mesoscopic model for dynamic simulations and structural characterization of cnt materials

IDENTIFICATION, KINETIC AND STRUCTURAL CHARACTERIZATION OF SMALL MOLECULE INHIBITORS OF ALDEHYDE DEHYDROGENASE 3A1 (ALDH3A1) AS AN ADJUVANT THERAPY FOR REVERSING CANCER CHEMO-RESISTANCE

Ngày tải lên : 24/08/2014, 09:51

... grateful to you for believing in me and letting me pursue my dreams The person I am today is because of you To my dear uncle and my aunt Khem Kandel and Laxmi Kandel: your support and friendship ... (GxxxxG) and are necessary for cofactor binding Also, residues Lys192, Glu399 and Phe401 are important for proper cofactor positioning and, thus, impact catalysis Crystal structures of mammalian ... chemotherapeutic agent and in the mobilization and conditioning regimens for blood and marrow transplantation Reviewing the chemistry and pharmacology of cyclophosphamide is crucial for understanding its...

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Tài liệu Báo cáo khoa học: Puriﬁcation and structural characterization of a D-amino acid-containing conopeptide, conomarphin, from Conus marmoreus docx

Ngày tải lên : 18/02/2014, 17:20

... of Glu, glycosylation of Ser or Thr, bromination of Trp, sulfation of Tyr, cyclization of N-terminal Gln, and epimerization of several different residues It is quite rare for such a variety of ... resonance assignments Table Structural statistics for the family of 20 structures of conomarphin and L-Phe13-conomarphin Complete proton resonances for both conomarphin and l-Phe13-conomarphin were ... marphin were 0.54 ± 0.24 A for the backbone atoms ˚ (N, CR, and C) and 1.25 ± 0.30 A for all heavy atoms, and the values for l-Phe13-conomarphin were ˚ ˚ 0.44 ± 0.16 A and 1.22 ± 0.22 A, respectively...

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Báo cáo khoa học: Functional and structural characterization of novel mutations and genotype–phenotype correlation in 51 phenylalanine hydroxylase deﬁcient families from Southern Italy docx

Ngày tải lên : 16/03/2014, 01:20

... to Erlandsen and Stevens [22] The details of the interactions displayed by residues in the neighborhood of Q301 were analyzed in the structure of the ternary complex of human PAH with BH4 and thienylalanine, ... residues are shown as ball -and- stick models (sticks of residues belonging to Ca8, to subunit A and to subunit B are drawn in yellow, cyan and green, respectively) For interaction details, see ... family and a shorter fragment of 253 bp present only in the proband, as well as in his mother who bears the same mutation (Fig 3) Direct sequencing of both cDNA bands conrmed the skipping of the...

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hydrothermal synthesis and structural characterization of fe2o3sno2 nanoparticles

Ngày tải lên : 19/03/2014, 16:48

... investigations on both 57Fe and 119Sn isotopes have been performed for a better understanding of the site occupancy of Sn4þ in the hematite lattice [12] Finally, it was found that the degree of order given ... in the presence of a few percent of (SO4)22 Figs 11 and 12 show the particle morphology and stoichiometry determined by SEM and EDX examinations of the hematite-tin oxide system for x ¼ ¨ 0:4: ... the a-Fe2O3 and x $ 0:7 for Fe3þ in SnO2 This paper is the ﬁrst report on the hydrothermal synthesis and structural characterization of (1 x)a-Fe2O3 – xSnO2 system over the full range of tin concentration,...

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Báo cáo khoa học: Biochemical and structural characterization of mammalian-like purine nucleoside phosphorylase from the Archaeon Pyrococcus furiosus pptx

Ngày tải lên : 23/03/2014, 09:21

... and 0.1% triﬂuoroacetic acid in H2O The retention times of inosine and hypoxantine, guanosine and guanine were 10.5 and 4.7 min, and 11.5 and 4.3 min, respectively The amount of purine base formed ... exactly those that are responsible for the different substrate speciﬁcity of hPNP and hMTAP (Glu201, Asn243 and Val245 of hPNP instead of Ser178, Asp220 and Asp222 of hMTAP, respectively) The last ... hMTAP and hPNP reported in Fig The amino acid residues of PfPNP and Fig Multiple sequence alignment of PfPNP, PfMTAP, hMTAP, and hPNP The phosphate (w) ribose, (m) and base (d) binding sites of...

