models for membrane traffic in eukaryotic cells

... ”want in answer ”adenocarcinoma” in question ”was” in question ”live” in answer Q avg pos votes ”would” in answer ”answer” in question ”just” in answer ”me” in answer ”be” in answer in the” in ... 2000 Information retrieval on the web ACM Computing Surveys, 32(2) Y Liu, J Bian, and E Agichtein 2008 Predicting information seeker satisfaction in community question answering In Proceedings ... by information gain for ASP (trained for all askers) and ASP Group (trained for the group of askers with 20 to 29 questions) Conclusions We have presented preliminary results on personalizing...

Ngày tải lên: 20/02/2014, 09:20

... Calpain–calpastatin interaction in stimulated cells M Averna et al Fig Effect of calpastatin on the binding of mAb 56.3 to immobilized calpain Immobilized calpain was exposed to increasing concentrations ... murine erythroleukemia (MEL) cells stimulated with the Ca2+ ionophore A23187 In resting cells, calpain was poorly stained by the mAb, indicating that it was mainly present in the low-affinity form ... of calpain staining increased 7– 8-fold, indicating that the protease was now mainly present in the high-affinity form In these conditions, although the highest amount of calpain is still in the...

Ngày tải lên: 07/03/2014, 12:20

... number of cells was analyzed (Fig 2B) In order to investigate whether CEdG has the potential to accumulate in genomic DNA of nongrowing cells, HSC-T6 cells were kept in minimal medium containing 1.5% ... nucleobases were detected in human urine [13], indicating the formation of DNA AGEs in the healthy human organism A significantly increased number of CEdGpositive cells were immunostained in glomeruli of ... method for the analysis of the CEdG formation rate in genomic DNA of cultured cells Furthermore, the in uence of CEdG DNA advanced glycation end-products in cells formation on cellular protein expression...

Ngày tải lên: 30/03/2014, 04:20

... al., 1999) In the current paper, we use an exemplar model for computing distributional representations for word meaning in context, using the context to activate relevant exemplars Comparing representations ... are more informative and noisier, while syntax-based representations deliver sparser and less noisy information Following the hypothesis that richer, topical information is more suitable for exemplar ... significance testing W Daelemans, A van den Bosch, and J Zavrel 1999 Forgetting exceptions is harmful in language learning Machine Learning, 34(1/3):11–43 Special Issue on Natural Language Learning K Erk...

Ngày tải lên: 30/03/2014, 21:20

... appropriate for Pinus pinaster in Galicia In Figure the observed dominant heights are plotted against the predicted dominant heights obtained in a cross-validation Ecoregional site index models for Pinus ... variability in site index models for even-aged stands of stone pine (Pinus pinea L.) in Spain, Ann For Sci 60 (2003) 259–269 [13] Carmean W.H., Site index curves for upland oaks in the Central States, For ... the models were Ecoregional site index models for Pinus pinaster 121 Figure Relative error in dominant height predictions related to choice of reference age for reduced, full and different models...

Ngày tải lên: 08/08/2014, 00:21

... achieved using interval mapping [17] and further, for inbred and outbred populations, accounting for all marker information on the corresponding chromosome [10, 11, 13] Because the within-sire allele ... concerning the rejection threshold when testing in this multi-QTL context, as compared to the single QTL case [17, 23! In developing software for analysing data from QTL detection designs in livestock, ... all the information on marker allele transmission: only unambiguous segregation information was included in our likelihood A more exhaustive use of this information has been proposed, using Monte...

Ngày tải lên: 09/08/2014, 18:21

... likelihood Estimating the sire marker genotypes by using only the previous likelihood function means neglecting information contained in p(hs Alternatively, ) i M il the within sire conditional ... marker information, The full maximum is obtained after a search on a continuous space i rj for the QTL location and effect, within sire mean and variance parameters and on a discrete space for the ... the model, Genet Sel Evol (1999) in press [5] Haley C.S., Knott S.A., A simple regression method for mapping quantitative trait loci in lines crosses using flanking markers, Heredity 69 (1992)...

