molecular cytogenetics of renal cell tumors

... survival outcomes in patients with renal cell carcinoma; SPECIFIC AIMS (MOLECULAR MODELS) To evaluate the molecular profiles of three primary subtypes of RCC clear cell RCC, papillary RCC and chromophobe ... clear cell renal cell carcinoma, which comprises the majority of all RCCs (Cheville et al 2003) On the other hand, oncocytoma is the most common benign renal tumour, comprising 5-8% of resected renal ... foundation from a clear understanding of the molecular epidemiology and pathology of RCC viii LIST OF FIGURES Figure : Histologic subtypes of epithelial renal tumours, 15 Figure 2: The Kattan...

Ngày tải lên: 11/09/2015, 09:56

... migration of these cells into the lesion at the site of bone destruction in GCTs We recently showed that VEGF stimulates the chemotaxis and cell proliferation of RAW cells, a model of mouse OPCs ... article as: Matsumoto et al.: Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone Journal of Orthopaedic Surgery and Research ... confocal laser scanning microscopy Tissue culture of giant cell tumors of bone Primary cultures of GCTs were obtained from surgical samples of lytic bone lesions As previously described [6],...

Ngày tải lên: 20/06/2014, 04:20

... migration of these cells into the lesion at the site of bone destruction in GCTs We recently showed that VEGF stimulates the chemotaxis and cell proliferation of RAW cells, a model of mouse OPCs ... article as: Matsumoto et al.: Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone Journal of Orthopaedic Surgery and Research ... confocal laser scanning microscopy Tissue culture of giant cell tumors of bone Primary cultures of GCTs were obtained from surgical samples of lytic bone lesions As previously described [6],...

Ngày tải lên: 20/06/2014, 07:20

... tomography, the depth of penetration of tumors ranged from to cm (median 1,9 cm), without a direct contact with the upper excretory urinary tract (renal pelvis) in each of the patients enrolled ... crucial to get a better understanding of the genesis of those reactions Ahead of its time are, on one hand, the recently applications of HAs in the premature rupture of membranes where the adhesive ... which compare the use of a HA and of the ISC in the enucleoresection of RCC The recent evidence related to the NSS capable, in selected cases, to offer the same results of partial and radical...

Ngày tải lên: 09/08/2014, 03:21

... possible the growth of renal cell carcinoma cells is arginase II independent resulting in the low inhibitory effect of nor-NOHA Page of 10 (page number not for citation purposes) Journal of Hematology ... from the tissue culture supernatants of murine renal cell carcinoma cell lines and determine their effect on cell proliferation In adult mammals, the majority of endogenous L-arginine is synthesized ... arginase inhibitor nor-NOHA on cell proliferation Effect of3 Effect of arginase inhibitor nor-NOHA on cell proliferation (A) Proliferation of CL-2, CL-19 and Renca cells was assessed by [3H]-thymidine...

Ngày tải lên: 10/08/2014, 22:20

... WSU-pre-ALL cell line (A1); WSU-DLCL2 cell line (A2); WSU-FSCCL cell line (A3) and WSU-WM cell line (A4) Cell lines were seeded in 24-well culture clusters at a density of × 105 viable cells/ml ... complexity in B -cell tumors Our results presented here, show that small-molecule inhibitors of the Bcl-2 family proteins has a therapeutic role in a wide spectrum of B -cell tumors All four cell lines ... deaths of any of the animals and no more than 10% loss of body weight during treatment, followed by weight gain To test the efficacy of Page of 13 (page number not for citation purposes) Journal of...

Ngày tải lên: 10/08/2014, 22:20

... pattern of renal tumors and account for the late appearance of metastatic disease in organs and sites that are considered outside of the “usual” metastatic pathway of RCC Rare metastatic sites of renal ... the considered usual chain of metastatic spread of renal tumors For that reason we excluded all sites of common metastases from renal tumors, including the lungs, adrenals, intestines and brain ... in the last five years) Out of these, 17 cases were metastasis of RCC of clear cell type Six of these cases were diagnosed as primary ovarian clear cell cancer, while renal primary was diagnosed...

