molecular insights and therapeutic potential

... Zapol and K J Falke 25 Gas Mixing and Distribution in the Lung, edited by L A Engel and M Paiva 26 High-Frequency Ventilation in Intensive Care and During Surgery, edited by G Carlon and W S Howland ... current understanding of SRBD is a detailed knowledge of the anatomical connectivity and molecular basis of action for the brainstem and forebrain networks that govern sleep and arousal, and the means ... Exercise Medicine, edited by S C Wood and R C Roach 77 Endotoxin and the Lungs, edited by K L Brigham 78 The Mesothelial Cell and Mesothelioma, edited by M.-C Jaurand and J Bignon 79 Regulation of Breathing:...

Ngày tải lên: 14/02/2014, 17:20

... Science and Therapeutic Potential, second edition, useful as a reference and a valuable tool for the improvement of reproductive medicine from the cell biology perspective ´n Carlos Simo and Antonio ... Marque ´n and Carlos Simo Gamete Generation from Stem Cells: An Ethicist’s View 14 Heidi Mertes and Guido Pennings SECTION II: FEMALE GAMETE Molecular Biology of the Gamete 22 Kyle Friend and Emre ... Methylation Pattern: Erasure and Reestablishment Nina J Kossack, Renee A Reijo Pera, and Shawn L Chavez Germ Line Stem Cells and Adult Ovarian Function 57 Roger Gosden, Evelyn Telfer, and Malcolm Faddy...

Ngày tải lên: 22/03/2014, 20:21

... potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer’s disease Journal of Translational Medicine 2011 9:127 Submit your next manuscript to BioMed Central and ... indicated doses of killed WSN-Ab1-10 and WSNWT viruses formulated in Quil A Lines and error bars indicate the average ± s.d (n = for groups immunized with and 25 μg and n = 16 for groups immunized ... significantly higher than that elicited by WSN-WT Anti-Ab and anti-influenza antibodies are therapeutically potent To show the therapeutic potential of dual chimeric vaccine we first analyzed binding...

Ngày tải lên: 18/06/2014, 22:20

... may limit the therapeutic potential of adult NSCs in vivo and ex vivo On the other hand, it may interact with the neurogenic niches to promote the regenerative potential in vivo, and the integration ... vivo and ex vivo Therapeutic strategies for promoting the potential of adult NSCs in vivo and ex vivo may involve pro- and anti-inflammatory treatments Future studies will aim at unraveling the molecular ... has the potential for self-repair and that newborn neuronal cells may contribute to the functioning, and physioand pathology of the CNS [36] However, adult NSCs remain elusive cells and to be...

Ngày tải lên: 08/08/2014, 17:20

... throughput analysis of molecular markers identified in squamous lung neoplasia antibody reagents and data interpretation need to be developed and standardized A comprehensive and integrated approach ... in lung and breast cancers and malignant phenotype suppression J Natl Cancer Inst 2001, 93:691-699 Antequera F and Bird A: Number of CpG islands and genes in human and mouse Proc Natl Acad Sci ... The understanding of lung cancer molecular approaches has led to the development of transgenic models using viral antigens, including SV40 large T antigen and polyomavirus (PyV) large and middle...

Ngày tải lên: 12/08/2014, 18:21

... culturing and activation of dendritic cells (DCs) 64 CD4+ T cell selection and proliferation 65 Molecular biology 66 2.3.1 Design and synthesis of EV71-specific primers and probes 66 2.3.2 Design and ... approximately 77% and 89% homology based on deduced amino acid sequences and hence falls within cluster A 1.3.2.1 VP1-based classification The understanding of the molecular epidemiology and evolution ... help in all administrative and technical matters Boon King, Eng Lee, Adrian, Andrew, Boon Eng, Si Ying, Wen Wei, Grace, Li Rui, Wei Xin and Joo Lee for their help and encouragement Thank you...

