molecular signatures of bladder cancer

... Deregulation of cell proliferation and evasion of apoptosis are two hallmarks of cancer cells To address the contradictory observations regarding the usage of PIO and the risk of bladder cancer, one ... transitional epithelium cells and human bladder cancer J82 cells to ascertain whether PIO promoted neoplastic changes of NUTE cells and proliferation of bladder cancer cells Materials and Methods ... Since the adoption of PIO, its use has been questioned due to concerns about the potential risk of bladder cancer There are currently two main views regarding PIO in bladder cancer risk First,

Ngày tải lên: 15/01/2020, 20:51

... variables to explore the prognostic Peng et al BMC Cancer (2020) 20:420 Page of 14 Fig Flow diagram of filtering studies role of miR-20a, such as ethnicity, cancer types, sample sources and sample sizes ... Colorectal cancer, GC Gastric cancer, GIC Gastrointestinal cancer, OS Overall survival Fig Forest plot of the relationship between miR-20a and overall survival in GIC GIC, gastrointestinal cancer ... vascularization and cancer metastasis [39] Studies have convinced the roles of sphingolipid signaling in a wide variety of biological mechanisms, and Peng et al BMC Cancer (2020) 20:420 Page 10 of 14 Fig

Ngày tải lên: 30/05/2020, 21:28

... suggestively associated with bladder cancer as those exposed for 5–30% of work time and more than 30% of work time experienced elevated odds of bladder cancer Longer duration of exposure (full model ... the relationship between bladder cancer and industries and occupations that Latifovic et al BMC Cancer (2020) 20:171 Page of 13 Table Select characteristics of bladder cancer cases and controls ... also been associated with bladder cancer [19, 20] Very few studies have investigated the role of workplace exposure to silica and asbestos in the etiology of bladder cancer Most published studies

Ngày tải lên: 17/06/2020, 03:18

... analysis, TCGA Background Lung cancer is one of the most aggressive cancers, with a five-year overall survival of 10–15% [1] Lung cancer can be classified into small cell lung cancer (SCLC) and non-SCLC ... comparison of cancer (sub)types The Cancer Genome Atlas (TCGA) is a large genomic initiative in which more than 10 000 patients were profiled using six different platforms to identify cancer- related signatures ... general cancer signatures [10, 33–39] or to pinpoint signatures specific to only one of the lung cancer types [40–42] Cline and colleagues [39] recently showed that there is a subset of 19 samples

Ngày tải lên: 17/06/2020, 17:06

... (Figs and 3) Loss of CD44 and rhamm inhibit growth of bladder cancer cells driven by loss of AGL Loss of AGL promotes anchorage dependent and independent growth of bladder cancer cells [4] Here ... treatment of AGL knockdown bladder cancer cells [5] Treatment with superfluous amounts of LMW HA had little impact on CD44 and RHAMM expression of UMUC3 and T24T bladder cancer cells irrespective of ... expression in the shCTL and shAGL bladder cancer cells (Fig 1a, b) Interestingly loss of HAS2 does not reduce expression of CD44 and RHAMM in bladder cancer cells irrespective of AGL expression status

Ngày tải lên: 20/09/2020, 17:59

... Malathi, Professor, Department of Genetics, University of Madras and Prof T.S Lokeswari, Prof and H.O.D, Department of Biotechnology, and Prof Solomon F.D Paul Prof and H.O.D, Department of Human ... Ravi et al BMC Cancer (2015) 15:768 DOI 10.1186/s12885-015-1784-x RESEARCH ARTICLE Open Access Molecular mechanism of anti -cancer activity of phycocyanin in triple-negative breast cancer cells ... P, Liu K, et al Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action Mol Cancer 2009;8:81 Kamath R,

