mineralogy and structure of pathogenic particles
Particle Toxicology - Chapter 11 pot
... lungs of rats only occurs with DEP and not with carbon black (Ma and Ma 2002) The mechanisms of transfer of organic compounds from particles to the target cells can involve the uptake of particles ... extracts of DEP and PM increase IL-8, TNF and COX2 Organic extracts of DEP increase IL-8 Organic extracts of DEP did NOT alter costimulatory molecules (B7) and MHC class II (CDIa) expression and antigen ... 635–644, 1998 Ma, J Y and Ma, J K., The dual effect of the particulate and organic components of diesel exhaust particles on the alteration of pulmonary immune/inflammatory responses and metabolic enzymes,...
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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc
... SRF of an, as yet, unidentified accessory factor [54] The regulation of c-jun is complex and may involve an increase in the levels of c-jun protein and/ or phosphorylation of specific serines (63 and/ or ... levels of CTGF/CCN2 peaked after h of incubation with S1P and decayed progressively thereafter These experiments revealed a stronger and earlier increase of Cyr61/CCN1 mRNA levels than those of Fig ... A-fos and A-ATF-2 proteins Immunodetection of endogenous c-fos and ATF-2 was performed with anti-c-fos and anti-ATF-2 Igs, respectively, using the same cell lysates Detection of K-CREB and endogenous...
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Withdrawing from Iraq- Alternative Schedules, Associated Risks, and Mitigating Strategies potx
... behavior of the main opposition groups and their forces—i.e., al-Sadr and Jaysh al-Mahdi (JAM), the Sunni and the Sons of Iraq (SoI), and the Kurds and Summary xxv the Peshmerga and of the GoI and ... advising and assisting by the end of August 2010, and the military com2 Agreement Between the United States of America and the Republic of Iraq on the Withdrawal of United States Forces from Iraq and ... Reviewers of This Report Finally, we appreciate the thorough and thoughtful reviews of our four reviewers: RAND colleagues Lynn Davis and John Dumond, Michael O’Hanlon of the Brookings Institution, and...
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Báo cáo khoa học: Liver receptor homolog-1 localization in the nuclear body is regulated by sumoylation and cAMP signaling in rat granulosa cells docx
... the effect of cAMP signaling on SUMO pathway is complex and cell type dependent Notwithstanding, the up regulation of E1, the down regulation of E2 or E3 and the increased expression of SENP2 lead ... incubating lL of in vitro 35S-labeled product with lg of Aos1 ⁄ Uba2, 150 ng of UBC9 and lg of SUMO-1 in sumoylation buffer (20 mm Hepes, pH 7.5, mm MgCl2 and mm ATP) SAE1 ⁄ SAE2, UBC9 and SUMO-1 ... lL of serum-free medium were placed in a mm cuvette (Bio-Rad, Hercules, CA, USA) A total amount of lg of DNA (2 lg of Myc-tagged LRH-1 expression plasmid, 1.5 lg of pDsRed-SUMO-1 and 1.5 lg of...
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Erectile Dysfunction – Disease-Associated Mechanisms and Novel Insights into Therapy Edited by Kenia Pedrosa Nunes potx
... Changes of adrenal hormones The role of adrenal hormones and their changes are not well established in the etiology of ED Studies have correlated the low levels of dehydroepiandrosterone with ED Androstenedione ... molecular basis and mechanisms of ED have yet to be completely understood In the last decades, elucidation of the macroscopic structures of the erectile system 4-5 ushered in a new era of therapeutic ... innervations of the penis is both autonomic (sympathetic and parasympathetic) and somatic (sensory and motor) From the neurons in the spinal cord and peripheral ganglia, the sympathetic and parasympathetic...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
... D19S425 and D19S418, at a distance of 32 centiRay (cR) [log of odds (LOD) score ¼ 6.47] and 29 cR (LOD score ¼ 6.28), respectively, and corresponded to an approximate physical distance of 960 and ... recruitment of SHP-1 and partial recruitment of SHP-2 The q FEBS 2001 recruitment of SHPs suggests that the function of siglec-10 is similar to that of other siglecs such as siglec-3/CD33 and siglec-7 ... spliced regions (S1 ¼ Ig domain and S2 ¼ Ig domain 5) of siglec-10 b-Actin was also probed as a control for mRNA integrity and loading washed and then twofold dilutions of the GST fusion proteins,...