Ngày tải lên: 10/08/2014, 23:20

... is a picture of renal ultrasound It shows echo-dense area in the renal area, suggestive of a renal tumour Renal Cell Carcinoma in the form of hoarseness or calverial metastasis of which only ... have been reported [3,4] Renal cell carcinoma represents a heterogenous group of tumors, the most common of which is clear cell adenocarcinoma RCC accounts for 3% of adult tumors The incidence has ... presentation of Renal Cell Carcinoma- a report of two cases and review of literature Clinical Neurology and Neurosurgery 2005, 107:329-333 Page of (page number not for citation purposes) Journal of Medical...

Ngày tải lên: 11/08/2014, 10:22

... [31] and occur in 45 to 90% of sporadic RCCs [4,32,33] Inactivation of the 3p25 TSG VHL is of critical importance to the pathogenesis of ccRCC and occurs in up to 86% of tumors [34] Although VHL ... knowledge of the molecular pathogenesis of RCC will increase and with it the potential for developing novel biomarkers and potential therapeutic interventions Abbreviations ccRCC, clear cell renal cell ... Author details Renal Molecular Oncology Group, Medical and Molecular Genetics, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham,...

Ngày tải lên: 11/08/2014, 12:20

... Disappearance of metastatic renal cell carcinoma to the base of the tongue after systemic administration of interferon-α Eur Urol 1993, 24:297-299 Page of (page number not for citation purposes) Journal of ... tissue leading to diagnosis of renal adenocarcinoma J Laryngol Otol 1994, 108:1108-1110 Aguirre A, Rinaggio J: Lingual metastasis of renal cell carcinoma J Oral Maxillofac Surg 1996, 54:344-346 ... 30% of patients with renal carcinoma present with metastatic disease, 25% with locally advanced renal carcinoma, and 45% with localized disease [1] About 75% of patients with metastatic renal...

Ngày tải lên: 11/08/2014, 21:22

... to tumor ulceration of secondarycarcinoma ;cell infiltrationmucosal epithelium noted Renal cell Renal cell carcinoma; ulceration of mucosal epithelium noted secondary to tumor cell infiltration ... surrounded of rich cell carcinoma; epithelial cellular network2shown with clear vascular network Histologic featuresin arenalcytoplasm and hyperchromatic Histologic features of renal cell carcinoma; ... SN: Renal cell carcinoma to the base of tongue: a case report Hinyokika Kiyo 2004, 50(11):791-793 Phillips CK, Taneja SS: The role of lymphadenectomy in the surgical management of renal cell...

Ngày tải lên: 11/08/2014, 21:22

... Persistence of circulating tumor cells may represent residual disease and is known to be associated with a higher risk of recurrence; however, the status of tumors during the period of dormancy ... existence of a more complex picture of immunosurveillance, which includes an active role of the immune system also in facilitating immunoselection of malignant cells and the emergence of tumor ... identification of the site of origin of unknown primary tumor, and for determination of donor-recipient origin in posttransplant lymphoproliferative disorders Microsatellites are short runs of tandemly...

Ngày tải lên: 11/08/2014, 23:21

... variants of the human POLDIP3 gene encoding proteins of 421 amino acids with a molecular mass of 46 kDa and 392 amino acids with a molecular mass of 43 kDa, which differ only by an insertion of 29 ... different cell lines, HeLa, human epithelial cells, and NIH ⁄ 3T3, murine fibroblasts Visualization of the fluorescent chimera proteins, ER, isoform ⁄ a of PDIP46 ⁄ SKAR or isoform ⁄ b of PDIP46 ... their position in isoform ⁄ a of PDIP46 ⁄ SKAR The asterisk indicates the peptide identified by manual analysis of MS ⁄ MS spectra Comparison of the intracellular localizations of the human ER and...

Ngày tải lên: 19/02/2014, 05:20

... according to the Heidelberg Classification of Renal Cell Tumours [2] Seven specimens of pRCC, seven of cRCC, six of chRCC, and six of RO, besides adjacent pieces of unaffected tissue, were used in this ... chromosomes, mutations of p53, LOH at 10q23.3 and telomere shortening have been reported [6] RO consists of mixtures of cells with normal and abnormal karyotypes [7] About 4% of renal cancers arise ... reticulum of mesangial cells and for butyrylcholinesterase in the reticulum of endothelial cells [32] Thus, it is likely that epithelial, mesangial and endothelial cells can all contribute to renal...

