molecular targeting therapy of cancer
a core shell shell nanoplatform upconverting near infrared light at 808 nm for luminescence imaging and photodynamic therapy of cancer
... photodynamic therapy of cancer Fujin Ai1,3, Qiang Ju2, Xiaoman Zhang1, Xian Chen2, Feng Wang2,3 & Guangyu Zhu1,3 Upconversion nanoparticles (UCNPs) have been extensively explored for photodynamic therapy ... center of large tumors through PDT, which significantly improves the anticancer efficacy using UCNP-based PDT system and broadens the types of tumors that could be cured Photodynamic therapy ... applications including Department of Biology and Chemistry, City University of Hong Kong, Kowloon Tong, Hong Kong SAR 2Department of Physics and Materials Science, City University of Hong Kong, Kowloon Tong,
Ngày tải lên: 02/11/2022, 08:45
Traffic lights for retinoids in oncology: Molecular markers of retinoid resistance and sensitivity and their use in the management of cancer differentiation therapy
... growth inhibition of human breast cancer cells regardless of estrogen receptor status Cancer Res 1997;57:2642–50 76 Schneider SM, Offterdinger M, Huber H, Grunt TW Activation of retinoic acid ... been discussed as an effective Table Overview of the human cancer types treated with retinoids in clinical studies Type of cancer Retinoid Type of treatment Reference Acute myeloid leukemia ATRA ... area of biological anticancer therapy, the discovery of biomarkers that indicate retinoid resistance or sensitivity in each individual patient seems to be important for the recent personalized therapy
Ngày tải lên: 03/07/2020, 00:52
Clinical significance of L-type amino acid transporter 1 expression as a prognostic marker and potential of new targeting therapy in biliary tract cancer
... tract cancer lack a survival benefit if treated with chemotherapy or radiation therapy Thus, we need a new effective therapy to improve the survival of patients To improve the outcome of therapy, ... patients may receive adjuvant chemotherapy to improve chance of cure, there is no established standard chemotherapy In advanced biliary tract cancer, combination chemotherapy with gemcitabine and a ... Recently, the expression of LAT1 has been described to be a significant factor indicating a poor outcome in various human cancers [12-17] Moreover, the potential of targeting therapy for LAT1 had
Ngày tải lên: 05/11/2020, 05:19
báo cáo khoa học: "The potential benefits of low-molecular-weight heparins in cancer patients" ppsx
... mortality [2] Cancer patients are at additional risk of VTE [3], and following cancer surgery VTE is the most common cause of death at 30 days [4] The probability of diagnosing concomitant cancer is ... deregulation of these factors is observed in cancer patients, resulting in disruptions to the normal process of clot lysis [25] Cancer patients may, therefore, possess abnormal expression of a number of ... increased risk of VTE, they are also at an increased risk of bleeding [30,31] Given that the risk of VTE outweighs the risk of bleeding in most cancer patients [30,31], the use of antithrombotic
Ngày tải lên: 10/08/2014, 22:20
Báo cáo y học: "A novel human ex vivo model for the analysis of molecular events during lung cancer chemotherapy" pptx
... Effects of chemotherapeutical treatment upon expression of Ki-67 and of Caspase-3 in four human breast cancer tissue specimens. Data are expressed as median values of percentages ± SEM of positively ... cell lung cancer (NSCLC) causes most of cancer related deaths in humans and is characterized by poor prognosis regarding efficiency of chemotherapeutical treatment and long-term survival of the ... of the patients. The purpose of the present study was the development of a human ex vivo tissue culture model and the analysis of the effects of conventional chemotherapy, which then can serve
Ngày tải lên: 12/08/2014, 15:20
siRNA, miRNA and their possible roles in molecular therapy of chronic human hepatitis b virus infection and hepatocellular carcinoma
... and is implicated in the tumorgenesis of several types of human cancers including B-cell lymphoma, breast cancer, colon cancer, lung cancer and pancreatic cancer Our data from the knock-down studies ... degree and generously offering me research scholarship II PUBLICATIONS The major part of this work has been published in: Genome-wide expression profiling of RNA interference of hepatitis B virus ... Course of HBsAg Inhibition by siRNA………………………… 4.3.6 Reversal of RNAi………………………………………………………… …… 87 90 92 93 94 96 4.4 Specificity of the Effects of siRNA…………………… ………………… 97 4.4.1 Effects of siRNA
Ngày tải lên: 14/09/2015, 12:11
In vivo and in vitro study on potential combination therapy of COL 3 and tamoxifen in breast cancer a pilot study
