microenvironment hypoxia and cancer stem cells

... Stem Cells to Overcome Drug Resistance 401 Miaorong She and Xilin Chen Chapter 21 Cancer Stem Cells and Chemoresistance Suebwong Chuthapisith Chapter 22 Cancer Stem Cells in Drug Resistance and ... Chapter Prostate and Colon Cancer Stem Cells as a Target for Anti -Cancer Drug Development Galina Botchkina and Iwao Ojima Niches and Vascularization 135 155 Importance of Stromal Stem Cells in Prostate ... Cruz and Isidro Sanchez-Garcia Part Stem Cells in Specific Tumors 61 Chapter Breast Cancer Stem Cells 63 Marco A Velasco-Velázquez, Xuanmao Jiao and Richard G Pestell Chapter Glioma Stem Cells: ...

Ngày tải lên: 12/08/2014, 06:20

... normal stem cells to cancer stem cells Adult normal stem cells represent one purported origin of cancer stem cells What causes the transformation from normal stem cells to cancer stem cells? ... checkpoint activation and apoptosis in cancer stem cells Another possible reason for increased genomic instability in cancer stem cells is malignant transformation of aged stem cells Stem cells have a ... Clarke, M.F., and Weissman, I.L (2001) Stem cells, cancer, and cancer stem cells Nature 414, 105-111 Ringrose, L., and Paro, R (2004) Epigenetic regulation of cellular memory by the Polycomb and Trithorax...

Ngày tải lên: 12/08/2014, 06:20

... [62] Murine and human hematopoietic stem cells [63-64], murine neural stem cells [65], normal and malignant human mammary stem cells [66], and normal and malignant human colorectal stem cells [62,67] ... normal neural stem cells and glioma stem cells, and may identify new CD133- glioma stem cells 4.4 New markers: Podoplanin and Integrin Alpha There are two new promising cancer stem cell markers ... factors For instance, Wnt ligands are produced and released from both stem cells and niche cells, BMP and Shh are released from niche cells and epithelial cells respectively, and Notch signaling is...

Ngày tải lên: 12/08/2014, 06:20

... 118 Cancer Stem Cells Theories and Practice Fig Expression of ALDH1, ALDH2 and CD133 mRNA in immortalized human airway cell and lung cancer cell lines Levels of mRNA of ALDH1, ALDH2 and CD133 and ... chemiluminescence system (ECL, Amersham) This is trial version www.adultpdf.com 124 Cancer Stem Cells Theories and Practice This is trial version www.adultpdf.com Cancer Stem Cells in Lung Cancer: Distinct ... 126 Cancer Stem Cells Theories and Practice Table Cancer stem cell markers in small cell lung carcinoma amd non-small cell lung carcinoma This is trial version www.adultpdf.com Cancer Stem Cells...

Ngày tải lên: 12/08/2014, 06:20

... in stem cell regulation and cancer formation and progression are an attractive area of research Self-renewal of cancer stem cells Stem cells are defined by their multi-lineage differentiation and ... (Papagiannakopoulos and Kosik, 2008) According to this cancer stem cell hypothesis, cancer stem cells are tumorinitiating cells that proliferate uniquely through self-renewal Cancer stem cells are thought ... distinction between normal adult stem cells and cancer stem cells Pharmacology & therapeutics 119, 74-82 This is trial version www.adultpdf.com 16 MicroRNAs and Cancer Stem Cells in Medulloblastoma Massimo...

Ngày tải lên: 12/08/2014, 06:20

... review this issue with depth Stem cells and cancer stem cell theory Stem Cells In order to understand cancer stem cells a brief description of normal adult stem cells and the environment in which ... metastasis, and immunosurveillance avoidance in tumors This is trial version www.adultpdf.com Cancer Stem Cells as a New Opportunity for Therapeutic Intervention 381 Cancer Stem Cells Cancer Stem Cells ... lung cancer Later, In 2008, Chen et al isolated CD133+ and - cancer cell populations from lung cancer cell lines and non-small cell lung cancer patients and reported that CD133+ lung cancer cells...

