mlhỉ and msh2 genes in colorectal cancer patients

... antigens and prognosis in colorectal cancer patients J Transl Med 2005, 3:3 Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava E, Kosma VM: Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal ... in carcinoma patients confirming the results of former studies investigating Vβ-repertoire restrictions in blood of patients with other tumor entities, which have been interpreted as indication ... carcinoma patients, unaffected colonic mucosa, carcinoma tissue) one has to keep in mind the differences in sample sizes and applied tests The highly significant difference in CD between blood and...

Ngày tải lên: 18/06/2014, 16:20

... becoming one of the most significant issues in treatment decision-making, in general, and more so in prostate cancer [1] Thus late rectal and urinary damage became a major concern in prostate cancer; ... volume and critical normal structure definition Treatment planning and irradiation were performed with the patients in supine position (using knee and ankle supports) with an emptied rectum and ... dynamics are summarized in Table The values of the last late GI and GU toxicity observed in patients during their last inspection are shown In the cohort of patients included in the WP group, pretreatment...

Ngày tải lên: 09/08/2014, 09:20

... always during RT Twenty-six patients received combined androgen blockade (CAB) consisting of antiandrogen and gonadotropin releasing hormone analogue (GnRH) Three patients received antiandrogen ... abdomen and pelvis and a total-body bone scan When clinically indicated a chest x-ray and/ or thoracic CT was performed Based on these examinations clinical staging was defined according to the ... receiving at least 95% of dose, corresponding to 76 Gy) and the Dmax and Dmin (maximum and minimum dose within the PTV) were calculated from the dose volume histograms Follow-up protocol Patients...

Ngày tải lên: 09/08/2014, 09:22

... in colorectal cancer CK2a protein expression was analyzed in 144 patients (104 with CRC and 40 with colorectal adenoma) Staining for CK2a was nearly negative in all of the normal Page of 11 colorectal ... The human colorectal cancer cell lines LoVo, SW480, HT29, HCT116 and LS174T were maintained in RPMI 1640 (Gibco, Grand Island, NY, USA) supplemented with 10% fetal bovine serum at 37°C in a 5% ... [18] In the present study, we assessed CK2a expression in colorectal cancer, adenoma, and normal colorectal epithelium and found CK2a involvement in CRC tumorigenesis Moreover, the role of CK2a in...

Ngày tải lên: 18/06/2014, 19:20

... derived from survivin-2B previously and reported that it had a high potency of CTL induction in various cancer patients including breast cancer, colorectal cancer, and gastric cancer patients [23] ... RT-PCR in normal tissues, and oral cancer cell lines and primary oral cancer tisExpression of survivin mRNA as assessed by RT-PCR in normal tissues, and oral cancer cell lines and primary oral cancer ... blotting analysis of survivin protein in oral cancer cell lines Western blotting analysis of survivin protein in oral cancer cell lines Lysates from oral cancer cell lines or normal oral mucosal...

Ngày tải lên: 18/06/2014, 15:20

... (27.3% in case of leukemic patients, 47.6% in case of solid-tumor cancer patients) In both leukemic patients and solid-tumor cancer patients, gram-negative bacteria causing nosocomial RTI were mainly ... predominant gram-negative bacteria in Bloodstream Infections (BSI), Urinary Tract Infections (UTI), Respiratory Tract Infections (RTI), Gastro-Intestinal Tract Infections (GITI), and Skin Infections ... predominant gram-negative bacteria in Bloodstream Infections (BSI), Urinary Tract Infections (UTI), Respiratory Tract Infections (RTI), Gastro-Intestinal Tract Infections (GITI), and Skin Infections...

Ngày tải lên: 18/06/2014, 15:20

... CPT-11 and to radiotherapy in colorectal cancer models [6,7] Cetuximab is active either as a single agent and in combination with chemotherapy Jonker et al showed that Cetuximab increased PFS and ... dosage and schedule both as single agent or in combination: a 2-hour intravenous infusion at 400 mg/m2 followed by weekly 1hour infusion of 250 mg/m2 In the GOIM study Cetuximab was administrated in ... are clearly shown in Figure where four distinct groups of patients can be separated according to the line of chemotherapy and EGFR-GCN Patients treated as first line and with an increased EGFR-GCN...

Ngày tải lên: 18/06/2014, 16:20

... SQ participated in acquiring clinical samples and follow-up clinical information MSC participated in study design and coordination, data analysis and interpretation and final writing of the manuscript ... analysis and interpretation, and drafted the manuscript PP and LG participated in acquiring clinical and laboratory data, data analysis and data interpretation and drafted the manuscript LG, JV, and ... understanding of lung cancer biology To what extent these genes contribute or are functionally involved in the different steps during tumorigenesis and cancer progression remains to be determined...

Ngày tải lên: 18/06/2014, 16:20

... DNA binding proteins and transcription factors TCF4 and LEF-1 are partners of nuclear b-catenin and effectors of the Wnt/b-catenin signalling pathway, which is decisively involved in tumorigenesis ... These surprising findings suggest that TCF4 might be the main binding partner for b-catenin during development and progression of colorectal cancer whereas an enhancement of Wnt/bcatenin transcriptional ... exclusive in colorectal cancer In accordance with published literature we found nuclear b-catenin positivity in 75% of cases In contrast LEF-1 expression was found only in 26% and TCF4 in 46% of colorectal...

