modular therapy approach in metastatic castration resistent prostate cancer

... that prostate cancer cells may survive androgen deprivation therapies by increasing intracrine androgen synthesis within the prostate [36,37] Androgen Ablation Therapy Androgen ablation therapy, ... greater growth inhibition of relapsed tumors Manipulating androgen/AR signaling may therefore be a potential therapy for AR-positive advanced prostate cancer Introduction In 1941, Huggins and Hodges ... Androgens as therapy for androgen receptorpositive castration- resistant prostate cancer Chih-Pin Chuu1,2*, John M Kokontis3, Richard A Hiipakka3, Junichi Fukuchi4, Hui-Ping Lin1,2, Ching-Yu Lin1,2,...

Ngày tải lên: 10/08/2014, 10:20

... combined navelbine and mitoxantrone, supporting the testing of combination therapy with estramustine, mitoxantrone, and vinorelbine in patients with CRPC One study demonstrated a potential clinical benefit ... receptor tyrosine kinase inhibitor ZD1839 in non-small cell lung cancer and other solid tumors Clin Cancer Res., 9: 2040-2048, 2003 Clin Cancer Res 2003, 9:1990-1994 Jaeschke R, Singer J, Guyatt ... contrast, resulted in clinically meaningful decline in QOL, warranting the study of other novel agents that target Bcl-2 family proteins Effects of therapy on PBMC Bcl-2 protein supports the feasibility...

Ngày tải lên: 18/06/2014, 16:20

... immunotherapy in metastatic castration- resistant prostate cancer J Clin Oncol 2010, 28:1099-1105 44 Sonpavde G, Slawin KM, Spencer DM, Levitt JM: Emerging vaccine therapy approaches for prostate cancer ... LD, Nelson PS: Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration- resistant tumor growth Cancer Res 2008, 68:4447-4454 Linja MJ, Savinainen KJ, Saramäki ... sufficient to confer castration- resistant growth to prostate cancer cells Interestingly, however, in model systems they may be inhibited by antiandrogens targeted to the ligand-binding domain, such as...

Ngày tải lên: 10/08/2014, 21:23

... urinary-related symptoms such as increased urinary frequency, urinary incontinence, pain upon urinating and difficulties initiating or maintaining urinary flow Difficulties in getting or maintaining ... of current pain, average pain, least pain in the last 24 hours and worst pain in the last 24 hours, using an 11-point numerical rating scale (NRS) ranging from (no pain) to 10 (pain as bad as ... entry into the study Interview methods All interviews were conducted by trained interviewers using a semi-structured interview guide The interview guide was informed by consideration of prostate cancer...

Ngày tải lên: 12/08/2014, 00:20

... and is divided into three distinct domains: the N terminal domain (NTD), the deoxyribonucleic acid (DNA) binding domain, and the ligand binding domain (LBD) The “hinge domain” links the LBD to ... phosphate-buffered saline prostate cancer polymerase chain reaction paraformaldehyde phosphatase and tensin homolog protein tyrosine kinase polyvinylidene fluoride quantitative real-time polymerase chain reaction ... CTD-2310E8 RP11-188K5 Invitrogen Invitrogen Invitrogen Invitrogen Invitrogen Invitrogen Invitrogen Invitrogen Invitrogen   33     Methods 6.1 Next generation sequencing (SOLiD4) DNA Extraction...

Ngày tải lên: 19/11/2015, 14:04

... defined in this regard the setup margin and the internal margin around the CTV to obtain the final PTV Methods The system for surface image registration installed in the Department of Radiotherapy ... obtaining informed consent following the rules of our institution All patients were affected by prostate cancer with Gleason score ranging from to (median 7.5) and PSA level at diagnosis ranging ... Cheng CW: Interfractional Prostate Shifts: Review of 1870 Computed Tomography (CT) Scans Obtained During Image-Guided Radiotherapy Using CT-on-Rails for the Treatment of Prostate Cancer Int J Radiat...