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báo cáo hóa học:" Bioactivity-guided identification and cell signaling technology to delineate the immunomodulatory effects of Panax ginseng on human promonocytic U937 cells" potx
... Cheng of Yale University and Prof Paul Tam of University of Hong Kong for their valuable advice and insightful comments We also thank Genome Research Centre of The University of Hong Kong for the ... of the suppressive effect of the PGSE on CXCL-10 induction, we measured the activities of MAP kinases, including ERK1/2 and p38MAPK, by Western analysis Intense activation of phospho-ERK1/2 and ... PGSE for 24 hours and followed by 20 units/ml of TNF-α for hours DNase-treated RNA samples were reverse transcribed and the levels of mRNA induction of (A) CXCL-10, (B) IL-8 and (C) TNFAIP3 as...
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báo cáo hóa học: " Treatment with gelsolin reduces brain inflammation and apoptotic signaling in mice following thermal injury" potx
... Better understanding of the improvement of neurological outcome with gelsolin may allow an in-depth understanding of the mechanisms by which gelsolin attenuates the acute response, and to what ... single dose of gelsolin can dramatically reduce mortality by ameliorating cerebral inflammatory lesions and apoptosis via acceleration of recruitment of monocytes and down-regulation of phospho-ERK1/2 ... manuscript, and participated in the writing of the manuscript QC participated in the design of the study and the preparation of the animal model JRK prepared all the cryostat sections LC and XMZ...
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Báo cáo hóa học: " Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain" pptx
... activation of AMPK (Figure 3A) and a reversible inhibition of both ERK (Figure 3B and C) and mTOR signaling (Figure 3D–H) Hence, resveratrol dose- and time-dependently activates AMPK and inhibits ERK and ... activation of mTOR’s negative regulator, TSC2 [49] This results in a profound inhibition of mTOR and its downstream targets involved in translation control (e.g 4EBP and ribosomal S6 kinase and rS6p ... (Ser473, cat# 4058), total AKT, GAPDH and eIF4A Statistical Analysis and Data Presentation Data are shown as means and the standard error of the mean (± SEM) of eight independent cell culture wells,...
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Associated Technologies And Milling Cutter by J Smith_2 doc
... effectiveness of the production process This latter point, not only influences method of component clamping, dictating: how, where and what will be the optimum method of ‘location and restraint’17 of the ... other important factors [Courtesy of Sandvik Coromant] Milling Cutters and Associated Technologies 163 Table 7: The ratio of cut width-to-diameter (W/D) Number of inserts in-cut Zc W/D: 0.88 0.80 ... life’ somewhat, but this is only part of the problem of off-centre cutting Returning to the cutter positioned centrally (i.e Fig 84g), here the direction of the radial component cutting forces...
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Associated Technologies And Milling Cutter by J Smith_4 pptx
... A Practical Handbook AB Sandvik Coromant Pub., 1994 Oxley, P.L.B Mechanics of Machining Ellis Horwood Pub., 1989 Shaw, M.C Metal Cutting Principles Oxford Univ Press, 1989 Society of Manufacturing ... Manufacturing Eng’rs., Tool and Manufacturing Engineers Handbook – Vol – Machining 4th Ed., SME Pub., Dearborn, Mich., 1983 Smith, G.T Advanced Machining – The Handbook of Cutting Technology, IFS/Springer ... 1989 Smith, G.T CNC Machining Technology Springer Verlag, 1993 Tlusty, G Manufacturing Processes and Equipment Prentice Hall, 2000 Usui, E Modern Machining Theory [i.e In Japanese] Kyoritu-shuppan...
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Molecular and Cellular Signaling docx
... brought in and out of the cell, and moved back and forth to the surface There is a continual flow of outbound traffic of cargo from the ER and Golgi to organelles and the cell surface, and there ... Role of Rho, Rac, and Cdc42, and Their Isoforms 11.16 Ran Family Coordinates Traffic In and Out of the Nucleus 11.17 Rab and ARF Families Mediate the Transport of Cargo ... Arrangement of Protein Secondary Structure Elements and Chain Topology Tertiary Structure of a Protein: Motifs and Domains Quaternary Structure: The Arrangement of Subunits...
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ERECTILE DYSFUNCTION – DISEASE-ASSOCIATED MECHANISMS AND NOVEL INSIGHTS INTO THERAPY pdf
... Changes of adrenal hormones The role of adrenal hormones and their changes are not well established in the etiology of ED Studies have correlated the low levels of dehydroepiandrosterone with ED Androstenedione ... molecular basis and mechanisms of ED have yet to be completely understood In the last decades, elucidation of the macroscopic structures of the erectile system 4-5 ushered in a new era of therapeutic ... innervations of the penis is both autonomic (sympathetic and parasympathetic) and somatic (sensory and motor) From the neurons in the spinal cord and peripheral ganglia, the sympathetic and parasympathetic...
