methods of analysis of drugs and drug metabolites

... the standard deviation of the residuals from the style analysis of the hedge fund strategy S using the nine indices, σI is the standard deviation of the residuals from the style analysis of the ... Value-atRisk and related measures of risk (expected shortfall, volatility) for major equity market indices using standard methods as well as the most recent state -of- the-art methods The analysis of the ... estimates the standard error of the parameter estimate by the empirical standard deviation of the B replications The result is called the bootstrap estimate of standard error and is evaluated...

Ngày tải lên: 16/04/2013, 20:00

... review of information provided to individual recipients of IND drugs, medical monitoring and reporting of the use of such drugs, information about shipment and storage of drugs, disposition of unused ... development or acquisition of drugs and biologics for CBW defense It also recommends organizational changes in the Office of the Secretary of iii iv The Acquisition of Drugs and Biologics for CBW ... purchases of all drugs and biologicals are a small part of the commercial market, accounting for less than percent of all U.S sales of human-use drugs in 1999; government purchases of vaccines...

Ngày tải lên: 17/02/2014, 11:20

... Result of Information Gathered: A) Source 1: Dr Nowinski's book describes specific cases of adolescent drug abuse that he has worked with He describes the different patterns of drug abuse and the ... dramatic rise in the use of marijuana and more use of stimulants, LSD and inhalants It also describes how this trend was a reversal from the recent downward patterns of drug use among teens D) ... is obvious that drug and alcohol abuse among adolescents is a prevalent and dangerous problem The use of these substances is dangerous and stupid I'm not going to be a hypocrite and say that I...

Ngày tải lên: 02/04/2014, 17:48

... 129(3):177-9 30 Langhoff O, Andersen JL: Consequences of late immobilization of scaphoid fractures J Hand Surg Br 1988, 13(1):77-9 31 Sjolin SU, Andersen JC: Clinical fracture of the carpal scaphoid– ... positive effect on the grip strength and range of motion of the wrist joint [33-35] The duration of immobilisation varies, depending on the type of fracture and the outcome on repeated radiological ... and grip strength Additional complications in case of an operation are malalignment, failure to place the screw, re-operation, infections and soft tissue injuries In case of a delayed union of...

Ngày tải lên: 21/06/2014, 06:20

... delivery of vaccines, genes, drugs and other biomolecules in the body They offer enhanced biocompatibility, superior drug/ vaccine encapsulation, and convenient release profiles for a number of drugs, ... number of biomolecules, drugs, genes and vaccines to the site of interest in-vivo During the 1980’s and 1990’s several drug delivery systems were developed to improve the efficiency of drugs and ... drugs bound to NPs and the type of interaction –between drugs and nanoparticles depend on the chemical structure of the drug, chemical structure of the polymer and the conditions of drug loading [41]...

Ngày tải lên: 11/08/2014, 08:20

... bio-ligands Ligands and theand2 of bio-ligands and binding ATP, ligands Additionalfor file 1ownerships of metabolism-relevantADP and block numbers of for proteins folds that bindligands ligands them ... essence of drug action is the binding between drugs and target biomolecules (most of which are proteins), the ligand-protein binding features As indicated above, approximately 30% of ligands are ... 2007, 100 10 1 10 Number of domains binding ligand (L) Figure Power-law behaviors of ligand-protein binding Power-law behaviors of ligand-protein binding The number of ligands (N) decays with an...

Ngày tải lên: 14/08/2014, 08:20

... studies of many groups of compounds The improvement of sensitivity and the miniaturization of CE technique are two major trends of capillary electrophoresis which have gain more and more attention ... Materials and Methods ……………………………………………… 100~105 4.3 Results and Discussion of Gentamicin Experiments…………….………105~113 4.3.1 Basic Consideration………………………………………….…… 105~107 4.3.2 Buffer System and pH ... Chapter Application of Fast Analysis of Stabilizers in Gunpowder on Portable CE with UV Detection …………………………….………80~94 3.1 Introduction ………………………………………………………….… 80~83 3.2 Materials and Methods …………………………………………….…...

