mitochondrial dynamics and huntington s disease a dance of fate
báo cáo hóa học: " Gait dynamics in mouse models of Parkinson''''s disease and Huntington''''s disease" doc
Ngày tải lên :
19/06/2014, 10:20
... disturbances are characteristic of Parkinson 's disease, Huntington' s disease, and amyotrophic lateral sclerosis Gait reflects several variables, including balance, proprioception, and coordination ... Goldberger AL: Gait variability and basal ganglia disorders: stride-to-stride variations of gait cycle timing in Parkinson 's disease and Huntington' s disease Mov Disord 1998, 13:428-437 Blin O, Ferrandez ... compare gait variability in the MPTP and 3NP mouse models of basal ganglia disease to a mouse model of motor neuron disease, we also examined gait in a mouse model of amyotrophic lateral sclerosis...
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Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt
Ngày tải lên :
16/03/2014, 18:20
... pattern of neurodegeneration in Huntington s disease: a comparative study of cannabinoid, dopamine, adenosine and GABAA receptor alterations in the human basal ganglia in Huntington s disease ... RPA analyses There was less primary transcript detected in the R6/2 HD striatal RNA samples compared to wild-type striatal RNA samples as determined by densitometric analysis, and the ratio of ... 3B) Based on these observations and RPA analysis of primary transcript levels, it appeared that the rate of transcription of the CB1 gene was decreased in the striata of R6 mice and that this decrease...
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Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx
Ngày tải lên :
23/03/2014, 07:20
... Mutant Htt Caspase-8 ? Normal Htt ? Pro-caspase Caspase1 Caspase Apoptosis Pro-caspase 2 Heterodimerization of HIPPI and HIP1 Recruitment of Pro-caspase Activation of caspase that leads to activation ... presence of endogenous HIP-1 is mediated through activation of caspase-8, caspase-1, caspase-9 ⁄ HIP-1 & HIPPI mediated apoptosis and transcription caspase-6, and caspase-3 Cleavage of Bid and ... indirectly alters gene expression comes from the observations that caspase-1, caspase-3, caspase-7, caspase-8 and caspase-10 expression is increased in cells expressing exogenous FEBS Journal 275...
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Báo cáo khoa học: Increased glucose metabolism and ATP level in brain tissue of Huntington’s disease transgenic mice pdf
Ngày tải lên :
23/03/2014, 10:20
... the same regions of the control animals (Table 2) Consistent with this, a smaller (15%) decrease was detected in the GAPDH activities of the whole brain homogenates of the diseased animals (data ... determined as previously described [51] The GAPDH assay was carried out in standard buffer containing mm arsenate, mm NAD+ and mm GAP as substrate CK activity assay was performed at 340 nm in buffer ... doubling of the ATP concentration should result in an enormous increase of all metabolite levels related to GAPDH and aldolase and (b) the absence of the reduction of Km of GAP for GAPDH and aldolase...
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Huntington’s Disease – Core Concepts and Current Advances Edited by Nagehan Ersoy Tunali potx
Ngày tải lên :
30/03/2014, 23:20
... Huntington s Disease: in vivo, in vitro, in silico 43 Nagehan Ersoy Tunalı Chapter Molecular Mechanism of Huntington s Disease — A Computational Perspective Giulia Rossetti and Alessandra Magistrato Part ... Distribution of phosphate-activated glutaminase, succinic dehydrogenase, pyruvate dehydrogenase and gammaglutamyl transpeptidase in post-mortem brain from Huntington' s disease and agonal cases ... neurons, huntingtin is found in the cytoplasm, within neurites and at synapses It associates with various organelles and structures, such as clathrin-coated vesicles, endosomal and endoplasmic...
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Báo cáo sinh học: "The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer’s disease" pdf
Ngày tải lên :
18/06/2014, 22:20
... Neurotoxicity assay) He participated in analyses and interpretation of data He drafted the manuscript AG has been involved in analyses and interpretation of data and statistical analysis She helped to draft ... Cell viability was calculated by dividing the absorbance of wells containing samples by the absorbance of wells containing medium alone Statistical Analysis Statistical parameters (mean, standard ... viruses IP analyzed binding of antisera to A plaques in brain tissue from an AD case NM participated in immunization of mice and analyzed antibody responses using ELISA LMS generated and characterized...
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Báo cáo khoa học: " Neoadjuvant radiotherapy of primary irresectable unicentric Castleman’s disease: a case report and review of the literature" pps
Ngày tải lên :
09/08/2014, 10:20
... radiotherapy was a possible strategy This case illustrates that this hypothesis was successful and should be considered as a strategy in case of irresectable unicentric disease The question remains which ... Yoshida K, Suzuki T, Sakata T, Kawai N, Matsuda A, Kayano H, Hirashima K, Matsutani M, Bessho M: Successful treatment of multicentric Castleman s disease with intracranial and retroperitoneal ... The Netherlands Authors’ contributions IAC, MMS, GAP have made substantial contributions to conception and design, and acquisition of data and analysis and interpretation of data IAC, MMS, T, MLM,...