Ngày tải lên: 09/08/2014, 09:22

... has mainly been tested in lung cancer, cervical cancer, head and neck cancer and colorectal cancers Several lines of evidence point to a role of COX-2 inhibition as treatment approach for prostate ... after radiotherapy In order to increase the dose, intensity-modulated radiotherapy or particle based therapy approaches are currently under investigation [1016] In addition to an increased radiation ... regarding the activity of coxibes in prostate cancer Cancer Type Treatment Investigation LNCaP PC Celecoxib In vitro PC Celecoxib In vitro/Xenograft LNCaP PC LNCaP PC Celecoxib Celecoxib In vitro In...

Ngày tải lên: 09/08/2014, 10:20

... angiogenesis by binding and activating VEGF tyrosine kinase receptors The development of small molecules that inhibit tyrosine kinases, primarily by binding the ATP binding domain, has led to investigation ... tyrosine kinase inhibitors as angiogenesis inhibitors In general, because tyrosine kinases are involved in many signaling pathways and the ATP binding sites are relatively conserved, tyrosine kinase ... pressure in tumors, enhancing delivery of chemotherapy to tumors [53] Unfortunately, clinical trials using PDGF-targeting therapy in patients with prostate cancer have been disappointing Imatinib...

Ngày tải lên: 10/08/2014, 22:21

... task of the clinician to be critical and to interpret the different aspects and findings in relation to each other Competing interests The author(s) declare that they have no competing interests ... involving the mediastinum HOA is also frequently seen in severe cystic fibrosis, bronchiectasis, chronic empyema and lung abscess and occasionally in certain liver disorders' [4] In some instances ... diagnosis of incurable bronchial carcinoma with hypertrophic osteoarthropathy was made with the prostate cancer as an "innocent" bystander Since the patient was rapidly deteriorating palliative...

Ngày tải lên: 11/08/2014, 23:21

... streptavidin (streptABC Kit, Dako) at a 1:400 dilution in PBS for 45 minutes at room temperature, and rinsed with PBS for 30 minutes Color was developed by incubating the slides in 0.06% diaminobenzidine ... purchased from BDPharmingen, CA, USA) Corresponding isotype-matched mAbs were used as controls Cells (1 × 106) were resuspended in PBS containing bovine serum albumin 0.1% and then incubated for 20 ... properties into the host genome (for a review see [17]) In our experiments, RNA molecules were introduced into immature and mature DCs, allowing both to be used in trials Previous studies in prostate...

Ngày tải lên: 14/08/2014, 19:22

... resulting in a change from thymine to cytosine which led to a substitution in valine to alanine at position 166 Patient had a mutation at nucleotide number 332 resulting in a change from guanine ... by side in the same experiment and were done from frozen samples This testing strategy was used to minimize variability from day to day in staining or thawing The samples were tested in independent ... guanine to thymine that led to a substitution in serine to isoleucine at position 111 Patient had a mutation at nucleotide number 343 resulting in a change from cytosine to guanine which led to...

Ngày tải lên: 18/06/2014, 16:20

... classification consisted in grade toxicity for an asymptomatic finding noted at the time of the follow-up physical examination; grade for a symptomatic finding requiring any form of medical therapy (e.g., ... radiation therapy, and without systemic therapy Having four or more involved lymph nodes, extracapsular extension and node size greater than centimetres were our main indications for radiation therapy ... Breslow index was 2.5 mm (0.15 to 33 mm) The Clark level was known in 66 patients and was: level I in patient, level II in patient, level III in 16 patients, level IV in 44 patients and level V in...

Ngày tải lên: 09/08/2014, 09:20

... needing knowledge on the combination of underlying biological information The presented results were obtained in a preclinical study in prostate cancer xenografts, and suggest that the combination ... are now increasingly becoming in routine use in many radiological departments, thus, the approach presented in the current study suggests a further use of these data, by exploiting them in prediction ... when using a BPNN, care should also be taken when training the network, in order not to under- or overtrain it [25] Since our RMSE function (Figure 4A) from training, testing and validating the...