... Overview of Combination Therapy in Cancer Treatment Sometimes, more than one type of treatment is used to treat breast cancer Combination therapy may be adjuvant therapy - two types of treatment ... Overview of Current Breast Cancer Therapy The current treatment of breast cancer is a multidisciplinary effort, with goals dependent on the specific clinical situation Various clinical breast cancer ... expect the improvements of the past decades to accelerate in the future[17] Table 1.1 Summary of breast cancer treatment Therapy Agent used Surgery purpose remove as much of tumor as possible[1]
Ngày tải lên: 09/10/2015, 11:24
DSpace at VNU: Targeting specificity of dendritic cells on breast cancer stem cells: in vitro and in vivo evaluations
... Conclusion Cancer stem cells in tumors represent cell populations that can cause failure of chemotherapy as a cancer treatment Targeting cancer stem cells is considered a promising therapy in cancer ... studies developed DC therapy targeting cancer stem cells,26 such as breast27 and glioblastoma cancer stem cells.28 More importantly, targeting glioblastoma cancer stem cells by DC therapy was permitted ... cytotoxicity OncoTargets and Therapy 2015:8 Targeting specificity of dendritic cells on breast cancer stem cells on the basis of changes in electrical impedance on the surface of the E-plate, a plate
Ngày tải lên: 16/12/2017, 00:33
Targeting autophagy in cancer therapy
... as cancer therapeutic agents, implications of micro RNA-regulated autophagy in cancer therapy, modulation of autophagy through targeting PI3 kinase in cancer therapy, targeting autophagy in cancer ... autophagy-based cancer therapy This volume in the Springer series, Current Cancer Research, will cover a wide range of topics, including an overview of autophagy as a therapeutic target in cancer, autophagy ... biology and molecular biology of autophagy and their association with cancer development and progression, this is the first book devoted solely to dealing with targeting autophagy in cancer therapy
Ngày tải lên: 14/05/2018, 15:15
Study protocol of the SWORD-study: A randomised controlled trial comparing combined online and face-to-face cognitive behaviour therapy versus treatment as usual in managing fear of cancer
... Cost-effectiveness of cognitive-behavioral group therapy for dysfunctional fear of progression in cancer patients Eur J Health Econ, 12(5), 489–497 Savard, J, & Ivers, H (2013) The evolution of fear of cancer ... al 1997) Coping with the experience of cancer will be measured with the Impact of Events Scale This scale consists of 15 items that ask for the frequency of cancer- related avoidant and intrusive ... Evaluation of two group therapies to reduce fear of progression in cancer patients Support Care Cancer, 18(4), 471–479 Horowitz, M, Wilner, N, & Alvarez, W (1979) Impact of event scale: a measure of
Ngày tải lên: 10/01/2020, 12:28
Internet-based, Digital health, Cognitive therapy, Colorectal cancer, Fear of cancer recurrence, Anxiety, Randomized controlled trial
... by cancer differ from those made by people diagnosed with cancer; analysis of years of south Australian Cancer council helpline data Support Care Cancer 2016; 24(6):2611–8 Watanabe et al BMC Cancer ... needs of cancer survivors: analysis of open-ended responses to the American Cancer Society study of Cancer survivors II Cancer 2015; 121(4):623–30 Miedema B, Easley J, Robinson LM Do current cancer ... public's cancer information needs: characteristics of callers to the National Cancer Information Center of the American Cancer Society J Cancer Educ 2005; 20(3):177–82 33 Shapiro CL Cancer survivorship
Ngày tải lên: 17/06/2020, 11:25
Synthesis and bio-molecular study of (+)-NAcetyl-α-amino acid dehydroabietylamine derivative for the selective therapy of hepatocellular carcinoma
... National Institute of Child Health, Karachi 75500, Pakistan Department of Chemistry, University of Karachi, Karachi 75270, Pakistan Full list of author information is available at the end of the article ... in laboratories of HEJ Research institute of Chemistry, University of Karachi Synthesis General procedure for the preparation of Amides from amino acids (DAAD 1–7) To a solution of dehydroabietylamine ... and loss of cellular attachment were observed at 24 h The extent of these morphological changes gradually increased from 24 to 72 h of drug Mustufa et al BMC Cancer (2016) 16:883 Page of 10 Table
Ngày tải lên: 20/09/2020, 18:47
gene therapy of cancer, methods and protocols
... field of gene therapy Even though surgery, radiotherapy, and chemotherapy are widely available and routinely used for cancer treatment, these therapies fail to cure approximately 50 percent of cancer ... volume of Gene Therapy of Cancer: Methods and Protocols in the Methods in Molecular Medicine series will provide researchers with a broad array of methods used to study cancer gene therapy in both ... short overviews of specialized gene therapy strategies for the treatment of particular malignancies Gene Therapy of Cancer: Methods and Protocols does not provide comprehensive reviews of all methodologies...
