... approaches involve some level of compromise Proceeding without any change will likely result in ever-diminishing procurement quantities, ultimately leading to a shrinking fleet size To counter the increasing ... as the increase of shipbuilding input cost (e.g., greater costs for labor or materials) A sustained increase might also be due to increased costs for a continuously improving product, in which ... that naval shipbuilding retains many of the dynamics of the commercial shipbuilding industry This report addresses, in part, Why Has the Cost of Navy Ships Risen? the validity of such comparisons...
Ngày tải lên: 17/02/2014, 22:20
... measures of in ation Even the rate of increase for electronic warfare aircraft, with the lowest rate of increase of the types listed above, was above that of other in ation indices The ordering of ... comparison indices These components not reflect the recent price increases in metals experienced since 2004, including the 40 percent increase in the price of steel in 2004 and 2005 and the near doubling ... Preface In recent decades, cost escalation for military fixed-wing aircraft of all types has exceeded that of commonly used in ation indices, including the Consumer Price Index, the Department of Defense...
Ngày tải lên: 17/02/2014, 23:20
Báo cáo khoa học: "Immunohistochemical Study of the Pancreatic Endocrine Cells inthe BALB/c mice: An Unique Distributional Pattern of Glucagon" pptx
... cholecystokinin, 40 secretin, glucagon, insulin, motilin and gastric acid and the absorption of amino acid, glucose and fatty acid in the 41 gastrointestinal tract So far as investigated, somatostatinimmunoreactive ... polypeptide Results In this study, all four kinds of the immunoreactive endocrine cells were detected with the antisera against insulin, glucagon, somatostatin and PP in the pancreas of BALB/c mice ... found in the lining epithelium of pancreatic duct, no insulin-immunoreactive cells were situated in the pancreatic duct portions In addition, some cells were randomly distributed in case of relatively...
Ngày tải lên: 07/08/2014, 15:20
Báo cáo khoa học: "Biological in-vivo measurement of dose distribution in patients’ lymphocytes by gamma-H2AX immunofluorescence staining: 3D conformal- vs. step-and-shoot IMRT of the prostate gland" ppsx
... 3Dconformal therapy contains beams, whereas in SSIMRT, dose is distributed within 7-9 beams The distribution of low doses is broader in a larger volume in SSIMRT Using the gamma-H2AX stain to detect DNA-double ... (DVH) Origin for this diagram was the irradiation planning data of a smaller selected group of 3Dand SSIMRT-prostate-patients from the main pool Each curve of this integral histogram contains patients, ... immunocytochemically using a fluorescence microscope [2,3] The number of foci can be used as a reliable parameter to estimate the delivered dose, since it increases linearly with the induction of DSB [4]...
Ngày tải lên: 09/08/2014, 09:20
Báo cáo y học: " Treatment of stasis dermatitis using aminaphtone: Giant lipoma of the adrenal gland: a case report." pot
... surface of the giant adrenal lipoma with golden yellow-tan color with an arrow showing the uninvolved adrenal gland B) Photomicrograph (hematoxylin and eosin stain) showing the tumor made up of mature ... manuscript and analysis and interpretation of patient data regarding the histopathologic disease AVV performed the histologic examination and helped in preparation of the final manuscript PRM did ... Mehta Institute of Kidney Diseases and Research Centre and Dr H.L Trivedi Institute of Transplantation Sciences, Ahmedabad, India Authors’ contributions RDP was the major contributor in writing...
Ngày tải lên: 11/08/2014, 00:22
Báo cáo y học: "The rapid growth of a pleomorphic adenoma of the parotid gland in the third trimester of pregnancy" pdf
... monitoring of tumors of the salivary glands diagnosed during pregnancy Indications for early surgical intervention should be discussed on a individual patient basis in a multidisciplinary setting ... over a term of several years Rapid increase or the appearance of facial nerve dysfunction may indicate malignant transformation, which has been reported in 4% of cases Rapid growth during the third ... and performed the final reading of the manuscript All authors have read and approved the final manuscript Competing interests The authors declare that they have no competing interests Received:...