Ngày tải lên: 09/08/2014, 18:21

... which is in agreement with the asymptotic in linear models In a linear model, the asymptotic distribution of Fisher theory test statistic is the same if the residual variance used in the denominator ... to build a model with one or several partially linked markers and the gain in using this information would be smaller than the gain presented in table VIL - - CONCLUSIONS situations, the power ... parameters p and p are given in table VII Note that the i , 25 informative progeny would correspond to the mean number of informative progeny for 50 dams and a single biallelic marker It appears...

Ngày tải lên: 09/08/2014, 18:21

... pathways in mammalian cells Red arrows indicate the inward endocytic pathway that, for example, internalizes ligand-bound receptors and delivers them to lysosomes for breakdown Black arrows indicate ... Defective downregulation of receptor tyrosine kinases in cancer EMBO J 2004, 23:2707-2712 Sorkin A, von Zastrow M: Endocytosis and signalling: intertwining molecular networks Nat Rev Mol Cell Biol ... and interesting effort, with great potential but also significant challenges In future studies we can anticipate integration of the strategy used by Collinet et al with proteomics and protein...

Ngày tải lên: 09/08/2014, 20:21

... a peak value Combining information of severity of illness at admission and information on the course of illness during treatment, in contrast to comparing them, seems promising and two strategies ... combining it with mean and max SOFA scores, event information and diagnosis information [5] Two studies built temporal SOFA models and are described in the next section [8,9] Two studies combined ... temporal SAPS II model including a weighted average of the SOFA scores Except for day the model including frequent IOF patterns performed best in terms of both discrimination and accuracy as...

Ngày tải lên: 13/08/2014, 11:23

... of numerous clinical data concerning the individual patient, particularly information relating to biomarkers However, translational integration of this large amount of information into one risk ... model use all available information including non-clinical information from genes and proteins, therapeutic interventions and genetic polymorphism or comorbidities Therefore, this study presented ... CD68, and rabbit anti-goat for Notch3 and GAS (all obtained from Dako) For semi-quantitative analysis, a grading scale was used: indicated very weak staining (

Ngày tải lên: 13/08/2014, 16:20

... diagrams for the increase in building height scenario at (a) pedestrian level and (b) mid-level for 0˚ north wind orientation 340  Figure 8.15: Comparison of VR readings for increase in ... Comparison of wind tunnel and CFD readings for point blocks, 22.5˚ north wind orientation, at both the pedestrian and mid-level 117  Figure 4.7: Comparison of wind tunnel and CFD readings for point blocks, ... north wind orientation, at both the pedestrian and mid-level 119  xxvi Figure 4.11: Box-plot for the difference between CFD and wind tunnel readings (CFD minus wind tunnel readings in m/s) for...

Ngày tải lên: 10/09/2015, 09:05

... Point Blocks, Random Configuration Wind Figure A2-4(a): POINT BLOCKS, Random Configuration - Velocity vectors for GBCR = 0.054 for wind form 0˚ north (mid-level) 391 Wind Figure A2-4(b): POINT ... vectors for GBCR = 0.126 for wind from 0˚ north (mid-level) Wind Figure A2-4(c): POINT BLOCKS, Random Configuration - Velocity vectors for GBCR = 0.234 for wind from 0˚ north (mid-level) 392 Wind ... vectors for GBCR = 0.054 for wind from 0˚ north (mid-level) Wind Figure A2-5(b): POINT BLOCKS, Group Configuration - Velocity vectors for GBCR = 0.162 for wind from 0˚ north (mid-level) 395 Wind...

