... StemCells to Overcome Drug Resistance 401 Miaorong She and Xilin Chen Chapter 21 CancerStemCellsand Chemoresistance Suebwong Chuthapisith Chapter 22 CancerStemCells in Drug Resistance and ... Chapter Prostate and Colon CancerStemCells as a Target for Anti -Cancer Drug Development Galina Botchkina and Iwao Ojima Niches and Vascularization 135 155 Importance of Stromal StemCells in Prostate ... Cruz and Isidro Sanchez-Garcia Part StemCells in Specific Tumors 61 Chapter Breast CancerStemCells 63 Marco A Velasco-Velázquez, Xuanmao Jiao and Richard G Pestell Chapter Glioma Stem Cells: ...
... normal stemcells to cancerstemcells Adult normal stemcells represent one purported origin of cancerstemcells What causes the transformation from normal stemcells to cancerstem cells? ... checkpoint activation and apoptosis in cancerstemcells Another possible reason for increased genomic instability in cancerstemcells is malignant transformation of aged stemcellsStemcells have a ... Clarke, M.F., and Weissman, I.L (2001) Stem cells, cancer, andcancerstemcells Nature 414, 105-111 Ringrose, L., and Paro, R (2004) Epigenetic regulation of cellular memory by the Polycomb and Trithorax...
... [62] Murine and human hematopoietic stemcells [63-64], murine neural stemcells [65], normal and malignant human mammary stemcells [66], and normal and malignant human colorectal stemcells [62,67] ... normal neural stemcellsand glioma stem cells, and may identify new CD133- glioma stemcells 4.4 New markers: Podoplanin and Integrin Alpha There are two new promising cancerstem cell markers ... factors For instance, Wnt ligands are produced and released from both stemcellsand niche cells, BMP and Shh are released from niche cellsand epithelial cells respectively, and Notch signaling is...
... 118 CancerStemCells Theories and Practice Fig Expression of ALDH1, ALDH2 and CD133 mRNA in immortalized human airway cell and lung cancer cell lines Levels of mRNA of ALDH1, ALDH2 and CD133 and ... chemiluminescence system (ECL, Amersham) This is trial version www.adultpdf.com 124 CancerStemCells Theories and Practice This is trial version www.adultpdf.com CancerStemCells in Lung Cancer: Distinct ... 126 CancerStemCells Theories and Practice Table Cancerstem cell markers in small cell lung carcinoma amd non-small cell lung carcinoma This is trial version www.adultpdf.com CancerStem Cells...
... review this issue with depth Stemcellsandcancerstem cell theory StemCells In order to understand cancerstemcells a brief description of normal adult stemcellsand the environment in which ... metastasis, and immunosurveillance avoidance in tumors This is trial version www.adultpdf.com CancerStemCells as a New Opportunity for Therapeutic Intervention 381 CancerStemCellsCancerStemCells ... lung cancer Later, In 2008, Chen et al isolated CD133+ and - cancer cell populations from lung cancer cell lines and non-small cell lung cancer patients and reported that CD133+ lung cancer cells...
... primitive cancercells PTL induces apoptosis in primitive cancercells Percent viability of prostate cancercellsandcells from a patient with BPH treated with increasing concentrations of PTL Cells ... signature StemcellsStemcells (c) Committed basal Committed basal Stem Committed cells basal (d) Malignancy signature Tumour Birnie et al R83.3 Gleason included Benign Figure Distinctive stem cell and ... interactions andstem cell self-renewal Results Identification of gene products associated with a cancerstem cell phenotype By comparing RNA expression patterns from stemand committed cells, independent...
... growth factor stimulated and not stimulated cells was calculated and compared for different periods before and after intervention Stem- Kine mobilizes CD34 and CD133 Cells Statistics Differences ... human stemcellsStemCells Dev 2006, 15(1):118-23 77 Shytle RD, Ehrhart J, Tan J, Vila J, Cole M, Sanberg CD, Sanberg PR, Bickford PC: Oxidative stress of neural, hematopoietic, andstem cells: ... infarction [59,60] and stroke [61], are associated with upregulated levels of these cells Given the possibility that both hematopoietic stemcellsand EPC may serve as endogenous “repair cells , we sought...
... normal stemcellsandcancerstem cells, there are mechanistic differences in some cancers Interestingly, the mechanistic differences in selfrenewal between normal stemcellsandcancerstemcells ... cancerstemcells Self-renewal and differentiation potentials are the features of stemcells Origin of cancerstemcells Self-renewal and differentiation potentials are the features of stemcells ... multi-potential stem cells, tissue-specific stem cells, progenitor cells, mature cells, andcancercells described the direct isolation of populations containing cancerstemcells in various...
... Therefore, the exogenous stem/ progenitor cells, such as embryonic stemcells (ESCs), bone marrowor fat-derived mesenchymal stemcells (MSCs), and recently amniotic fluid stem/ progenitor cells, could be ... fluid stemcells can integrate and differentiate into epithelial lung lineages StemCells 2008, 26:2902-2911 Takahashi K, Yamanaka S: Induction of pluripotent stemcells from mouse embryonic and ... population of endothelial cells resistant to bronchiolar and alveolar damages and which is capable of giving rise, not only to Clara cells, but also to type I and type II alveolar cells in vitro was...
