mesenchymal stem cells for the treatment of cancer

... TRANSPLANTATION OF MESENCHYMAL STEM CELLS FOR THE TREATMENT OF PARKINSON’S DISEASE IN A MOUSE MODEL CHAO YIN XIA MD A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ANATOMY ... understanding of etiology and pathogenesis of INTRODUCTION PD, the application of animal models for studying PD, and possible therapeutic application of stem cells in the treatment of PD will be ... degenerated cells and the transplanted stem cells 4.2 Stem cell transplantation Stem cells are defined by their capability for self-renewal and multipotent differentiation On the basis of these properties,...

Ngày tải lên: 11/09/2015, 09:05

... FLSs [32] Therefore, we further investigated the effect of UC-MSCs on the invasive behavior of FLSs by the Cell Migration/Invasion Assay, and the MMP9 secretion of FLSs As a result, the invasive ... in the joint of the CIA mice The short-term presence of UC-MSCs in the spleen suggests that the therapeutic effect of UC-MSCs does not rely on the capacity to engraft and survive long-term in the ... and the downregulated Th1/Th17 cells Furthermore, in the UC-MSCs treated mice, the expansion of Th2/Tregs and the production of anti-inflammatory IL-10 were elevated MSCs have the capability of...

Ngày tải lên: 12/08/2014, 15:22

... the inclusion of lysine residues in the protein sequence of the A fragment but not the B fragment of PE Because only the A fragment must traffic to the cytosol for activity, the lack of lysine residues ... of patients showed a partial response to treatment 4692 J E Weldon and I Pastan The future of PE-based RITs Many obstacles have been overcome in the development of RITs for the treatment of cancer, ... misfolded protein in the ER to exploit the ERAD system for transport across the ER membrane to the cytosol [91,92] To date, we are unaware of direct evidence for transport of PE through the Sec61p translocon...

Ngày tải lên: 22/03/2014, 15:21

... Introduction 1.1 Stem cells Stem cells have the remarkable potential to differentiate into specialized cells and thereby are key factors for the development of the whole organism All types of stem cells ... by the integration of wild-type genes into the AAVS1 locus The use of AAVs was further simplified by the arrival of commercially available systems Following the hypothesis that homology of the ... 2004) Neural stem cells of this process can give rise to neurons and glia, the two lineages most cells of the central nervous system belong to, and are therefore called multipotent In the adult...

Ngày tải lên: 26/11/2015, 09:54

... from data in the RCT The survival of patients receiving ASC/BSC was calculated from the survival of the patients in the cetuximab monotherapy arm of the RCT The data from the monotherapy arm NICE ... beyond the confines of the lymph nodes to other parts of the body, is generally defined as stage IV of the American Joint Committee on Cancer (AJCC) tumour node metastases (TNM) system or stage D of ... represents 12% of all new cancer cases in women and 14% of all new cancer cases in men The incidence of colorectal cancer increases with age In people between the ages of 45 and 49 years the incidence...

Ngày tải lên: 14/02/2014, 22:20

... Board of Directors of the AUA Funding of the Panel and of the PGC was provided by the AUA, although Panel members received no remuneration for their work Each member of the PGC and of the Panel ... Cryosurgery for the Treatment of Localized Prostate Cancer The supporting systematic literature review and the drafting of this document were conducted by the Cryosurgery for Treatment of Localized ... addressed Placement of a thermosensor to monitor the temperature of the external sphincter can reduce the potential of thermal injury to this muscle The thermosensor is introduced through the perineal...

Ngày tải lên: 28/03/2014, 23:20

... well-documented therapeutic target, the exact function of CD52 remains unknown In the ID8VEGF tumors, VLC account for the vast majority of tumorassociated host hematopoietic cells, thus the majority of the ... critical role for these cells in tumorigenesis and indicate that these cells may be novel therapeutic targets for solid tumor therapy Genetic manipulations to inhibit or eliminate these cells in both ... overall survival of treated animals (Figure 6D) These results confirm the anti-tumor activity of anti-VLC therapy, as observed by others, and further support the use of anti-CD52 therapy in humans...

Ngày tải lên: 18/06/2014, 15:20

... demonstrated by further clinical study Additional studies appear warranted for the use of Apatone as a co–adjuvant, or for emerging salvage chemotherapy in the treatment of late stage prostate cancer Acknowledgements ... seen before treatment once treatment ended (Fig 1a and 1b) Thirteen of the 17 patients had a successful outcome; a decrease in PSAV and a lengthening of PSDT (Table 2) The probability of 13/17 ... compensate for their elevated BMI values Both patients subsequently became “responders” In addition, 15 of 17 patients opted to continue Apatone therapy following the 12 week trial The PSA values of these...

Ngày tải lên: 08/08/2014, 17:20

... guidelines for the screening and selection of patients for Page of 10 APBI [22,23], and these guidelines formed the basis for patient selection in the EBT multicenter study [20] Of the 65 patients ... during the 5-day treatment period Patient compliance with the treatment regimen was excellent Patients expressed satisfaction with the conduct of the study as well as the delivery of the radiotherapy ... shielded treatment rooms that are required for the delivery of HDR brachytherapy The EBT system does not require a heavily shielded treatment room or an HDR brachytherapy afterloader The EBT system...

Ngày tải lên: 09/08/2014, 01:24

... date of diagnosis of metastases was 3.4 years the median survival time from the start of TACE treatment was 1.34 years The median survival time of the palliative group was 1.4 years, of the symptomatic ... device to be safe in the treatment of metastatic colorectal cancer[ 14] The goals of this analysis was to: 1) gain a better understanding of the value of drug eluting bead therapy when administered ... toxicity, and, if the data allowed, the response to therapy Follow-up assessments included a tri-phase CT scan of the liver within at least one to two months from the treatment Evaluation of the enhancement...

