... comprises all 10 transmembrane helices This model is then used to propose an alternative hypothesis for the proton transport pathway This hypothesis is based on the assumption that as in the case of ... and yeast H+-ATPases on the basis ofthe ACT1_RABIT crystal structure [9] From these models is was proposed that proton transport in the H+-ATPases is mediated through specific binding of a hydronium ... proposal is that the fold of PMA1_NEUCR seems very sensitive to mutations directed against residues adjacent tothe catalytic Asp378 Nevertheless, most ofthe residues lining cavities 1–5 are...
... misprints; grammatical errors; localisms; peculiar nuances; comments based upon the sound (or the spelling) of source occurrences, such as puns whose sense it is impossible to render into the ... type; otherwise L is raised by unity The designators C, v, and P ofthe temporary profile TP are revised—in the light ofthe SC to form the Selected Profile (SP) The status flag v furnishes clues ... Hl, to be considered with subsequent strings, Such apparent inconsistencies must all be resolved at the conclusion ofthe sentence, as a necessary (but not sufficient) criterion of successful syntactical...
... requires analysisof historical results, projections of future revenues and expenditures, and an assessment ofthe Government 's long-term fiscal sustainability This Report discusses the Government s ... These exposures are discussed later in this Management Discussion and Analysis (MD&A) section as well as in the supplemental disclosures of this Report Assets – “What We Own” As of September ... advances tothe GSEs if, at the end of any quarter, the FHFA, acting as the conservator, determines that the liabilities of either GSE exceeds its respective assets GSE funding is subject to a...
... in the FIDIC forms In the text of this book cross-references to other relevant clauses or sub-clauses are provided Nonetheless, it is appropriate that professional users ofthe FIDIC forms should ... Access tothe Site, but also to his right to take possession ofthe Site It is intended that the relevant dates for taking possession are to be given in the Appendix tothe Tender If no date (s) ... parties The Employer remains responsible to ensure that a viable access is possible In such instances the issue of access tothe Site should be clarified in the pre-tender period It should not be assumed...
... Proposition 3.24 The infinite sequence S0 , · · · , Sn , · · · ofthe sets of standard polyominoes is the greatest infinite sequence of subsets ofthe sequence M0 , · · · , Mn , · · · ofthe sets of ... Putting these facts together, we see that for the values of n listed in the theorem, the sets ofthe minimal antecedents through the sequence of transformations ofthe canonical polyomino coincides ... (the bars b1 , b2 are one dimensional sections of c along the vectors e1 and e2 ) Several cases arise according to these coordinates and, in case of equality, according tothe lengths ofthe s3 ...
... the motion of a line, painted on the side ofthe bucket, must be made to assume the desired positions A linkage is the usual solution PLANARMECHANISMSVERSUSSPATIALMECHANISMS The above discussion ... transmission angle in more detail in later chapters 3.4 DIMENSIONAL SYNTHESIS Dimensional synthesis of a linkage is the determination ofthe proportions (lengths) ofthe links necessary to accomplish ... more variables than equations The latter situation is more common for linkages (Dimensional synthesis of cams is quantitative.) Dimensional synthesis assumes that, through type synthesis, you have...
... INTRODUCTION With the fundamentals of position analysis established, we can now use these techniques to synthesize linkages for specified output positions analytically The synthesis techniques presented ... than that ofthe graphical synthesis cases in Chapter 3, wherein there was also the possibility of a toggle position between design points In fact, these analytical synthesis methods are just an ... intercept is used as a new guess value This process is repeated until the value ofthe function Yi at the latest Xi is close enough to zero to satisfy the user The Newton 's algorithm described above...
... tangent tothe slider motion and is the line along which all sliding occurs between links and The axis of transmission is defined to be perpendicular tothe axis of slip and pass through the slider ... P referenced tothe origin ofthe global coordinate system The right side defines it as the sum ofthe absolute acceleration of some other reference point A in the same system and the acceleration ... velocity analysis in Section 6.2 (p 244) apply as well to graphical acceleration analysis Historically, graphical methods were the only practical way to solve these acceleration analysis problems With...
... followers The base circle's and prime circle's centers are at the center of rotation ofthe earn The base circle is defined as the smallest circle which can be drawn tangent tothe physical cam suiface ... followers and is measured tothe center ofthe follower The prime circle is defined as the smallest circle which can be drawn tangent tothe locus ofthe centerline ofthe follower as shown in ... exactly tothe conveyor, in order to carry the tools alongside for a long enough time to their job These cam driven "chaser" mechanisms must then return the tool quickly to its start position...
... determine the best sizes and shapes ofthe parts We must estimate the masses ofthe links and other parts ofthe design in order to make a first pass at the calculation We will then have to iterate to ... about the shapes, sizes, and materials of these parts, redesign them, and repeat the force, stress, and deflection analyses Design is, unavoidably, an iterative process The topic ofstress and ... low stress levels In some cases the stresses will be excessive We will probably discover that the parts fail under the dynamic forces Then we will have to go back to our original assumptions about...