Ngày tải lên: 18/06/2014, 16:20

... 42 43 in advanced cancer patients of a diversified prime -and- boost vaccination protocol using recombinant vaccinia virus and recombinant nonreplicating avipox virus to elicit anti-carcinoembryonic ... McLaughlin S, Schlom J, Weiner LM: Pilot study of a dual gene recombinant avipox vaccine containing both carcinoembryonic antigen (CEA) and B7.1 transgenes in patients with recurrent CEA-expressing ... D, Thiel E: Clinical and Immunologic Responses to Active Specific Cancer Vaccines in Human Colorectal Cancer Clin Cancer Res 2006, 12:3064-3069 14 Alejandro R, Jadad MD, DPhil R, Andrew Moore...

Ngày tải lên: 18/06/2014, 19:20

... cases of invasive cancer than in cases of non-invasive cancer [8,9] The principal objective of this study was to determine the relationship between serum IL-6 and CRP levels and staging and prognosis ... Murai M: Serum interleukin as a prognostic factor in patients with prostate cancer Clin Cancer Res 2000, 6:2702-2706 Wise GJ, Marella VK, Talluri G, Shirazian D: Cytokine variations in patients with ... significance of interleukin serum levels in patients with ovarian cancer Br J Cancer 1995, 71:354-356 De Vita F, Orditura M, Auriemma A, Infusino S, Roscigno A, Catalano G: Serum levels of interleukin as...

Ngày tải lên: 09/08/2014, 01:24

... Stefanick ML: Influence of a diet very high in vegetables, fruit, and fiber and low in fat on prognosis following treatment for breast cancer: the Women's Healthy Eating and Living (WHEL) randomized ... within 2.5 years (P\0.001) [32] In the BIG 1-98 trial, significant predictors of early recurrence in multivariate analysis also included tumor size and grade and node positivity [33] and in the ... new era in breast cancer Invasion, size, and nodal involvement dramatically decreasing as a result of mammographic screening Arch Surg 1996, 131(3):301-308 Fisher B, Slack NH, Bross ID: Cancer...

Ngày tải lên: 09/08/2014, 03:21

... apoptosis in colorectal cancer cell lines [13,14] In this study we investigated whether doxycycline works in synergy with cisplatin and oxaliplatin or not in HT 29 colorectal cancer cell line Methods ... activity levels in cells treated with cisplatin and oxaliplatin in combination with doxycycline (p = 0.001 and p = 0.039 respectively) These findings corresponded with the findings obtained in caspase ... Discussion Colorectal cancer constitutes the third most common cancer and the second leading cause of cancer deaths in UK About one in 20 men develops colorectal cancer in their lifetime (Cancer...

Ngày tải lên: 09/08/2014, 04:20

... clavicular fossa and above the seventh rib Any relapse involving the axillary lymph nodes, and/ or other nodes in the infra or supraclavicular fossa or in the internal mammary chain was considered ... or followed LRR Clinical characteristics of patients with LRR are shown in Table LRRs’ histologic types were invasive ductal carcinoma for patients and invasive lobular carcinoma Cosar et al ... supraclavicular and internal mammary lymph nodes alone) Local recurrence was defined as any relapse in the area of surgery between the sternum and the anterior axillary line, and below the inferior...

Ngày tải lên: 09/08/2014, 09:20

... observed Initial DNA damage levels in breast cancer patients Radiation-induced apoptosis in breast cancer patients Initial DNA damage was determined as radiationinduced double-strand breaks (DSB) in ... involved in conception and design of the study and has made the DNA-DSB experiments and analyses PCL has been involved in conception and design of the study and in drafting the manuscript and has ... late toxicity in our series This finding opens the possibility to develop new predictor assays taking into account the initial DNA damage and radiation-induced apoptosis levels, and introduces new...

Ngày tải lên: 09/08/2014, 09:20

... concentrations and s-creatinine, this could in part be explained by an impaired renal function in elderly patients, which is in line with previous findings demonstrating an association between increased ... trypsin inhibitor (TATI), also called pancreatic secretory trypsin inhibitor (PSTI) and serine protease inhibitor Kazal type (SPINK1), is a biomarker of poor prognosis in colorectal cancer patients, ... Tumourassociated trypsin inhibitor, carcinoembryonic antigen and acute-phase reactant proteins CRP and alpha1-antitrypsin in patients with gastrointestinal malignancies Clin Biochem 2004, 37:56-60...

Ngày tải lên: 09/08/2014, 09:21

... collected from the patients at six points: before treatment and at the beginning, in the middle of and at the end of RT and at and weeks after the completion of RT By using meticulous handling procedure, ... combinations of etoposide and cisplatin (6 patients) or docetaxel and cisplatin (4 patients) Other chemotherapeutic agents included weekly taxol (4 patients) or cisplatin (1 patient) Twelve patients ... http://www.ro-journal.com/content/4/1/59 For finally 34 evaluable patients, the histology was 14 squamous cell carcinomas, adenocarcinomas, 11 small cell carcinomas and others Twenty-five patients were male and nine patients were...

Ngày tải lên: 09/08/2014, 10:20

... both in monomeric (active) and dimeric (inactive) state [16] The protein contains several important domains such as 1) the C-terminal protein kinase domain (PI3K-domain), 2) the substrate binding ... substrate binding domains, Leucine zipper, ATP-binding domains, FAT domain and PI3K domain [17] together with exonic information (The size of the exons and the distance between them are not indicative ... the domains of the protein described by [17], such http://www.ro-journal.com/content/2/1/25 as the PI3K domain, substrate binding domains and ATPbinding domains, is illustrated in Figure Single...

Ngày tải lên: 09/08/2014, 10:21