methods and tools for identification of physiologic systems

... similar software programs and it is completely free to the public The main purpose of this thesis is to develop and apply computational methods and tools for ADR and toxicity prediction The methods ... followed by identification and optimization of the lead compounds, and then subsequent rounds of preclinical and clinical testing for therapeutic efficacy and safety before it becomes approved for general ... Singapore for the reward of research scholarship and Department of Pharmacy for the support of all resources and opportunities In addition, I am very appreciative of my PhD committee members for their...

Ngày tải lên: 10/09/2015, 09:02

... DIVIDE -AND- CONQUER STRATEGY FOR IDENTIFICATION OF STRUCTURAL SYSTEMS AND MOVING FORCES TRINH NGOC THANH B.Eng (HCMUT) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CIVIL ... overview and discussion of identification methods that have been often used for identifying structural systems and moving forces 1.2 Literature Review It is important to understand the strengths and ... encompassing classical, non-classical methods, substructural identification methods and moving force identification methods are reviewed An understanding of these methods and the results obtained from...

Ngày tải lên: 11/09/2015, 10:00

... candidates for such a problem The development of closed-loop systems It is always problematic for a clinician to relinquish the task of classification and intervention for personal, legal, and ... amplitude of the QRS complex and T wave, the onset of the Q wave and offset of the T wave are difficult features to measure (even for highly trained experts) Changes in the QRS complex, ST segment, and ... average of the potentials of the other two limbs.11 aVF is the difference between the LL and average of the arm leads; aVR is the difference between the RA and the average of LL and LA, and aVL...

Ngày tải lên: 13/08/2014, 12:20

... file, and a binary annotation file The header file contains information about the binary file format variety, the number and type of channels, the lengths, gains, and offsets of the signals, and ... increasingly is becoming the standard for ECGs); HL7 [26, 27] (an XML-based format for the exchange of data in hospitals); and WaveForm DataBase (WFDB), a set of libraries developed at MIT [28, ... patient groups and activities [5] A good method to control for both mental and physical activity is to use some form of objective measure of level of consciousness Although none exists for conscious...

Ngày tải lên: 13/08/2014, 12:20

... types of noises and artifacts (see above) that can occur simultaneously, and partially because these noises and artifacts are often transient, and largely unpredictable in terms of their onset and ... Although the Task Force of the European Society of Cardiology and the North American Society of Pacing Electrophysiology [46] provided an extensive overview of HRV estimation methods and the associated ... University of Oxford, 2002 Clifford, G D., F Azuaje, and P E McSharry, “Advanced Tools for ECG Analysis,” http://www.ecgtools.org/ Press, W H., et al., Numerical Recipes in C: The Art of Scientific...

Ngày tải lên: 13/08/2014, 12:20

... downsampling, for instance), information is often lost and the transformation is not invertible In general, lossy transformations involve a noninvertible transformation of data using a transformation ... rates and HRVs (determined separately by the standard deviation and the LF/HF ratio) An algorithm can therefore be tested on a vast range of ECGs (some of which can be extremely rare and therefore ... Glass, L., and K Tateno, “Automatic Detection of Atrial Fibrillation Using the Coefficient of Variation and Density Histograms of RR and DRR Intervals,” Medical and Biological Engineering and Computing,...

Ngày tải lên: 13/08/2014, 12:20

... xn and zn is given by [51] ρ= [xn − µx ][zn − µz ] σ x σz (6.13) where µx and σx are the mean and standard deviation of xn , and µz and σz are the mean and standard deviation of zn A value of ... problems of obtaining accurate estimates The ability to measure the complexity of an observed system may be useful for classifying states of health and disease and could form the basis of a diagnostic ... PCA and ICA both involve projecting data onto a set of axes which are determined by the nature of those data, and are therefore methods of blind source separation (BSS) (Blind because the axes of...

Ngày tải lên: 13/08/2014, 12:20

... interpretation of the basis functions in terms of feature location, width, and amplitude Using a Gaussian representation, onsets and offsets of waves are easily located in terms of the number of standard ... applications and the use of methods for indirect extraction of respiratory information is particularly attractive to pursue One example of application would be the analysis of the influence of the ... minimized by first finding estimates of γ and Q for every value of τ and then selecting that τ for which ε is minimum For a fixed value of τ , the optimal estimator of Q is given by [34] T ˆ Qτ = Vτ...

Ngày tải lên: 13/08/2014, 12:20

... number of EDR signals, and L the number of samples of the EDR signals For single-lead EDR algorithms based on wave amplitudes (Section 8.2.1) and for EDR algorithms based on HR (Section 8.3), J = For ... series of events which are visually informative and accessible for analysis at any time instant Therefore, a technique which converts such point event series into a form suitable for standard ... properly modify data according to the context of the specific problem at hand for the purposes of automated analysis Since the information content of a set of 245 P1: Shashi August 24, 2006 246 11:50...

Ngày tải lên: 13/08/2014, 12:20

... distributions of the performance statistics Due to relative complexity of the performance measures and of the evaluation protocol, an automated tool to objectively evaluate and compare the performance and ... onset and offset of particular features of the ECG (referred to as an interval) is of great importance since it provides a measure of the state of the heart and can indicate the presence of certain ... original database, and performance statistics are derived for each new database The mean, standard deviation and median of expected performance, as well as the minimum expected performance (5% confidence...

