molecular basis of the electrical activity of the atrioventricular junction and purkinje fibres
Báo cáo khoa học: Molecular basis of cytokine signalling – theme and variations docx
Ngày tải lên :
15/03/2014, 09:20
... receptor of the ligand, whereas the main core structure binds into the epitope for the type II receptor of the BMP ligand Therefore, the binding of the receptors of both subtypes is blocked and BMP activity ... the coreceptor IL-2Ra interacts only with the IL-2 ligand It has no contacts with the other two chains This is a telling example of the importance of concentrating the ligand at the surface of ... across the small ridge, like a paper clip, onto the other side of BMP-2 and provides a 1000-fold increase in affinity The SD1 and the clip 112 together compete efficiently for receptor binding and therefore...
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Báo cáo khoa học: Molecular basis of perinatal hypophosphatasia with tissue-nonspecific alkaline phosphatase bearing a conservative replacement of valine by alanine at position 406 Structural importance of the crown domain potx
Ngày tải lên :
07/03/2014, 05:20
... value of the mutant TNSALP was less than one-tenth of the Kcat ⁄ Km value of the soluble form of the wild-type enzyme, indicating that the replacement of valine with alanine at position 406 in the ... of TNSALP In support of our hypothesis, the cysteine residue at position 433 in one subunit of TNSALP (R433C) becomes crosslinked to the counterpart of the other subunit [29], implying that the ... anti-TNSALP serum The arrowhead indicates the top of the resolving gel The values are the means of two independent experiments (D) COS-1 cells expressing the wild-type TNSALP, or the TNSALP (V406A)...
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Báo cáo khoa học: Molecular basis of the unusual catalytic preference for GDP/GTP in Entamoeba histolytica 3-phosphoglycerate kinase doc
Ngày tải lên :
16/03/2014, 01:20
... that the amino group at carbon of the guanine ring may interact with the side chain of Glu309, whereas the carbonyl group at position of the guanine ring may interact with the hydroxyl group of the ... to that of Gly312 in the pig enzyme On the other hand, the Leu residue present in the horse and yeast enzymes is conserved in the majority of PGK sequences reported to date; however, in the EhPGK, ... analyzed The analysis of the predicted structure suggested that the presence of the shorter lateral chain of Val311 instead of Leu allows for the movement of Tyr239 and Glu309 towards the guanine ring,...
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Báo cáo khoa học: The molecular basis of heme oxygenase deficiency in the pcd1 mutant of pea pot
Ngày tải lên :
30/03/2014, 11:20
... characterized the contribution of these assay components by omitting them individually In the absence of ferredoxin the reaction rate decreased to 46.5% of the complete reaction while the absence of ascorbate ... indicate the direction of the major changes in absorption over the course of the measurements (C) Michaelis– Menten plot of the PsHO1 reaction for heme concentrations of 1, 2, 5, 10 and 20 lM ... conservation between HO1s and HO2s would also account for the failure of the PsHO1 probe to detect any HO2-like sequences in Southern blot experiments Whatever the basis of the recovery of phytochrome responses...
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THE MOLECULAR BASIS OF PLANT GENETIC DIVERSITY pdf
Ngày tải lên :
28/06/2014, 11:20
... etc Another impact of the Pleistocene glacials pertained to the connection between the Borneo and Thai-Malay Peninsula (the continent of Asia) The land bridge of the Sundaland accelerated the migration ... used at the level of the individual, and produces distances generated from the bands rather than taking into account the diversity of the population The disadvantage is that it treats the data ... by counting the number of alleles per locus and taking the average of these counts These values then can be compared with the effective number of alleles (ne), which is the number of alleles needed...
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Báo cáo sinh học: "X-chromosome inactivation: the molecular basis of silencing" ppt
Ngày tải lên :
06/08/2014, 18:21
... Tsix The role of DNA methylation Figure Transcription of Xist and Tsix on the X chromosome The coding sequences of Xist and Tsix overlap on opposite strands of the X-chromosome DNA effect: the ... initiated A second cause of non-random X-chromosome inactivation is the selective death of cells that inactivate the incorrect number of X chromosomes: because the fates of the X chromosomes are ... selected as the XA and the other as the XI in each cell In addition to having opposing roles in random choice, Xist and Tsix also negatively regulate each other in ES cells Xist and Tsix are...
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Báo cáo y học: "The molecular basis of lung cancer: molecular abnormalities and therapeutic implications" potx
Ngày tải lên :
12/08/2014, 18:21
... are seen in the transition from normal to intraepithelial cancer to invasive disease The understanding of the timing of instability during progression, the rate of instability and the mechanisms ... described and favor the clonal progression of cancer Yet cancer remains a rare event if one considers the total number of bronchial epithelial cells and the proliferation rate of patches of clonal ... Tumor expression profiles are also influenced by the surrounding non-malignant cells The combination of tumor and cell line profiling allows for the study of the regulatory role of both entities...
