melting studies of al rich al ni ti alloys
Trinucleotide (CAG) repeat polymorphism of the androgen receptor gene in human disease
Ngày tải lên :
11/09/2015, 09:05
... Determination of the CAG repeat length 28 1.3 Statistical analysis 39 1.4 Clinical characteristics of patients with > 26 CAG repeats 52 Analyses of patient population from The National University of Singapore ... amplification 24 GeneScan analysis 25 Statistical analysis 25 RESULTS 28 Analyses of patient population from Baylor College of Medicine, Houston 28 1.1 Characteristics of subjects 28 1.2 Determination ... risk of male infertility (Baylor) 50 Table Clinical characteristics of patients with > 26 CAG repeats in the AR gene (Baylor) 53 Table Clinical characteristics of the infertile group of patients...
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GT-repeat polymorphism in the heme oxygenase1 gene promoter and the risk of carotid atherosclerosis related to arsenic exposure ppt
Ngày tải lên :
10/08/2014, 05:21
... a history of hypertension was significantly associated with an increased risk of carotid atherosclerosis Although statistically not significant, the frequency of total cholesterol of ≥ 200 mg/dL ... it exists at all, is only slight and limited to high arsenic exposure; in addition, the statistical testing was of borderline significance The resulting slight effect could partially be attributed ... risk of atherosclerosis from carriers to non-carriers of the class S allele was also measured by arsenic exposure All analyses were performed using SAS (Win8e; SAS, Cary, NC, USA) statistical software,...
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Shorter GT repeat polymorphism in the heme oxygenase-1 gene promoter has protective effect on ischemic stroke in dyslipidemia patients potx
Ngày tải lên :
10/08/2014, 05:21
... extracted all of the clinical information, and reconfirmed the diagnosis of chronic diseases such as dyslipidemia LYC carried out all of the molecular genetic studies WHP conceived of the study, ... development of the disease when certain conditions of enhanced oxidative stress coexist, including the abnormal composition of cholesterol levels in patients with normal total cholesterol levels Many studies ... abnormalities, obesity, or plaque score if necessary Two sides p value was calculated, and significant level was accepted at P < 0.05 Statistical calculations were performed using SAS software...
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Báo cáo y học: "Association of the D repeat polymorphism in the ASPN gene with developmental dysplasia of the hip: a case-control study in Han Chinese" potx
Ngày tải lên :
12/08/2014, 15:22
... differentiation and proliferation of perichondrial cell and fibroblast cells [17,18,21] Inhibition of TGF-b/Smad and BMP2/ Smad signaling may reduce the differentiation and proliferation of perichondrial ... significance remained after applying the Bonferroni correction No significance was found in other alleles for comparisons of one allele vs all remaining alleles combined after stratification of ... of the delegation of clinical geneticists to China, Spring 1986 Biol Soc 1987, 4:61-77 Hartofilakidis G, Karachalios T, Stamos KG: Epidemiology, demographics, and natural history of congenital...
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Báo cáo y học: "Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis" ppsx
Ngày tải lên :
09/08/2014, 07:20
... development of RA if a particular threshold of TNF-α activity is exceeded in genetically susceptible individuals Genetic regulation of TNF receptor levels may also influence the long-term outcome of the ... Maini RN: Localization of tumor necrosis factor receptors in the synovial tissue and cartilage-pannus junction in patients with rheumatoid arthritis: Implications for local actions of tumor necrosis ... Statistical Software, Kaysville, Utah, USA) P < 0.05 were considered statistically significant Results sTNFR levels in rheumatoid arthritis Both sTNFRs were detected in the sera of all patients...
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Báo cáo y học: "A polymorphism in the human serotonin 5-HT2A receptor gene may protect against systemic sclerosis by reducing platelet aggregation" potx
Ngày tải lên :
09/08/2014, 13:21
... Odds ratios and their relative 95% confidence intervals were also calculated from × contingency tables Statistical significance was also evaluated using a 1,000-fold permutation test Genetic-association ... undertaken to analyse, for the first time, the distribution and the functional role of a naturally occurring amino acidic substitution of the 5-HTR2A gene in a population of Italian SSc patients The ... data, and statistical analysis MC participated in collection of data, interpretation of data and genetic analysis MM performed genetic analysis FC was responsible for manuscript preparation and interpretation...