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Ceftriaxone-induced up-regulation of cortical and striatal GLT1 in the R6/2 model of Huntington’s disease pps
Ngày tải lên :
10/08/2014, 05:21
... were analyzed by means of a two-way analysis of variance (ANOVA) and Bonferroni post hoc tests All statistical tests required a level of significance of at least P < 0.05 Results Body weights Table ... collection, analysis, and interpretation SJB performed statistical analyses and genotyping, and helped with data interpretation BRM participated in study design, and helped with data collection and analysis ... and striatal GLT1 expression relative to saline Quantitative analysis revealed a significant effect of ceftriaxone in both brain regions at and 13 weeks of age (P < 0.0001 in each case) Discussion...
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báo cáo khoa học: "Budd-Chiari syndrome in a 25-year-old woman with Behçet’s disease: a case report and review of the literature" pps
Ngày tải lên :
11/08/2014, 00:22
... Behcet s disease Analysis of a series of 10 cases Ann Med Interne (Paris) 1999, 150(8):587-590 Jayachandran NV, Rajasekhar L, Chandrasekhara PK, Kanchinadham S, Narsimulu G: Multiple peripheral arterial ... can be associated with Behçet s disease In countries where the prevalence of Behçet s disease is high, such as Turkey and others in the Middle and Far East, evidence suggests that this disease ... international criteria for diagnosis of Behçet s disease, those with Budd-Chiari syndrome and seven male patients (mean age, 29 years) already diagnosed with Behçet s disease who had Budd-Chiari syndrome...
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Báo cáo y học: "Adalimumab - an effective and promising treatment for patients with fistulizing Crohn’s disease: a case series" pdf
Ngày tải lên :
11/08/2014, 00:23
... luminal and fistulizing disease was achieved soon after the initiation of adalimumab and sustained thereafter with maintenance doses of adalimumab No further surgical intervention was necessary and ... confirmed with a Crohn s Disease Activity Index (CDAI) score of 320 and a Peri-anal Disease Activity Index (PDAI) score of 14 An examination under anesthesia revealed complex peri-anal disease and non-cutting ... rapid fistula closure and sustained luminal disease remission Case presentation We report the cases of three patients, of European Caucasian ethnicity and Greek nationality, with active luminal...
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Báo cáo y học: "Perforated Meckel’s diverticulum presenting with combined bowel and urinary obstruction and mimicking Crohn’s disease: a case report" pps
Ngày tải lên :
11/08/2014, 03:21
... diverticulum was also resected, with a primary anastomosis accomplished On abdominal exploration, no other obvious abnormalities were seen to support a diagnosis of Crohn s disease or malignancy Fecal diversion ... the suspicion for Crohn s disease Endorectal ultrasound findings were more consistent with the appearance of a complicated abscess rather than malignancy A fine-needle aspirate of the abscess fluid ... formation of an ileocecal fistula and a pelvic abscess via local inflammation, which remained relatively asymptomatic until the abscess became large enough to cause external compression of both...
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Báo cáo y học: "Perforated Meckel’s diverticulum presenting with combined bowel and urinary obstruction and mimicking Crohn’s disease: a case report" doc
Ngày tải lên :
11/08/2014, 07:20
... diverticulum was also resected, with a primary anastomosis accomplished On abdominal exploration, no other obvious abnormalities were seen to support a diagnosis of Crohn s disease or malignancy Fecal diversion ... the suspicion for Crohn s disease Endorectal ultrasound findings were more consistent with the appearance of a complicated abscess rather than malignancy A fine-needle aspirate of the abscess fluid ... formation of an ileocecal fistula and a pelvic abscess via local inflammation, which remained relatively asymptomatic until the abscess became large enough to cause external compression of both...
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Báo cáo y học: " Synchronously diagnosed eosinophilic granuloma and Hodgkin''''s disease in a 12-year-old boy: a case report" pptx
Ngày tải lên :
11/08/2014, 19:21
... Langerhans cells and inflammatory cells, especially eosinophils, can vary among different lesions and in various areas of the same lesion Langerhans cells in a typical case are mononuclear histiocyte-like ... physical examination A thoracoabdominal spiral CT scan was performed and showed mediastinal, cervical, right axillary and retroperitoneal lymphadenopathies, pulmonary nodules and hepatic and splenic ... Discussion Synchronously diagnosed collision tumors are considered as rare events Langerhans cell histiocytosis (LCH) and Hodgkin 's disease (HD) has been reported previously as metachronously diagnosed...