Ngày tải lên: 12/09/2015, 08:19

... membrane potential induced by D-glucose, thioglycosides I and VII and phlorizin As expected, the maximal effect was observed with D-glucose with FRET values of 5.62 and 2.29 for hSGLT1 and hSGLT2, ... (hSGLT1 and hSGLT2) and to the inhibition exerted by the same concentration of phlorizin, exceptions are thioglycosides I and VII Thioglycoside I inhibited hSGLT2 stronger than hSGLT1 and to a ... Current therapies and emerging targets for the treatment of diabetes Current Pharmaceutical Design 2001; 7: 417-450 Wood IS, and Trayhurn P Glucose transporters (GLUT and SGLT): expanded families...

Ngày tải lên: 26/10/2012, 10:04

... and K Griebenow Structural dynamics and serine protease catalysis Table Kinetic and thermodynamic parameters derived from amide H D exchange rates for a-CT and for the various lactose-a-CT and ... R J Sola and K Griebenow Structural dynamics and serine protease catalysis modelling and structural dynamics simulation techniques (MD and GNM) we have provided structurally dynamic insights ... for the p-nitroanilide (pNA) substrate Glycoconjugate modelling and molecular dynamics simulations For all molecular modelling and molecular dynamics (MD) simulation experiments the yasara suite...

Ngày tải lên: 19/02/2014, 05:20

... by FLT3-ITD and is important for FLT3-ITD-mediated cell growth and anti-apoptotic effects [48] Taken together, FLT3-ITD constitutively induces STAT5 and Pim serine threonine kinases, and their ... production leads to increased DNA double-strand breaks (DSBs) and repair errors They found that FLT3-ITD-transfected cell lines and FLT3-ITD-positive AML cell lines and primary cells exhibit increased ... effects of ATO and MEK inhibition, as well as ATO and FLT3 inhibition, on FLT3-ITD cells [101] The combination of ATO and AG1296, an FLT3 inhibitor, profoundly inhibited the growth and induced apoptosis...

Ngày tải lên: 10/08/2014, 21:23

... were at 270-70 and 270-116 for PGP and 312-140 and 312-112 for N-α-PGP The R2 value for the calibration curves for PGP was 0.988 and the detection limit was 10 pg/ml The intra- and inter-assay ... idea that N-α-PGP and PGP are novel biomarkers and therapeutic targets for COPD Necessary future directions include measuring N-α-PGP and PGP in a larger cohort of COPD patients and controls, correlating ... analyses and collagen digestion assays; BN performed the animal studies; SP and MD provided the sputum and serum samples and provided clinical information on the COPD patients; AG performed the MPO and...

Ngày tải lên: 12/08/2014, 14:20

... presentation and progression ………………………………… 1.1.3 Relationship between disease pathogenesis and immunity …………… 11 1.2 Dengue virus structure and genome ….……………….………….………… 12 1.3 Prevention and control ... disease pathogenesis and immunity The pathogenesis of severe dengue is multifactorial and is influenced by the viral strain, age, host genetics and prior immune status Clinical and epidemiological ... 1.5.2 Subversion of innate immunity to establish infection in monocytes…….42 1.6 Molecular insights of neutralization and enhancement of DENV infection … 45 1.6.1 The role of FcγR DENV neutralization...

Ngày tải lên: 08/09/2015, 22:14

... cancer treatment Leong-Uung Ling*, Hui-Min Lin and Gigi N.C Chiu 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutic, Geneva, Switzerland, October 21-24, 2008 Use of Liposomal ... breast and ovarian cancer cells Leong-Uung Ling*, Bee-Jen Tan and Gigi N.C Chiu Gem4 Summer School, Singapore, July 2-4, 2007 10 Safingol - a potential therapeutic agent for human breast and ovarian ... Mcl-1, Bcl-w and A1 They have as many as four BH domains and are essential for cell survival and normal embryogenesis On the other hand, pro-apoptotic Bcl-2 members lack BH4 domain and can be further...

