mode of action of steroid hormones
Báo cáo Y học: Endogenous cardiac glycosides, a new class of steroid hormones pot
... in the abundance of various isoforms would have profound effects on cell function [101] BINDING OF CARDIOTONIC STEROIDS TO SERUM PROTEINS As hydrophobic substances, steroid hormones are transported ... proliferation as well as the expression of isoforms of Na+/K+-ATPase When infused for weeks in rats, ouabain and digoxin differentially affected the expression of isoforms of the sodium pump in different ... administration of certain precursors increases the rate of synthesis of the cardiotonic steroid or, if given in their radioactive form, leads to the formation of radioactive cardiotonic steroids Progesterone...
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Tài liệu Báo cáo khoa học: Characterization and mode of action of an exopolygalacturonase from the hyperthermophilic bacterium Thermotoga maritima doc
... zone of the cytoplasmic fraction (not shown) No activity on PGA was observed when the corresponding medium fraction was concentrated and similarly analysed Mode of action of PelB To examine its mode ... Hiromi K (1970) Interpretation of dependency of rate parameters on the degree of polymerization of substrate in enzyme-catalyzed reactions Evaluation of subsite afnities of exo-enzyme Biochem Biophys ... thaliana (AAF21195.1) The mode of action (endo or exo) and the amount of GalpA cleaved off, respectively, are annotated in parentheses A question mark indicates unknown activity mode The secondary structure...
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Báo cáo khoa học: Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus doc
... potential implications for the current understanding of its mode of action The cagPAI and the Cag type IV secretion apparatus Gene arrangement and variants of the cagPAI The cagPAI, which was originally ... the molecular mechanisms of effector protein secretion This minireview describes the composition of the cagPAI and the properties of both conserved and unique components of the Cag-T4SS, together ... into various host cells is a hallmark of CagT4SS activity Despite the molecular characterization of a number of effects in host cells, the exact function of CagA translocation during infection...
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Báo cáo khoa học: Exo-mode of action of cellobiohydrolase Cel48C from Paenibacillus sp. BP-23 A unique type of cellulase among Bacillales ppt
... insoluble fraction of either digested sample, indicating that the main activity of Cel48C is that of a cellobiohydrolase, acting processively on these substrates To analyse the exo -mode of action of Cel48C, ... products of hydrolysis of cellopentaose (G5) and is shown as size marker of action and knowledge of their natural substrate may be of great interest to understand the biological role of family ... degradation of cellopentaose produced both cellobiose and cellotriose As in the case of ASC, analysis of the kinetics of cellotetraose digestion showed the presence of minor amounts of cellotriose...
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Báo cáo khoa học: Peptides that bind the HIV-1 integrase and modulate its enzymatic activity – kinetic studies and mode of action pptx
... inhibitory activity of this group of peptides is attributable to their effect on the turnover number of IN, and suggest a different mode of action from that of the rst group The third group of peptides, ... Structural analysis of their interaction sites within IN provided insights into their mechanism of action Results and Discussion Effect of peptides on the IN-catalyzed 3Â-end processing reaction Figure ... resembles that of INS [56] To convert some of these peptides into efcient antiHIV drugs, it is essential to elucidate their mode of action and their effects on the kinetic parameters of the 3Â-end...
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Báo cáo khoa học: Contribution of a central proline in model amphipathic a-helical peptides to self-association, interaction with phospholipids, and antimicrobial mode of action ppt
... interaction of PCPs with membranes was predominantly influenced by initial electrostatic interactions, whereas the interaction of PFPs with membranes was most affected by hydrophobic interactions ... role of a central Pro on the biological activity, peptide structure, and interaction with membranes One interesting finding of this study was that introduction of a Pro in the middle position of ... induction of plasma membrane leakage alone may not be sufficient to explain the action of these peptides Our results indicate that Pro residues of amphipathic a-helical peptides may promote formation of...
