met mutations in cancers of unknown primary origin cups

... in patients with suspected occult primary breast carcinoma (following negative mammography and sonography findings) The results of these imaging modalities can influence surgical management; a ... utility of PET in patients with cervical CUP These trials have included a small number of patients; primary tumors were identified in ~21–30% The diagnostic contribution of PET to the evaluation of ... tissue obtained by fine-needle aspiration or core-needle biopsy should first be stained with hematoxylin and eosin and subjected to light microscopic examination On light microscopy, 60% of CUPs are...

Ngày tải lên: 07/07/2014, 04:20

... enolase CDX-2 Gastrointestinal cancer Calretinin, mesothelin Mesothelioma Leukocyte common antigen Lymphoma S-100, HMB-45 Melanoma URO-III, thrombomodulin Bladder cancer Α Fetoprotein Hepatocellular ... timeconsuming and expensive, is rarely needed Figure 95-1 Approach to cytokeratin (CK7 and CK20) markers used in CUP Table 95-2 Additional Immunohistochemical Stains Useful in the Diagnosis of CUP ... marker panel However, these cancers rarely present as CUP, so the yield of these tests may be low Fig 95-1 delineates a simple algorithm for immunohistochemical staining in CUP cases Table 95-2 lists...

Ngày tải lên: 07/07/2014, 04:20

... expression profiles found in malignant tissue as a basis for predicting the tissue of origin These approaches have been effective in blind testing against known primary cancers and their metastasis ... for intestinal organogenesis, is often used to aid in the diagnosis of gastrointestinal adenocarcinomas Thyroid transcription factor (TTF-1) is a 38-kDa homeodomaincontaining nuclear protein that ... Typically, a training set of gene profiles from known cancers (preferably from metastatic sites) are used to train the software The program can then be used to predict the origin of a test tumor,...

Ngày tải lên: 07/07/2014, 04:20

... Neuroendocrine Carcinoma Low-grade neuroendocrine carcinoma often has an indolent course, and treatment decisions are based on symptoms and tumor bulk Urine 5-HIAA and serum chromogranin may be ... carcinoma involving the cervical lymph nodes are candidates for node dissection and radiation therapy, which can result in long-term survival The role of chemotherapy in these patients is undefined, ... with local pain secondary to significant growth of the metastasis or the hormone-related symptoms are not controlled with endocrine therapy Patients with high-grade neuroendocrine carcinoma are...

Ngày tải lên: 07/07/2014, 04:20

... management of patients with carcinoma of unknown primary site Br J Cancer 89(Suppl 1):S59, 2003 Culine S et al: Cisplatin in combination with either gemcitabine or irinotecan in carcinomas of unknown primary ... for irinotecan and cisplatin The role of second-line chemotherapy in CUP is poorly defined Gemcitabine as a single agent has shown a partial response rate of 8%, and 25% of patients had minor ... defining the origin of tumours J Pathol 205:236, 2005 [PMID: 15641019] Greco FA, Hainsworth JD: One-hour paclitaxel, carboplatin, and extendedschedule etoposide in the treatment of carcinoma of...

Ngày tải lên: 07/07/2014, 04:20

... potential hereditary cancers Physical examination, including a digital rectal examination in men and breast and pelvic examinations in women, should be performed Determining the patient's performance ... found Aneuploidy has been described in 70% of CUP patients with metastatic adenocarcinoma or undifferentiated carcinoma The overexpression of various genes, including Ras, bcl-2 (40%), her-2 (11%), ... results in an increase in metastatic spread or survival relative to the primary Whether the CUP metastases truly define a clone that is genetically and phenotypically unique to this diagnosis remains...

Ngày tải lên: 07/07/2014, 04:20

... PET-FDG imaging modified the management of 13.7% of patients Our findings indicate that PET-CT changed the stage in a large number of patients: upstaging approximately 43.4% and down staging 5.7% ... carcinoma [21] Additionally, our study highlights the importance and usefulness of pre- treatment PET-CT in detecting RPLN status and its role in guiding definitive treatment in OPSCC Our findings ... http://www.wjso.com/content/8/1/70 primary tumor originated from or invaded the posterior or lateral wall of the oropharynx [9] Histology confirmed RPLN metastatic distribution was similar to our findings of PET-CT distribution...

Ngày tải lên: 09/08/2014, 03:22

... spring collections (0.1869 in cellar, 0.1254 in vineyard and 0.1549 in pine-wood), the number of loci used (48 in cellar, 27 in vineyard and 34 in pine-wood) and the number of generations between ... means of five different indexes were small and similar in all cases, independently of the index used, being a little larger in autumn than is spring Assuming that the number of different loci reported ... geographic two of the captures were carried out inside a cellar in Requena (Valencia, Spain), two in a vineyard in El Pont6n (4 km away from the cellar) and the last two in a semi-built-up pine-wood...

Ngày tải lên: 09/08/2014, 22:22

... samples were often identified as esophageal cancers Also, AGEP tends to confuse cancers originating from one part of the intestinal tract with cancers originating from another part of it In fact, ... Lung metastasis 0.5 Lung metastasis Intestinal metastasis Lung metastasis 10 Lung metastasis Lung metastasis Peritoneal metastasis 12 Lung metastasis Lung metastasis 11 Lung metastasis Intestinal ... metastasis 11 Lung metastasis Intestinal metastasis 15 Skin metastasis 14 Liver metastasis Intestinal metastasis Intestinal metastasis 13 Intestinal metastasis 17 Lung metastasis Count (c) Histogram 60...