Ngày tải lên: 23/09/2020, 00:04

... than 90 % of all bladder cancers, approximately 80 % of which are nonmuscleinvasive bladder cancer (NMIBC) The vast majority of cancer- specific deaths are due to muscle-invasive bladder cancer (MIBC), ... Prognosis Background Bladder cancer is one of the most common cancers worldwide and the most frequent malignancy of the urinary tract [1] In China, bladder cancer is the tenth most common cancer, accounting ... bladder cancer However, only a few of the exposed individuals develop bladder cancer in their lifetime, suggesting that genetic factor may also play a crucial role in the pathogenesis of bladder cancer

Ngày tải lên: 28/09/2020, 16:33

... Todenhöfer et al BMC Cancer (2015) 15:155 Page of 11 Table Prediction of recurrence by single urine markers in case of negative cystoscopy in the follow up of non muscle invasive bladder cancer Urine ... role of urine markers in the surveillance of patients with non-muscle invasive bladder cancer (NMIBC) is discussed extensively In case of negative cystoscopy the additional prognostic value of ... approach to directly compare the ability of a urine marker panel to predict the risk of recurrence and progression in bladder cancer (BC) patients with no evidence of relapse during surveillance for

Ngày tải lên: 30/09/2020, 11:03

... underlying the differences of MMP and TIMP expression in the molecular subtypes for the development of specific therapeutic targets for breast cancer subtypes Keywords: Breast cancer, Molecular subtype, ... the expression of MMPs and TIMPs in various molecular subtypes of breast carcinoma McGowan and Duffy [17] investigated the mRNA expression of MMPs in breast cancer by analysis of a published ... studies have shown the expression and activity of MMPs to be linked to the advanced stage of breast cancer, increased invasion of tumor cells and building of metastatic formations [16-18] Likewise,

Ngày tải lên: 30/09/2020, 13:22

... key characteristic of the ? ?molecular signature” of subsets of breast cancer In Page 10 of 12 our opinion, MMP-9 expression could help segregate subsets of aggressive breast cancer into clinically ... subtypes of breast cancer Hence, MMP-9 is a promising prognostic biomarker of high-grade breast cancer In our opinion, MMP-9 expression could help segregate subsets of aggressive breast cancer ... degree of differentiation of breast cancer cells and that its overexpression tightly correlates with the most aggressive subtypes of breast cancers Hence, MMP-9 is a potentially useful biomarker of

Ngày tải lên: 14/10/2020, 13:59

... subset of gastric cancer cases Keywords: SOX2, CDX2, Gastric cancer, Prognosis, Survival Background Gastric cancer is one of the most commonly diagnosed cancers and now the third leading cause of cancer- related ... Porto, Portugal Department of Pathology and Oncology, Faculty of Medicine of the University of Porto, Porto, Portugal Full list of author information is available at the end of the article mechanisms ... the activation of independent molecular * Correspondence: ralmeida@ipatimup.pt † Equal contributors Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua Dr

Ngày tải lên: 14/10/2020, 16:56

... transcriptional regulation of bladder cancer Still, much more research needs to be done to characterize molecular signatures of this cancer in depth At this point, the use of bladder cancer cell lines is quite ... of WNT/β-catenin pathway in neuronal differentiation of bladder cancer cells The information we provide for the potential involvement of FGFR1 in neuroendocrine features of bladder cancer (Figure ... analysis of a bladder cancer cell line: an experimental model of tumour heterogeneity British Journal of Cancer 61: 369-376 664 Cancer Genome Atlas Research N (2014) Comprehensive molecular characterization

Ngày tải lên: 12/01/2022, 22:32

... two major molecular subtypes of non-muscle invasive disease Urothelial carcinoma of the bladder (UC) arises in the transitional epithelium that lines the inner surface of the urinary bladder Clinically, ... basis of whether tumor cells have invaded into the muscle layer beneath the mucosa of the bladder (non-muscle invasive and muscle invasive disease respectively)1 Early efforts in molecular profiling ... indicative of a component of non-tumor cells in the biopsy sample The infiltrated subgroup of tumors was therefore not considered an intrinsic subtype of UC and immunohistochemical evaluation of paraffin

