moderation is less more

... Americans are feeling less and less satisfied even as their freedom of choice expands This book is intended to explain why this is so and suggest what can be done about it Which is no small matter ... contributes to bad decisions, to anxiety, stress, and dissatisfaction—even to clinical depression Many years ago, the distinguished political philosopher Isaiah Berlin made an important distinction between ... decision-making information is not the point of all this advertising The point of advertising is to sell brands According to James Twitchell, the key insight that has shaped modern advertising...

Ngày tải lên: 22/07/2014, 21:17

... which is remarkably similar to the pooled estimate from the most recent meta-analysis Although this may suggest a beneficial effect of CHX-SOD, it cannot be demonstrated by a study of this sample ... ICU patients is accumulating The optimal frequency and concentration for CHX-SOD remains to be demonstrated From Scannapieco and colleagues’ study we can conclude that twice daily is not necessarily ... adults: systematic review and meta-analysis BMJ 2007, 334:889 Bonten MJ, Bergmans DC, Ambergen AW, de Leeuw PW, van der Geest S, Stobberingh EE, Gaillard CA: Risk factors for pneumonia, and colonization...

Ngày tải lên: 13/08/2014, 18:22

... mutant mtDNA, below which no diseased phenotype is observed [137] This threshold is variable, but is usually quite high, around 70–90% [138] In practical terms, this means that a substantial fraction ... defenses of antioxidants and mtDNA repair, is required to sustain this rate A second, equally important, question is whether this level of ROS imbalance is physiologically attainable To our knowledge, ... of the ‘vicious cycle’ The main premise of the ‘vicious cycle’ hypothesis is the existence of a feed-forward cycle of ROS production and mtDNA mutations This notion appears to have some footing...

Ngày tải lên: 29/03/2014, 22:21

... multiple tissues The M:F ratios for Z genes appear to have a bimodal distribution in several (but not all) tissues in zebra finch and chicken Bimodality could be evidence for the existence of two discrete ... M:F Figure Comparison of male and female gene expression in mammals In mouse (a) and humans (b), each tissue has a distinct distribution of M:F ratios, but in each case the distribution for X ... of (Figure 1b), and this symmetry is as good as, or better than, that for some of the autosomal distributions for mammalian tissues measured here in which no female shift is predicted (Figure...

Ngày tải lên: 06/08/2014, 18:21

... nucleosome depletion at the HIS3 promoter could be enhanced or diminished by adding or removing polyA sequences [7] However, in vivo studies are subject to the criticism that it is nearly impossible ... yeast promoters is visible as a prominent valley in both datasets, whereas the stereotyped positioning of the +1 nucleosome relative to the transcription start site is clearly visible as a prominent ... the dyad axis, the frequency of each dinucleotide was calculated from reconstitution data, and then 147-bp sequences were scored for their match to this distribution Predictions of this model correlated...

Ngày tải lên: 06/08/2014, 19:21

... The reduced tissue mineral density and mineral:collagen ratio in OA tissue [15,36] is consistent with this hypothesis Although the cellular basis for the reduced mineralization is not clear at ... Available online http://arthritis-research.com/content/11/1/R11 These collective findings have led to the hypothesis that the trabecular tissue is mechanically compromised in OA, probably as a result ... TR/TE of ~4,000 milliseconds/15 milliseconds, 60 milliseconds, 2.5 to mm slices, no skip/gap, 256 × 256 matrix, 12 cm field of view (for distal femur and proximal tibia), and acquisition time 4.50...

Ngày tải lên: 09/08/2014, 01:22

... of etanercept on this outcome are already maximal, making an additional effect of MTX much harder to detect It is important to underscore that the comparison in this study is between, on the ... This work was supported by the Swedish Rheumatism Association References In view of our results with respect to DAS28 values and the core set of disease activity indices, it was somewhat surprising ... antagonist registry: a comparison of two α TNFα antagonists [abstract] Arthritis Rheum 2001, 44:S79 Van der Heijde DMFM, van’t Hof MA, van Riel PLCM, van de Putte LBA: Development of a disease activity...

