molecular genetics of acute leuke

... complete loss, within affected cells, of the two alleles of a given CCM gene Loss of one of the alleles (first hit) would be the result of a germline mutation and loss of the second allele (second hit) ... None of these mutations was detected through direct sequencing of lesion DNA, emphasizing the lack of sensitivity of direct sequencing of lesion DNA These data established the existence of biallelic ... for clinical care of the patients and were an important step towards the understanding of the mechanisms of this disorder This minireview summarizes the advances in CCM molecular genetics and the...

Ngày tải lên: 15/03/2014, 10:20

... Departments 75235 of Human Genetics, Medicine, and Molecular Biophysics and Biochemistry, Yale MICHAEL J SICILIANO(15), Department of University School of Medicine, New Genetics, The University of Texas ... OKAYAMA(32), Laboratory of Cell Biology, National Institute of Mental ERIC J STANBRIDGE (23), Department of Health, National Institutes of Health, BeMicrobiology and Molecular Genetics, thesda, Maryland ... Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 GERALD A GILLESPIE (35), Department of Human Genetics, Yale University School of Medicine,...

Ngày tải lên: 11/04/2014, 09:52

... studies, absence of power calculations, and an unknown number of unpublished negative studies, it is possible that many of these associations were found merely due to chance The choice of control groups ... plurality of the studies selecting healthy subjects or population-based control individuals These findings present a mixed picture – owing to the number of studies with small sample sizes, a lack of ... elements of these criteria as a guide, Flores and colleagues discovered a few notable trends in the published literature [1] Most of the published studies reported positive associations, in a total of...

Ngày tải lên: 13/08/2014, 11:23

... results of joint analysis of the TDT and case-control studies 55 iii LIST OF FIGURES Figure 1-1 Schematic of placental localization and function of MDRPs ATP hydrolysis drives the efflux of Antiepileptic ... frequencies of SNPs and association analysis of each SNP in controls and mothers of oral cleft children 53 Table 14 Genotype and allele frequencies of SNPs and association analysis of each ... of Medicine for awarding financial assistance for presenting my research work in the 32nd Annual Scientific Meeting of Human Genetics Society of Australasia My sincere thanks also goes to Prof...

Ngày tải lên: 16/09/2015, 14:04

... apoptosis in acute myeloid leukemia cells To understand the potential role of BPA in biological systems of leukemias we tested the action of BPA in three different acute myeloid leukemia models ... activity of these compounds [17,18] In the present manuscript, we decided to investigate the effects of different doses of BPA on acute myeloid leukemia models to understand the mechanism(s) of BPA ... an increase of the G1 peack at low dose BPA (30 μM) and an increase of the G2-M fraction of cells at the highest concentration of BPA (100 μM) Differently, in the K562 cells, a model of AML derived...

Ngày tải lên: 18/06/2014, 15:20

... protein of 993 amino acids with a molecular weight of 158-160 kDa, as well as a non-glycosylated isoform of 130-143 kDa that is not associated with the plasma membrane [10,12] After the cloning of ... function of C/EBPa through phosphorylation of the N-terminal serine 21 of this protein by activation of ERK [56] Following this aberrant phosphorylation of C/EBPa, the differentiation of FLT3-ITD ... Tandem duplication of the FLT3 gene in acute lymphoblastic leukemia: a marker for the monitoring of minimal residual disease Leukemia 2000, 14:522-524 Xu B, Tian H, Zhou SY: Detection of FLT3 gene...

Ngày tải lên: 10/08/2014, 21:23

... infections and risk of acute lymphoblastic leukemia in the offspring American journal of epidemiology 2003;158(3) 207-213 Infectious Etiology of Childhood Acute Lymphoblastic Leukemia, Hypotheses ... experience and the risk of childhood acute lymphoblastic leukemia American journal of epi‐ demiology 2000; 152(5):1136-44 Model for Identifying the Etiology of Acute Lymphoblastic Leukemia in Children ... Epidemiology of Acute Lymphoblastic Leukemia - From the Molecules to the Clinic Figure Interaction among the three phenomena Acute lymphoblastic leukemia (AL) in childhood is the result of the interactions...

Ngày tải lên: 17/03/2014, 12:20

... Craniosynostoses Molecular Genetics, Principles of Diagnosis, and Treatment Monographs in Human Genetics Vol 19 Series Editor Michael Schmid Würzburg Craniosynostoses Molecular Genetics, Principles of Diagnosis, ... the dawn of human history Our understanding of the clinical manifestations of the disease process has advanced considerably in the last century, with molecular etiologies of many forms of syndromic ... review of craniosynostosis The authors take us on a tour of ancient times, later historical developments, the advent of modern classifications, and the evolution of the molecular causes of craniosynostosis,...

Ngày tải lên: 28/03/2014, 22:20

... Modification of PAL and C4H Genetic Modification of 4CL Genetic Modification of C3H Genetic Modification of CCoAOMT Genetic Modification of CCR Genetic Modification of F5H Genetic Modification of COMT ... COMMENTARIES, EV ALUATIONS Genetics and he techniques of “MolecularTrees makes itBreeding of assistanceknowledge anddiverseofaspects great Forest clear that “T molecular biology are in addressing ... of wood and tree production, with the goal of enabling new kinds of highly domesticated, biosafe plantations to be employed Highlights of the book include a description of the EST databases of...