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Báo cáo sinh học: "The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling" potx
... by the activation of any of the known cell-death pathways Expression of the caspase inhibitors p35 or DIAP1, or of p21, an inhibitor of p53-induced apoptosis [42], and loss of eiger, which encodes ... females and then screened the F1 generation for reversion of the strong gain -of- function phenotype and its associated semilethality Several loss -of- function alleles of dFOXO were isolated and molecularly ... effector of Drosophila insulin signaling and a regulator of stress resistance dFOXO is a critical target of dPKB but mediates only part of its function Genetic studies in C elegans and Drosophila...
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Báo cáo sinh học: "Dishevelled and Wnt signaling: is the nucleus the final frontier" potx
... subcellular localization of Dsh and the choice of effector molecules downstream of Dsh govern the selectivity of specific pathway activation Dsh-localization studies in Drosophila [21] and recently Caenorhabditis ... through Frizzled independent of LPR5/6 Utilizing the PDZ and DEP domains of Dsh, this pathway mediates cytoskeletal changes through activation of the small GTPases Rho and Rac (c) For the Wnt-Ca2+ ... localization of Dsh in this pathway See text for further details domains of Dsh to induce the stabilization of cytosolic -catenin; this allows for cytoplasmic accumulation and subsequent translocation of...
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Báo cáo y học: " Eph Receptors and Ephrin Signaling" pps
... exception of EphA4 which can bind to ephrinA and ephrinB ligands, and ephrinA5 which can 264 also bind to EphB2 [2, 3] Figure Domain structure of Eph receptors and ephrinA and ephrinB ligands Eph ... asymmetry of craniofacial structures and abonormalities of the thoracic skeleton A gene for Int J Med Sci 2008, CFNS has been mapped to the pericentromeric region of the X chromosome, and the ephrinB1 ... expression and thus disruption of the normal coupling of bone resorption and bone formation [92] Bone is a frequent site of metastasis for prostate cancer, and tissue microarray analysis of metastatic...
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Báo cáo y học: "Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury" potx
... upregulation of BMP-2 mRNA after injury Several factors can determine activation of BMP signaling independently of the expression of one ligand, including secretion and solubility of the ligand(s), ... cartilage of adult individuals is commonly regarded as a passive target of different pathogenic elements, such as mechanical wear and inflammation, leading to cartilage matrix breakdown and loss of ... different time-points and the knees dissected for histological and histochemical analysis The same procedure has been performed in month old mice of the same strain and sex and produced analogous...
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Báo cáo y học: "Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study" pot
... RNase inhibitor and 2.5 μM of random hexamer (both from GE Healthcare, Baie d'Urfé, QC, Canada), 2.5 U/μL of reverse transcriptase (Invitrogen Corporation), mM of MgCl2, and 1× of polymerase chain ... the standard curves The CT was converted to number of molecules, and the values for each sample were calculated as the ratio of the number of molecules of the target gene to the number of molecules ... design, acquisition of data, analysis and interpretation of data, statistical analysis, and manuscript preparation NA participated in acquisition of data, analysis and interpretation of data, statistical...
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Báo cáo y học: "Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells" doc
... also increased expression of RAGE, NFκB p65 and of the proinflammatory cytokines TNF-α and IL-6 In contrast, AGE-BSA decreased expression of RANKL and osteo- Page 14 of 19 (page number not for ... Newcastle, UK) and normalised for the respective densities of β-actin bands as loading controls Measurement of TNF-α, IL-6, sRANKL and osteoprotegerin release To assess the release of the proinflammatory ... temperature and consisted of μg of nuclear proteins, binding buffer (15 mM Tris-HCl, pH 7.9, 60 mM KCl, mM MgCl2, mM EDTA, mM EGTA, 10% glycerol, mM DTT), μg of poly(dIdC), μg BSA and 40 fmol of labelled...
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báo cáo khoa học: "Different patterns of NF-B and Notch1 signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma" ppt
... positive association of NF-B and VEGF-C expression with lymph node metastasis, independent of T stage, sex, age, and differentiation of tumor cells 0.002 Association of NF-B and Notch1 with tumor-induced ... ZC and HL conceived of the study; CS, YS, YL, YL and BZ performed experiments; ZC and LC analyzed data and prepared the figures; CS, ZC and HL drafted the manuscript All authors have read and ... dehydrated, and mounted Negative controls were prepared by substituting PBS for primary antibody Assessment of immunohistochemical staining Nuclear staining of NF-B and cytoplasmic staining of Notch1 and...
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