modulation of radiation responses opportunities for therapeuticexploitation

... shape the beams in order to conform the radiation to the target The superposition of radiation of several beams from different directions enables high doses of radiation to the target while the ... min{z, 0} for the minimum ROBUST OPTIMIZATION OF RADIATION THERAPY 11 variant of the function and ρ(z) = max{z, 0} for the maximum variant, where z is a real number For an ROI consisting of the ... number of segments increased to the sum of those of a small number of plans Salari and Unkelbach [79] used column generation [77] to generate a single set of apertures ROBUST OPTIMIZATION OF RADIATION...

Ngày tải lên: 10/12/2016, 13:45

... intraperitoneal injection of 50 mg of OVA adsorbed to mg of alum (Imject, Pierce, Rockford, IL) followed by an intranasal challenge with 50 mg of OVA after or weeks To test the effects of boosting IFN-c ... humans because of the use of lipofectamine, which is toxic to humans Oromucosal therapy with recombinant IFN reduced the severity of viral infection,44 but intranasal administration of IFN-c pDNA ... pathology of asthma and therefore may be potential targets of agents such as CIN for ameliorating asthmatic symptoms CD4+ T helper cells can either promote (Th2) or inhibit (Th1) the inflammation of...

Ngày tải lên: 08/08/2014, 21:20

... Institute for Corporate Ethics Olsson Professor of Business Administration Darden School of Business, University of Virginia Jared Harris Assistant Professor of Business Administration Darden School of ... challenge for leaders, therefore, is to promote a way of doing business that integrates considerations of business, ethics, and society For example, if a company is creating value for all of its ... management policy role of the chief public relations officer The membership consists primarily of chief public relations and communications officers of Fortune 500 corporations, the CEOs of the world’s...

Ngày tải lên: 18/02/2014, 00:20

... result of an aberrant shift in activity of tau kinases and phosphatases [3] Thus, although targeting plaques and NFTs may ameliorate some of the consequences of AD and no doubt lessen the burden of ... to neuronal dysfunction, the occurrence of plaques may be several steps downstream from the more critical causes of AD Modulation of metal availability for treating AD Ab readily binds Cu and ... metals can promote the formation of Ab oligomers, aggregates and fibrils [48,52–55] Metal mediated oligomerization of Ab may therefore contribute to the potent inhibition of synaptic transmission...

Ngày tải lên: 07/03/2014, 10:20

... spectrum of the turnover form of the T2Cu center are slightly different from that of the as-puried form (cf Table 2) which suggests the existence of modications in the catalytic center of the enzyme ... allowed, for the rst time, the determination of the redox potentials of both copper centers Our studies suggest that the presence of substrate plays an important role in the modulation of the redox ... recent model for the catalytic mechanism of Cu-Nir supposes that nitrite binds to the oxidized form of the T2Cu center, displacing a solvent molecule and forming a hydrogen bond between one of its...

Ngày tải lên: 07/03/2014, 15:20

... extent have learners of all abilities: • benefited from exposure to a range of models of effective writing • become more familiar with the characteristics of different forms of writing, especially ... of Unit Make sure you are familiar with the relevant Programme(s) of Study for Writing in the national curriculum Order for Welsh/English, and/or the writing requirements for other subjects of ... copies of school/cluster/LA data and/or this information on OHT/PowerPoint slide Copies of Sheets 1.1 to 1.5 for each member of the group Task summary Task 1: Why we need to improve the teaching of...

Ngày tải lên: 10/03/2014, 05:20

... updated information from the DOE Office of Science.4 Statement of Task The statement of task for this study charged the committee to provide recommendations for a science research program for managing ... review of its organization, which was directed by the Secretary of Energy (DOE, 2002) As a result of the review, the Office of Biological and Environmental Research within the Office of Science ... continue for decades for some wastes, and during the operating life of the disposal facility For example, substantial deformation of the salt will occur during the operational phase of WIPP,...