Ngày tải lên: 09/08/2014, 01:23

... neoepitope-specific ELISA is clearly a more powerful tool to distinguish diseased and injured joints from healthy than quantification of aggrecan fragments either by 1-F21 ELISA or by measuring ... of ARGS is more sensitive in distinguishing diseased and injured joints from healthy ones than methods that not rely on the specific detection of this aggrecan neoepitope The ARGS ELISA could ... and KS capture ELISA plates, Maria Hansson for help in the modification of the ARGS ELISA and data acquisition, Jan-Åke Nilsson for useful comments on the statistical analysis and Ewa Roos for...

Ngày tải lên: 09/08/2014, 14:21

... cycle This pathway is called the primary processing path­ way [5,6] The mechanism of their production, however, has been largely unclear During spermatogenesis in Drosophila males, antisense piRNAs ... spermatocytes, suggesting that Hsp90 is involved in a piRNA-mediated mechanism that silences the expression of repetitive sequences and transposons Consistent with this, the authors found that Hsp90 ... Hannon GJ: Argonaute2 is the catalytic engine of mammalian RNAi Science 2004, 305:1437-1441 doi:10.1186/gb-2010-11-3-109 Cite this article as: Sato K, Siomi H: Is canalization more than just a beautiful...

Ngày tải lên: 09/08/2014, 20:21

... of Received: 15 March 2010 Accepted: 25 October 2010 Published: 25 October 2010 References Center for Disease Control: Water-related disease outbreaks Morbid Mortal Weekly Report 1991-1992 Griffin ... doi:10.1186/1743-422X-7-282 Cite this article as: Balkin and Margolin: Detection of poliovirus by ICC/ qPCR in concentrated water samples has greater sensitivity and is less costly using BGM cells in ... which showed a higher rate of infection The benefits of using the tubes were the lower risk of contamination, less manipulation required, and the vast cost difference between culture flasks and pp...

Ngày tải lên: 12/08/2014, 01:22

... determine More importantly, the pathophysiology of tissue injury in the critically ill can be quite complex, involving many interacting factors [10,11] The history of clinical trials in sepsis should ... 2002, 288:2827-2835 10 Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis N Engl J Med 2003, 348:138-150 11 Cohen J: The immunopathogenesis of sepsis Nature 2002, 420:885-891 12 ... critically ill, the potential for EPO to be of benefit in the critically ill is an important issue At a minimum, EPO is clearly effective in reducing the number of RBC units transfused in patients with...

Ngày tải lên: 12/08/2014, 20:20

... (Gp160 MM56 584-592) ERYLKDQQL ERYLKDQQL ERYLKDQQL ERYLKDQQL Unknown RDISGWILSTY (Rev 53-63) RDISGWILSTY RDISGWILSTY RDISGWILSTY RDISGWILST/AY d14 TSTLQEQIGW d75 TSTLQEQIGW d186 TSNLQEQIGW d375 TSNLQEQIGW ... Wherry EJ, Blattman JN, Murali-Krishna K, van der Most R, Ahmed R: Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment ... and those which persisted at frequencies high enough for analysis over the first year of infection were selected for study It is thus conceivable that our mapping may have missed T cell responses...

Ngày tải lên: 13/08/2014, 01:20

... patient basis – the same basis on which tight control has a clinical impact It is also something not reported in most similar studies, making this study unique for its transparency Variability is particularly ... transparent per patient reporting is a stronger template on which to make comparisons and derive lessons learned Thus, a second clear outcome highlighted by this study is the need for a consensus statement ... Combined with differences in cohort and critical illness, it is very difficult to take significant lessons away from many of these studies This is not a fault of the study authors or implementation,...

Ngày tải lên: 13/08/2014, 08:20

... a graph is always less or equal to its contiguity Then the question naturally arises to know if there are some graphs for which the linearity is significantly less than the contiguity More formally, ... (σj )1≤j≤2k It is enough for j , since they admit a 2k − 1-line-model by recursion hypothesis, w ∈ U≤k−1 but one order is missing for uj which is minimally of linearity k and is then only guaranteed ... by the lemma is tight We now prove the main result aimed by this paper: linearity is a strictly more powerful encoding than contiguity, which means, more formally, that there exists some graph...

