micro nanoparticles as a flexible antigen delivery platform

... physic-chemical properties (size and charge) of each separate material, including PCFC-g-PEI and FA-PEAs, as well as the FA-PEAs: pVHL complexes Because PCFC-g-PEI and FA-PEAs are amphiphilic ... free FA-PEAs (data not shown) So far as FA-PEAs:pVHL complexes were concerned, as shown in Table 2, the particle size was 277.5 nm at the mass ratio (FA-PEAs versus pVHL) of 5, while the particle ... of apoptosis Cancer Gene Ther 2010, 17:212-222 Morikawa T, Sugiyama A, Kume H, Ota S, Kashima T, Tomita K, Kitamura T, Kodama T, Fukayama M, Aburatani H: Identification of Toll-like receptor as...

Ngày tải lên: 18/06/2014, 19:20

... physic-chemical properties (size and charge) of each separate material, including PCFC-g-PEI and FA-PEAs, as well as the FA-PEAs: pVHL complexes Because PCFC-g-PEI and FA-PEAs are amphiphilic ... free FA-PEAs (data not shown) So far as FA-PEAs:pVHL complexes were concerned, as shown in Table 2, the particle size was 277.5 nm at the mass ratio (FA-PEAs versus pVHL) of 5, while the particle ... of apoptosis Cancer Gene Ther 2010, 17:212-222 Morikawa T, Sugiyama A, Kume H, Ota S, Kashima T, Tomita K, Kitamura T, Kodama T, Fukayama M, Aburatani H: Identification of Toll-like receptor as...

Ngày tải lên: 20/06/2014, 03:20

... other platforms in a number of ways that have great relevance for its use as a tool for rehabilitation evaluation and intervention Some of these characteristics appear to be advantageous whereas ... Bjorkdahl A, Pascher R, Rydmark M: Virtual reality and haptics as an assessment devise in the postacute phase after stroke Cyberpsychol Behav 2002, 5:207-211 Jack D, Boian R, Merians A, Tremaine ... rehabilitation Virtual reality applied to rehabilitation Virtual reality has a number of well-known assets, which make it highly suitable as a rehabilitation intervention tool [11] These assets...

Ngày tải lên: 19/06/2014, 10:20

... injuries and elevated alanine aminotransferase and aspartate aminotransferase These observations mimic the liver alterations in dengue infected humans (Paes et al., 2005) Atrasheukay and co-workers ... retro-orbital pain, myalgia, anorexia, abdominal discomfort, lymphoadenopathy and leucopenia Hemorrhage and positive tourniquet test have also been reported in a few cases (Ahmed et al., 2001, Narayanan ... as an effective dengue vaccine delivery vehicle through the oral or nasal route L lactis is a lactic bacterium whose GRAS (Generally Recognized As Safe) status represents an important advantage...

Ngày tải lên: 04/10/2015, 16:12

... Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties ACS Nano 2008, 2:2121-2134 Ahamed M, Akhtar MJ, Siddiqui MA, Ahmad J, Musarrat J, Al-Khedhairy AA, AlSalhi MS, Alrokayan SA: ... citrate buffer at pH 4, 5, and revealed faster metal release at pH than at pH (see Additional file 3), which was surprising and further illustrated that metal release is affected by more than ... particles, as well as preliminary in vitro toxicity in cancer cells Page of 10 Results Synthesis and characterization of Cu-loaded polymeric nanoparticles Carboxylate-functionalized, acrylate-based nanoparticles...

Ngày tải lên: 21/06/2014, 02:20

... 0) and condensation ( m phase < 0) is assumed Where m phase is mass transfer: for evaporation & & & & ( m phase = mevap ) and for condensation ( m phase = mcond ) (kg/s) So that the mass balance ... water is the same as the gas phase temperature 2.2.2 Gas diffusion layers The physics of multiple phases through a porous medium is further complicated here with phase change and the sources and ... field, mass transport and electrochemistry in an air-breathing cathode of a planar PEM fuel cell In their results, electrochemical/mass characteristics such as flow velocities, species mass fraction,...

Ngày tải lên: 05/09/2013, 14:58

... Obstetric anesthesia workload demand in Israel has increased due to both an increase in the requests for labor analgesia and a marked increase in the cesarean delivery rate We propose a new workload-driven ... anesthesia workload and that a typical epidural takes about half the time of a typical cesarean Accordingly, the OAAI for each hospital was calculated as ((0.75 * number of epidurals per year) + (1.5 ... anesthesia activity index (OAAI) The majority of anesthesia workload in the labor ward comprises epidural labor analgesia and cesarean delivery The OAAI is a formula composite comprising data...

