meta analysis of clinical trials

... Rennie D, Stroup DF: Improving the quality of reports of meta- analyses of randomised controlled trials: the QUOROM statement Quality of Reporting of Meta- analyses Lancet 1999, 354:1896-1900 20 ... any study, this is a rate of 0.2% over the course of an average treatment period of at least year Discussion Meta- analysis of small studies is problematic [63] because of possible inadequacies ... numbers of patients and events increase the risk of chance findings [64] The ideal is meta- analysis of high-quality, large, randomised trials [63], but without them we have to make the best of the...

Ngày tải lên: 09/08/2014, 08:23

... Rennie D, Stroup DF: Improving the quality of reports of meta- analyses of randomised controlled trials: the QUOROM statement Quality of Reporting of Meta- analyses Lancet 1999, 354:1896-1900 Jadad ... Proceedings of the Annual Meetings of the American Society of Clinical Oncology (through 2005) were systematically searched for evidence relevant to this meta- analysis The selection of studies ... overall value of this form of therapy for DCIS patients Finally, none of these trials was sufficiently powered to detect differences in overall survival Similar rate of distant metastases and...

Ngày tải lên: 09/08/2014, 10:21

... the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996, 17:1-12 DerSimonian R, Laird N: Meta- analysis in clinical trials Control Clin Trials 1986, ... outcomes of analysis Fourth, we included in our meta- analysis trials that were performed on populations that had a different profile of risk factors Fifth, we analyzed only the effect of antibiotic ... reduction of occurrence of negative outcomes [36] Another limitation of our meta- analysis is that the effect of prophylactic antibiotics administered via the respiratory tract on the length of the...

Ngày tải lên: 13/08/2014, 03:20

... included trials, 283 of 1,220 patients (23%) died At least one death occurred in 10 of the 11 included trials, allowing those 10 trials (with a total of 1,185 patients) to be included in a meta- analysis ... renal effects of hyperoncotic colloids The present meta- analysis of randomized trials was designed to test the hypothesis that hyperoncotic colloids per se increase the incidence of AKI Materials ... RCTs with a total of 1,220 patients fulfilled all eligibility criteria and were included in the meta- analysis [17-27] All trials had been published Three of the 11 included trials were reported...

Ngày tải lên: 13/08/2014, 21:21

... dosing In trials of to weeks, 88% of the doses were 200 mg daily In trials of 12 weeks' duration, 46% of doses were 200 mg and 46% were of 400 mg daily In trials of 24 weeks or longer, 92% of doses ... because of adverse events or lack of efficacy This systematic review and meta- analysis of celecoxib in osteoarthritis and rheumatoid arthritis was conducted using information from company clinical ... expected in clinical practice, where the population may be sicker, or take more medications, than in clinical trials Using company clinical trial reports removes some of the problems of selective...

Ngày tải lên: 09/08/2014, 06:22

Ngày tải lên: 09/08/2014, 07:20

... lung disease, randomized controlled trials, observational studies, multicenter studies, clinical trials phase II, clinical trials phase III, and clinical trials phase IV Diffuse alveolar damage ... experimental arm of the randomized clinical trials Additionally, we performed a meta- analysis of the randomized controlled trial results comparing CYC treatment with control treatments Using a test of interaction, ... was limited by the small number of eligible studies and a lack of variability in quality across studies Results of the meta- analysis In the randomized clinical trials, the FVC mean difference...

Ngày tải lên: 09/08/2014, 13:22

... Magnitude of risks and benefits of the addition of bevacizumab to chemotherapy for advanced breast cancer patients: Meta- regression analysis of randomized trials Journal of Experimental & Clinical ... in metastatic breast cancer: a meta- analysis of randomized controlled trials Breast Cancer Res Treat 122(1):1-7 34 Miles DW, Romieu G, Dieras V, Chen D, Duenne A, Robert N: Meta- analysis of patients ... Magnitude of benefit of adjuvant chemotherapy for non-small cell lung cancer: Meta- analysis of randomized clinical trials Lung Cancer 2008, 63(1):50-7 24 Parmar MKB, Machin D: Survival analysis: ...

Ngày tải lên: 10/08/2014, 10:21

... reliability determined the adequacy of randomisation, concealment of allocation, blinding of outcome assessors and adequacy Page of 14 of data analysis (was intention-to-treat -analysis performed?) (internal ... W, Bernardy K, Arnold B, Offenbächer M, Schiltenwolf M: Efficacy of multicomponent treatment in fibromyalgia syndrome: a metaanalysis of randomized controlled clinical trials Arthritis Rheum 2009, ... validity) of the randomised controlled trials' analysis Author, year Adequate randomisation Adequate allocation concealment Blinding of assessor Intention-to-treat analysis Inclusion of patients...

Ngày tải lên: 12/08/2014, 12:20

... Rennie D, Stroup DF: Improving the quality of reports of meta- analyses of randomised controlled trials: the QUOROM statement Quality of Reporting of Meta- analyses Lancet 1999, 354:1896-1900 Jadad ... because meta- analyses are often handicapped by the heterogeneity of the included trials Moher and colleagues [34] demonstrated that meta- analyses with lowquality trials (Jadad assessment scale of ... quality assessment score was less than three [26] Two trials Figure Flowchart of randomised controlled trials selected for the meta- analysis meta- analysis ARDS = acute respiratory distress syndrome...

Ngày tải lên: 13/08/2014, 16:20

... Rennie D, Stroup DF: Improving the quality of reports of meta- analyses of randomised controlled trials: the QUOROM statement Quality of Reporting of Meta- analyses Lancet 1999, 354:1896-1900 Prakash ... http://ccforum.com/content/14/5/R194 Page of 10 Clinically important gastrointestinal bleeding The events of clinically important GI bleeding were explored in three studies [16,23,30] The pooled analysis of the clinically ... = 61.7%) On the basis of the results of the sensitivity analysis, one study [30] was excluded The subsequent analysis was based on two trials [16,23], and a total of 12 clinically important GI-bleeding...

