methods for the analysis of mtdna

... Statistical Methods for the Analysis of Survival Data in Cancer Clinical Trials Thesis submitted in accordance with the requirements of the University of Liverpool for the degree of Doctor in ... Illustration of the behaviour of the Step distribution 126 7.7 Illustration of the behaviour of the Trapezium distribution 127 7.8 Figure to show the performance of the ALC for normal, ... Bayesian Analysis of time-to-event data 78 5.1 Introduction 78 5.2 The use of Bayesian methods for the analysis of time-to-event data 78 5.3 Applied Bayesian analysis

Ngày tải lên: 03/09/2021, 22:51

... overestimation of this parameter. RESULTS Power of the 2 methods Table II shows the power of the 2 methods of estimation for all simulated variants. For a QTL effect of 40, the ... on the size of the biasing factor in the range of realistic values for Ot. Figure 1 shows the value of k as a function of 01 for 4 different values of Ot. The maximum ... information about the quality of their estimator of the QTL variance The only result they give indicates that their algorithm leads to an overestimation of The estimation of

Ngày tải lên: 09/08/2014, 18:21

... on the other hand, is homozygous for the « high » allele (A All of the l ) l progeny from the standard cross have inherited the A allele from the father and are, therefore, heterozygous A The ... outline the sequence of analysis using a hypothetical example The hypothetical standard for this example is homozygous for « - » alleles (M ATHER & JINKS, 1982) and has low expression of the character ... indicate the degree to which Z-values in the resulting dendrogram were concordant with the original Z-values The use of this analysis assumes the presence of clusters The acknowledgment of this

Ngày tải lên: 09/08/2014, 22:22

... present study was the development of a human ex vivo tissue culture model and the analysis of the effects of conventional chemotherapy, which then can serve as a tool to test new chemotherapeutical ... of 11 (page number not for citation purposes) the potential of the chemotherapeutic drugs to induce reduction of proliferation and induction of apoptosis within the chosen conditions. To further ... responsible for the surgical part of the investiga- tion. CM and ARR carried out the LIFE/DEAD-assay and 2-pho- ton microscopy. PZ was involved in the design of the study, evaluation of the results

Ngày tải lên: 12/08/2014, 15:20

... quantity of water formed during the reaction The fraction of the various forms of hydrogen can be determined from the ratios of the areas of the corresponding... performed the ... value of H, of the surface is lower or equal to the pK, of the indicator. The lower the value of H, (and the lower the pKJ, the higher is the acid strength of the solid. Benzene, ... introduced for the quantity of base consumed in the neutralization of such... the distribution of the acid strength of the centers by means of where B is the quantity of adsorbed

Ngày tải lên: 29/07/2015, 02:27

... prevention of which is of paramount importance in the final formulation of solid dosage forms Therefore, until these issues all get resolved, the. .. emulsions and the on-line monitoring of ... SAs form and the mathematical modeling thereof Owing to the increased need for novel... Microfluidics for Microparticle Production In the microfluidic production of microparticles (the ... the morphology of these particles is often inaccessible with conventional 14 methods, the monodispersity of microfluidic... to the commonly used Classical Nucleation Theory (CNT), the

Ngày tải lên: 09/09/2015, 11:29

... DEVELOPMENT OF NOVEL METHODS FOR THE SYNTHESIS OF HOMOALLYLIC ALCOHOLS PART II : MULTIGRAM SYNTHESIS OF (−)-EPIBATIDINE KEN LEE CHI LIK B.Sc (Hons.), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF ... SUMMARY PART I: Development of Novel Methods for the Synthesis of Homoallylic Alcohols In the development of novel methods for the synthesis of homoallylic alcohols, two conceptual strategies ... up the large scale synthesis of epibatidine. However, if not for the generous assistance from the following people, I would not have “survive these ordeals.” I would therefore like to thank the

Ngày tải lên: 16/09/2015, 17:11

... measurement of the data in term of its distribution. The value of the score is high if the two means of the classes are very different and the data of each class are crowded near the mean of the data. 7 Fisher ... columns of the tables are the eigenvalues of the new features. In this case, it basically describes the spreading of the data in the new feature space. The higher the value of the eigenvalue, the ... INTO THE USE OF GAUSSIAN PROCESSES FOR THE ANALYSIS OF MICROARRAY DATA SIAH KENG BOON NATIONAL UNIVERSITY OF SINGAPORE 2004 AN INVESTIGATION INTO THE USE OF GAUSSIAN PROCESSES FOR THE ANALYSIS

Ngày tải lên: 28/09/2015, 13:38

... applied, the mobile layer of buffer cations migrates towards the cathode. As it does, it drags the bulk of the buffer solution along with it and thereby generating the EOF. The strength of this EOF ... after it is deformed by the application of external forces. Hence, soft lithography technique is commonly utilized for the microfabrication of such microchips35. The design of the fluid circuit ... the studies of the small biomolecules. It can be tailored to fit the demands of the 74 analytical challenges. The analysis of adenosine only took approximately 10 mins while the analysis of

Ngày tải lên: 02/10/2015, 12:56

... Methods for the Evaluation of Mechanical and Magnetic Performance of Hard Disk Drives ZHU JIN （B.Eng (hons) HUST, P.R.China） A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF ENGINEERING DEPARTMENT OF ... Exploration of In-Situ Diagnosis Methods for the Evaluation of Mechanical and Magnetic Performance of Hard Disk Drives ZHU JIN NATIONAL UNIVERSITY OF SINGAPORE 2005 Exploration of In-Situ Diagnosis Methods ... fluctuation of actual head disk system Work presented in this thesis is focused on the exploration of suitable methodology for disk drive level analysis of flying height variation Based on the relationship