Ngày tải lên: 14/09/2015, 10:36

... presents one of the simplest and most effective means of influencing the EOF of the separation system Normally the EOF increases with decreasing buffer concentration and enables analysis of highly ... reversal of the field, separation of slowly and rapidly migrating inorganic anions can be achieved in a single analysis 12 Figure 1.6 Illustration of double layer and reversal of EOF by addition of ... consumption of sample and reagent, and reduced production of waste, as well as portability and disposability of the devices are also the potential advantages of on-chip CE [89] Another direction of development...

Ngày tải lên: 14/09/2015, 10:37

... of 0.4 mL of blank blood and 0.4 mL of IS- containing pentane solution in a glass vial with a Teflon-septum screw cap, which has been cooled with ice, and vortex-mixed for s; a 3-µL aliquot of ... Assessment and some comments on the method > Figure 8.1 shows gas chromatograms of isobutyl nitrite (injected amount µg) and isobutyl alcohol (injected amount 10 µg); they appeared at 3.4 and 7.4 of ... detection limits of isobutyl nitrite and isobutyl alcohol in liquid specimens were 62 ng and 1.9 µg/mL, respectively [7] > Figure 8.2 shows EI mass spectra of isobutyl nitrite (A) and isobutyl alcohol...

Ngày tải lên: 18/10/2013, 00:15

... (1981) Trace Analysis of Chemical Warfare Agents An Approach to the Environmental Monitoring of Nerve Agents Ministry of Foreign Affairs of Finland, Helsinki, pp 27, 28, 37–39, 59–64, 72–79 and 90–99 ... quantitative analysis of DAEMS, various concentrations of DAEMS are spiked into blank serum specimens containing a fixed amount of DAEMO (IS) each and extracted as described before Since the base peaks of ... stream of nitrogen gas at room temperature e iii The residue is dissolved in 100 µL of the dichloromethane solution of DAEMO (IS solution); a 1-µL of it is injected into GC/MS for analysis f VX and...

Ngày tải lên: 18/10/2013, 00:15

... (1992) Methods for analysis of cannabis and its components In: The Pharmaceutical Society of Japan (ed) Standard Methods of Chemical Analysis in Poisoning – With Commentaries, 4th edn., Nanzando, ... spectra of ∆9-THC, CBD, CBN and 5α-cholestane (IS) are shown in > Fig 2.3 ⊡ Figure 2.3 EI mass spectra of ∆9-THC, CBD, CBN and 5α-cholestane 189 190 Cannabinoids and their metabolites GC/MS analysis ... 188 Cannabinoids and their metabolites GC analysis of cannabinoids in plant specimensa Reagents and their preparation • • • Extraction and purification of cannabinoids [3]: Cannabis...

Ngày tải lên: 24/10/2013, 19:15

... [4] HPLC analysis Reagents and their preparation • • Standard solutions of morphine for a calibration curve (2, and 20 µg/mL): see “Reagents and their preparation”, above of GC and GC/MS analysis ... method Qualitative analysis is made by the comparison of the retention time of a peak of a specimen with that of the authentic standard and also by the confirmation of the absence of such a peak ... low levels of morphine starting from a large amount of a specimen cannot be a proof of the intake of the drug The level of morphine in urine of healthy subjects determined by GC/MS was reported...

Ngày tải lên: 24/10/2013, 19:15

... volume of the supernatant solution is transferred to a new polypropylene tube of the same type, followed by addition of 0.5 mL of concentrated sulfuric acid f and 0.5 mL of mesitylene Nitrate and ... addition of 20 mg of anhydrous sodium carbonate and vortex-mixed for After centrifugation at 3,000 rpm for min, 1- or 4-µL of the upper layer is injected into GC Various known amounts of nitrate and ... concentration ii Analysis of nitrite i A 0.2-mL volume of a test specimen and 0.1 mL of 0.1 M hydrogen peroxide solution are placed in a 1.5-mL volume polypropylene tube with a cap and vortex-mixed...