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Báo cáo Y học: Isolation, enzymatic properties, and mode of action of an exo-1,3-b-glucanase from Trichoderma viride doc
... exo-1,3-b-glucanase from T viride AZ36 Mode of action in the hydrolysis of laminarins The mode of action of the exo-1,3-b-glucanase was studied using laminarin from L digitata with a ratio of 1,3-b- and Exo-1,3-b-glucanase ... were incubated with 2– U of enzyme at 37 8C for various time intervals For studies of the mode of action in the hydroysis of laminarins, intermediate products were fractionated by HPLC on a Dextro-Pak ... Employing this model kinetic analysis of the hydrolysis of oligosaccharides with different DP is an effective tool for characterization of subsite structure of the active center of exo-glucanases...
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Báo cáo khoa học: Mode of action of the microbial metabolite GE23077, a novel potent and selective inhibitor of bacterial RNA polymerase docx
... specificity of action of GE23077 on cellular RNA synthesis and strongly suggest that its restricted antimicrobial activity is a result of its inability to cross bacterial membranes Mechanism of action of ... elongation As a first step in the elucidation of the mechanism of action of GE23077, it is crucial to assess whether it exerts its action at the level of transcription initiation, like lipiarmycin ... in the mode of action of the two antibiotics, together with the observation that GE23077 is active on rifR RNAP mutants, raises the question of what is the resistance mutation frequency of the...
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stenersen - chemical pesticides - mode of action and toxicology (crc, 2004)
... inhibit synthesis of amino acids 81 5.2.1 The mode of action of glyphosate 81 5.2.2 Degradation of glyphosate 83 5.2.3 Selectivity 84 5.2.4 Mode of action of glufosinate ... activator Their mode of action is based on more new principles Most of them are listed below, together with the year of registration Chapter one: Introduction Pesticide Mode of Action Imazapic ... CHEMICAL PESTICIDES MODE OF ACTION AND TOXICOLOGY CHEMICAL PESTICIDES MODE OF ACTION AND TOXICOLOGY Jørgen Stenersen CRC PR E S S Boca Raton London New York Washington, D.C Library of Congress Cataloging-in-Publication...
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HERBICIDES – MECHANISMS AND MODE OF ACTION ppt
... importance of herbicides within crop protection products only a low number of biochemical mode of action can be shown for the marketed herbicides Herbicides with mode of action represent around 75% of ... increasing the prevalence of herbicide resistance (Lein et al., 2004) Therefore, characterization of new modes of action by exploring novel targets is of high importance for discovery of new compound classes ... our knowledge of enzyme reaction mechanisms has improved Recent findings on the interaction of herbicides with target site enzymes and receptor proteins involved in their mode of action will be...
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báo cáo khoa học: " Mode of antiviral action of silver nanoparticles against HIV-1" doc
... but its mode of action was not fully elucidated Is gp120 its principal target? Do silver nanoparticles act as entry inhibitors? In this study, we investigated the mode of antiviral action of silver ... effects of silver nanoparticles Nanomedicine 2007, 3:95-101 Lok CN, Ho CM, Chen R, He QY, Yu WY, Sun H, Tam PK, Chiu JF, Che CM: Proteomic analysis of the mode of antibacterial action of silver ... interaction AIDS Res Hum Retroviruses 1990, 6:12811287 doi:10.1186/1477-3155-8-1 Cite this article as: Lara et al.: Mode of antiviral action of silver nanoparticles against HIV-1 Journal of Nanobiotechnology...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 2 pptx
... 2.2.2 Dose and effect The law of mass action tells us that the amount of reaction products and the velocity of a chemical reaction increase with the concentrations of the reactants This means that ... potentiate each other The LD50 of deltamethrin alone was 1.2 µg/g of insects, whereas fenitrothion had an LD50 of 3.5 µg/g of insects It is shown that the LD50 of mixtures of various compositions is ... Interaction may be caused by simultaneous or successive administration 2.3.1 Definitions It is important but difficult to give stringent definitions of various types of interactions or joint action...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 3 pps
... inactive lipoamide Figure 3.1 The mode of action of arsenic glutaminergic synapses, and calcium is a very important mediator of the impulses Furthermore, the halt of aerobic energy production is ... fluoroglycofen-ethyl COCH3 NO2 O COCH2COCH2CH3 CF3 O OCH2CH3 NO2 Cl oxyfluorfen Bifenox, fluoroglycofen-ethyl, HC-252, lactofen, and oxyfluorfen have analogous structures and modes of action The ... function of tubulin Taxol acts by stabilizing the microtubule too much, whereas colchicin and most of the benzimidazoles act by inhibiting the formation of the microtubules Although the mode of action...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 4 ppt