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Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt
Ngày tải lên :
16/03/2014, 18:20
... Examination of the regulation of individual mutant huntingtin-affected genes such as CB1 may increase our understanding of at least one abnormal function of mutant huntingtin by allowing us to identity ... no striatum-specific use of particular CB1 transcription initiation sites or change in transcription initiation site usage due to the expression of mutant huntingtin We also detected a RPA product ... how mutant huntingtin leads to cell-specific dysregulation of the levels of CB1 mRNA The overall goal of this research was to determine how expression of mutant huntingtin selectively alters the...
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Báo cáo Y học: Amino acids 3–13 and amino acids in and flanking the 23FxxLF27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor pdf
Ngày tải lên :
17/03/2014, 10:20
... the GalAD transactivating function So, AR3)13 is not essential but rather modulates N/C interaction, most probably by affecting the transactivation function of AR.NTD Alternative explanations ... explain the stimulation of AR23FxxLF27/AR.LBD inter- action by substitution of Q24 and N25 by alanine residues Structural analyses of AR.LBD/AR16)36 complexes have to reveal the function of amino ... Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary...
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Báo cáo y học: "No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary Sjögren''''s syndrome" pptx
Ngày tải lên :
09/08/2014, 07:20
... involved in genetic predisposition to a specific pattern of autoantibody secretion either (T allele frequency in patients without autoantibody: 45%; in patients positive for anti-SSA autoantibody only: ... Departments of Rheumatology of Bicêtre and Strasbourg Hospitals Ninety healthy French blood donors were genotyped as controls All patients and control individuals were Caucasians The characteristics of ... BAFF mRNA normalized level was 43.39 (25th to 75th percentile: 17–62.2) Two of the 40 patients had outlying BAFF/β-actin values of 269 and 183.8 These patients had no specific clinical features;...
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Báo cáo y học: "Replication of association of the D-repeat polymorphism in asporin with osteoarthristis" docx
Ngày tải lên :
09/08/2014, 08:22
... difficulties in defining what constitutes replication of previous genetic association in the context of studies with different patient selections, ethnicities, environmental and cultural influences ... JJ, Gonzalez A: Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians Arthritis Res ... Karachalios T, Malizos K, Tsezou A: Asporin and knee osteoarthritis in patients of Greek origin Osteoarthritis Cartilage 2006, 14:609-611 Ioannidis JP, Ntzani EE, Trikalinos TA, Countopoulos-Ioannidis...
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Báo cáo y học: "A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity" doc
Ngày tải lên :
09/08/2014, 10:21
... subgroup of RA patients There are strong medical and biological arguments in favour of subgrouping RA patients, and an analysis of nonstratified samples might conceal a true association In the initial ... RFnegative disease (P = 0.01) We also detected a weaker association in anti-CCP antibody negative men (P = 0.003; Table 3), although the anti-CCP antibody negative versus anti-CCP antibody positive ... [http://www.ncbi.nlm.nih.gov/SNP] 34 Barrett JC, Fry B, Maller J, Daly MJ: Haploview: analysis and visualization of LD and haplotype maps Bioinformatics 2005, 21:263-265 35 Simple Interactive Statistical Analysis...
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Báo cáo y học: "Association of the T allele of an intronic single nucleotide polymorphism in the colony stimulating factor 1 receptor with Crohn''''s disease: a case-control study" ppt
Ngày tải lên :
11/08/2014, 10:23
... action of an environmental trigger(s) including alteration in host intestinal flora on a genetically susceptible host mucosal immune system and intestinal epithelial barrier [1] A variety of ... terminal web of the epithelial cell and in the lateral junctions of the cells The localization of CSF1R in actin -rich areas of the cell is not surprising in view of data from in vitro studies ... Superficial epithelium of the terminal ileum with cytoplasmic staining of the terminal web and lateral junctions of the epithelial cells (green arrow) B Staining of the superficial epithelium of the...