Ngày tải lên: 11/09/2015, 10:02

... cycle dependent kinases and their associated cyclins Potential PLKs’ downstream substrates and upstream regulators discovery will further enhance our understanding in the molecular mechanism of ... (Bharadwaj and Yu, 2004) PLK1 may directly regulate these components such as BubR1 (Matsumura et al., 2007) and possibly Mad2 (Eckerdt and Strebhardt, 2006) in order to prevent APC/C inhibition and ... in Hepatology and Gastroenterology research laboratory for all their helps and guidance I would also like to take this opportunity to thank my parents and friends for their loves and supports...

Ngày tải lên: 16/10/2015, 15:38

... (filer paper), BWX and PWSD The enzyme kinetic studies for cellulase and xylanase (Km and Vmax) were performed with 1-10 mg/ml of CMC and BWX, respectively [35] The crude cellulase and xylanase were ... albumin as standard [38] All experiments were run in duplicate and standard deviations (SD) were calculated using Microsoft Excel and results were presented as average ± SD Results and discussion ... degradation and conversion for sustainable production of bioenergy and highvalue products; enzyme production and catalysis, bioremediation and biorefineries Lew is the author of patents and over...

Ngày tải lên: 05/09/2013, 16:11

... only understand the process of randomization, but also the risks and beneWts of treatment and non-treatment, and the treatments currently available The ACTG 076 regimen is expensive and relatively ... Obstetrics and Gynaecology 180: 259–64 Grubb, A and Pearl, D.S (1990) HIV Testing and the Law Blood Testing, AIDS and DNA ProWling Law and Policy Family Law Series Bristol: Jordan and Sons Ltd ... competent, informed and voluntary The information required is such that the patient understands in broad terms the nature and purpose of the procedure, and the principal risks, beneWts and alternatives...

Ngày tải lên: 01/11/2013, 08:20

... Semchyshyn and Volodymyr I Lushchak Chapter Oxidative and Nitrosative Stresses: Their Role in Health and Disease in Man and Birds 47 Hillar Klandorf and Knox Van Dyke Chapter Nitric Oxide Synthase and ... mutagenic and teratogenic actions of RCS and ROS, and products of these interations have powerful Interplay Between Oxidative and Carbonyl Stresses: Molecular Mechanisms, Biological Effects and Therapeutic ... Akar and Olga Bỹyỹkleblebici Section Cellular and Molecular Targets Chapter 10 155 + + Renal Redox Balance and Na , K -ATPase Regulation: Role in Physiology and Pathophysiology Elisabete Silva and...

Ngày tải lên: 12/02/2014, 16:20

... Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate p,p’DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane ... TDS-like effects of ECs and EC mixtures in animal studies, together with new understanding about when and how androgens regulate development of the male reproductive system and how this may relate ... fungicides (such as Vinclozolin, DDE and Procymidone) exert their antiandrogenic effects by binding to the AR – and then instead of activating it, sit there and block it and thus prevent activation of...

Ngày tải lên: 13/02/2014, 10:20

... al., 1996; Da Ros and Prato, 1999; Tagmatarchis and Shinohara, 2001; Bosi et al., 2003; Nakamura and Isobe, 2003; Sarova et al., 2006; Bianco and Da Ros, 2007) 1.2 Cell Protection and Antioxidant ... fullerene and light, so the polymer was tested on mice affected by bone tumor After injection and irradiation, tumor size and weight were reduced and the mouse survival time was extended (Jiang and ... and therapeutic properties of conventional drugs and to overcome problems such as limited solubility, poor distribution, lack of selectivity and tissue damage Cell membranes act as barriers and...

Ngày tải lên: 17/02/2014, 05:20

... opportunities and their merits and limitation Moreover, the nature of gearing and potential effected of high gearing on perceived risk and cost of capital I-Analysis of the reasons behind takeovers and ... be applied to evaluated and rank potential investment opportunities and their relative merits and limitations In this report, I will give methods to evaluate and rank potential investment opportunities ... involved in takeovers and large companies tended to engage in higher gearing and this led to higher retention ratio and eventually higher growth is attained (international business and management)...

Ngày tải lên: 17/02/2014, 13:02