... elucidated 4.1 The mechanism of action of δ-endotoxins As mentioned, the δ-endotoxin (Cry protein) that makes up most of the conspicuous crystals is the main insecticidal component of B thuringiensis At ... activity of δ-endotoxin against natural tolerant insects This synergy may result from the inhibitory effect of β-exotoxin on the regeneration of midgut cells damaged by δ-endotoxin A new variant of ... engineered plants that produce them, results in cessation of feeding of Lepidoptera larvae and paralysis of the gut that retards the passage of food and allows the spores to germinate The larvae...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 5 docx
... a buffer of pH 7.6 at 37˚C and have the unit min–1 G Schrader (1951, 1963) also synthesized a lot of other derivatives of parathion Parathion-methyl is of similar toxicity and mode of action but ... integrated pest control programs Three series of compounds with this type of mode of action have been found, exemplified by polyoxin B, diflubenzuron, and buprofezin Diflubenzuron belongs to the group ... velocity constants of the reactions defined by the rates of changes in concentrations Square brackets symbolize concentrations of the respective substances The velocity of the first reaction step is...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 6 ppsx
... mechanism is of importance in understanding the mode of action of some pesticides The passage of a nerve impulse at a point on the axon is associated with a sudden drop, and even reversal, of the voltage ... have their modes of action by binding to one of the sites It is also important to know that cross-resistance between all the DDT analogues and the pyrethroids often occurs This type of resistance ... Modification of every part of the molecule with retention of activity Maintenance of high insecticidal potency while minimizing fish toxicity (e.g., the non-ester silafluofen) Development of compounds...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 8 pptx
... binding of the substrate to the enzyme, oxidation of Fe+++ to Fe++, change of the valence electrons of Fe++ from low-spin to high-spin orbital, binding of oxygen to iron, and successive transfer of ... interesting subjects of plant toxins in many of his publications Besides producing all kinds of toxins for the purpose of deterring enemies, plants produce many carotenoids, steroids, higher alcohols, ... containing dieldrin, resulting in an exposure of mg of dieldrin/kg of body weight/day and xenobiotics However, the enormous number of species, the high frequency of mutations per unit time in reproductive...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 9 pdf
... presence of Cyt1A facilitates the binding of the other toxins in resistant larvae The mode of action of B thuringiensis toxins includes: Solubilization of the toxic crystals Cleavage of the protoxin ... resistant individuals already there, before exposure to the pesticides? • Is knowledge of the biochemical mode of action of resistance useful in the effort to find remedies against resistance? • Why is ... enzymes, often referred to as cytochrome P450 or mixed-function oxidases, is often involved in resistance because they are able to catalyze oxidation and detoxication of a wide variety of substances...
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Báo cáo khoa học: "Anti-viral properties and mode of action of standardized Echinacea purpurea extract against highly pathogenic avian Influenza virus (H5N1, H7N7) and swine-origin H1N1 (S-OIV)" docx
... in the use of these inhibitors The objective of the present study was to investigate the anti-IV activity in more detail, and to elucidate possible mechanisms of action on a variety of IV strains ... concentration of EF that leads to complete prevention of CPE to the EF, but only as a result of direct contact Pre-incubation of cells with extract, followed by virus infection, or post-exposure of the ... affected Interaction of Echinaforce® with Viral HA The first step in entry of IV into cells depends on the interaction between the viral HA and a specific cellular sialic Page of (page number...
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Considering mechanistic data to assess mode of action or human relevance
... of Kinetic & Dynamic Data for Dose– Response 25 Mode of Action/ Human Relevance Framework Is the weight of evidence sufficient to establish a mode of action (MOA) in animals? NO Implications of ... likelihood of causing adverse effects in particular subgroups of humans, based on consideration of results of toxicological/epidemiological studies and mechanistic data (mode of action) • Weight of evidence ... the basis of fundamental qualitative (Q.2) or quantitative (Q.3) differences? • Often, mode of action versus chemical specific • Often consideration of biology/physiology – e.g.,lack of relevant...
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Tìm thêm: xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25