metastasectomy of lymph node metastases

... elective surgical removal of cervical lymph nodes seems to be necessary to eliminate possible occult lymph node metastases An accentuation of Gal3 positive cells in the lymph node sinus was detected ... with the presence of lymph node metastases (N+) [32, 33] Increased PD-L1 mRNA expression in peripheral blood of oral cancer patients was also shown to be associated with lymph node metastases [34] ... grading in lymph node specimens was apparent There was no significant difference in Gal3 expression between the lymphatic compartment of tumor free lymph nodes and metastatic lymph nodes Statistical

Ngày tải lên: 03/07/2020, 01:40

... Because of the high probabilities of pelvic, para-aortic and occult supraclavicular lymph node metastasis that is part of the TNM staging system but not part of the International Federation of Gynecology ... recommended [1] A series of studies demonstrated that at diagnosis, up to 47 % of cervical patients had lymph node metastasis on PET [2] The presence of PET-positive lymph nodes may identify patients ... Access Patterns of failure after use of 18F-FDG PET/CT in integration of extended-field chemo-IMRT and 3D-brachytherapy plannings for advanced cervical cancers with extensive lymph node metastases

Ngày tải lên: 21/09/2020, 09:17

... diagnosed with axillary lymph node metastases on Takada et al BMC Cancer (2020) 20:598 Page of 13 Fig Comparison of tumor-infiltrating lymphocyte (TIL) density by differences in lymph node metastasis ... frequently metastasizes to the axillary lymph nodes, and the status of axillary lymph nodes metastasis is a prognostic factor in early breast cancer Sentinel lymph node (SLN) biopsy (SLNB) is commonly ... correlation between TILs and lymph node metastasis in both groups Interestingly, Caziuc evaluated not only SLNs but also axillary lymph nodes in cases of additional axillary lymph node dissection due

Ngày tải lên: 03/07/2020, 02:56

... the importance of incorporating lymph node status during the development of prognostic gene signatures Ellen may be a useful tool to predict outcome of patients regardless of lymph node status, ... intervention and resection of smaller primary tumours is associated with a reduced incidence of spread to regional lymph nodes [7] More importantly, the absence of lymph node involvement is significantly ... involved axillary lymph nodes, in the absence of significant co-morbidities, are currently offered adjuvant systemic chemotherapy [3, 4] However, the biological significance of nodal metastases is

Ngày tải lên: 20/09/2020, 14:08

... with the presence of lymph node metastases (p ≤ 0.03) 65% of lymph node metastases were Gb3 positive and in 40% of tested patients, we observed a statistically significant increase of metastatic ... and the presence of lymph node metastases 33 of 62 Gb3 positive patients (53.2%) had lymphatic extension, whereas 29/62 patients (46.8%) had no lymph node metastases Absence of Gb3 expression ... expression in lymph node metastases in studied patients (p ≤ 0.04) Our results show that Gb3 is expressed in 65% of lymph node metastases Furthermore, 40% of patients showed an increase of the relative

Ngày tải lên: 14/10/2020, 13:23

... matched lymph node metastases in 11% of the patients (p = 0.06) The luminal A subtype in the primary tumour shifted to a subtype with a worse prognostic profile in the lymph node metastases in of ... http://www.biomedcentral.com/1471-2407/13/558 Page of 10 Primary tumour N = 425 No lymph node metastasis Lymph node metastases, N = 128 N = 297 ER analysis in primary tumour and corresponding lymph node assessed N = 262 ... lymph node metastases Furthermore, the survival analyses show that the St Gallen molecular subtypes have similar prognostic implications in primary tumours and matched lymph node metastases Node

Ngày tải lên: 05/11/2020, 05:39

... Lymphatic Vessels 1.1.1 Lymphatic vasculature 1.1.2 Lymphatic vessels markers 1.1.3 Development of the lymphatic vasculature 1.2 Lymph nodes 1.2.1 1.3 Structure of the lymph node ... 2.9.1 Isolation of cells from lymph nodes 2.9.2 Isolation of dendritic cells from lymph nodes (Dendritic cell migration assay) 2.9.3 2.10 46 47 Isolation of B cells from lymph nodes Flow cytometry ... 74 Implication of FDCs in the induction of LN lymphangiogenesis in response to immunization 3.3 77 Discussion 83 Chapter 4: Regulation of lymph node lymphangiogenesis by lymphotoxin β receptor