... overexpression P63+ basal /stem cells were transformed into AR+ or ARcancer cells but rarely into ChgA+ neuroendocrine cancercells Conventional human prostate cancercells include malignant cells of luminal, ... Cancer 2006, 42:1213-1218 Lawson DA, Witte ON: Stemcells in prostate cancer initiation and progression J Clin Invest 2007, 117:2044-2050 Lang SH, Frame FM, Collins AT: Prostate cancerstemcells ... co-expressed with P63+ in some cancercells of the advanced prostate cancer (arrow-indicated respectively in (c) and (f)) (C) P63+ cancercells recapitulated prostate-like glandular structure formation...
... SCLC comparisons and thus specific to LCNEC Interestingly, AK1C1, AK1C3, AL1A1, and CD44 have been reported to be biomarkers of cancerstemcells (see Discussion) In Table BASP and SEGN are significantly ... AK1C3 [19] and CD44 [20] have been proposed to be the markers of cancerstemcells Their expression in tumor cells could correlate with their aggressive biological behavior, drug resistance and poor ... expression profiling of cancerstem cell in human lung adenocarcinoma A549 cells Mol Cancer 2007, 6:75 19 Pfeiffer MJ, Smit FP, Sedelaar JP, Schalken JA: Steroidogenic enzymes andstem cell markers...
... demonstrating the existence of SP cells in both fetal liver cellsand in primary rodent HCC cancercells induced by chemical carcinogens Since the HCC cancercellsand fetal liver cells used in our study ... tissue and tumors With the accumulation of evidence for cancerstemcells , it is proposed that miRNAs might play a role in malignant transformation from normal stemcells into cancerstemcells ... phenotype of liver cancerstem cells, as distinguished from normal hepatic stemcellsand from oncogene and tumor suppressor gene mutations The gene and protein networks directly targeted and affected...
... developed from × 105 and × 106 MCF-7 cellsand from × 103 and × 104 BCSCs 24-well plates on top of irradiated NIH/3T3 feeder cells At day 3, the number of adherent cells increased, and three to five ... isolated tumorigenic breast cancercells with stem/ progenitor cell properties from a breast cancer cell line, and Huang [17] screened side population (SP) cells from a breast cancer cell line Here, ... expressed in human embryonic stemcellsand other stem cells, indicating that these miRNAs may play a constitutive role in maintaining the biological characteristics of stemcells [40,41] Future work...
... The existence of cancerstemcells would explain why only a small minority of cancercells is capable of extensive proliferation within the tumor Furthermore, these cancerstemcells may be inherently ... intestinal stem cell marker LgR5 might also be suited to identify cancerstem cells, these might be the actively cycling Barrett (cancer) stemcells Our findings are in line with current cancer models ... selection theory If LgR5 marks stem cells, there are many of LgR5 negative non -stem cells, which are nevertheless cycling Therefore a combination of clonal selection andcancerstem cell model, as previously...
... MF, Weisman IL: Stem cells, cancerandcancerstemcells Nature 2001, 414:105-111 15 Shipitsin M, Polyak K: The cancerstem cell hypothesis: in search of definitions, markers, and relevance Lab ... Vormoor J: Understanding the cancerstem cell Br J Cancer 2010, 103:439-445 11 Lindeman GJ, Visrader JE: Insights into the cell of origin in breast cancerand breast cancerstemcells Asia Pac J ... of stemcells is calculated by assuming one stem cell per 57 000 non -stem cells [28] A greater proportion of stemcells would result in a less dramatic difference Naugler Theoretical Biology and...
... [1,2] Other adult stemcells include neural stemcells (NSCs) [3], and the mesenchymal stemcells (MSCs) that give rise to osteoblasts, chondrocytes, adipocytes, and skeletal and smooth muscle myocytes ... neural stemcells Science 2000, 287:1433-1438 Prockop D: Marrow stromal cells as stemcells for nonhematopoietic tissues Science 1997, 276:71-74 Smith AG: Embryo-derived stem cells: of mice and ... (NMF) and kmeans clustering to analyze their transcriptomes and determine the relationship between MAPCs, MSCs and ESCs, using mouse and rat MAPCs and mouse MSCs and ESCs Results Isolation and...
... Telmer and Eva Turley Breast CancerStemCells 235 Chapter 11 The Microenvironment of Breast CancerStemCells Deepak Kanojia and Hexin Chen Chapter 12 Involvement of Mesenchymal StemCells in ... of breast cancer cells, molecular tumor classification methods, in vitro cancer models, breast cancerand microenvironment, breast cancerstem cells, gene regulation in breast cancer, and mechanism ... Tumor Microenvironment, StemCellsand Metastasis McAteer, J., and Davis, J (2002) Basic cell culture technique and the maintenance of cell lines (Oxford, England, Oxford Press) McGarrity, G., and...