Ngày tải lên: 09/08/2014, 09:20

... treated for prostate cancer by one radiation oncologist with RA Data gathered for these prostate cancer patients included the indication for radiation therapy This was either definitive radiation ... treating radiation oncologist if the IM dose constraints for external beam radiotherapy for prostate cancer were met as per the current local guidelines as detailed in Table These constraints ... radiotherapy is delivered by a certain number of machine monitor units (MUs), a measure of machine radiation output MUs are important as second cancer risk in patients treated with radiotherapy...

Ngày tải lên: 09/08/2014, 09:21

... Kemmerling L, Born EJ, Mini R, Greiner RH, Aebersold DM: Daily organ tracking in intensitymodulated radiotherapy of prostate cancer using an electronic portal imaging device with a dose saving acquisition ... rectum and bulb of the penis using MRI delineation for radiotherapy of the prostate Int J Radiat Oncol Biol Phys 2003, 57:1269-79 Sobin LH, Wittekind CH: The prostate In TNM Classification of Malignant ... summarized in Table Incidence of single symptoms (dysuria, incontinence, retention, frequency/urgency, hematuria) as well as the highest toxicity occurred in a given patient concluding all single...

Ngày tải lên: 09/08/2014, 09:22

... be defined in current and future clinical trials In Canada, a clinical trial is underway evaluating linac based IMRT and helical tomotherapy, clinically assessing a dose regimen of 68 Gy in 25 ... sacrum, including at least a posterior 0.75 cm margin on the prostate and seminal vesicle Superior and inferior margins were identical to the anterior/posterior fields The simultaneous in- field ... fraction) in intermediate and high-risk prostate cancer patients The increasingly higher doses also intensifies toxicities to the organs at risk (OARs) which can be partially overcome by using advanced...

Ngày tải lên: 09/08/2014, 10:21

... pCX-shh-IG injection (arrowheadindicated in (c) and (d), also magnified in the inlets) (C) The pCX-shh-IG-injected prostate tissue sections were stained strongly for Hedgehog protein in PIN and CaP, in ... control prostate (arrowhead-indicated in (a)) and in PIN and CaP lesions of the pCXshh-IG-injected prostates (arrowhead-indicated in (b) and (c)) All luminal cells (arrowhead-indicated in (d)) ... with tumor initiation and progression in the pCX-shh-IG-injected prostate (arrow-indicated in (b), (c) and (d)), in contrast to the normal P63+ cells in the pCX-IG-injected prostate (indicated...

Ngày tải lên: 10/08/2014, 05:21

... delocalization of circulating transduced cells in the lymph nodes [28], and intestine [29] In our study, we detected no engineered cells in the lymph nodes or spleen, indicating that the delocalization ... after each infusion, the engineered cells disappeared from the bloodstream within a few days Poor persistence of circulating engineered cells has been reported in HIV-infected macaques and in SCID ... third infusion in macaque IFN3 (Fig 1A) Discussion In this study, we assessed the feasibility and efficacy of a gene therapy method based on the introduction into PBL of an IFN-β gene resulting in...

Ngày tải lên: 13/08/2014, 13:20

... lighting can have an effect on productivity Juslen (2006) also found that by increasing an illumination levels it is possible to increase a person’s productivity This result in line with finding ... is best used for assembly works in the automotive industry The finding also will be useful to engineers in design humidity systems in order to improve the comfort in the workstation area and control ... selected work station in the automotive industry where it refers mainly towards the assembly section or the manual production line where human energy are involve for in the manufacturing activity Figure...

Ngày tải lên: 25/04/2013, 08:19

... new approach had enable a more effective solution to a host of related issues confronting the coastal zone including engineering, environmental, socio-economic problems in a single project in ... Malaysia In the context of engineering, the design of beach nourishment was modified based on the coral reef mapping, and confirmed by marine biologists Hydraulic Modeling A detailed numerical modeling ... 3) A two tier seawall using a combination of retaining wall and Labuan Block was designed in an optimum manner to achieve the following objectives : - protect the coastline from erosion - avoid...

Ngày tải lên: 25/04/2013, 08:20