Ngày tải lên: 10/09/2015, 09:29

... Introduction Sentinel lymph node is defined as the first lymph node in the lymph nodes receiving lymph nodes from primary tumors Since the past 19 years, approved sentinel lymph node biopsy is a technique ... Detection rate = Number of detected cases with sentinel lymph node / total number of cases performed - Sensitivity = Number of sentinel lymph node (+) / Number of patients with lymph node metastasis ... frozen secton) / Number of lymph nodes detected = (a + d) / (a + b + c + d) - The rate of false negative = Number of sentinel lymph node (-) / Number of patients with lymph node metastasis on final

Ngày tải lên: 10/01/2020, 09:49

... Increased expression of LAMTOR5 in HNSCC with lymph node metastases (A) Representative immunohistochemical staining of LAMTOR5 in primary HNSCC tissue (SCC, left) and metastatic lymph node (LN, right; ... Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China Department of Oral ... Journal of the National Cancer Institute 2014; 106 Ferris RL Immunology and Immunotherapy of Head and Neck Cancer Journal of clinical oncology : official journal of the American Society of Clinical

Ngày tải lên: 15/01/2020, 18:14

... positive lymph nodes, and the rate of positive lymph nodes was 36.0% (9/25) In the Chen et al BMC Cancer (2020) 20:423 Page of 10 Correlation analysis of levels of SCC antigen with survival time of ... existed in the rate of positive lymph nodes between the above two groups (χ2 = 8.694, P = 0.003) For the assessment of the survival times of patients, the AUC value of the SCC of the conventional ... OS and PFS of patients with SCC antigen levels < 2.7 ng/mL in the NACT group was Table The value of SCC antigen levels on assessment of rate of positive lymph nodes and survival time of patients

Ngày tải lên: 30/05/2020, 21:44

... Dongqing Wang and Shui Yu Lymphatic metastasis intensity (LMI) was used to describe as the ratio of the number of positive lymph nodes to the number of examined lymph nodes Lymphatic metastasis ratio ... study, more than half of patients have severe lymph node involvement and were not suitable candidates for selective lymph node dissection Approximately 80% of them displayed lymph node metastasis with ... regional cervical lymph node recurrence and persistent disease remained the major cause of failure following curative intent of definitive IMRT Because of high rate of node failure of level VIb and

Ngày tải lên: 17/06/2020, 11:40

... Development of nomograms to predict axillary lymph node status in breast cancer patients Kai Chen1,2*† , Jieqiong Liu1,2†, Shunrong Li1,2† and Lisa Jacobs3* Abstract Background: Prediction of axillary lymph ... IBCSG 23–01 trial [1] demonstrated that patients with micrometastases in sentinel lymph nodes (SLNs) can be spared from axillary lymph node dissection (ALND) Furthermore, ALND does not provide ... possibility of abandoning SLNB in a select group of patients [7] However, the safety of the selection criteria used in these studies is unconfirmed Predictive models for axillary lymph node (ALN)

Ngày tải lên: 06/08/2020, 06:46

... such as lymph node ratio (LNR; the ratio of metastatic/positive lymph nodes to total number of lymph nodes examined), when determining patient prognosis in CRC The log odds of positive lymph nodes ... number of examined lymph nodes examined or the lymph node yield (LNY) can be used as a marker for the quality of an oncological resection [4] In CRC surgery, harvesting a minimum of 12 lymph nodes ... suggested to be correlated with understaging of the disease [5] Lymph node ratio (LNR) (defined as the ratio of metastatic lymph nodes to the total number of lymph nodes examined) has been investigated

