methods and criteria to evaluate clinical relevance

... ObsessiveCompulsive Inventory-Revised scale: Replication and extension to nonclinical and clinical individuals with OCD symptoms BMC Psychiatry 2011 11:129 Submit your next manuscript to BioMed Central and take ... 0.81 to 0.93) and for the subscales (ranged from 0.65 to 0.90), good to excellent test-retest reliability (coefficient r ranged from 0.57 to 0.91), good discriminant validity and satisfactory ... internal consistency and inter-item correlation for the subscales ranged from 0.64 to 0.83 and 0.73 to 0.94, respectively Data analysis A confirmatory factor analysis was performed to examine the latent...

Ngày tải lên: 11/08/2014, 15:22

... functional site ATOM-TYPE-IS-N2 ATOM-TYPE-IS-N3 ATOM-TYPE-IS-Na ATOM-TYPE-IS-O ATOM-TYPE-IS-O2 ATOM-TYPE-IS-OH ATOM-TYPE-IS-S Scores for query sites (predictions) ATOM-TYPE-IS-SH ATOM-TYPE-IS-OTHER ... enough examples to evaluate specificity SeqFEATURE had a sensitivity of 86.2% at our most lenient cutoff, and specificity and PPV comparable to Pfam and Gene3D at our more stringent cutoffs Interestingly, ... Background sites of same atom type and atom density Scoring function Shell 012345 ATOM-TYPE-IS-C ATOM-TYPE-IS-CT ATOM-TYPE-IS-Ca Score cutoff based on training data ATOM-TYPE-IS-N Positive training...

Ngày tải lên: 14/08/2014, 08:20

... development in the future 15 Criteria 3: Monitoring systems and monitoring tools Description of monitoring input, process and outputs Tools for doing input survey Tools for survey, evaluate graduates, ... Social knowledge and humanity need to be added to the curriculum Criteria Criteria 1: The program reflects the vision and objectives of the school The curriculum takes into account and reflects the ... the use of the tools, equipment, computing resources, and laboratories 19 Criteria4 : Maintenance and Upgrading of Facilities The tools, equipment, computing resources, and laboratories are periodically...

Ngày tải lên: 21/07/2016, 10:53

... adherence patterns, clinical events and CD4 cell count criteria to determine the viral status of Ugandans on ART The goal was to determine if the criteria listed above could be used to minimize viral ... TCQ, RC and AK contributed to study design, study oversight and conduct and manuscript writing LS and LJ performed data analysis and contributed to manuscript writing RD performed laboratory analyses ... a standard across many RLS It is our view that this standard of care needs to be improved to reduce the late detection of viral failure and to minimize unnecessary switching of patients to second-line...

Ngày tải lên: 20/06/2014, 08:20

... chiropractors inserted the previously chosen symptoms and activity onto the follow-up form prior to this being given to the patient to score Therefore, the patient was aware of the symptoms they ... Description Symptom S1 The symptom which is most important to the patient described in the patient’s own words Symptom S2 Optional and is second symptom which is part of the same problem as symptom Activity ... data were coded and entered into an Excel spreadsheet and then imported into SPSS v16.0 to perform statistical analysis The Wilcoxon signed rank test was used to compare baseline and post-treatment...

Ngày tải lên: 25/10/2012, 10:06

... by putting them into practice, experimenting with various tools and user interactions, and evolving these business processes to deal with unknown and possibly unknowably demands from the market ... agile methods: § Can these methods be evaluated using the scientific principles found in the high– ceremony methods? § Can the management of ERP systems acquisition and deployment be reduced to ... about how problems are to be understood.” A pre–paradigm is characterized by an abundance of initiatives, the development of standards, and the increasing use of methods and structure [42, 60]...

Ngày tải lên: 18/02/2014, 07:20

... computes an update to the weight vector based on the current example The resulting weight vector tends to be overfit to the last few examples; one way to reduce overfitting is to use the average ... label, and for an incorrect link Since the history-based feature set used in the parsing algorithm makes it impossible to use independence to factorize the scoring function, an exact search to find ... classification methods as well, including SVM, MIRA, and OPA There has been some work on machine learning methods where this parameter is tuned automatically (Tipping, 2001), and a possible extension to...