... and the average shaft (i) to compute the needed system Is The physical flywheel 's mass moment of inertia If is then set equal tothe required system Is But if the moments of inertia ofthe other ... at the local CGs of each "leg" ofthe link as shown in Figure l2-lb These point masses each have a mass equal to that ofthe "leg" they replace and are supported on massless rods at the position ... rollers, crankshafts, camshafts, axles, clusters of multiple gears, motor rotors, turbines, propeller shafts The common denominator among these devices is that their mass may be unevenly distributed...
... and the average shaft (i) to compute the needed system Is The physical flywheel 's mass moment of inertia If is then set equal tothe required system Is But if the moments of inertia ofthe other ... at the local CGs of each "leg" ofthe link as shown in Figure l2-lb These point masses each have a mass equal to that ofthe "leg" they replace and are supported on massless rods at the position ... rollers, crankshafts, camshafts, axles, clusters of multiple gears, motor rotors, turbines, propeller shafts The common denominator among these devices is that their mass may be unevenly distributed...
... balance mass has to be kept close tothe centerline to clear the piston at BDC Figure 13-2c shows the shape of typical crankshaft counterweights Figure 13-24a shows the shaking force from the same ... angle relationship one tothe other, in order to stagger the motions ofthe pistons in time It should be apparent from the discussion of shaking forces and balancing in the previous chapter that ... allow the student to exercise many variations of an engine design in a short time Some examples are provided as disk files to be read into the program These are noted in the text The student is encouraged...
... in the basics Therefore, a result ofthe "basics later" approach often is to remove from the gifted engineering student the means to express himself visually and physically Machine design tasks ... angle) as well as the magnitude and angle ofthe vector are displayed The programs also allow alternate presentations of polar plots, showing just the vectors, just the envelope ofthe path ofthe ... combination of successive Time Step, Crank Angle, and Time Step analyses can be used to simulate the start-up, steady-state, and deceleration phases, respectively, of a system for a complete analysis CALCULATE...
... nondiabetics) and to assess the effects of concurrent medications and various risk factors on the ultimate outcome The longer time period provides for an assessment ofthe effects of chronic usage ... number of subjects in this type of trial provides an opportunity to study the effects ofthe intervention on different subgroups (women as well as men, smokers as well as nonsmokers, diabetics and ... any other long-term effects The initial Phase I or safety trials focus on the potential adverse effects ofthe intervention in humans In the case of drugs and biologics, these trials are used to...
... interpret angiograms, X-rays, EEGs, and ECGs should consist of experts in the specific diagnostic area The assignment -of- cause committee would consist of specialists in the disease process The trial modification ... consensus, assign and organize tasks, and make, not defer, decisions He or she is responsible for establishing milestones, making personnel asignments, and tracking progress Procrastinators need ... feel such services are warranted The primary duty of committee members is to ensure the safety ofthe participants in the trials Their secondary responsibility is to ensure the integrity of the...
... nonsmokers, or on the basis of some other important cofactor, then you will want to randomize separately within each ofthe distinct groups The rationale is exactly the same as discussed in the ... Normal Distributions data gathered at the first stage should be used to obtain estimates both ofthe effect and ofthe variance in response, and, thus, to determine the size ofthe samples to be ... person -to- person variation First, some components ofthe baseline measurements such as demographics and risk factors can be used for forming subgroups or strata for analysis Second, obtaining a baseline...
... trials Analogous tothe preceding section, it consists of a listing of your company s responsibilities with respect tothe patients, the investigators, and the regulatory agency It is a form of ... adverse events, the importance of tracking adverse event needs to be stressed with the site coordinators at the remaining sites If these latter sites may be deviating from the protocol—a visit is ... and to ask questions I hereby consent to take part in this study Signature of Participant Date Signature of Investigator Date Signature of Witness Date PROCEDURES MANUALS The design process is...
... Although there has been extensive research in the area, no single set of demographic factors has proved to be consistent predictors of success (See, for example, some ofthe articles in Haynes, Taylor, ... at least a quarterly basis (and more often if there is actual news) The contents of such a newsletter might include current statistics on the study s progress, profiles of study investigators, and ... the pills because I was throwing up.” Such responses should trigger calls from your staff tothe subject s physician for further investigation As the “blindness” ofthe treatment must be preserved,...
... appears to stores all its data inside tables Each table consists of a set of rows and columns similar (from the user s point of view, though not the computer s) tothe rows and columns of 146 ... few seconds to sort But a typical clinical database requires 200,000 Kbytes of storage and 1000 to 10,000 seconds to sort if the sorting methods used by Excel (one ofthe fastest spreadsheets) ... information systems (to say nothing of other executives who may have fallen under the spell of a salesperson) Three issues are discussed: Choice of data management software and the options available to...