molecular signatures predicting response to therapy

... acts as cell modulator by driving lots of stressinducing signals to different antiproliferative cellular responses [7] p53 can be activated in response to DNA damage (such as cytotoxic agents), oncogene ... expression in relation to main tumor characteristics and treatment response Page of Table HER2 expression in relation to main tumor cheracteristics and treatment response p53 expression Total Low High ... Negative Positive Treatment response n.s n.s n.s = not significant; CR = complete response; PR = partial response; SD = stable disease; PD = disease progression #According to Elston and Ellis classification...

Ngày tải lên: 10/08/2014, 10:21

... therefore to compare anti-CRP antibody levels in well-characterized lupus nephritis patients and to seek potential associations with histopathology, renal activity and response to therapy Materials ... biopsies were graded according to a standardized semiquantitative histological scoring protocol for activity and chronicity indices [31] Renal disease activity and response to therapy Renal disease activity ... confidence interval = 0.87 to 2.84) nor a positive anti-dsDNA antibody test as judged by the CLIFT (relative risk = 1.18, 95% confidence interval = 0.42 to 3.26) predicted response to therapy, whereas...

Ngày tải lên: 12/08/2014, 11:22

... or the cytoskeleton Only a few are specific to xenobiotic detoxification One, the glutamine synthetase gene was previously shown to be associated with the response of various organisms to pesticide ... Oyster response to pesticide exposure 51 Mullen L & Goldsworthy G (2003) Changes in lipophorins are related to the activation of phenoloxidase in the haemolymph of Locusta migratoria in response to ... ecotoxicological damage and those involved in the response of the FEBS Journal 272 (2005) 390–403 ª 2005 FEBS Oyster response to pesticide exposure organisms to the pollutant In previous studies, we demonstrated...

Ngày tải lên: 30/03/2014, 15:20

... antiretroviral therapy are seen routinely at three- to four-month intervals for clinical evaluation, monitoring of CD4 count, viral load, haematology and biochemistry Those not on antiretroviral therapy ... compared to those infected with any of the four non-B subtypes, patients with subtype B were more than twice as likely to be male (89.1% vs 35.3% to 48%) (all p < 0.001), to be white (78.9% vs 2.8% to ... this was used to assign a definitive subtype Two further subtyping methods were applied as a validation of the phylogenetic analysis results and to enable a subtype to be assigned to samples for...

Ngày tải lên: 20/06/2014, 08:20

... death, or date of switch to a protease inhibitor (PI) to evaluate the response to non-nucleoside reverse transcriptase inhibitor (NNRTI)-based treatment Results From August 2003 to September 2005, ... Figure Immunological response in HIV-infected women A Immunological response in HIV-infected women exposed to nevirapine or acquired PMTCT resistance to nevirapine B Immunological response in HIV-infected ... from NNRTI-based to PI-based HAART during follow up Among the 19 women who switched to PI-based HAART, only four switches were related to treatment failure; the other 15 were done to manage NNRTIrelated...

Ngày tải lên: 20/06/2014, 08:20

... Acting Beta Response by Genotype), in an attempt to answer the question of the role of SNPs and response to LABAs Several studies have demonstrated a distribution of therapeutic response to both ... unable to demonstrate a similar association.16 To attempt to understand this SNP’s association with medicine response, Sampson and colleagues examined LTC4S SNP and clinical response to the LTM ... appears to be a daunting task, it is a worthwhile one, as once understood, we may be able to rely on a patient’s genetics to aid in choosing the most appropriate therapy As clinicians attempting to...

Ngày tải lên: 08/08/2014, 21:20

... the long term, for up to years [5,6] Our study is the first to examine the clinical response to discontinuation of long-term infliximab therapy R441 Arthritis Research & Therapy Vol No Baraliakos ... respectively) Response to retreatment All 41 patients who were reinfused responded well to the restart of therapy with infliximab They showed a clear improvement of signs and symptoms and reached ... infliximab is also likely to be different from patient to patient The best dosage probably needs to be defined individually We also found that there seem to be predictive factors for the duration...

Ngày tải lên: 09/08/2014, 06:22

... designed to determine whether there are serum proteomic profiles in SJIA that are reflective of active disease and predictive of response to therapy, as well as to determine whether SELDI-TOF MS ... responded to conventional therapy (therapy and definition of clinical response are described in detail in the Materials and methods section) were analyzed before and after therapy by SELDITOF MS ... anti-IL-6 receptor antibody (MRA; Chugai Pharmaceuticals, a subsidiary of Roche Pharmaceuticals) All 15 patients had a clinical response to MRA The mean period from acute status to clinical response...

Ngày tải lên: 09/08/2014, 06:22

Ngày tải lên: 09/08/2014, 06:23

... consent and patients stopped for protocol violation Of the remaining 474 patients, 102 (22%) patients, who were not optimally responding to treatment according to the treating rheumatologist's opinion, ... Research & Therapy Vol No Vander Cruyssen et al tant enough to incorporate in a model to discriminate the physician's decision Building a model to discriminate the physician's decision to give a ... value to give a dose increase as a measure of insufficient response) ; NPV, negative predictive value (predictive value to continue on the current dose as a measure of good response) calculator,...

Ngày tải lên: 09/08/2014, 06:23

... far has been challenging to achieve Prediction of individual therapy response is critically dependent on the ability to quantify tumor heterogeneity and heterogeneous response of tumors with otherwise ... clinical prognostic factors Established, non-invasive methods that effectively evaluate the heterogeneous therapy responses are elusive in clinical practice Radiological response to treatment is most ... therapeutic decisions and predicting therapeutic outcome [14,15] Artificial neural networks (ANNs) are attractive analytical tools in medicine due to their ability to learn from historical examples,...