Ngày tải lên: 09/08/2014, 04:21

... tomotherapy for locally advanced pancreatic cancer [35] To the best of our knowledge, this is first comprehensive analysis of the clinical application of helical tomotherapy for a group of inoperable ... prematurely stopping radiotherapy There was no direct treatment- related grade 3/4 toxicity or death Therefore helical tomotherapy is a safe option in the treatment of advanced pancreatic cancer This study ... lung), the metastatic lesions were also targeted as another PTV The distribution of isodoses in the helical tomotherpy treatment planning is shown in Figure The dose and volume constraints for the...

Ngày tải lên: 09/08/2014, 09:20

... clinical trial of vaginal EBT for the treatment of endometrial cancer EBT treatment was delivered successfully for all 48 fractions of treatment in this study The EBT device performed as expected ... given the option of treating with an EBT prescription dose of 6.0 Gy x to the vaginal surface or 8.0 Gy x to the vaginal surface Treatment planning was performed according to the standard of care ... Rotmensch J, Wazer DE: A dosimetric comparison of xoft axxent electronic brachytherapy and Ir192 hdr brachytherapy in the treatment of endometrial cancer Brachytherapy 2008, 7(4):351-4 Rivard MJ, Davis...

Ngày tải lên: 09/08/2014, 09:20

... digital photo, illustrating the method of immobilization of the treatment area and a simulation of the set-up of the system prior to the first fraction, was taken A typical treatment area definition ... responsible for the development of the protocol and case report form; recording of the clinical data from the patient records; analysis of the data; and writing, final review, and approval of this ... radiation of epithelial skin cancer Int J Radiat Oncol Biol Phys 1990, 19:235-242 Silva JJ, Tsang RW, Panzarella P, Levin W, Wells W: Results of radiotherapy for epithelial skin cancer of the pinna: the...

Ngày tải lên: 09/08/2014, 09:20

... around the world to search for new therapeutic options [5]; one of these options involves the use of Dendritic Cell (DCs) immunotherapy Clinical trails based on DCs have been conducted for the treatment ... one-third of these patients progress to incurable metastatic disease, for which there are few treatment options The chemotherapy currently used has limited efficacy [3,4] This lack of treatment ... for days For immature DC recovery, cultured cells were harvested on the 5th day For mature DCs, TNF-α (50 ng/ mL) was added to the medium on the 5th day and cultured cells were harvested on the...

Ngày tải lên: 14/08/2014, 19:22

... analogues 115 4.15 Methology suitable for the radiosynthesis of the E isomer of CA-1 121 4.16 Radiosynthesis of the E isomer of CA-1 123 4.17 Scale-up synthesis of OXi8007 124 4.18 Proposed nitrogen ... chemotherapy is used as a primary treatment or as an adjuvant to the other therapies, it often has unpleasant side effects because of the limited selectivity that these drugs have for cancer cells; ... nutrients the cells will not survive The last approach is related to 10 the synthesis of compounds that induce differentiation and decrease the rate of proliferation of cancerous and precancerous cells...

Ngày tải lên: 14/11/2014, 11:32

... common types of stem cells in bone marrow: (i) hematopoietic stem cells and (ii) mesenchymal stem cells These cell types are believed to be ideal for myocardial transplantation for their ability ... for their valuable insights and the cherished opportunities to be a part of the pioneering efforts at the National Heart Centre, Singapore to bring adult stem cell therapy from the bench to the ... ES cell stem therapy is not ideal for clinical use The derivation of human ES cell lines and the establishment of a cardiomyocyte differentiation system are promising for the development of heart...

Ngày tải lên: 12/09/2015, 09:42

... 100% relief of their pain in 86% of the patients with a median relief period of months The range of relief varied from zero days to up to 13 months for the facet injection group None of the lumbar ... median period of pain relief being months The range of relief for the radiofrequency group was from zero days to 16 months for all 26 patients who underwent the radiofrequency procedure Of the 14 patients ... that the direct visualization of the joint allows better de-innervation of the joint and removal of the entire end-plate receptors that adhere to the bone and capsular tissue Limitations of the...

Ngày tải lên: 26/10/2012, 09:32

... laminoforaminoplasty, should decrease the risk of major adverse events, allow for same day hospital discharge, and decrease the need for postoperative analgesia and immobility [5] [6] In the current ... and neural structures increases the risk of adverse events with invasive approaches Open surgical correction is the current standard of care for foraminal stenosis of cervical and lumbar vertebrae ... follow-up Results The author acknowledges that there are no conflicts of interest or financial benefits with the results of the study All twelve patients (10 males, females) completed the surgery without...

Ngày tải lên: 26/10/2012, 09:57

... ethanol at a final concentration of 10%, then transported to the laboratory of UT at 4oCstored Then, each of the samples were divided into two One of them was for DNA extraction and was washed ... general, the higher concentration of primers can lead to the formation of primer dimers Also, the cost of the chemicals should be minimized if the same quantitativeness can be achieved The results ... Another was for FISH analysis and was stored at -80oC The extraction of DNA was performed with Fast DNA SPIN Kit for Soil (Qbuiogene, USA) according to the instruction by the manufacturer In the...

Ngày tải lên: 05/09/2013, 09:38

... SRT The PO43 P removal in the CARS system was mainly attributed to the sludge discharge from the system, which was governed by the SRT Thus, the SRT affected the CARS performance significantly The ... in the PO43 P removal These results revealed that the selection of the operational parameters of the CARS process had a great influence on the overall system performance Adsorptive capability of ... characteristic of the system for the Langmuir model that can be considered as an indicator of adsorptive capacity and appetency, respectively; and KF and n are constant characteristics of the system for the...

Ngày tải lên: 05/09/2013, 09:38