Ngày tải lên: 12/08/2014, 06:20

... primitive cancer cells PTL induces apoptosis in primitive cancer cells Percent viability of prostate cancer cells and cells from a patient with BPH treated with increasing concentrations of PTL Cells ... signature Stem cells Stem cells (c) Committed basal Committed basal Stem Committed cells basal (d) Malignancy signature Tumour Birnie et al R83.3 Gleason included Benign Figure Distinctive stem cell and ... interactions and stem cell self-renewal Results Identification of gene products associated with a cancer stem cell phenotype By comparing RNA expression patterns from stem and committed cells, independent...

Ngày tải lên: 14/08/2014, 08:21

... growth factor stimulated and not stimulated cells was calculated and compared for different periods before and after intervention Stem- Kine mobilizes CD34 and CD133 Cells Statistics Differences ... human stem cells Stem Cells Dev 2006, 15(1):118-23 77 Shytle RD, Ehrhart J, Tan J, Vila J, Cole M, Sanberg CD, Sanberg PR, Bickford PC: Oxidative stress of neural, hematopoietic, and stem cells: ... infarction [59,60] and stroke [61], are associated with upregulated levels of these cells Given the possibility that both hematopoietic stem cells and EPC may serve as endogenous “repair cells , we sought...

Ngày tải lên: 18/06/2014, 16:20

... normal stem cells and cancer stem cells, there are mechanistic differences in some cancers Interestingly, the mechanistic differences in selfrenewal between normal stem cells and cancer stem cells ... cancer stem cells Self-renewal and differentiation potentials are the features of stem cells Origin of cancer stem cells Self-renewal and differentiation potentials are the features of stem cells ... multi-potential stem cells, tissue-specific stem cells, progenitor cells, mature cells, and cancer cells described the direct isolation of populations containing cancer stem cells in various...

Ngày tải lên: 20/06/2014, 07:20

... Therefore, the exogenous stem/ progenitor cells, such as embryonic stem cells (ESCs), bone marrowor fat-derived mesenchymal stem cells (MSCs), and recently amniotic fluid stem/ progenitor cells, could be ... fluid stem cells can integrate and differentiate into epithelial lung lineages Stem Cells 2008, 26:2902-2911 Takahashi K, Yamanaka S: Induction of pluripotent stem cells from mouse embryonic and ... population of endothelial cells resistant to bronchiolar and alveolar damages and which is capable of giving rise, not only to Clara cells, but also to type I and type II alveolar cells in vitro was...

Ngày tải lên: 10/08/2014, 05:21

... overexpression P63+ basal /stem cells were transformed into AR+ or ARcancer cells but rarely into ChgA+ neuroendocrine cancer cells Conventional human prostate cancer cells include malignant cells of luminal, ... Cancer 2006, 42:1213-1218 Lawson DA, Witte ON: Stem cells in prostate cancer initiation and progression J Clin Invest 2007, 117:2044-2050 Lang SH, Frame FM, Collins AT: Prostate cancer stem cells ... co-expressed with P63+ in some cancer cells of the advanced prostate cancer (arrow-indicated respectively in (c) and (f)) (C) P63+ cancer cells recapitulated prostate-like glandular structure formation...

Ngày tải lên: 10/08/2014, 05:21

... SCLC comparisons and thus specific to LCNEC Interestingly, AK1C1, AK1C3, AL1A1, and CD44 have been reported to be biomarkers of cancer stem cells (see Discussion) In Table BASP and SEGN are significantly ... AK1C3 [19] and CD44 [20] have been proposed to be the markers of cancer stem cells Their expression in tumor cells could correlate with their aggressive biological behavior, drug resistance and poor ... expression profiling of cancer stem cell in human lung adenocarcinoma A549 cells Mol Cancer 2007, 6:75 19 Pfeiffer MJ, Smit FP, Sedelaar JP, Schalken JA: Steroidogenic enzymes and stem cell markers...