Ngày tải lên: 05/10/2015, 22:15

... lost The extent of losses depends on the amount of lipids in the sample as well as on the polarity of the analytes with the most non-polar ones showing the highest losses In the presence of elevated ... for the Analysis of Pesticides Page of 12 QuEChERS A Mini-Multiresidue Method for the Analysis of Pesticide Residues in Low-Fat Products Aim and Scope This manuscript describes a method for the ... employ the internal standard at the end of the procedure (to an aliquot of the final extract) assuming the volume of the organic phase as being exactly 10 mL It should be furthermore noted that the

Ngày tải lên: 06/10/2016, 09:38

... pantothenic acid can be used for biotin assays with the exclusion of the relevant vitamin (in this case biotin) from the formulation The use of the same organism (L plantarum) for assaying the ... need for establishing the activity of the enzymes before they could be relied upon for use in an of? ??cial assay procedure Measurement of enzyme activity requires a stable standard of bound pantothenic ... pH of the extract is adjusted to that of the basal medium (typically pH 6.8) This step is necessary to ensure that the pH of the medium is not altered by the addition of different amounts of the

Ngày tải lên: 11/04/2017, 11:13

... with the technical aspects of data import and management, and refer the interested reader to the documentation of the software package prada for a thorough discussion of these [19] Selection of ... used for the different assays, each specifically measuring the phenotype of interest In the case of cell proliferation, the antibody detected the incorporation of the thymidine analog BrdU into the ... obtained either adaptively, for each well, or more globally, for the whole plate Because of the potential problems with over-fitting in the adaptive approach, we choose the latter, making use of the...

Ngày tải lên: 14/08/2014, 17:22

... β-CD-NH2 and the backward movement of the neutral sample partitioned in the micelles of sodium dodecyl sulfate (SDS) Stability of the inclusion complexes formed between the carrier and the solute ... displacer plug was introduced before sample injection to reduce the length of the concentrated sample zone and increase the peak height by slowing down the forward movement of the neutral sample associated ... With the high separation efficiency, high resolution and portability, CE has been proven a powerful method for the studies of many groups of compounds The improvement of sensitivity and the miniaturization...

Ngày tải lên: 14/09/2015, 10:36

... Where, Δp: the pressure difference; r: the inner diameter of the capillary; 20 t: the injection time; η: the viscosity of the buffer; L: the total length of the capillary In the case of all hydrodynamic ... macromolecules The transport of the solutes through the 15 capillary is based on the charge of the macromolecules, but the separation is dependent on the molecular size Besides the gel forming medium, other ... than the EOF as their velocity direction is the same as that of the EOF, so very rapid analysis times are therefore achieved with positively charged compounds The neutral compounds move at the...

Ngày tải lên: 14/09/2015, 10:37

... of 95 ml) The A280 to A260 ratio of the UV-absorbing peak indicated it was composed mainly of nucleic acid In the profile of the NaOH-extracted polymer (B), the elution volume (80 ml) of saccharide ... compared to the other methods The SDS-extracted polymer included a small amount of material other than protein Furthermore, the steaming- and washing-extracted polymers contained large amounts of phosphorus ... buffer at a flow rate of ml/h and ml fractions were collected The void volume of the column was determined by the elution of Blue Dextran (Pharmacia) Other analyses - 147 - Journal of Water and Environment...

Ngày tải lên: 05/09/2013, 09:08

... assessment of the trajectory of interconversion rates as a function of time of cold exposure, (b) comparison of the magnitudes of the various interconversion rates, and (c) lineup of the accessions ... photosynthesis, gas exchange of plants was measured by infrared gas analysis Measurements were performed during the first h 508 of the light phase, representing the time period of photosynthetic ... terms of the absolute values but also in the progression of the acclimation process This is an important outcome, as it allows estimation of the impact of different metabolic responses on the improvement...

Ngày tải lên: 14/02/2014, 22:20

... scrutinized the German version of this text Prof Nirschl suggested the idea of this book Prof Reimert organized the continuation of the research unit after the DFG funding as well as Prof Kasper, Prof ... derivation due to the time-dependence of the unit vectors Using the product rule for the derivation and the fact that the time derivative of the unit vector is the cross product of !rf with this ... the scaling of the argument on index k of the measured data in reciprocal space As the sum is finite, it only represents an approximation of the delta function The position of the origin and the...

Ngày tải lên: 29/05/2014, 18:32

... program power system analysis These static load models are adequate for some types of power system dynamic analysis but not for others There remains a necessity for the development of accurate dynamic ... data 2.6 APPROACHES FOR STABILITY ANALYSIS The complete model for the stability analysis of a typical power system is a set of DAEs numbering on the order of thousands or tens of thousands At present, ... integration of the fault-on system In the second step, the direct methods directly determine, without numerical integration of the postfault system, whether the initial state of the postfault...

Ngày tải lên: 30/05/2014, 23:38

... knowledge related to the mechanics of human movement The work at the University of California formed the basis for many of the fundamental techniques currently used for the study of human locomotion ... patterns of locomotion requires new methods that would limit the risk of producing artifact due to markers or the constraints of the testing methods For example, the constraints of the laboratory ... Journal of NeuroEngineering and Rehabilitation 2006, 3:6 the capture and analysis of human movement For example, the Weber brothers (1836) reported one of the first quantitative studies of the temporal...

Ngày tải lên: 19/06/2014, 10:20