Ngày tải lên: 15/03/2014, 15:20

... review of each of these topics, we discuss opportunities for further research March 2008 INTERNAL AUDIT INDEPENDENCE AND OBJECTIVITY: A REVIEW OF CURRENT LITERATURE AND OPPORTUNITIES FOR FUTURE ... IIA Code of Ethics consists of a number of basic principles which internal auditors are expected to uphold, together with rules of conduct which describe the norms of behaviour expected of internal ... a low of 15% to a high of 69% of internal audit activities Paape, Scheffe and Snoep (2003) found that 64% of respondents to their survey of Anderson (2003) provides a general discussion of research...

Ngày tải lên: 15/03/2014, 23:20

... differently. The impact of this differential recording of race on the completeness and  accuracy of the numbers and rates of health events for AI/ANs is difficult, if not  Opportunities for Change: Improving ... Who are Urban Indians?  Urban Indians are members of,  or descendants of members of,  one of the many  Indian tribes or other organized groups of aboriginal inhabitants of the Americas  who live in cities. The Indian Health Care Improvement Act defines the term  ... towards American Indians and Alaska Natives: “It is, in part, because of the  failure of former Federal Indian policies and programs on the reservations that  thousands of Indians have sought a better way of life in the cities.  Unfortunately, the same policies and programs that failed to provide Indians ...

Ngày tải lên: 16/03/2014, 05:20

... the surface of the wire to a concentration of  1012 cmÀ2 and mirrored in the metal The barrier lowering for this concentration at a distance of nm from the MS interface, enough for appreciable ... oxidation of the wires in dry atmosphere at 800 1C for 90 min, the wires were embedded in a SiO2 shell of about 10 nm, with a silicon core of 15–20 nm width Following evaporation and patterning of Pd, ... charge For nanowire widths in the 10 nm range, surface charges may exist close enough to the MS interface to influence the shape of the Schottky barrier The result of a theoretical calculation for...

Ngày tải lên: 16/03/2014, 15:14

... association of sEPCR with RCR-2 was assessed for at a flow rate of 20 lLÆmin)1 (B) Binding of sEPCR N30Q to RCR-2 The amount of immobilized RCR-2 corresponded to 1500 RU The experiment was otherwise performed ... analysis was performed using the biaevaluation software 3.0 (BIAcore) The association and dissociation phases of all sensograms were fitted globally Kinetics of wild-type and variant forms of sEPCR binding ... suggest that the epitope 100 for RCR-2 on sEPCR is on the face of sEPCR opposite to its known binding site for protein C The stability of immobilized RCR-2 as a capture ligand for sEPCR and protein...

Ngày tải lên: 16/03/2014, 18:20

... Notably, this type of experiment may be performed by direct modulation of the intermediate, without changing parameters inside the modules The way the formalism is applied and the type of conclusions ... the sensitivity of the rate of the supply module to changes in the concentration of its product and the sensitivity of the rate of the demand module to changes in the concentration of its substrate, ... and v2 were measured for different ranges of values of S (see Fig of [17]) As a consequence, all values of mean-control coefficients calculated by this analysis involve values of mean-elasticity...

Ngày tải lên: 30/03/2014, 10:20

... of foot faults in the left and right forelimbs The sum of foot faults (SOFFF) in the forelimbs is defined as the number of faults of right and left forelimbs, whereas the differentiation of forelimb ... foot faults (DOFFF) is the difference between the number of faults for the right and left forelimbs SOFFF and DOFFF were used as an index of motor deficit CSF aspiration 80 μL of CSF were aspirated ... b-actin (forward: 5′-CTA CAA TGA GCT GCG TGT GG-3′, reverse:5′-CAG TCA GGA TCT TCA TGA GG-3′) The thermo-profile was 50°C for and 95°C for 10 min, followed by 40 cycles of 95°C for 15 s, 60°C for...