Ngày tải lên: 09/08/2014, 09:20

... regulation of immune responses) is associated with poor clinical response to therapy, thereby providing clinicians with potential tools to identify these patients prior to initiation of adalimumab ... its natural inhibitors (such as soluble TNF receptors or IL-1 receptor antagonists) Molecular signatures, therefore, are more suited to evaluate the biological action of a cytokine than raw evaluation ... quantification) according to response to therapy Effects of adalimumab therapy on synovial gene expression profiles Next, we investigated the effects of adalimumab therapy on global gene expression...

Ngày tải lên: 09/08/2014, 14:20

... utility to predict good to excellent response to etanercept therapy (equivalent to response ≥ ACR50 for the ABCoN and Swedish cohorts, and to response ≥ ACR70 for the Japanese cohort), and to predict ... Research & Therapy Vol 11 No Hueber et al Figure Elevated pretreatment blood cytokines are associated with response to etanercept therapy Logistic regression analysis was applied to cytokine therapy ... to 500) CRP (mg/l) 60 (2 to 79) ACR response < 20 15 (51.7) ACR response > 50 14 (48.3) Shared epitope present 16/24 (66) Disease duration (months) 96 (12 to 396) Swedish Age (years) 54 (32 to...

Ngày tải lên: 09/08/2014, 14:21

... inhibitor, ritonavir (RTV), in children [9] We investigated the role of baseline HIV drug resistance mutations and response to therapy Results There were very few primary resistance mutations to ... as this regimen was demonstrated to result in a suboptimal virologic suppression compared to protease inhibitor-based regimens A total of 92 children assigned to a RTV-containing regimen had both ... Genetics-Bayer Diagnostics, Toronto, Canada) according to the manufacturer's instructions The International AIDS Society-USA recommended guidelines for resistance to protease inhibitor (PI) and nucleoside...

Ngày tải lên: 10/08/2014, 05:20

... RR = objective response rate (complete response + partial response) ; TTP = time to progression; OS = overall survival was found to be a predictive marker for lack of response to cetuximab treatment, ... Predictor of Response to EGFR Targeted Therapy The EGFR signaling pathway and targeted therapies for CRC EGFR is a member of the HER (ErbB) family of human epidermal growth factor receptors that ... S, Marrapese G, Sartore-Bianchi A, Di Nicolantonio F, Gambacorta M, Siena S, Bardelli A: Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment...

Ngày tải lên: 10/08/2014, 22:20

... low-grade toxicity and a 19% overall response rate, all partial responses[22] Our patient was given FOLFOX therapy because the urothelial cancer failed to respond to G-C combination therapy, as ... related to therapy exceeded 3%, and 25% of the patients developed neutropenic sepsis, so its use was limited to young patients or those with good general performance[10] Gemcitabine was reported to ... TCC showed a complete response due to synergistic effects of FOLFOX4, rather than to those of oxaliplatin as a single drug The efficacy of 5-FU and leucovorin combination therapy for colorectal...

Ngày tải lên: 10/08/2014, 22:20

... risk factors, and this seems to be due to alterations in the metabolism of endogenous hormones, including sex steroids, insulin and the insulin-like growth factor (IGF) and IGF receptor (IGFR) ... an apoptotic effect through activation of p53 and Bax protein These actions are mediated directly by somatostatin receptors present on tumor cells and indirectly via somatostatin receptors located ... by the Editor-in-Chief of this journal Abbreviations AE: adverse event; AMT: Auron Misheil Therapy; CT: computed tomography; HCC: hepatocellular carcinoma; IGF: insulin-like growth factor; IGFR:...

Ngày tải lên: 10/08/2014, 23:20

... remained sensitive to imatinib therapy, as evidenced by her good response to subsequent imatinib rechallenge However, it appears that the sensitive residual tumor cells need to be continuously ... two peritoneal nodules had increased in size by 50% since the last tumor assessment Disease progression was confronted through dose escalation to imatinib 800 mg/day Our patient’s response to dose ... possessing KIT exon 11 mutations at high risk of recurrence (mitotic rate ≥5 mitoses/50 HPF and tumor size ≥5 cm, or mitotic rate ≥10 mitoses/50 HPF, or tumor size ≥10 cm) [9,10] Our previous retrospective...

Ngày tải lên: 10/08/2014, 23:20

... treatment response Hepatology 2000, 31(6):1360-1370 Lo S, Lin HH: Variations within hepatitis C virus E2 protein and response to interferon treatment Virus Res 2001, 75(2):107-112 Saito T, Ito T, tto ... 2008, 68:1273-1317 Shiratori Y, Kato N, Yokosuka O, Imazeki F, Hashimoto E, Hayashi N: Predictors of the efficacy of interferon therapy in chronic hepatitis C virus infection Tokyo-Chiba Hepatitis ... phosphorylation homology domain and response to interferon therapy Hepatology 2000, 32(5):1138-1144 Gerotto M, Dal Pero F, Pontisso P, Noventa F, Gatta A, Alberti A: Two PKR inhibitor HCV proteins correlate...

Ngày tải lên: 11/08/2014, 21:21

... help to guide therapy with corticosteroids and thereby improve outcomes, particularly in vasopressor-refractory septic shock, although this is contoversial [6,8,9,11,13,17] With the aim being to ... predictors were independent of sepsis, interval until testing, intubation with etomidate, baseline cortisol and albumin levels The results not only help in predicting a diminished response to ACTH ... [5,7,8,10,15,22,24] Etomidate is commonly used to facilitate endotracheal intubation; it is an inhibitor of 11β-hydroxylase, which is involved in cortisol synthesis A single bolus of etomidate has been shown to...

Ngày tải lên: 13/08/2014, 03:21