Ngày tải lên: 19/09/2020, 22:11

... The main aim of this study was to evaluate the significance of MCT expression in a comprehensive series of primary CRC cases, lymph node and hepatic metastasis Methods: Expressions of MCT1, MCT4, ... a tendency for association with the presence of lymph node metastasis All of these features, with exception of low CEA levels, are characteristic of more aggressive tumours and poor prognosis ... 11Center of Molecular and Environmental Biology (CBMA)/Department of Biology, University of Minho, Braga, Portugal 12 Laboratory of Medical Investigation (LIM) 14, Faculty of Medicine, University of

Ngày tải lên: 20/09/2020, 15:00

... composed of depth of tumor invasion (T), regional lymph node metastasis (N) and distant metastasis (M) There were collinearities between TNM stage and tumor invasion, regional lymph node metastasis ... likely to have regional lymph node metastasis (OR = 0.55, 95 % CI, 0.31–0.98) than CC genotype carriers This meant the risk of having a higher degree of regional lymph node metastasis for TT genotype ... supplemented with riboflavin, blood riboflavin in 34.2 % of the subjects was still lower than normal, despite sufficient dietary riboflavin [32] Our study shows that the CC genotype of rs13042395 can

Ngày tải lên: 20/09/2020, 15:05

... advantage of dual tracers remained stable over years He et al BMC Cancer (2016) 16:107 Page of 12 Table Subgroup analyses of studies on the sentinel lymph node identification Subgroups No of studies ... Recently, sentinel lymph node biopsy (SLNB) has replaced axillary lymph node dissection (ALND) to be the standard procedure for axillary staging in patients with clinically node- negative breast ... Page of 12 Table Quality assessment of included studies by a revised 6-item scale Author (year) Description of Reasons for patients’ withdrawal characteristics Description of Evaluation of measures

Ngày tải lên: 21/09/2020, 11:38

... resection of lesions In 2000, the National Comprehensive Cancer Network (NCCN) recommended pathologic examination of at least 12 lymph nodes (LNs) in the staging of colon cancer (CC) The number of metastatic ... incidence and mortality rate of CRC are increasing [4] Surgical resection remains the mainstay of treatment of local and regional disease Lymphadenectomy, a critical component of surgical procedures ... Background: Colon cancer with lymph node metastases has been considered as advanced stage and to have poor survival We postulated that patients with solitary lymph node metastasis are a distinct

Ngày tải lên: 05/11/2020, 00:34

... modifications of the US features of the corresponding lymph nodes Discussion Lymph node evaluation is an important step in the staging, prognosis and follow up of PCL, although there are differences in lymph ... or central lymph node involvement respectively [6] In case of MF and SS, the evaluation of the lymph nodes is different; in fact, because of the negative impact on survival rates of “palpable ... http://www.biomedcentral.com/1471-2407/14/8 Page of 10 Figure Case 15, lymph nodal involvement from cutaneous B-cell lymphoma A: FNC smear of lymph nodal involvement from cutaneous B-cell lymphoma showing monomorphous large lymphoid

Ngày tải lên: 05/11/2020, 01:55

... staining) was also significantly associated with tumor progression (P < 0.001), lymph node metastases (P = 0.002), lymphovascular invasion (P = 0.002), and perineural invasion (P = 0.002) in the ... invasiveness/migratory ability of GCs, and may also be used as a predictive biomarker for prognosis or aggressiveness of GCs Keywords: Stomach, Adenocarcinoma, Snail, Lymph node metastasis, Survival ... South Korea Full list of author information is available at the end of the article of membranous β-catenin and translocation into the nuclear compartment), and upregulation of mesenchymal markers

Ngày tải lên: 05/11/2020, 07:45

... use of sentinel lymph node technology with identification of the sentinel node, only possible after the use of this technology We conclude with a review of the literature outlining treatment of ... the presentation of ectopic breast cancer in the vulva We demonstrate use of sentinel lymph node technology with identification of the sentinel node, only possible after the use of this technology ... treatment of melanoma in the early 1990’s[8] The assessment of regional lymph nodes in breast cancer paralleled the work in melanoma, in an effort to limit the morbidity of axillary lymph node dissection[9]

Ngày tải lên: 20/10/2022, 00:32