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Báo cáo khoa học: Synthesis and structural characterization of a mimetic membrane-anchored prion protein doc

Ngày tải lên : 23/03/2014, 10:21

... composed of 35% a helix and a small amount of b sheet, whereas PrPSc appears to have elevated levels of b sheet [7,8] Higher resolution studies of the structure of PrPC have made use of NMR and ... spontaneous formation and subsequent accumulation of abnormal conformations of PrP Therefore, in vitro studies employing a lipidanchored prion molecule offer the potential to unravel the effect of different ... changes that lead to aggregation and ⁄ or ﬁbrillization of PrP, depending on the lipid environment and starting conformation of the protein [33,34] The a-helical isoform of PrP, representing the cellular...

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Báo cáo khoa học: Isolation and structural characterization of the Ndh complex from mesophyll and bundle sheath chloroplasts of Zea mays pptx

Ngày tải lên : 23/03/2014, 13:20

... manuscript and Dr Ch Peters and Patric Hoert (University of Freiburg, Germany) for providing the Reﬂex III for measurements and for the mass spectrometry measurements We also thank to the Deutsche Forschungsgemeinschaft ... (1D, the horizontal bands) and then in nondenaturing conditions by BN ⁄ PAGE (2D) The molecular mass standards and direction of migration are indicated for both the ﬁrst (1D) and second (2D) dimension ... GELGIYLVGDDSLFPWR and IRPPGFINLQILPQLVK (one missed cleavage) All of these peptides were part of the maize NdhH subunit Database analysis of a MALDI-TOF-MS measurement of a 21-kDa trypsin-digested gel band...

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Báo cáo khoa học: Identiﬁcation and structural characterization of a sialylated lacto-N-neotetraose structure in the lipopolysaccharide of Haemophilus inﬂuenzae pptx

Ngày tải lên : 23/03/2014, 21:21

... glycoforms, suggesting the presence of alternate sialylated structures In this study we describe the identification and structural analysis of a Sial-lNnT unit in H influenzae LPS MATERIALS AND ... further information on the nature of the sialylated glycoforms Comparison of the total ion electropherogram in negative ion mode (Fig 3A) and selective ion scanning for m/z 290, specific for sialic ... spectra of O-deacylated LPS from the parent strain RM118 and RM118 lgtC, Sial-Lac glycoforms were observed in addition to the higher mass sialylated glycoforms As expected Sial-Lac-containing glycoforms...

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Analysis and practical implementation of a model for combined growth and metabolite production of lactic acid bacteria

Ngày tải lên : 05/05/2014, 08:44

... part of projects OT/99/24 and COF/98/008, the Institute for the Promotion of Innovation by Science and Technology in Flanders (IWT), the Fund for Scientific Research-Flanders (FWO) as part of project ... the parameters a, b and c of expression (14) and a1, b1, c1 and pH0 of expression (15) are identified Simulations of relations (14) and (15) with the estimated parameter values for the case study ... simulating cell growth and lactic acid formation making use of model Eqs (1) – (8), time-dependent courses of LaHtot, pH and [LaH] are obtained Next, through elimination of time, plots of [LaH] versus...

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Báo cáo sinh học: " Application of FTA technology for sampling, recovery and molecular characterization of viral pathogens and virus-derived transgenes from plant tissues" doc

Ngày tải lên : 19/06/2014, 08:20

... consisted of 30 cycles of 94°C for min., 58°C for and 72°C for MSV F &MSVR : PCR conditions consisted of 30 cycles of 94°C for min, 59°C for and 72°C for mins C1F &C2R: PCR conditions consisted of 94°C ... PCR conditions consisted of 30 cycles of 94°C for min, 58°C for and 72°C for mins JSP001 &JSP002: PCR conditions consisted of 30 cycles of 94°C for min, 45°C for and 72°C for mins Uni F &Uni R: ... consisted of 94°C for 10 mins followed by 35 cycles of 94°C for 30 secs., 60°C for and 72°C for 1.5 mins followed and extension of mins at 72°C AC1F &AC1R : PCR conditions consisted 94°C of mins followed...