Ngày tải lên: 20/02/2014, 12:20

... In order to understand the drivers of urban development and their possible future impacts on land development, and to develop scenarios that can be used to test alternative approaches to minimizing ... aspects of the real system to model and what aspects to ignore Critical issues that must be considered include what level of detail to try to match (data resolution) and how to handle issues of ‘‘deep ... values decreasing linearly to the top and bottom; and ‘‘valley’’-similar to tent, but with high values on the top and bottom edges and decreasing towards the center 2.2.6 ABM 2Dq, with greenbelt...

Ngày tải lên: 23/03/2014, 13:20

... question for NLG researchers and developers (as opposed to doctors and health administrators who just want to know if they should use STOP as a black-box system), but the clinical trial does not distinguish ... page of a STOP questionnaire 3.1 Practical Aspects of the Clinical Trial The STOP clinical trial took 20 months to run (of which the first months overlapped software development), and cost about ... cost of the clinical trial But the cheapness of (1) and (2) were partially due to the fact that they were too small to produce statistically solid findings, and the cheapness of (2) and (3) were...

Ngày tải lên: 23/03/2014, 19:20

... (boxplot, histogram, scatterplot, pie chart, and dotplot) • Select random samples And we showed how to expand Excel’s capabilities by downloading and installing add-ins The best way to summarize and review ... column and in the top cell (just below the label row) of the new column, we put the command =rand() We copied this command all the way down the column, using Windows’ standard cut and paste commands ... 6, and Chapters and on “Reporting Your Findings” and “Problem Solving” convert the text into an invaluable professional resource An Instructor’s Manual is available to qualified instructors and...

Ngày tải lên: 01/06/2014, 10:03

... according to the usual practice (standard of care) and followed over time using standardized methods and forms to make possible a valid and reliable description of case-mix, pattern of care and outcomes ... conduct and supervision In order to be able to conduct and monitor the progress of the trial for the patients' safety and according to the World Medical Association Declaration of Helsinki and the ... sample and on relevant sub-groups to screen predictors of poor analgesic care and to identify patients at greater risk of under-medication Data collected over time will be used to develop and test...

Ngày tải lên: 20/06/2014, 15:20

... (DGL), and membrane-associated guanylate inverted-1 (MAGI-1); apoptosis factors such as the pro-apoptotic Bcl2 and Bak; replication factors and DNA repair factors such as mcm7 and XRCC1; and other ... interacting with E2F factors and with histone deacetylases; Induce a peripheral tolerance in cytotoxic T lymphocytes (CTL) and Downregulate the expression of TLR9, contributing to immune response ... be cited: transcription factors such as p300, myc, interferon regulatory (IRF3), autocrine motility factor (AMF-1/gPS2); factors that determine adhesion, cytoskeleton and polarity, such as paxillin,...

Ngày tải lên: 27/06/2014, 15:20

... appropriate index to evaluate the heart size in the horse and that it should not be considered as a tool for assessing potential performance On the other hand, there are currently more suitable and accurate ... Medicine and Science, 2000 11 O’Callaghan MW Comparison of echocardiographic and autopsy measurements of cardiac dimensions in the horse Equine Vet J 1985, 17, 361-368 12 Patteson M Cardiac anatomy and ... correlate with the heart size and it cannot be regarded as a suitable index for predicting potential performance The lack of correlation between BW and HS and between LVMM and HS observed in this study...

Ngày tải lên: 07/08/2014, 18:20

... Spinner and Tefft equation applied to samples with transversal rectangular section: MATERIALS AND METHODS 2.1 Testing methods The first three testing methods have been previously described and illustrated ... mass in grams (g) and L, b and h are respectively the length, width and thickness in millimetres (mm) A shock was applied perpendicularly to the sample length and tangentially to the rings, the ... (MOE4PT), the resonance frequency and ultrasound methods (respectively MOEGR through Fr and dimensions, and MOEUS through VUS and density), each data corresponding to the mean of three successive...