Ngày tải lên: 13/08/2014, 12:20

... particular, the Q and Toff single-beat segmentation errors of 5.5 ms and 12.4 ms for lead II, and 3.3 ms and 9.5 ms for lead V2, are significantly better than the corresponding errors for the HMM with ... approach for the task of automated ECG interval analysis: the choice of representation for the ECG signal and the choice of model for the segmentation We have demonstrated that wavelet methods, and ... way that the differences of morphology of the ECG waveforms are suppressed for the same type (class) of heartbeats, and enhanced for waveforms belonging to different types of beats This is a very...

Ngày tải lên: 13/08/2014, 12:20

... structure and key relationships between diagnostic features in a data set [27] Hierarchical clustering has also provided the basis for the implementation of systems for the analysis of large amounts of ... learning systems for ECG classification should also offer improvements in connection to information representation and the assessment of classification results Ideally, an ECG classification platform ... data are commonly stored and analyzed using different formats and software tools Thus, there is a need to develop cross-platform solutions to support data analysis tasks and applications [64] A...

Ngày tải lên: 13/08/2014, 12:20

... breaking up of the large haplotype block and thus allowing inference of the relative effects of each SNP The task of demonstrating the basis for causality, even of haplotypes, is not trivial, and thus ... University of Queensland, School of Medicine, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland 4102, Australia 15Gastrointestinal and Liver Unit, Prince of Wales Hospital and University ... standard of care is pegylated interferon and ribavirin, which clears the virus only after weekly injections for up to 48 weeks and in less than half of those infected with the most common form...

Ngày tải lên: 11/08/2014, 12:21

... or protein profiles of IVD cells and AC cells Hypoxia inducible factor isoforms (HIF1A and HIF1B), glucose transporter type Page of 20 (GLUT-1), matrix metalloproteinase (MMP-2) and vascular ... pattern of expression, that is high expression of ACAN in NP and AC, high expression of type I collagen in AF compared with NP and AC, and high expression of versican (VCAN) in both NP and AF ... Faculty of Medical and Human Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK and 2Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road,...

Ngày tải lên: 12/08/2014, 11:23

... the possibility to study the changes of expression of thousands of genes simultaneously depending on the pathogen A large variety of methods for normalising and analysing microarray data has, however, ... statistical methods for the detection of differentially expressed genes For each of these steps, the techniques used by the workshop participants will be presented and compared MATERIALS AND METHODS ... Benjamini and Hochberg threshold for IDL, INRA_J and PTP teams Normalisation and analyses methods used by these teams are presented in Tables I and II control procedures and different normalisation and...

Ngày tải lên: 14/08/2014, 13:22

... and cleaning up of the data, removal of systematic biases and drifts (a process often referred to as 'normalization'), and transformation to a format and scale that is suitable for the following ... technical aspects of data import and management, and refer the interested reader to the documentation of the software package prada for a thorough discussion of these [19] Selection of well measured ... by the forward light scatter, α and β are the coefficients of the model, and xspecific is the specific fluorescence We compute α and β by robust fit of a linear regression of xtotal on s, and obtain...

Ngày tải lên: 14/08/2014, 17:22

... designated for formal verification and validation of UML-based design of embedded systems It first introduces an approach of using the AsmL language for acquiring formal models of the UML semantics and ... LTL formulas The proof is simple by structure induction and therefore omitted here 3.2 Textual Representation The idea of textual representation for LTL formulas is inspired by the form of regular ... concepts for the structural and logical decomposition, modelling of concurrency/parallelism aspects, and the definition of the behaviour of the system under development For the definition of the...

Ngày tải lên: 08/03/2016, 11:22

... China Sea via the Gulf of Thailand, Andaman Sea and Bay of Bengal and role of geographic barrier based on ITS, AFLP and microsatellite analyses • To show the important role of sulfur-containing ... that often enter coastal waters as a result of runoff from the land (Phillip and Menez, 1988) Seagrasses also trap fine sediments and particles from both substratum and water The removal of particles ... Gulf of Thailand and the Thai Andaman Sea Genetic diversity and population structure of H ovalis from the Western Pacific to the Western Indian Ocean Discussion New records of Halophila major for...

Ngày tải lên: 20/05/2016, 16:28

... CG-3’ for the downstream primer PCR amplification for β-actin was performed for 36 cycles (1 at 94ºC, at 60ºC, 40 sec at 72ºC) and for TNFα for 40 cycles (1 at 94°C, at 60°C, 40 seconds at 72°C) Identification ... years) and acute exacerbation at time of recruitment They were randomized to be treated with inhalation of a 10 ml of 0.1 M fucose / 0.1 M galactose solution in 0.9 % NaCl twice daily for 21 ... 20 U/ μl RNAse inhibitor and 0.5 μl 50 U/ μl reverse transcriptase (Perkin Elmer Biosystemsm Roche, Branchburg, USA) The mixture was incubated at 42ºC for 30 and at 99ºC for Samples were stored...

Ngày tải lên: 03/11/2012, 11:48

... two promoters, prof dr Suzanne Hulscher and prof dr Pieter Augustinus and my former promoter, prof dr Kees Vreugdenhil Their outstanding knowledge and experience in both science and management ... comprise: a spatial arrangement of elements, ordered levels (hierarchy) of subsystems or /and elements, and concentration and types of algebraic relationships between subsystems and/ or elements These three ... etc.) Examples of open systems are: groundwater systems, social systems, as well as most of the natural systems Four types of variables characterize a model of a system (Kramer and De Smit, 1991):...

Ngày tải lên: 06/11/2012, 10:35