Ngày tải lên: 05/03/2014, 15:20

... purchased from Takara (Kyoto, Japan) and Toyobo (Osaka, Japan), respectively QuikChange XL Site-Directed Mutagenesis Kit was from Stratagene (La Jolla, CA, USA) Construction of plasmids A BamHI ... plasmid, pSVLfLuc plasmid was cotransformed with hIZA1s expression vectors and Renilla luciferase vector as an internal standard The promoter activity of pSVL was normalized to Renilla luciferase ... Materials A plasmid containing hIZA1 cDNA (IMAGE clone, No 5300612) and a transfection reagent, lipofectamine 2000tm, were purchased from Invitrogen (Carlsbad, CA, USA) pGEX-6p-3 vector was from Amersham...

Ngày tải lên: 30/03/2014, 11:20

... modified a- Fe2O3 nanoparticles (OA–Fe2O3) had dispersed better than the bare a- Fe2O3 nanoparticles (Fig 1a and b) The a- Fe2O3 nanoparticles formed the small conglomerations composed with several pieces ... the nanoparticles and nanocapsules were characterized with a JEM-1200 EX/S transmission electron microscope (TEM) The nanoparticles and nanocapsules were dispersed into water and deposited on a ... Oleic acid (OA) and divinyl benzene (DVB) (analytical reagents, Tianjin Chemicals Co Ltd., China) were used as received without any further treatment Styrene (St, analytical reagent, Tianjin...

Ngày tải lên: 22/06/2014, 01:20

... patients with both skeletal and extra-skeletal metastases FA-2 Assays The serum samples were transported at -20°C to the Williamson Laboratory at St Bartholomew's Hospital FA-2 radioimmunoassays ... incorporated into daily clinical practice Abbreviations FA-2: Foetal antigen 2; CA15.3: Cancer antigen 15.3; CEA: Carcinoembryonic antigen; PBC: Primary breast cancer; LAPC: Locally advanced primary ... bony metastases These preliminary data point out that FA-2 is a potential helpful blood marker for bony metastases from breast cancer It would therefore appear that serum FA-2 measurement may be...

Ngày tải lên: 09/08/2014, 03:21

... European Journal of Cancer 2000, 36:1149-1160 39 Upadhyay KK, Bhatt AN, Mishra AK, Dwarakanath BS, Jain S, Schatz C, Le Meins JF, Farooque A, Chandraiah G, Jain AK: The intracellular drug delivery ... Matsumura Y, Suzuki M, Shimizu K, Goda R, Nakamura I, Nakatomi I, Yokoyama M, Kataoka K, Kakizoe T: NK105, a paclitaxelincorporating micellar nanoparticle formulation, can extend in vivo antitumour activity ... Copolymers Biomacromolecules 2009, 10:2310-2318 26 Blum RH, Carter SK: Adriamycin Annals of Internal Medicine 1974, 80:249-259 27 Al-Shabanah OA, El-Kashef HA, Badary OA, Al-Bekairi AM, Elmazar M: Effect...

Ngày tải lên: 11/08/2014, 08:20

... JL: Capillary lengths, anastomoses, and estimated capillary transit times in skeletal muscle [abstract] Am J Physiol 1977, 233(1):H122-H129 Bertuglia S, Colantuoni A, Arnold M, Witte H: Dynamic ... Regulation of oxygen consumption by vasomotion Math Biosci 2004, 191(1):101-108 15 Pradhan RK, Chakravarthy VS, Prabhakar A: Effect of chaotic vasomotion in skeletal muscle on tissue oxygenation Microvasc ... U.S .A. : Charles C Thomas Publisher 1961 Stansberry KB, Shapiro SA, Hill MA, McNitt PM, Meyer MD, Vinik AI: Impaired Peripheral Vasomotion in Diabetes Diabetis Care 1996, 19:715-721 Intaglietta...

Ngày tải lên: 13/08/2014, 16:20

... a wider range of devices, and as machines and objects rather than humans become the main users, then broadband will give birth to a wide range of devices and applications, as yet unimagined Again, ... broadband economy In that year, in addition to the market leaders, broadband penetration in a further three Asian economies exceeded per 100 inhabitants, in Taiwan, China (9.4), Japan (7.4) and ... Telecommunication Indicators Database and AT&T 10 Broadband 2002 2007 2008 DRAFT Broadband and economic growth The example of China catching up with the United States, and of other developing Asian nations prospering...