Ngày tải lên: 13/08/2014, 21:21

... recent meta- analysis of the effects of prone positioning on intensive care unit (ICU) mortality Along with a global meta- analysis, a subgroup meta- analysis is performed on the group of studies that ... previous aggregate meta- analysis we emphasised the substantial clinical (rather than statistical) heterogeneity of primary studies, making it difficult to conduct a study-level meta- analysis evaluating ... minimisation of ecological bias therefore makes these new Page of studies an interesting opportunity for a new updated study-level meta- analysis In the present article, we update our recent meta- analysis...

Ngày tải lên: 14/08/2014, 07:21

... Optimising Analysis of Stroke Trials (OAST) Collaboration, Bath PM, Gray LJ, Collier T, Pocock S, Carpenter J: Can we improve the statistical analysis of stroke trials? Statistical reanalysis of functional ... detection of smaller treatment effects Key messages • None of the phase III clinical trials for Traumatic Brain Injury (TBI) has shown an overall significant treatment effect Inefficient analysis of trials ... dichotomized [25,26] The Optimising Analysis of Stroke Trials (OAST) Collaboration has shown the benefit of ordinal analysis in the field of stroke [27] Other examples of ordinal outcome scales can...

Ngày tải lên: 14/08/2014, 08:21

... defensive avoidance, reactance) outcomes META- ANALYSIS Rationale Meta- analysis is a quantitative method that synthesizes the results of a particular group of studies Researchers gather all available ... representation of the values for each of the cells of the studies is available from the authors upon request.) The next step was to conduct a standard × analysis of variance The analysis indicated ... differences not appear to have much influence on the processing of fear appeals, given the results of this meta- analysis and other studies This meta- analysis tested trait anxiety both by itself for its...

Ngày tải lên: 05/03/2014, 22:21

... Textbook of Clinical Trials Textbook of Clinical Trials Edited by D Machin, S Day and S Green  2004 John Wiley & Sons, Ltd ISBN: 0-471-98787-5 Textbook of Clinical Trials Edited by David ... t.wykes@iop.kcl.ac.uk Preface This Textbook of Clinical Trials is not a textbook of clinical trials in the traditional sense Rather, it catalogues in part both the impact of clinical trials – particularly the ... interaction of statistical and clinical disciplines The impact of the results from clinical trials, particularly the randomised controlled trial, on the practice of clinical medicine and other areas of...

Ngày tải lên: 23/03/2014, 01:20

... drug therapy We defined LTBI as the clinical circumstance of a positive tuberculin skin test (TST) result in the absence of symptoms or clinical findings suggestive of active infection In analyzing ... 886 titles of potentially relevant articles from our search of computerized databases and 58 additional references from our manual search of the bibliographies of retrieved articles Of the 944 ... significantly reduces the rate of MTB reactivation,12 some transplant centers neither test for nor treat LTBI because of the perceived lack of efficacy and potential toxicity of drug therapy in liver...

Ngày tải lên: 29/03/2014, 03:20

... report [10] dealing with the tracking of off-shore clinical trials was telling It reported that the number of foreign clinical investigators conducting clinical research under an IND increased ... meeting the Nation's goal of improving the health of its citizens *NIH definition of Clinical Studies: "The definition of Clinical Studies for this study is taken from 45CFR46 Clinical research is ... pstable.htm] 10 Rehnquist J, Office of the Inspector General: The Globalization of Clinical Trials A Growing Challenge in Protecting Human Subjects, US Department of Health and Human Services,...

Ngày tải lên: 18/06/2014, 16:20

... Meta- analysis in clinical trials Control Clin Trials 1986;7:177-88 29 Babapulle MN, Joseph L, Belisle P, Brophy JM, Eisenberg MJ A hierarchical Bayesian meta- analysis of randomised clinical trials ... (CIs) Trials in which the event of interest was not observed in either study group were omitted from the analysis of that event For trials in which only one of the groups had no event of interest, ... curves across all trials and constructed with the use of S-Plus software, version 4.5 (Insightful) A Sirolimus Stent of Our analysis included 14 trials and 4958 patients, 1411 of whom had diabetes...

Ngày tải lên: 27/06/2014, 00:20

... German version of WAIS) The sample size of the trials ranged between 10 and 98 The mean IQ of the 16 studies ranged from 96.5 to 117.6 Using a random effects metaanalysis, the estimate of the pooled ... results of the various studies and an estimate of the overall effect size of all the studies together considering the data available for each study included in the meta- analysis [25] Each line of ... studies, with a total sample size of 365 AN patients The sample size of the trials ranged between 10 and 46 The mean IQ of the 14 studies ranged from 96.1 to 116.8 A meta- analysis using a random effects...

Ngày tải lên: 09/08/2014, 01:21

... age of 20 years Consequently, Figure B-HCC versus C-HCC: Results of the meta- analysis on 5-year disease-free survival All based on a random-effects meta- analysis Zhou et al World Journal of Surgical ... http://www.wjso.com/content/9/1/108 Page of 10 Figure B-HCC versus NBNC-HCC: Results of the meta- analysis on 5-year disease-free survival All based on a fixed-effects meta- analysis the mean age at occurrence of HCC is lower ... data of subsets of patients The characteristics of these 20 studies are summarized in Table Patients Characteristics Results from overall meta- analysis are outlined in Table The mean age of patients...

Ngày tải lên: 09/08/2014, 02:21