Ngày tải lên: 11/08/2014, 00:23
báo cáo khoa học: " Oncocytic carcinoma of the parotid gland with late cervical lymph node metastases: a case report" potx
... was no lymph node involvement either clinically or radiologically Our patient was followed up accordingly, and four years after surgery started complaining of swelling and pain in the left cervical ... gland resembling a mixed tumor (red arrow) B) Histopathological image showing peri-neural invasion by the tumor and cohesive clusters of neoplastic cells (hematoxylin and eosin stain, original magnification ... revealing a cervical lymph node enlargement (red arrow) B) Histopathological study of cervical specimen showing metastatic tumor infiltration by oncocytic cells (hematoxylin and eosin stain, original...
Ngày tải lên: 11/08/2014, 03:20
Báo cáo y học: "Laparoscopic resection of a primary hydatid cyst of the adrenal gland: a case report" pot
... biochemistry and urinalysis were within normal limits Plain radiographs of the abdomen showed a small round opacity, about 3-cm in diameter, in the left upper region of the abdomen, with evidence of calcifications ... Pathological examination of the specimen con- This case is unusual due to the organ involved Hydatid cysts can occur almost anywhere in the body [1,7] The adult worm lives in the small intestine of the ... Histology (stain hematoxylin and eosin; magnification ×200): Histology (stain hematoxylin and eosin; magnification ×200): necrotic material with calcified protoscolic of adrenal cysts in the general...
Ngày tải lên: 11/08/2014, 10:22
Báo cáo y học: " Magnetic resonance imaging with pathological correlation in a case of mantle cell lymphoma of the parotid gland: a case report" ppsx
... with a stage III or IV disease According to Argatoff et al., in a clinicopathological study of 80 cases, extranodal involvement at presentation occurred in 76% of cases and the most common sites ... the risk of developing a lymphoma is increased In this case the typical inhomogeneous nodular MRI picture seen in Sjögren’s syndrome will change into a homogeneous pattern that can involve the ... fluorescence in situ hybridization (FISH) probes [5] This translocation can rarely occur in other types of B-cell NHL, in lymphocytic leukemia, and in multiple myeloma [2] Therefore, cytogenetic findings...
Ngày tải lên: 11/08/2014, 12:20
báo cáo khoa học: " Diseases of the salivary glands in infants and adolescents" ppt
... duct) in 66.7% of cases, and in 33.3% they were localized outside the gland in the vicinity of the hilus and of the distal portion of the excretory duct Following submandibulectomy or slitting of ... rate of 50% for patients with acinic cell carcinoma, including highgrade carcinomas in the statistical evaluation Data from our clinic on this malignancy include only patients with low-grade acinic ... is a painful swelling of the afflicted gland that abates postprandial The literature describes sialolithiasis in infants mostly in single case reports The youngest documented case in a single...
Ngày tải lên: 11/08/2014, 20:20
Báo cáo y học: "Cetuximab in the treatment of metastatic mucoepidermoid carcinoma of the salivary glands: A case report and review of literature" doc
... SG was involved in the conceptual design of this study, in the clinical management of the patient, and in the writing and editing of the manuscript VA was involved in the Page of (page number ... expression in several salivary gland carcinomas, including MECs and adenoid cystic carcinomas (ACCs) In MECs, the percentage of membrane staining of EGFR is approximately 77% which is higher than in ... for elicitation of biological activity Our findings also emphasize the importance of CT-PET in monitoring neoplastic diseases during molecular targeted therapies The inability of cetuximab to...
Ngày tải lên: 11/08/2014, 21:22
disorders of the pituitary gland
... thyroid gland Caused by a deficiency of iodine in the diet, by the inability of the thyroid to use iodine, or by relative iodine deficiency caused by increasing body demands for thyroid hormones ... common, and hypertrophied joints may become painful and stiff Osteoporosis of the spine and joint pain develop Acromegaly Medical Management Treated by surgical removal of the pituitary gland ... controlled by limiting the intake of fluids The need for drinking and voiding frequently limits activities Weakness, dehydration, and weight loss develop Medical Management Desmopressin (DDAVP)...