Ngày tải lên: 11/08/2014, 12:21

... malignancy in a single patient including a cervical carcinoma, a basal cell carcinoma of the skin and a neuroendocrine carcinoma from an unknown primary site: A case report and review of the literature ... risk of developing second NMSC in women with cervical, vulvar and vaginal carcinomas This finding was interpreted to demonstrate the role of HPV in the etiology of NMSC [8] Hennig et al., in a ... Figure Chromogranin staining of the liver specimen the involvement of Epidermodysplasia verruciformis- associated HPV in the carcinogenesis of skin squamous cancers [7] Levi et al in the Vaud cancer...

Ngày tải lên: 10/08/2014, 23:20

... for fever of unknown origin in mechanically ventilated patients in intensive care unit Cause of fever Sole cause One of multiple causes Central line infection 43 Upper respiratory tract infection/pneumoniaa ... macroscopic examination The initial (macroscopic) interpretation of the material obtained during the draining procedure by the ENT surgeon was pus in fluid from 17 of 101 patients (17%), purulent in 38 ... in Fig During a period of 15 months a total of 351 patients met the initial inclusion criteria In 153 patients a probable cause of fever was found on routine analysis Therefore 198 patients met...

Ngày tải lên: 12/08/2014, 22:22

... guidelines not recommend routine octreotide in NVUGB [11] In contrast, high dose proton pump inhibitors (PPIs) improve outcomes of patients at high risk of peptic ulcer rebleeding, including mortality ... difference in outcomes between omeprazole and a combination of somatostatin and ranitidine in severe GI bleeding [27] It is thus unlikely that somatostatin or octreotide can improve on results of high ... length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients Crit Care 2001, 5:368-375 Erstad BL: Octreotide for acute variceal bleeding Ann...

Ngày tải lên: 12/08/2014, 23:24

Ngày tải lên: 16/02/2014, 15:20

... heated odor of pine and hemlock, and I sat up, peering ahead into the dusky sea of pines Fresher and fresher came the wind from the sea, in puffs, in mild, sweet breezes, in steady, freshening currents, ... sat sewing in the dull light that straggled out from the parlor windows She had a certain coquetry of her own, using the usual methods with an individuality that was certainly fetching For instance, ... please." The passage he indicated was the famous chapter beginning: "Is the mammoth extinct? Is the dingue extinct? Probably And yet the aborigines of British America maintain the contrary Probably...

Ngày tải lên: 17/02/2014, 09:20

... Asymmetric interactions in the adenosine-binding pockets of the MS2 coat protein dimer BMC Mol Biol 2, 48 Lima, L.M.T., Foguel, D & Silva, J.L (2000) DNA tightens the dimeric DNA-binding domain of ... existence of internal cavities in this region The figure shows the region on coat protein in the asymmetric unit of the capsid around residue 88 The methionine residue is shown in yellow and the valine ... tool for using to study cavities in proteins [24,25] The coat protein of bacteriophage MS2 contains two tryptophan residues, thus permitting the use of intrinsic fluorescence as a probe of structural...

Ngày tải lên: 19/02/2014, 12:20

... scale using a continuous flow apparatus (PE Biosystem, Pioneer, Framingham, USA) starting from Fmoc-PAL-PEG-PS resins The coupling reaction was performed with 0.5 M of HATU in presence of M of DIEA ... lacking the residues 110–113 (excluding the two valine amino acids), showed a decrease in the formation of amyloid fibrils, suggesting the importance of the hydrophobic NH2-end of the peptides In ... the same way, removing the CONH2-terminus of the peptides resulted in increased amyloid fibril formation This increase may be due to a direct inhibitory effect of this nine-amino-acid sequence,...

Ngày tải lên: 21/02/2014, 01:21

... on the two further subunits of the native oxidase In focussing on the main interaction domain on subunit II, we introduced additional mutations in exposed residues in the relevant area above the ... sequence by another aromatic side chain, Y122 Table summarizes the kinetic effects of single mutations in either residue, and of several double mutants, indicating that in no case any major changes on ... area of exposed acidic residues on subunit II which are involved in the initial docking (see above) of the horse heart cytochrome c In viewing down the axis from W121 to the CuA center as in Fig...

Ngày tải lên: 22/02/2014, 07:20

... expressing mutant GALE was increased to reach a detectable level of protein Tubulin serves as a loading control The relative amount of mutant protein was calculated based on the ratio of the band intensities ... galactose was determined by measuring BrdU incorporation The level of BrdU incorporation into each cell line cultured in the absence of galactose was set to 100% and the corresponding results from ... accordingly Relative protein abundance (RPA) was calculated based on the ratio of intensity of the myc–GALE to tubulin bands in the western blot and normalized by setting the amount of GALE in ldlD(myc–GALE)...

Ngày tải lên: 07/03/2014, 00:20

... provide information on the local repartition of the angles involved in the SREfos helix bending Relative effect of bending strain There are several indications of a redistribution of the strains ... constant of core-SRF, alone in solution, remains unknown In vivo, binding of coreSRF to DNA is never in equilibrium but rather is a kinetic process Yet, nothing could exclude that two independent ... bend: partial unstacking of some adenine, thymine and guanine bases and a more distinct presence of 2¢-endo conformations of furanose rings at 10 °C against a higher percentage of 3¢-endo ⁄ anti...

Ngày tải lên: 07/03/2014, 09:20

... group of GHMP kinases in which proton transfer does not play a major role in the rate determining step of catalysis That five of the 10 disease-causing mutations resulted in insoluble protein in ... play a major role in the rate-determining step of catalysis Several of the disease-causing mutations are not soluble following induction in E coli Although all the mutant galactokinases constructed ... motifs in galactokinases [12] Mutations that resulted in soluble protein on induction in E coli are shown above the bar representing the sequence of the protein, while those that were insoluble...

Ngày tải lên: 08/03/2014, 02:20