Ngày tải lên: 18/06/2014, 16:20

... contractions of the First Dorsal Interosseous muscle at 20% of maximal effort Two contractions where the activities of and MUs were identified yielded a total of 16 pairs of coactive MUs The periods of ... epoch duration [24] However for delays of the order of magnitude of ± 50 ms and FFT lengths of approximately s, this type of bias is very small and unlikely to account for the observed differences ... results in an effective pass band of 0–5 Hz The peak of the signal is 0.75 and occurs at a lag of 3.5 ms Page of 12 (page number not for citation purposes) Journal of NeuroEngineering and Rehabilitation...

Ngày tải lên: 19/06/2014, 10:20

... Agroindustries and Postharvest Officer of the Food and Agriculture Organization of the United Nations, Regional Office for Asia and the Pacific, Bangkok, Thailand These are indicators of severe land scarcity, ... inadequacy of high level technical understanding and lack of professional management skills in the workforce restricts innovation and consistent performance The physical working environment for many ... SUBTOTAL ASIA-PACIFIC* REST OF WORLD WORLD * data for forests and woodland, from Global Forest Resources Assessment of 2005, other data from 2003 Source: Selected Indicators of Food and Agricultural...

Ngày tải lên: 06/07/2014, 22:20

... (X) by (−1)n Λn (X) for every n ≥ Observe that the formal set X − Y can also be defined by setting X −Y = X +(−Y ) The expression of a Schur function of a formal sum of sets of indeterminates is ... modulation is used For a large number of other modulation methods the information transmitted is more complex, and contains more than one bit However, performance analysis for these modulations can ... the demodulation process several noisy copies of these two signals: one speaks then of demodulation with diversity It appears that the probability of errors encountered in such contexts is of the...

Ngày tải lên: 07/08/2014, 13:21

... affects the splicing of CTLA-4 mRNA; interestingly, this results in a lower expression of the soluble form of CTLA-4 mRNA The authors of the study speculate that a reduced interaction of B7 and soluble ... surface expression of CTLA-4 is a major control point for the regulation of the inhibitory function of CTLA-4 on T cells A quantitative increase in the surface expression of CTLA-4 has been suggested ... [11], indicating that it is an important regulator of responses of antigen-experienced T cells This was confirmed by comparing the T cell responses of monospecific CTLA-4–/– and CTLA-4+/+ cells [17]...

Ngày tải lên: 09/08/2014, 01:23

... List of abbreviation ASTRO: Americal Society of Therapeutic Radiation Oncology; CRT: Conformal Radiation Therapy; CT: Chemotherapy; CTV: Clinical Target Volume; EORTC: European Organization on Radiation ... definitive radiation therapy for carcinoma of the uterine cervix: A dosimetric analysis Int J Radiat Oncol Biol Phys 1997, 37:351-358 Corn BW, Lanciano RM, Greven KM, et al: Impact of improved irradiation ... therapy techniques for treatment of pelvic tumors Analysis of acute toxicity Radiation Oncology 2010 5:117 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient...

Ngày tải lên: 09/08/2014, 09:20

... histograms for all available fractions in patients 7–9 relative lack of anatomic attachments of the jejunum and ileum allow for complex motion The result of this motion may be that irradiation of different ... limit motion of the duodenum than the rest of the small bowel Consequently, the motion of the duodenum is different from the rest of the small bowel This difference in motion between radiation treatments ... 80% of the prescribed dose Second, our data suggests that relative motion of the duodenum is quite distinct from the remainder of the small bowel Percent volumes of the duodenum receiving 80% of...

Ngày tải lên: 09/08/2014, 10:21

... This type of analysis masks the cumulative effect of these leakages This study has shed light on the nature of missed opportunities and health systems leakages on the continuum of care for PMTCT ... understanding of the underlying reasons for the missed opportunities which arose from health systems failures Finally monitoring and evaluation of the quality of care even in the context of dual/triple ... South African Department of Health; 2006 Dorrington R, Bradshaw D, Budlender D: HIV/AIDS profile of the provinces of South Africa - indicators for 2002 Cape Town , Centre for Actuarial Research,...

Ngày tải lên: 10/08/2014, 05:20