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Báo cáo y học: "A1298C polymorphism in the MTHFR gene predisposes to cardiovascular risk in rheumatoid arthritis" ppt
Ngày tải lên :
12/08/2014, 12:20
... TRV-R participated in the acquisition and interpretation of data LR participated in the acquisition and interpretation of data JAM-F participated in the acquisition and interpretation of data ... acquisition and interpretation of data and in revising the data critically for important intellectual content JL participated in the analysis of the data JM and MAG-G made substantial contributions ... Hospital Xeral-Calde and Hospital Clínico San Carlos are the referral centers for the population of each respective area, the first CV event was defined as an event (case) of CV complication diagnosed...
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Báo cáo y học: " A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis" doc
Ngày tải lên :
12/08/2014, 15:22
... predict disease outcome in RA Since tight control of the clinical activity of Page of RA substantially improves patient outcomes [22,23], identification of patients who require early aggressive ... formation [36,38] In an animal model of osteoarthritis, intra-articular injection of IL-4 inhibits chondrocyte production of nitric oxide and subsequent cartilage destruction [39] IL-4 may also ... accumulation of information regarding Th17 cells and RA [25], demonstration of a functional impact of the IL-4R polymorphism on IL-17 secretion provides further mechanistic insight that could be pertinent...
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Báo cáo khoa học: "Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study" docx
Ngày tải lên :
13/08/2014, 03:20
... design of the study and drafting of the manuscript RM participated in the design of the study, genotype analysis, statistical analysis and drafting of the manuscript TR participated in the design of ... nonvascular function of NOS Specifically, inhibition of the constitutively expressed isoform of NOS, which is essential to maintain organ perfusion, may be detrimental [8] However, and of considerably ... study, patient recruitment, data and sample collection, ELISA and DNA analysis, statistical analysis, and drafting of the manuscript FD and VC participated in the ADMA analysis DK participated...
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Báo cáo sinh học: " Expression pattern and polymorphism of three microsatellite markers in the porcine CA3 gene" pptx
Ngày tải lên :
14/08/2014, 13:22
... for alleles A, B and C, respectively Allele B is also prevalent in the two pig breed types, with the exception of Meishan pigs, in which allele A is prevalent (Tab IV) 3.4 Association analysis of ... accuracy of the alleles analysed in our study, different samples of DNA alleles were cloned and sequenced 2.4 Statistical analysis Allele frequencies were studied in seven different pig populations ... cDNA and 0.3 µM of a terminal concentration of each primer PCR was run on the Applied Biosystems 7500 Real-Time PCR System Fluorescent signals were continually monitored at the end of each PCR cycle...
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The androgen receptor centric transcriptional network in prostate cancer
Ngày tải lên :
09/09/2015, 10:14
... transcriptional complex is responsible for initiating the required chromatin remodeling and epigenetic modifications that ensure chromatin competency for transcriptional regulation A multitude of AR ... transcriptional activation unit AF-2 and a hinge region connecting LBD and DBD (Fig 1.1) (Brinkmann et al. , 1989; Chang et al. , 1988; Jenster et al. , 1995; Koochekpour, 2010) The functional domains of ... Transcriptional Complex of AR As a transcription factor, AR does not function alone Gene transcription regulation via AR is a well-regulated process involving the participation of a diversity of other...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
Ngày tải lên :
07/03/2014, 01:20
... pre-initiation complexes (PICs) Injection of anti-actin Ig into the nuclei of salamander oocytes results in contraction of the lateral loops and the inhibition of transcription [8] Furthermore, Hofmann ... actin is associated with actively transcribed genes and has an essential role in the activation of transcription In addition, actin is required for the initiation of transcription through participation ... promoting AR activity [96] Because several putative actin-binding sites and functional NLS of SV are important for the AR transactivation function, and the minimal functional fragment of SV, which...
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Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt
Ngày tải lên :
17/03/2014, 23:20
... Culture Collection and maintained Ham’s F12K medium and alpha minimum essential medium, respectively, that containing 10% fetal bovine serum and · antibiotic–antimycotic solution Transfections using ... is used as a positive control Luciferase activity for each construct was normalized to b-gal activity, and the relative increases were calculated as the ratio of normalized activity in MREa/mutant ... modification Internal sequencing of a peptide generated by formic acid digestion of the 70 kDa protein was identical to an internal sequence of the Ku-70 protein X, Residues not properly identified...
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