Ngày tải lên: 03/04/2014, 12:10

... Department of Sciences of Life and Reproduction, Section of Biochemistry, University of Verona, Italy 2Department of Medicine, Section of Hematology, University of Verona, Italy 3Department of Biochemistry ... Cavalieri et al.: Pro-apoptotic activity of a-bisabolol in preclinical models of primary human acute leukemia cells Journal of Translational Medicine 2011 9:45 Page 13 of 13 Submit your next manuscript ... 50 ) included Ph+ and PhB-ALL cases Thus, a proportion of the Ph-B-ALL cases

Ngày tải lên: 18/06/2014, 19:20

... continuous variable since there was a linearity of the odds ratios for outcome The influence of neuroserpin decrease at 24 h on serum levels of molecular markers of brain injury was assessed by logistic ... hours and levels of molecular markers of brain damage at 24 hours after ischemic stroke We suggest that neuroprotective properties of neuroserpin might be related to the inhibition of tPA-mediated ... BB, Gordon DL, Marsh EE: Classification of subtype of acute ischemic stroke Definitions for use in a multicenter clinical trial Toast Trial of org 10172 in acute stroke treatment Stroke 1993, 24:35-41...

Ngày tải lên: 18/06/2014, 19:20

... continuous variable since there was a linearity of the odds ratios for outcome The influence of neuroserpin decrease at 24 h on serum levels of molecular markers of brain injury was assessed by logistic ... hours and levels of molecular markers of brain damage at 24 hours after ischemic stroke We suggest that neuroprotective properties of neuroserpin might be related to the inhibition of tPA-mediated ... BB, Gordon DL, Marsh EE: Classification of subtype of acute ischemic stroke Definitions for use in a multicenter clinical trial Toast Trial of org 10172 in acute stroke treatment Stroke 1993, 24:35-41...

Ngày tải lên: 20/06/2014, 03:20

... the course of dis- 17 18 19 20 21 22 23 24 25 26 27 ease in patients with acute myeloid leukemia Haematologica 2007; 92:1268-9 Falini B, Martelli MP, Bolli N, et al Acute myeloid leukemia with ... Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis Cancer 2009; ... and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML) Blood 2006; 107: 4011-20 Falini B, Sportoletti P, Martelli MP Acute myeloid leukemia with mutated...

Ngày tải lên: 08/08/2014, 18:21

... frequency of TRBV-BD1 sjTRECs and sequences of the junction regions of each TRBV-BD1 sjTRECs were confirmed by direct sequencing of PCR products (data not shown) Comparison of the frequencies of TRBV ... Forty-three acute leukemia patients (median age, 30.6 ± 10.2 years; range, 17-52 years; classified according to the French-American-British (FAB) criteria as 27 cases of acute lymphocytic leukemia ... reactions were performed with approximately 100 ng of genomic DNA, 25 pmol of each primer, 10 nmol of each dNTP, 1.25 U of AmpliTaq Gold polymerase, pmol of 6-FAM-TAMRA probe, and PCR buffer with 4.5...

Ngày tải lên: 10/08/2014, 21:23

... suppression of the formation of IgM in B cells, the formation of matrix metalloproteinase-3, and the differentiation of osteoclasts [9,10] The bone marrow karyotyping revealed an abnormal karyotype of ... reported case of co-existing AML-MLD and EBV-associated T-LPD in RA It is possible that the development of AML was secondary Page of (page number not for citation purposes) Journal of Hematology ... rapidly Three weeks after the diagnosis of T-LPD, the patient died of multiple organ failure with pneumonia and sepsis An autopsy revealed the presence of leukemic cell infiltration into multiple...

Ngày tải lên: 10/08/2014, 22:20

... autonomous proliferation of leukemia blasts is associated with the degree of aggressiveness of acute leukemia [1,4] In the present study, we examined the ability of patientderived acute leukemia cells ... growth pattern of acute leukemia cell lines in Aggressive growth pattern of acute leukemia cell lines in SCID mice in SCID mice, displayed an aggressive growth pattern 17 of 22 (77%) AML leukemia samples ... crisis of chronic myelogenous leukemia [16,17] The subcutaneous engraftment and growth of human leukemias in this model are associated with dissemination of leukemia blasts and reflect a pattern of...

Ngày tải lên: 10/08/2014, 22:20

... identification of a new coronavirus as the causative agent of SARS and of a southern Chinese province as the first area of occurrence, animal species of this area have been speculated to be the origin of ... spikes of the SARS-CoV (Figure 3) Intra- and extracellular proteases often cleave the S protein into S1 and S2 domains, with the cleavage process often increasing infectivity of the virus Molecular ... active site of ACE2 may be useful for the development of therapeutic strategies Virus entry After binding to the receptor, the next molecular step of potential use for the development of anti-SARS...

Ngày tải lên: 12/08/2014, 18:21

... validation of targets for asthma BG is the head of division of Molecular Immunogenetics, IGIB-CSIR, India He has been working on genetic and molecular biology of asthma pathogenesis and mentor of AK ... on the Genetics of Asthma: Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S populations: collaborative study on the genetics of asthma ... which might not be taken care of by the present therapeutic regimen Increased prevalence of severe asthmatics may be explained by the hypothesis that lack of treatment of airway remodeling during...

Ngày tải lên: 13/08/2014, 13:22

... in 86% of the strains of the clonal complex (CC)2, 58% of the CC9 strains, nor in any of the CC8 strains [31] The Symbioflor strain, used as a probiotic, is one representative of the 7.4% of E ... analysis of other strains' genotypes in this area seemed to confirm the hypothesis of a hot region for rearrangement (data not shown) A homologue of Tn916 in OG1RF An analysis of the G+C content of ... phenotype of clinical isolates of Enterococcus faecalis in urine Appl Environ Microbiol 2002, 68:3152-3155 Roberts JC, Singh KV, Okhuysen PC, Murray BE: Molecular epidemiology of the fsr locus and of...

Ngày tải lên: 14/08/2014, 20:22