Ngày tải lên: 24/10/2013, 19:15

... Assessment and some comments on the method The present method for analysis of Met-Hb in blood is simple and rapid, and is not interfered with by the coexistence of high concentrations of CO-Hb ... cuvettes to stand for min, the absorbances of cuvettes B and D at 630 nm are read using cuvettes A and C as references, respectively These readings are A2 and A4, respectively x The percentage of Met-Hb ... A and B, a 0.5-mL volume each of distilled water is added To cuvettes C and D, a 0.5-mL volume each of % potassium ferricyanide solution is added vi To cuvettes A and C, a 3-mL volume each of...

Ngày tải lên: 24/10/2013, 19:15

... extract of mL blood, to which 100 ng cocaine, 100 ng EME and 200 ng BE had been added 211 212 Cocaine and its metabolites ⊡ Figure 4.2 Mass spectra of the authentic cocaine and its metabolites and ... mixture of chloroform and isopropanol or ethanol should be used The simultaneous analysis can be made using chloroform/isopropanol (9:1) or (3:1), and using columns of Bond Elut Certify® and Extrelut® ... PFPA and 50 µL HFIP, capped airtightly and heated at 70 °C for 30 for derivatization A 1–2 µL aliquot of it is subjected to GC/MS analysis 209 210 Cocaine and its metabolites c) Construction of...

Ngày tải lên: 29/10/2013, 01:15

... Acute Poisonings by Medical Drugs Van Medical, Tokyo, p 222 (in Japanese) 12) Moffat AC, Jackson JV, Moss MS et al (eds) (1986) Clarke’s Isolation and Identification of Drugs, 2nd edn The Pharmaceutical ... history of intravenous use of pentazocine and tripelennamine, T,s and Blues J Forensic Sci 28:489–495 3) Kintz P, Tracqui A, Lugnier AJ et al (1990) Simultaneous screening and quantification of several ... detection and quantitation of both therapeutic and toxic levels of pentazocine in blood The recovery of pentazocine using the Sep-Pak C18 cartridge was close to 100 % for both whole blood and urine...

Ngày tải lên: 29/10/2013, 02:15

... (1992) Standard Methods of Chemical Analysis in Poisoning – With Commentary – Nanzando, Tokyo, p 43 and p 151 (in Japanese) 3) Cody JT (2000) Hallucinogens In: Bogusz MJ (ed) Handbook of Analytical ... about 10 µg and LSD is rapidly metabolized in human bodies As metabolites of LSD, 2-oxo-LSD, 3-, 13- and 14-hydroxy-LSDs and an N-de-ethyl-LSD are known [3] After oral ingestion of 160 µg LSD, ... amount of chloroform four times The combined chloroform extract is evaporated to dryness; the residue is dissolved in a small amount of methanol to be subjected to further analysis TLC analysis...

Ngày tải lên: 08/11/2013, 01:15

... O-methylation and conjugation; HMMA is the major urinary metabolite of MDMA [6–9] For more reliable and effective proof of the use of MDAs, their metabolites with the cleavage of methylenedioxy ... disorders, and drug- related accidents or suicides The effects of other MDAs are similar to those of MDMA Symptoms, and toxic and fatal concentrations ⊡ Table 7.2 Acute and chronic effects of MDMA ... sulfate, and evaporated to dryness under a stream of nitrogen after adding 10 µL of 2.5 M HCl solution To the residue is added 0.2 mL of trifluoroacetic anhydride and 0.2 mL of ethyl acetate, and...

Ngày tải lên: 08/11/2013, 01:15

... utilizing the ETS® analyzer and a 25-ng/ mL cutoff J Anal Toxicol 16:107–108 8) Diosi DT, Harvey DC (1993) Analysis of whole blood for drugs of abuse using EMIT d.a.u reagents and a Monarch 1000 chemistry ... developed for drugs of abuse Clin Chem 39:1899–1903 10) Kandiko CT, Browning S, Cooper T et al (1990) Detection of low nanogram quantities of phencyclidine extracted from human urine preparation of an ... fluid, vitreous humor and urine than in blood Villain et al [21] and Elliott [31] have tentatively set positive cutoff limits of GHB at 50 and 30 µg/mL for postmortem blood, and 10 and 20 µg/mL for...

Ngày tải lên: 08/11/2013, 01:15