Ngày tải lên: 10/08/2014, 09:22

... demonstrating the existence of SP cells in both fetal liver cells and in primary rodent HCC cancer cells induced by chemical carcinogens Since the HCC cancer cells and fetal liver cells used in our study ... tissue and tumors With the accumulation of evidence for cancer stem cells , it is proposed that miRNAs might play a role in malignant transformation from normal stem cells into cancer stem cells ... phenotype of liver cancer stem cells, as distinguished from normal hepatic stem cells and from oncogene and tumor suppressor gene mutations The gene and protein networks directly targeted and affected...

Ngày tải lên: 10/08/2014, 10:20

... developed from × 105 and × 106 MCF-7 cells and from × 103 and × 104 BCSCs 24-well plates on top of irradiated NIH/3T3 feeder cells At day 3, the number of adherent cells increased, and three to five ... isolated tumorigenic breast cancer cells with stem/ progenitor cell properties from a breast cancer cell line, and Huang [17] screened side population (SP) cells from a breast cancer cell line Here, ... expressed in human embryonic stem cells and other stem cells, indicating that these miRNAs may play a constitutive role in maintaining the biological characteristics of stem cells [40,41] Future work...

Ngày tải lên: 10/08/2014, 10:20

... The existence of cancer stem cells would explain why only a small minority of cancer cells is capable of extensive proliferation within the tumor Furthermore, these cancer stem cells may be inherently ... intestinal stem cell marker LgR5 might also be suited to identify cancer stem cells, these might be the actively cycling Barrett (cancer) stem cells Our findings are in line with current cancer models ... selection theory If LgR5 marks stem cells, there are many of LgR5 negative non -stem cells, which are nevertheless cycling Therefore a combination of clonal selection and cancer stem cell model, as previously...

Ngày tải lên: 10/08/2014, 10:21

... MF, Weisman IL: Stem cells, cancer and cancer stem cells Nature 2001, 414:105-111 15 Shipitsin M, Polyak K: The cancer stem cell hypothesis: in search of definitions, markers, and relevance Lab ... Vormoor J: Understanding the cancer stem cell Br J Cancer 2010, 103:439-445 11 Lindeman GJ, Visrader JE: Insights into the cell of origin in breast cancer and breast cancer stem cells Asia Pac J ... of stem cells is calculated by assuming one stem cell per 57 000 non -stem cells [28] A greater proportion of stem cells would result in a less dramatic difference Naugler Theoretical Biology and...

Ngày tải lên: 13/08/2014, 16:20

... [1,2] Other adult stem cells include neural stem cells (NSCs) [3], and the mesenchymal stem cells (MSCs) that give rise to osteoblasts, chondrocytes, adipocytes, and skeletal and smooth muscle myocytes ... neural stem cells Science 2000, 287:1433-1438 Prockop D: Marrow stromal cells as stem cells for nonhematopoietic tissues Science 1997, 276:71-74 Smith AG: Embryo-derived stem cells: of mice and ... (NMF) and kmeans clustering to analyze their transcriptomes and determine the relationship between MAPCs, MSCs and ESCs, using mouse and rat MAPCs and mouse MSCs and ESCs Results Isolation and...

Ngày tải lên: 14/08/2014, 08:20

... Telmer and Eva Turley Breast Cancer Stem Cells 235 Chapter 11 The Microenvironment of Breast Cancer Stem Cells Deepak Kanojia and Hexin Chen Chapter 12 Involvement of Mesenchymal Stem Cells in ... of breast cancer cells, molecular tumor classification methods, in vitro cancer models, breast cancer and microenvironment, breast cancer stem cells, gene regulation in breast cancer, and mechanism ... Tumor Microenvironment, Stem Cells and Metastasis McAteer, J., and Davis, J (2002) Basic cell culture technique and the maintenance of cell lines (Oxford, England, Oxford Press) McGarrity, G., and...

Ngày tải lên: 27/06/2014, 17:20