Ngày tải lên: 21/08/2014, 15:25

... Plastic Strain Ratio at 45o Diagonal Direction Plastic Strain Ratio at Transverse Direction Average plastic strain ratio Planar Anisotropy Flow Stress Forming Limit Diagram Micro- Optical Electronics ... however has not yet received proper attention of manufacturers and even researchers particularly at micro scale, where just scanty information are available on it There are various parameters related ... deformation operation, the processes can be also classified as primary and secondary working Primary working operations include taking pieces of metallic products that are generally in a cast state,...

Ngày tải lên: 22/12/2014, 20:33

... Tổng quan PaaS (Platform as a Service) • Tổng quan PaaS • Các phương pháp tiếp cận PaaS Khám phá PaaS • Google App Engine • Microsoft Azure • Salesforce.com • Intuit Sử dụng PaaS Tổng quan PaaS Tổng ... PaaS Tổng quan PaaS • PaaS tảng điện toán đám mây Ở bao gồm công cụ phát triển ứng dụng, môi trường trung gian để thư nghiệm ứng dụng tạo khả triển khai ứng dụng • PaaS hỗ trợ triển khai ứng dụng ... tác nhóm phát triển • PaaS bao gồm dịch vụ tảng SOAP, XML… • Cung cấp khả triển khai, quản lý, kiểm tra trì ứng dụng phát triển Tìm hiểu PaaS • PaaS phải đáp ứng yêu cầu sau:  Những ứng dụng tổng...

Ngày tải lên: 07/04/2015, 23:36

... Bacteria as Vaccine Delivery System 67 2.10.2 Attenuated B pertussis as a Live Recombinant Nasal Delivery Vector 68 2.10.3 FHA as an Antigen Carrier 70 2.10.4 Other Antigen Carriers ... strains expressing H5 epitopes 162 xvii ABBREVIATIONS aa Amino acid AC Adenylate cyclase ACE 3-amino-9-ethyl-carbazole ACT Adenylate cyclase toxin ADCC Antibody-Dependent Cellular Cytoxicity ADP ... Cytoxicity ADP Adenosine diphosphate AMs Alveolar macrophages Amp Ampicillin APS Ammonium persulphate APC Antigen- presenting cell BALFs Broncho-alveolar lavages fluids BALT Bronchial-associated lymphoid...

Ngày tải lên: 11/09/2015, 10:00

... interaction for intracellular uptake after the nanocarriers reach the target site from blood circulation and extravasation There are advantages and drawbacks for each of this strategy that will ... Poly(carbonate)s are an emerging class of biomaterials in comparison to the widely used poly(amino acids) and poly(esters) Aliphatic poly(carbonate)s appears to 12 be suitable for use as a drug delivery ... of nanosized asymmetrical poly(ester) dendrimers with one hemisphere attached to DOX and another functionalized with PEG as an anticancer nanomedicine that had comparable antitumour efficacy as...

Ngày tải lên: 30/09/2015, 06:07

... Satyanarayana and Sujeet Kumar Sinha, “Releasing high aspect ratio SU-8 microstructures using AZ photoresist as a sacrificial layer on metallized Si substrate” Submitted for publication in “Microsystem ... As SU-8 gives excellent sensitivity and achievable vertical side wall Plastic MicroParts SU-8 has special advantage for fabricating micro parts directly in synthetic material Packaging SU-8 allow ... Characteristics between plastic transparency mask, soda lime glass mask and quartz mask………………………………………………………… 42 Table 5.1 Experimental data on the material designed and existing process used and...

Ngày tải lên: 02/10/2015, 17:14

... chemotherapy, radiation therapy, immunotherapy, monoclonal antibody therapy and gene therapy Each method has its advantages and disadvantages, and depends on the physiology of the individuals as an ... of a wide range of local or metastatic malignancies such as ovarian, breast, head and neck and non-small-cell lung cancers (NSCLC) (Eisenhauer and Vermorken, 1998) On the other hand, they are also ... Chapter Human breast adenocarcinoma MCF-7 and human colon cancer HT-29 cell lines are employed to assess cellular uptake of the NPs as well as to evaluate the cell viability of the NP formulations,...

Ngày tải lên: 09/10/2015, 11:18

... understanding and application Especially in areas like urban legislation, where many active actors and stakeholders have a technical and nonlegal background, yet they assume an active role in legislating ... Make Legislation Easily Accessible Urban legislation concerns statutes dealing with ma ers as distinct as planning legislation, building standards, and management and governance issues Adding to ... is a secure, renewable, and long-term user right comparable to a lease According to the Urban Land Regulations,14 DUATs in urban areas cannot be issued before the land is provided with urban basic...

Ngày tải lên: 26/08/2016, 07:50