Ngày tải lên: 06/03/2014, 22:21

... glioma invasion Increased expression of integrin αvβ3 results in increased motility of glioma cells with a de‐ Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications ... of communication to other cell cell junctions and to cellsubstratum junctions Cadherin cluster forms a transmembrane core of adherens junctions at sites of the cell cell contacts During tumor ... Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications nectin is almost absent but it is effective in the microenvironment of glioma cells, which coexpress large amounts of...

Ngày tải lên: 23/03/2014, 10:20

... http://www.translational-medicine.com/content/7/1/2 Figure Characterization of T cell responses Characterization of T cell responses (A) CD8+CD107a+ effector cells, (B) CD8+perforin+ effector cells, (C) PD-1+ T cells, (D) CD4+CD25+FoxP3+ Tregs ... imaging Two of these patients had complete regression of metastatic disease but had large primary renal tumors in place Primary tumors are known to be more resistant to immunotherapy and often require ... PL, Hawkins RE: Expression of the 5T4 oncofoetal antigen in renal cell carcinoma: a potential target for T -cell- based immunotherapy Br J Cancer 2005, 93:670-677 Page 10 of 11 (page number not for...

Ngày tải lên: 18/06/2014, 15:20

... the differentiation of renal tubules representing the origin of clear cell renal cell carcinoma (RCC) and in the regulation of the cell cycle of parietal epithelial cells of the Bowman's capsule ... pathophysiological situations of the kidney such as acute ischaemic renal failure, renal hypertrophy, von Hippel Lindau (VHL) disease as well as neoplastic transformation of renal cells it may play a fundamental ... underlying molecular mechanism of the heterogeneity of UCHL1 expression levels The silencing of UCHL1 was discovered by cDNA microarrays and chemical genomic screening of head and neck squamous cell...

Ngày tải lên: 18/06/2014, 15:20

... patterns: down-regulation of groups of miR at hours of maturation with sustained low expression throughout the rest of maturation and up-regulation of other groups of miR at hours of maturation and sustained ... These Treg cells can counter the effects of Th1 responses by cytotoxic T cells, Th1 cells, and NK cells In contrast, we found that LPS and IFN-g maturated DCs did not increase the levels of CCL22 ... results of result of gene expression profiling Jin et al Journal of Translational Medicine 2010, 8:4 http://www.translational-medicine.com/content/8/1/4 Page of 15 Figure Change in the expression of...

Ngày tải lên: 18/06/2014, 16:20

... prospect in future Methods Cell Lines The human CCRCC cell line OS-RC-2 and mouse macrophage cell line Ana-1 were purchased from the Institute of Cell Biology, Chinese Academy of Sciences (Shanghai, ... methods [20], the renal cancer cell line, phagocytic cells and endothelial cells were used to detect the toxicity of three modified PEI-derived materials in vitro The OS-RC-2 cells were seeded ... half of cells were alive with 200 μg/ml 2-kD PEI treatment, while 60% cells had viability even exposed to more than 200 μg/ml of FAPEAs or HPEI Generally, for OS-RC-2 cells, the cytotoxicity of...

Ngày tải lên: 18/06/2014, 19:20

... Journal of Translational Medicine 2011, 9:133 http://www.translational-medicine.com/content/9/1/133 Page of 10 Figure Effects of NVP-BEZ235 on renal cell carcinoma cells in vitro Targets of NVP-BEZ235, ... Classification of renal cell carcinoma based on expression of VEGF and VEGF receptors in both tumor cells and endothelial cells Lab Invest 2008, 88:962-972 Camp RL, Chung GG, Rimm DL: Automated subcellular ... percent of the viability of the untreated (control) cells Activity of the dual PI3K-mTOR inhibitor NVP-BEZ235 in RCC cell lines Given the synergism seen between the LY294002 and rapamycin in RCC cell...

Ngày tải lên: 18/06/2014, 22:20