Ngày tải lên: 19/11/2022, 11:49

... Table of contents Contents TITLE PAGE i ACKNOWLEDGEMENTS ii TABLE OF CONTENT iv SUMMARY vii LIST OF TABLES xi LIST OF FIGURES xiii LIST OF ABBREVIATIONS xx REVIEW OF THE LITERATURE Gastric cancer ... karyotyping of seventeen gastric cancer cell lines 7.1 Gastric cancer spectral karyotypes 7.2 148 Recurrent patterns of translocations Multimodality whole genome characterization of gastric cancer ... gastric cancers 13 Molecular characterization of 18q21q22 breakpoint genes 284 13.1 mRNA expression profiling 13.2 Expression of breakpoint genes by immunohistochemical staining v Table of contents...

Ngày tải lên: 14/09/2015, 08:38

... cloning of tumor suppressor genes in hereditary cancers 288 14 Bladder Cancer 289 14.1 Histology and etiology of bladder cancer 290 14.2 Molecular alterations in invasive bladder ... evolving scope of molecular diagnostics 427 21.2 Molecular diagnosis of hematological cancers 429 21.3 Molecular detection of carcinomas 433 21.4 Molecular classification of carcinomas ... left blank MOLECULAR BIOLOGY OF HUMAN CANCERS This page intentionally left blank Molecular Biology of Human Cancers An Advanced Student’s Textbook by WOLFGANG ARTHUR SCHULZ Department of Urology...

Ngày tải lên: 08/04/2014, 12:51

... results of result of gene expression profiling Jin et al Journal of Translational Medicine 2010, 8:4 http://www.translational-medicine.com/content/8/1/4 Page of 15 Figure Change in the expression of ... analysis of maturing DCs revealed two distinct patterns: down-regulation of groups of miR at hours of maturation with sustained low expression throughout the rest of maturation and up-regulation of ... Marincola FM: Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness Cancer Res 2002, 62:3581-3586 Jin et al Journal of Translational Medicine 2010,...

Ngày tải lên: 18/06/2014, 16:20

... used bladder cancer disease specific instruments only, five used general instruments only (not specific to bladder cancer) , and five studies used a combination However, only one of the bladder cancer ... included examination of patient characteristics and quality of life, thematic content coding of responses to the Brief Quality of Life Appraisal Profile, examination of the relationship of goal attainment ... idiographic measure of quality of life Analysis of the Construct Validity of the Brief QOL Appraisal Profile A key concept we used to examine the psychometric properties of the Appraisal Profile is construct...

Ngày tải lên: 20/06/2014, 15:20

... Tissue microarrays (TMAs) of lung cancer Tissue microarrays (TMAs) of lung cancer TMAs are comprised of core biopsies of 0.6 mm in diameter of different tumors and of uninvolved lung from the ... [98] of patients with or without cancer We recently acquired experience in this method for profiling of proteins in cancer tissue [99] We applied MALDI-MS to 79 surgically resected lung cancers ... exposure of the whole airway mucosa to tobacco smoke could cause the entire bronchial tree to be at increased risk of developing lung cancer, leading to the concept of field cancerization Field cancerization...

Ngày tải lên: 12/08/2014, 18:21

... 1.1 Bladder cancer 1.1.1 Epidemiology of bladder cancer Overview Bladder cancer is the most common cancer of the urinary tract According to WHO statistics for 2000, bladder cancer is the ... for bladder cancer and probably accounts for 50% of bladder cancer cases diagnosed in the United States It is estimated that smokers’ risk of bladder cancer may be up to three times that of non-smokers ... the treatment of superficial bladder cancer From the clinical point of view, therefore, therapeutic targeting of superficial bladder cancers in an in vivo model of liposome-mediated bladder- directed...

Ngày tải lên: 16/09/2015, 17:14