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Báo cáo y học: " Fluorodeoxyglucose-positron emission tomography/computed tomography in the staging and evaluation of treatment response in a patient with Castleman''''s disease: a case report" pps
Ngày tải lên :
11/08/2014, 23:21
... results of these reports and on those of the present study, PET seems to represent the most appropriate approach In fact, Castleman 's disease, as with aggressive lymphomas and many solid tumours, ... this result, the patient underwent excision of the mesenterial lymphatic mass and histopathological analysis showed Castleman 's disease of the hyalin-vascular subtype From October 2006 to February ... Conclusion This case report shows that FDG-PET/CT could have an important role in the staging of Castleman 's disease and in its evaluation of treatment response No clinical signs suggestive of recurrence...
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Báo cáo khoa học: " Challenging complications of treatment – human herpes virus 6 encephalitis and pneumonitis in a patient undergoing autologous stem cell transplantation for relapsed Hodgkin''''s disease: a case report" doc
Ngày tải lên :
12/08/2014, 04:21
... Fujimaki K, Mori T, Kida A, Tanaka M, Kawai N, Matsushima T, Kishi K, Fujisawa S, Sakura T, Yokota A, Kanda Y, Taguchi J, Akiyama H, Kanamori H, Maruta A, Okamoto S, Sakamaki H: Human herpesvirus ... in a patient with relapsed Hodgkin 's disease Whereas asymptomatic HHV6 reactivation is frequently reported in patients after allogeneic stem cell transplantation, severe disease is rare in patients ... Wasfy S, Kumar P, Calderwood S, Freedman M, Saunders F: The utility of plasma polymerase chain reaction for human herpes virus-6 among pediatric bone marrow transplant recipients: results of a...
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Báo cáo khoa học: " Challenging complications of treatment – human herpes virus 6 encephalitis and pneumonitis in a patient undergoing autologous stem cell transplantation for relapsed Hodgkin''''s disease: a case report" ppsx
Ngày tải lên :
12/08/2014, 04:22
... Fujimaki K, Mori T, Kida A, Tanaka M, Kawai N, Matsushima T, Kishi K, Fujisawa S, Sakura T, Yokota A, Kanda Y, Taguchi J, Akiyama H, Kanamori H, Maruta A, Okamoto S, Sakamaki H: Human herpesvirus ... in a patient with relapsed Hodgkin 's disease Whereas asymptomatic HHV6 reactivation is frequently reported in patients after allogeneic stem cell transplantation, severe disease is rare in patients ... Wasfy S, Kumar P, Calderwood S, Freedman M, Saunders F: The utility of plasma polymerase chain reaction for human herpes virus-6 among pediatric bone marrow transplant recipients: results of a...
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Nitrogen Dynamics and Biomass Production in a Vertical Flow Constructed Wetland Cultivated with Forage Rice and their Mathematical Modeling
Ngày tải lên :
05/09/2013, 09:38
... experimental and model analysis approaches MATERIALS AND METHODS Pot Experiment A series of experiments was performed at an open-air experimental station located in Ibaraki Prefecture, Japan Figure shows ... experimental case as calculated with the finally calibrated parameters is shown in Fig along with the measured values Underestimations and overestimation were occurred in the low-water-supply case and ... denitrification rate constant, kden,i, was estimated to be 40 /day, although many studies have reported smaller values for the nitrification and denitrification rate constants (e.g., Selim and Iskandar...
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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Autosomal-recessive genes in Parkinson’s disease – a common pathway? docx
Ngày tải lên :
18/02/2014, 14:20
... Parkinson s disease Lancet Neurol 7, 97–109 Hayashi S, Wakabayashi K, Ishikawa A, Nagai H, Saito M, Maruyama M, Takahashi T, Ozawa T, Tsuji S & Takahashi H (2000) An autopsy case of autosomalrecessive ... Specifically, this association is mediated by pathogenic DJ-1 mutations and oxidative stress [76] These data suggest a link DJ-1 and Parkin in a common pathway in mammals A described case of autosomal-recessive ... Proposed cross-talk of pathways Extracellular and intracellular cues activate universal cellsignalling cascades including MAPK and phosphatidylinositol 3-kinase (PI3K) pathways that can target...
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Infliximab therapy in pediatric Crohn’s disease: a review docx
Ngày tải lên :
22/03/2014, 10:20
... Franchis and coworkers showed that once patients achieved disease remission on mesalamine, less than 50% of patients were able to sustain disease remission after one year of maintenance therapy.9 ... Dovepress Parashette et al to frequent relapses and less than favorable maintenance of clinical remission Since CD may progress from intestinal inflammation to strictures and penetrating disease, ... treatment of active CD Several studies have shown adalimimab to be superior to placebo for inducing and maintaining remission It has also been shown to spare corticosteroids and salvage those patients...
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