Ngày tải lên: 08/08/2014, 01:22

... reaction to additives) and unfounded (e.g., thimerosal, mercury, and autism) risks related to vaccine ingredients Clinicians need to be informed of details of vaccine additives and should be able to ... fears One strategy to attend to this concern is for a clinician to rehearse means to communicate with the patient as to why multiple injections are needed as a means to induce tolerance Certain ... extracts to vaccines) “Allergy shots are often called “vaccines” because (1) they are injected and (2) the intention of both is to confer immunity.” “ allergy shots must stop after to years and at...

Ngày tải lên: 08/08/2014, 21:20

... http://arthritis-research.com/content/5/5/R292 thought to contribute to the pathogenesis and regulation of the spondyloarthropathies [3] In other autoimmune diseases, including rheumatoid arthritis, Wegener’s granulomatosis, and multiple ... was to examine the prevalence and clinical relevance of CD4+CD28– T cells in a cohort of AS patients in comparison with healthy control individuals, and to characterize NK cell features and functional ... subset of proinflammatory, cytotoxic CD4+ T cells was described that is rare in healthy individuals [17–20] These T cells are clonally expanded and lack the important CD28 co-stimulatory molecule on...

Ngày tải lên: 09/08/2014, 01:23

... ability to detect change over time, and also includes the variability in measurement related to differences in patient repositioning at the second radiograph When the aim is to select a tool to evaluate ... 0.54 0.09 ± 0.36 -0.01 to +0.19 -0.63 to +0.81 0.81 (0.69–0.89) -0.61 (-0.65 to -0.57) -0.49 ± 0.67 -0.05 ± 0.16 -0.09 to -0.01 -0.37 to +0.27 0.97 (0.95–0.98) -0.82 (-0.84 to -0.80) -0.47 ± 0.62 ... 0.02 ± 0.18 -0.2 to +0.06 -0.34 to +0.38 0.95 (0.92–0.97) -0.76 (-0.77 to -0.73) -0.39 ± 0.61 -0.46 ± 0.59 0.07 ± 0.30 -0.01 to +0.15 -0.53 to +0.67 0.87 (0.78–0.92) -0.64 (-0.67 to -0.61) -0.49...

Ngày tải lên: 09/08/2014, 07:20

... growth factor, plateletderived growth factor, basic fibroblast growth factor and transforming growth factor-β) After binding to their membrane receptor these cytokines and growth factor generate ... (receptor activator of nuclear factor-κB ligand), which is the major factor involved in osteoclast differentiation and activation [37] One of the strongest predictors of long-term outcome in RA and ... production and secretion of cytokines and growth factors by infiltrating cells and resident synovial cells This leads to increased production of ADAMTSs and MMPs by synovial fibroblasts and by chondrocytes,...

Ngày tải lên: 09/08/2014, 10:21

... potential candidate factors to follow tissue maturation and healing: HA and CS Many questions remain to be addressed, such as the correlation of marker levels with defect size, number, and location ... confirmatory studies (ideally in human patients), they hold promise for non-invasive monitoring after cartilage repair procedures Reliable, reproducible, and relatively inexpensive methods to evaluate ... well as histologic grading Animals treated with ACs demonstrated better visual and histological appearance than those treated with drilling Three of the five AC biopsies were near normal, and the...

Ngày tải lên: 09/08/2014, 14:21

... surgery and to assess predictors of success Page of Materials and methods Patients From January 2007 to June 2008, 110 consecutive patients scheduled for first-time open heart surgery and known ... concomitant to cardiac surgery appears to be an efficient measure to improve outcome The intention of this prospective study was to assess safety of the Epicor ablation procedure and to identify predictors ... Diagnosis and classification of AF were established by standard ECG and holter ECG in all patients prior to admission AF was defined paroxysmal in 29%, persistent in 31% and long standing persistent...

Ngày tải lên: 10/08/2014, 09:22