Ngày tải lên: 14/10/2015, 08:24

... hàng phân phối thời trang cao cấp Những nhãn hiệu biết phát huy mạnh chiến lược “càng đắt” (less is more) phải kể đến Harley Davidson Harley Davidson chưa công nhận thương hiệu sang trọng, song ... tượng địa vị thương hiệu Rolex vững Louis Vuitton ngoại lệ phá vỡ quy luật “càng đắt” nhãn hiệu cao cấp Dù sản xuất với số lượng lớn nhà máy toàn giới, Louis Vuitton giữ nét quyến rũ nhãn hiệu ... ngày nay, bạn sở hữu nói lên đẳng cấp bạn Nếu người xe hiệu BMW đời 7, sử dụng phục trang hãng Louis Vuitton, đeo đồng hồ Thụy Sỹ có mác Rolex, dù cố tình hay vô ý họ tự tách biệt khỏi đa số người...

Ngày tải lên: 23/12/2013, 00:16

... hàng phân phối thời trang cao cấp Những nhãn hiệu biết phát huy mạnh chiến lược “càng đắt” (less is more) phải kể đến Harley Davidson Harley Davidson chưa công nhận thương hiệu sang trọng, song ... tượng địa vị thương hiệu Rolex vững Louis Vuitton ngoại lệ phá vỡ quy luật “càng đắt” nhãn hiệu cao cấp Dù sản xuất với số lượng lớn nhà máy toàn giới, Louis Vuitton giữ nét quyến rũ nhãn hiệu ... đáng để người tiêu dùng phải thèm muốn Đâu bí mật hãng này? Câu trả lời khả kiểm soát sản phẩm Louis Vuitton tự tiến hành tất phân đoạn trình làm sản phẩm, từ khâu thiết phân phối Việc giữ cho chất...

Ngày tải lên: 16/01/2014, 11:37

... hàng phân phối thời trang cao cấp Những nhãn hiệu biết phát huy mạnh chiến lược “càng đắt” (less is more) phải kể đến Harley Davidson.Harley Davidson chưa công nhận thương hiệu sang trọng, song ... tượng địa vị thương hiệu Rolex vững Louis Vuitton ngoại lệ phá vỡ quy luật “càng đắt” nhãn hiệu cao cấp Dù sản xuất với số lượng lớn nhà máy toàn giới, Louis Vuitton giữ nét quyến rũ nhãn hiệu ... khách hàng không tiếp tục mua Bạn thử tưởng tượng, người đeo kính hiệu Gucci, dùng túi xách Christian Dior, mặc trang phục Dolce & Gabbana liệu thương hiệu có “làm mưa làm gió” nhờ tính chất...

Ngày tải lên: 21/01/2014, 17:20

... Abraham_Lincoln This linguistic index is used to postfilter the output of a conventional statistical search algorithm An input natural language query is first submitted to the statistical search ... it is clear that the impact on F-measure from eliminating terms in main clauses is disproportionate to the reduction in index size Table Alta Vista: Effect of diminating main clauses Precision ... said that the President would not resign in disgrace Of course, more fine-grained distinctions of this type can only be made given sufficiently rich linguistic analyses as input Another compelling...

Ngày tải lên: 31/03/2014, 04:20

... hàng phân phối thời trang cao cấp Những nhãn hiệu biết phát huy mạnh chiến lược “càng đắt” (less is more) phải kể đến Harley Davidson Harley Davidson chưa công nhận thương hiệu sang trọng, song ... tượng địa vị thương hiệu Rolex vững Louis Vuitton ngoại lệ phá vỡ quy luật “càng đắt” nhãn hiệu cao cấp Dù sản xuất với số lượng lớn nhà máy toàn giới, Louis Vuitton giữ nét quyến rũ nhãn hiệu ... ngày nay, bạn sở hữu nói lên đẳng cấp bạn Nếu người xe hiệu BMW đời 7, sử dụng phục trang hãng Louis Vuitton, đeo đồng hồ Thụy Sỹ có mác Rolex, dù cố tình hay vô ý họ tự tách biệt khỏi đa số người...

Ngày tải lên: 23/07/2014, 22:20

... Products Better than Ads Earned media that results from public relations efforts may be more important than advertising to brand value, especially for companies that sell feature-rich, highinvolvement ... Brands report, show that on average 27% of brand value is tied to how often the brand name appears in the press In industries that involve more research before purchases are made, the editorial ... than industries selling low involvement products, which are more likely to be bought on impulse At the other end of the spectrum, advertising expenditures are a leading indicator only for “low involvement”...

Ngày tải lên: 05/11/2013, 14:15