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Báo cáo y học: "Application of the comprehensive set of heterozygous yeast deletion mutants to elucidate the molecular basis of cellular chromium toxicity" potx
Ngày tải lên :
14/08/2014, 08:20
... global effects of Cr treatment on the heterozygous mutants Analysis of the global effects of Cr treatment on the heterozygous mutants The plot shows the distribution of the sizes of the growth effects ... resistance of the cell to the toxic action of the metal Over-representation of specific Gene Ontology terms in the annotations of genes found in the haploinsufficiency and haploproficiency datasets ... Discussion The lack of understanding of the cellular and molecular mechanisms that cause metal toxicity has contrasted starkly with our appreciation of the detrimental consequences of metal toxicology...
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Báo cáo y học: "Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus" pdf
Ngày tải lên :
14/08/2014, 08:20
... protein and the T54S mutant structure The side chains of the residues H57 and S139 in the wild-type structure extend out of the surface of the mutant structure One of the hydroxyl groups of the SCH ... atoms On the basis of these structures, the conformations of the residues in the binding pocket and the pocket surface were analyzed The tool VMD [52] was applied for the visualization of simulated ... displacement of the side chain of this residue, thereby changing the shape of the cavity Thus, the V36 mutants affect only the shape of the cyclopropyl binding cavity, which is in agreement with the corresponding...
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Investigating the molecular basis of siah1 and siah2 e3 ubiquitin ligase substrate specificity
Ngày tải lên :
23/09/2015, 14:47
... Molecular Basis of Siah2 Substrate Specificity Given the different roles of Siah1 and Siah2 in cancer and their different cellular functions, it is important to understand the structural basis ... Furthermore, it was found that the amounts of PHD3 bound to full length Siah2 and the SBD of Siah2 were similar The comparable binding of PHD3 to full length and SBD of Siah2 suggests that the ... affinities of Siah1 and Siah2 SBD for PHD3 Homology modeling and docking of Siah2 SBD and PHD3 Interaction of chimeric forms of Siah1 and Siah2 SBD with PHD3 The three dimensional (3D) models of Siah2...
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Epsilon sarcoglycan gene and the molecular basis of myoclonuys dystonia syndrome
Ngày tải lên :
05/10/2015, 21:24
... with the PCR products of the deletions and another round of PCR was performed using P14 and the respective primers P16, 17 and 18 to obtain the final constructs as shown in Figure The sequences of ... template These PCR products were then gel purified To fuse the Igκ and FLAG to the N-terminal of εSG, the PCR product containing the Igκ , FLAG and a small portion of ε-SG ECD was mixed together ... the brain (Shiga K et al 2006) The sarcoglycans are part of the dystrophin glycoprotein complex (DGC) They are known to stabilize the DGC (Hack A.A et al 2000) The molecular architecture of the...
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THIẾT KẾ BÀI TẬP VỀ TÍNH MẠCH LẠC VÀ LIÊN KẾT DỰA TRÊN CÁC BÀI LUẬN IELTS MẪU VÀ NGHIÊN CỨU THỬ NGHIỆM TRONG DẠY HỌC VIẾT LUẬN IELT = designing exercises on coherence and coherence and cohesion on the the basis of ielts model essays and experimenting them
Ngày tải lên :
02/03/2015, 14:30
... signals from the book by Oshima and Hogue (1999: 63), and then she deleted all of the conjunctions and references and typed the instruction Exercise 10: Exercise 10 was the result of the author‟s ... tenses, and word forms The original essay is also the source of the key The author gave the key in the form of a table so that students could see the list of common mistakes more easily and they ... which the meaning of one of the words includes the meaning of the other For example, in English the words animal and cat are related in such a way that cat refers to a type of animal, and animal...
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Molecular mechanisms underlying the thermal stability and acid induced unfolding of CHABII
Ngày tải lên :
26/11/2015, 12:54
... all the NMR and force field data The quality of the ensemble of protein structures can be evaluated by the number and the size of constraint violations, the total potential energy as well as the ... on the refolding of α-Lactalbumin showed that the intermediate, often called the burst-phase intermediate, accumulated quite quickly at the beginning of the refolding within the dead time of the ... initiate the quick formation of the compact hydrophobic core at the beginning of protein folding while the formation of the secondary structures can happen concomitantly or following the formation of...