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báo cáo hóa học:" Application of FTA technology for sampling, recovery and molecular characterization of viral pathogens and virus-derived transgenes from plant tissues" doc

Ngày tải lên : 20/06/2014, 04:20

... consisted of 30 cycles of 94°C for min., 58°C for and 72°C for MSV F &MSVR : PCR conditions consisted of 30 cycles of 94°C for min, 59°C for and 72°C for mins C1F &C2R: PCR conditions consisted of 94°C ... PCR conditions consisted of 30 cycles of 94°C for min, 58°C for and 72°C for mins JSP001 &JSP002: PCR conditions consisted of 30 cycles of 94°C for min, 45°C for and 72°C for mins Uni F &Uni R: ... consisted of 94°C for 10 mins followed by 35 cycles of 94°C for 30 secs., 60°C for and 72°C for 1.5 mins followed and extension of mins at 72°C AC1F &AC1R : PCR conditions consisted 94°C of mins followed...

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INTERLEUKIN 6 RELEASE FROM t98g HUMAN GLIAL CELL LINE AS a PREDICTIVE MARKER FOR CHRONIC PAIN, AND THE CHARACTERIZATION OF SUBSTANCE(S) INVOLVED IN PAIN

Ngày tải lên : 02/10/2015, 17:15

... Aim and Scope of Study Chronic pain associated with neuroinflammation and nerve injury is often unrelenting and difficult to treat, impacting the quality of life of an individual A number of pain ... key tool in understanding the status and functions of the CNS, and investigating the mechanisms of chronic pain The importance of biological markers for assessing the extent of chronic pain or ... impacting the quality of life of patients suffering from it 1.1.4.2 Osteoarthritis The most common form of arthritis, osteoarthritis is one of the main causes of chronic pain and long-term disability...

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Electromagnetic properties and macroscopic characterization of composite materials

Ngày tải lên : 30/09/2015, 06:38

... PROPERTIES AND MACROSCOPIC CHARACTERIZATION OF COMPOSITE MATERIALS QIU CHENGWEI B ENG., UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA, 2003 A DISSERTATION SUBMITTED FOR THE JOINT DEGREE OF DOCTOR OF ... intensity of the plasmonic rod of k0 a = 0.1 and r = −1 in the cases of first two terms 40 2.17 The energy intensity of the plasmonic rod of k0 a = 0.1 and r = −1 in the case of ... configuration of a chiral medium composed of the same handed wire-loop inclusions distributed uniformly and randomly 102 4.2 The frequency dependence of relative ( + , µ+ ) in the range of [5, 25]...

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Tài liệu Mesoscopic Model for Mechanical Characterization of Biological Protein Materials docx

Ngày tải lên : 22/02/2014, 08:20

... Here, we present the mesoscopic model of biological protein materials composed of protein crystals prescribed by Go potential for characterization of elastic behavior of protein materials Specifically, ... potential in the form of Eq (4) consists of potential for backbone chain stretching and the potential for native contacts Go potential is a versatile model for protein modeling such that Go model enables ... topology of protein structure is responsible for mechanical properties of protein crystals MODELS MESOSCOPIC MODEL FOR BIOLOGICAL PROTEIN MATERIALS We assume that the mechanical response of biological...

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Establishment and characterization of a murine model for allergic dermatitis and asthma using dermatophagoides mite allergens

Ngày tải lên : 12/09/2015, 10:54

... analysis of cDNA coding for Der p 3.3.2 SDS-PAGE analysis of native and recombinant Der p 3.3.3 Presence of isoforms in native Der p 3.3.4 Comparison of IgE reactivity to recombinant Der p and native ... murine model for allergic dermatitis and asthma through skin sensitization, and to further exploit the model for mechanistic studies The first part of this study focused on the cloning and characterization ... severity of AD was a risk factor for subsequent development of asthma and allergic rhinitis Approximately 60% of patients experience the development of signs of AD before their first birthday, and...

