a surrogate for the...
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báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
Ngày tải lên :
19/06/2014, 22:20
... phenol-red-free DMEM the top and the bottom of the filter, 400 μl of 10% FBS/phenolred-free DMEM and 200 μl of 0.45% albumin conjugated to Evan’s blue dye were added to the bottom and the top of the well, ... Anandamide inhibits VCAM-1 induced by TMEV in brain endothelial cells by CB1 receptors The endothelial blood brain barrier protects the CNS from the changing environment in both physiologic and ... added to the upper side of the insert (endothelial culture) and IL1-b (10 ng/ml) was added to the bottom side (astrocyte culture) for hours 2.5 × 105 leukocytes were added to the upper side of the...
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báo cáo hóa học: " Neuro-Inflammation, Blood-Brain Barrier, Seizures and Autism" pot
Ngày tải lên :
19/06/2014, 22:20
... Substances originating in the gut or the brain can trigger mast cells to release mediators that could disrupt the gutblood barrier and blood- brain barrier (BBB), thus contributing to the pathogenesis ... Erickson, M A.: The blood- brain barrier and immune function and dysfunction Neurobiol.Dis 2010, 37:26-32 44 Quan, N.: Immune -to- brain signaling: how important are the blood- brain barrierindependent ... “immunology: barrier to electrical storms” [46] Mast cells were considered as the “immune gate to the brain [47] ASD patients are prone to stress [48], and prenatal stress has been linked to risk...
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Báo cáo hóa học: " Pyrosequencing of 16S rRNA gene amplicons to study the microbiota in the gastrointestinal tract of carp (Cyprinus carpio L.)" doc
Ngày tải lên :
20/06/2014, 23:20
... probably also the case for other cultured fish Therefore it could be possible to lower the amount of fish meal, one of the major components of fish food, in the food for these fish Furthermore, it ... Possibly, the heterotrophic Planctomycetes found in carp gut confer a similar ability of polysaccharide breakdown to the host Furthermore, a separate lineage within the Planctomycetes, the anammox ... 2011) The GI microbiota is important for the health of the animal and therefore this study could be relevant for aquaculture Furthermore, the presence of different nitrogen cycling bacteria in the...
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Báo cáo hóa học: " Signal Processing of Ground Penetrating Radar Using Spectral Estimation Techniques to Estimate the Position of Buried Targets" pot
Ngày tải lên :
23/06/2014, 01:20
... (SNR) was analyzed to investigate the efficiency and the robustness of the proposed method (5) A field experiment was performed to support the simulation and to obtain a real image of the buried targets ... analyzer generates the identical signal, and the phase and the amplitude of the reflected signals also not change from snapshot to another MUSIC fails to work properly when the signals are coherent ... response) when the slope of Y is low It is observed in Figure 3b that the IFFT response gives correct amplitude The amplitude of the second signal was set to the half of the first signal and the third...
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Hình thái và chức năng của hàng rào máu não (blood brain barrier)
Ngày tải lên :
19/07/2014, 20:48
... rõ ràng Tuy nhiên, VEGF(vascular endothelial growth factor), cytokine yếu tố Scatter (scatter factor), yếu tố phát triển tế bào gan (hepatocyte growth factor HGF) tiết từ u tế bào hình loại u ... gian gây viêm (inflammatory mediators) diện phân tử kết dính (adhesion molecules) Vấn đề bàn luận sau 5.1.Các chất trung gian gây viêm trình bệnh thần kinh 5.1.1.Các Cytokine Bước trình viêm ... viêm tiết chất trung gian khác Các cytokine chẳng hạn như: yếu tố hoại tử u (Tumor Necrosis Factor TNF), interleukin-1 (IL-1) interleukin-6 (IL-6) đóng vai trò then chốt trình phát triển đáp ứng...
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Research report: "To study the effect of substituents on the properties of aniline by the method of approximate quantum AM1" pps
Ngày tải lên :
23/07/2014, 13:21
... properties are closely tied together Hammett constants which used as regression indicator to investigate the change of properties yield rather good correlations for these properties except for ... AM1 method are shown in the Table The obtained values are reasonable close to the experimentally observed ones [10] but for
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