Ngày tải lên: 10/09/2015, 09:06

... decisions are made individually for each path rather than for the entire line Therefore, no signaling is needed in UPSR For instance, as shown in Fig 2.5(b), in the case of a cable cut, the tail-end ... FIPP Failure Independent Path-Protecting HALCS Heuristic Algorithms of Lightpath-protecting p-Cycle Selection ILP Integer Linear Programming IRA Independent Reconfiguration Approach IRAP Independent ... switching by pre-configuring spare capacity for protection along the cycle It also achieves high spare capacity efficiency by supporting independent routing of traffic without constraints arising from...

Ngày tải lên: 11/09/2015, 10:18

... (rubber wood chips) and Lv et al [12] (pine sawdust) for air and airesteam gasification In both ANNs models, the data sets containing the information (the values of input and output variables) of different ... of variables for inclusion as inputs to the model is a crucial step in model development, as the performance of the final model is heavily dependent on the input variables used In this study, ... the operating conditions; many idealized assumptions have to be made in the development of these models Different kinds of models have been implemented for gasification systems, including equilibrium,...

Ngày tải lên: 02/08/2016, 09:34

... operating line can be constructed on the equilibrium curve (Figure 10) The operating line is the straight line of slope L/G, joining the terminal conditions v, Y Figure 10 Operating diagram for ... difficulties included obtaining uniform flow of solid particles and fluid without channelling or local irregularities, as well as those of introducing and removing the solid continuously into the ... difficulties in maintaining packing stability Column diameters are limited to constructional details For diameters c m columns are usually made from pipes and for diameters 1-4 m (a maximum value for...

Ngày tải lên: 25/08/2016, 19:14

... of galectin that contain transmembrane domains have been detected in chicken osteoblast-like cells and in intestine [26]) Finally, there is evidence for galectin as a factor in RNA splicing, based ... CD98 increases over time almost linearly after forskolin treatment Fusion of BeWo cells is enhanced by forskolin treatment, which, by activating adenylyl cyclase, results in an increase in intracellular ... role for galectin 3, an S-type lectin containing a carbohydrate-binding domain, as a physiological ligand of CD98 in vivo [18] Figure 5A shows the primary intracellular distribution of galectin in...

Ngày tải lên: 23/03/2014, 09:20

... transferred in an individual pore [33] These micro-scale models are useful and suitable for predicting the performance of the membrane, particularly if one is interested in designing new membranes ... full models The model can then be employed for wide-ranging parameter and design studies, for multi-objective optimization, and as a building block for stack models Finally, Chapter 11 contains ... time required for (N) setting up and solving the automated, reduced stack model in which each cell operates at (H) 0:8 V, ( ) 0:5 V, and ( ) 0:2 V for an increasing number of cells in the stack...

Ngày tải lên: 30/09/2015, 06:29

... through the water-sediment interface So we obtain a system of three models for the oil slick, oil in water column and in the bottom sediment environments Since these models are related to each ... Hai In this case, the oil slick is transformed into shape of an ellipse with centre in the oil slick origin In the case of NE wind, the oil slick is quickly approached Do Son - Hai Phong shoreline, ... oil concentration in sediment after (a) and 24 (b) hours in the NE wind Conclusion The preliminary results for the combined system of 2D, 3D hydrodynamicenvironmental models for SPM and bottom...

Ngày tải lên: 13/02/2014, 12:20

... Pharmigen, San Diego, CA, USA) binding and PI staining were performed according to [44] Following incubation with 1.0 lgÆmL)1 annexin V and 4.0 lgÆmL)1 PI for 20 min, cells were analyzed by flow cytometry ... domains (instead of liquidcrystalline domains) in the membranes, making these molecules unavailable for the required interactions [30,33] Addition of UFAs could restore the liquidcrystalline ... (*P < 0.05) (D) Annexin V–FITC binding and PI staining were performed in order to assess cell death Fluorescence was analyzed by flow cytometry in 104 cells per sample (E) Cells were exposed to...

Ngày tải lên: 14/02/2014, 22:20