Ngày tải lên: 11/04/2014, 09:42
Báo cáo sinh học: "The iSBTc/SITC primer on tumor immunology and biological therapy of cancer: a summary of the 2010 program" doc
... therapy and improve outcomes of patients with cancer In conclusion, the 2010 Primer on Tumor Immunology and Biological Therapy of Cancer provided a comprehensive overview of the principles of ... in Cancer Immunotherapy Kim A Margolin, MD (University of Washington, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance) presented on the immunobiology of cytokines A model of ... Society for Biological Therapy of Cancer, iSBTc), aims to improve cancer patient outcomes by advancing the science, development and application of biological therapy and immunotherapy The society...
Ngày tải lên: 18/06/2014, 19:20
Báo cáo sinh học: "Review of the 25th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer (now the Society for Immunotherapy of Cancer)" potx
... Page of Author details Society for Immunotherapy of Cancer, Milwaukee, WI, USA 2University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA 3Department of Cutaneous Oncology, Moffitt Cancer ... the field, the 25th Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc, recently renamed the Society for Immunotherapy of Cancer, SITC) provided a scientific ... patients with a large variety of cancers Targeted Therapeutics and Immunotherapy Mary L Disis, MD (University of Washington) and Keiran S Smalley, PhD (H Lee Moffitt Cancer & Research Institute)...
Ngày tải lên: 18/06/2014, 19:20
báo cáo hóa học:" Review of the 25th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer (now the Society for Immunotherapy of Cancer)" pot
... Page of Author details Society for Immunotherapy of Cancer, Milwaukee, WI, USA 2University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA 3Department of Cutaneous Oncology, Moffitt Cancer ... the field, the 25th Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc, recently renamed the Society for Immunotherapy of Cancer, SITC) provided a scientific ... patients with a large variety of cancers Targeted Therapeutics and Immunotherapy Mary L Disis, MD (University of Washington) and Keiran S Smalley, PhD (H Lee Moffitt Cancer & Research Institute)...
Ngày tải lên: 20/06/2014, 03:20
báo cáo khoa học: "New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer" doc
... hypomethylating agents for epigenetic therapy of cancer Current Cancer Drug Targets submitted and under review 2009 Marks PA: Discovery and development of SAHA as an anticancer agent Oncogene 2007, 26:1351-1356 ... section of azacitidine) 11 Yoo CB, Jones PA: Epigenetic therapy of cancer: past, present and future Nat Rev Drug Discov 2006, 5:37-50 Hashimshony T, Zhang J, Keshet I, Bustin M, Cedar H: The role of ... for treatment of CTCL More than 11 HDAC inhibitors are in various stages of clinical development HDAC inhibitors may have more potential in the combination therapy of a wide range of malignancies...
Ngày tải lên: 10/08/2014, 22:20
The use of gold nanostructures in the imaging and therapy of cancer
... diagnosis of cancer and reducing incidence of cancer in high-risk individuals It could also potentially serve to monitor the progression of cancer Also, with an image map of the expression level of ... characterization of gold bioconjugates…………………… 80 3.3.2 FACS analysis of EGFR expression…………………………………….…83 3.3.3 Increase in optical contrast of cancer cells……………………………… 84 3.3.4 Molecular mapping of EGFR ... through the combination of phenotypic markers and expression profiling of molecular markers using the gold nanostructure probes xiv LIST OF TABLES Table 4.1 Reaction volumes of various reactants...
Ngày tải lên: 11/09/2015, 09:02
Photosensitizing effects of chlorin e6 polyvinylpyrrolidone for fluorescence guided photodynamic therapy of cancer
... Laboratory of Optical Imaging and Photodynamic Therapy of Cancer, National Cancer Centre Singapore and the Department of Pharmacy, National University of Singapore Supervisors: Associate Professor ... Laboratory of Optical Imaging and Photodynamic Therapy of Cancer, National Cancer Centre Singapore Principle Investigator, Biophotonics Laboratory, Singhealth Adjunct Professor, Department of Pharmacy, ... clinical patients xii LIST OF FIGURES Figure 1.1 Principles of photodynamic diagnosis and therapy Figure 1.2 Molecular structure of Ce6 and PVP (C6H9NO) and the absorption spectra of Ce6-PVP formulations...
Ngày tải lên: 11/09/2015, 09:09