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Structural characterization of nogo proteins implications for biological functions and moleculedesign of therapeutic applications

Ngày tải lên : 14/09/2015, 12:53

... 3.1 Structural Characterization of Inhibitory Domains of Nogo 54 3.1.1 Expression and structural characterization of NogoA-(567-748) and Nogo-66 55 3.1.2 CD and NMR characterization of Nogo-40 60 ... 3.6 Structural Characterization of NgBR 134 3.6.1 Cloning and expression of NgBR and its dissected domains 136 3.6.2 Bioinformatics characterization 138 3.6.3 Structural characterization of the ... 3.3.4 CD and NMR characterization of the Nogo-B N-terminus 99 Figure 3.3.5 CD and NMR characterization of the Nogo-33 101 Figure 3.3.6 CD and NMR characterization of the first group of the dissected...

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Tài liệu Báo cáo khoa học: Structural and biochemical characterization of a human adenovirus 2/12 penton base chimera pptx

Ngày tải lên : 19/02/2014, 06:20

... strength of the solvent environment and ⁄ or presence of small organic compounds (dioxane and MPD) seems to favor formation of dodecahedra over isolated pentamers Previous structural analysis of the ... jellyroll domain formed by two b-sheets and a distal domain formed by insertions between the strands of the jellyroll domain (Fig 3) Antiparallel b-sheets made up of strands CHEF and BIDG pack against ... those for hAd2 For hAd2pb, high concentrations of ammonium sulfate (1.6 m) and dioxane (10%) were necessary for dodecahedra formation [20], whereas hAd2 ⁄ 12pb crystallized in the dodecahedral form...

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Tài liệu Báo cáo khoa học: "A Uniﬁed Syntactic Model for Parsing Fluent and Disﬂuent Speech∗" ppt

Ngày tải lên : 20/02/2014, 09:20

... left-right dual of a leftcorner transform It transforms all right recursive sequences in each tree into left recursive sequences of symbols of the form A1 /A2 , denoting an incomplete instance of category ... rules, and therefore potentially makes better use of limited data Evaluation The evaluation of this system was performed on the Switchboard corpus, using the mrg annotations in directories and for ... While an integrated system for processing and parsing speech may use both acoustic and syntactic information to ﬁnd repairs, and thus may have access to some of this information about where interruptions...

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Tài liệu Báo cáo khoa học: "A SPEECH-FIRST MODEL FOR REPAIR DETECTION AND CORRECTION" docx

Ngày tải lên : 20/02/2014, 21:20

... improve the modeling of fragments Table 2: Length of Reparandum Offset Word Fragments (N=288) bution of initial phonemes for all words in the corpus of 6,414 ATIS sentences, and for all fragments, ... here are for prediction on only TI repair utterances 6We performed the same analysis for the last and first syllables in the reparandum and repair, respectively, and for normalized f0 and energy; ... marking the reparandum offset From the point of view of repair detection and correction, acoustic-prosodic cues to the onset of the reparandum would clearly be useful in the choice of appropriate...

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Tài liệu Báo cáo Y học: Structural and biochemical characterization of neuronal calretinin domain I– II (residues 1– 100) Comparison to homologous calbindin D28k domain I–II (residues 1 –93) pdf

Ngày tải lên : 22/02/2014, 07:20

... loops of EF-hand proteins, have chemical shifts 10 p.p.m for ﬁlled loops and chemical shifts of < p.p.m for empty loops [50] The chemical shifts of CR I–II, Calb I– II and Fig ‘Glycine 6’ of the ... single bands of monomeric weight and S100B provides a positive control with a yield of cross-linked dimer of < 30% The CR I – II and Calb I – II sequences have high sequence identity, Fig 1, and ... fragments correspond to CR(1–60) and CR(61–100) for the upper and lower bands, respectively Fig 1H,15N HSQC of 15N-labeled CR I –II with assignments Of note are residues G34 and G81, the ‘position 6’...

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