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Tài liệu Báo cáo khoa học: Molecular basis of glyphosate resistance – different approaches through protein engineering doc
Ngày tải lên :
14/02/2014, 14:20
... some of the key findings that have led to our current understanding of the molecular mode of action of glyphosate and the molecular basis for glyphosate resistance Structure and function of EPSPS ... the size of the side chain, directly increasing the volume of the active site, and enhance the flexibility of loops 20 and 130, allowing them to open wider to accommodate longer ligands When these ... reveal the nature of the active site or the mode of action of glyphosate A decade later, the crystal structure of EPSPS was determined in complex with S3P and glyphosate [15] The compactness of the...
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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
Ngày tải lên :
16/02/2014, 09:20
... change the transcription level of Bcl-2 family genes and the phosphorylation state of their proteins, thereby changing the amount and localization of Bcl-2 family members However, each type of cancer ... members and INK4 family members Members of the KIP family can inhibit the catalytic activity of CDK2, and Members of the INK4 family are specific inhibitors of the cyclin D–CDK4 ⁄ complex It is not ... sequestration of Bax in the cytoplasm and increases the ability of Bax to heterodimerize with the anti-apoptotic Bcl-2 family members Mcl-1 and Bcl-xL, thereby inhibiting activation of apoptosis...
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Molecular Basis of Pulmonary Disease Insights from Rare Lung Disorders pdf
Ngày tải lên :
05/03/2014, 23:20
... the importance of the integrity of the alveolar epithelium in the pathogenesis of parenchymal fibrosis Opportunities to approach lung disease pathogenesis from the vantage point of a primary molecular ... assessed and then “crossed over” to the other treatment The cross-over design makes the same assumptions as “N -of- 1” trials where participants are randomized to pairs of therapies given in random ... object to the concept of randomization and many investigators feel that randomization, in of it itself, is unethical (5) Randomization requires that the investigator and the subject consider themselves...
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Molecular basis of heredity
Ngày tải lên :
13/03/2014, 16:34
... stable DNA can be boiled and even autoclaved without degrading! 5’ and 3’ The ends of the DNA or RNA chain are not the same One end of the chain has a 5’ carbon and the other end has a 3’ carbon ... bond Covalent bond between the phosphate group (attached to 5’ carbon) of one nucleotide and the 3’ carbon of the sugar of another nucleotide This bond is very strong, and for this reason DNA is ... Model of DNA Two sources of information: Base composition studies of Erwin Chargaff • indicated double-stranded DNA consists of ~50% purines (A,G) and ~50% pyrimidines (T, C) • amount of A =...
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Molecular basis of heredity - Bio Cơ sở phân tử của di truyền - sinh học
Ngày tải lên :
13/03/2014, 17:04
... stable DNA can be boiled and even autoclaved without degrading! 5’ and 3’ The ends of the DNA or RNA chain are not the same One end of the chain has a 5’ carbon and the other end has a 3’ carbon ... bond Covalent bond between the phosphate group (attached to 5’ carbon) of one nucleotide and the 3’ carbon of the sugar of another nucleotide This bond is very strong, and for this reason DNA is ... Model of DNA Two sources of information: Base composition studies of Erwin Chargaff • indicated double-stranded DNA consists of ~50% purines (A,G) and ~50% pyrimidines (T, C) • amount of A =...
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Báo cáo khoa học: Molecular basis of toxicity of Clostridium perfringens epsilon toxin ppt
Ngày tải lên :
14/03/2014, 22:20
... specificities of aerolysin and e-toxin, and the different function of LSL, is the result of the different structures and properties of these domains The second and third domains of e-toxin exhibit ... activation of the toxin in the gastrointestinal tract compromises the intestinal barrier of intoxicated animals, allowing the dissemination of toxin via the bloodstream to the main target organs of the ... to form the walls of the pore composed of 14 b-strands Prevention of disease A number of commercially available vaccines exist for the prevention of C perfringens enterotoxaemia, and these have...
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Báo cáo khoa học: Molecular basis of cerebral neurodegeneration in prion diseases pdf
Ngày tải lên :
30/03/2014, 09:20
... Dpl [32,34,35] The neurotoxic potential of PrP variants was found to correlate with the disruption of the HD, indicating that the deletion of this domain, rather then the absence of the octarepeat ... globular domain of PrPC, but lacks the N-terminal octarepeats and the internal HD [33] (Fig 2) Interestingly, the expression of PrPDF, a mutant devoid of the octarepeats and the HD (D32– 134), ... that the deletion of the internal HD could change a neuroprotective activity of wildtype PrP to the pro-apoptotic activity of mutants, such as PrPDF The HD might directly mediate an interaction of...
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