Ngày tải lên: 13/08/2014, 09:37
Apoptosis of the pancreatic acinar cells and acute pancreatitits
... changes in caerulein-induced pancreatitis comprise: (a) inhibition of the normal transport of exocrine proteins, (b) 12 changes in the cellular compartmentation of exocrine proteins, and (c) activation ... pancreatic acini 64 2.2D Effect of inhibitors on caspase activation and annexin-V binding in isolated pancreatic acini 65 2.3 Detection of mitochondrial membrane potential in pancreatic acinar cells ... and inhibitors significantly attenuated both annexin V staining and caspase activation These results indicate an important role of caspase 3, and activation in the crambene-induced apoptosis in...
Ngày tải lên: 11/09/2015, 14:20
Báo cáo khoa học: Binding of ATP at the active site of human pancreatic glucokinase – nucleotide-induced conformational changes with possible implications for its kinetic cooperativity doc
... site of the hexokinase family of enzymes, positioned in the phosphate-binding loop and part of a classical ATPbinding motif (phosphate site) in hexokinases and homologous proteins [22] In the ... ATP-binding site in the MD simulated model structure of the binary hGK–ATP complex and the domain motion induced by ATP binding to the hGK apoenzyme (A) Close-up view of the ATPbinding site in ... residues involved in ATP binding; and (d) relating this information to steady-state enzyme kinetic data To achieve these aims, we used a combined experimental approach including intrinsic tryptophan...
Ngày tải lên: 06/03/2014, 00:20
Báo cáo khoa học: Glucose oxidase prevents programmed cell death of the silkworm anterior silk gland through hydrogen peroxide production ppt
... indicating that V5 ASGs contained the inhibitor (Fig 1D) Changes of inhibitor-producing activity during the larval period We examined the inhibitor activity in the CM of ASGs from day of the ... These results indicated the importance of spinning to the loss of GOD activity in ASGs Finally, we examined the localization of the GOD enzyme by active staining for the silk glands of V3 larvae; ... at the early spinning stage Because the onset of spinning on day is induced by 20E, 20E indirectly induces the responsiveness of ASGs to 20E After discarding GOD through spinning, ASGs exhibit...
Ngày tải lên: 15/03/2014, 00:20
Báo cáo khoa học: Identification and characterization of plasma kallikrein–kinin system inhibitors from salivary glands of the blood-sucking insect Triatoma infestans pptx
... triafestin-2 inhibited kallikreinkinin system activation by inhibiting the reciprocal activation of FXII and PK without affecting their amidolytic activities Activation of the kallikrein kinin system ... inhibition of the intrinsic coagulation pathway Triafestin inhibits FXII and PK reciprocal activation and bradykinin generation To investigate inhibition of the kallikreinkinin system by triafestin-1 ... following the kallikreinkinin system in plasma (data not shown) Therefore, we suggest that both triafestin-1 and triafestin-2 inhibit activation of the plasma kallikreinkinin system, leading to inhibition...
Ngày tải lên: 16/03/2014, 05:20
Báo cáo khoa học: Role of the structural domains in the functional properties of pancreatic lipase-related protein 2 pot
... the N-terminal and C-terminal domains of hoPL were involved in the inactivation of the protein at the water–triglyceride interface The inactivation of N2Cc in the absence of bile salts was prevented ... protein bearing the N2 domain than in the protein bearing the Nc domain Thus, the accessibility of the active site in the N2 proteins was independent of the nature of the C-terminal domain, in contrast ... protein The chimeric protein composed of the N-terminal domain of hoPL and of the C-terminal domain of hoPLRP2 was named NcC2 Conversely, the other chimeric protein, bearing the N-terminal domain...
Ngày tải lên: 16/03/2014, 06:20
Báo cáo khoa học: Characterization of the dimerization process of a domain-swapped dimeric variant of human pancreatic ribonuclease pdf
... form two kinds of domain-swapped dimers: one interchanging an N-terminal domain (minor dimer) and the other interchanging a C-terminal domain (major Mechanism of dimerization of an HP-RNase variant ... 7), indicating that nearly 100% of the dimer was interchanging the N-terminal moiety This result is in agreement with the fact that in the Fig Assessment of the degree of swapping of the N-terminal ... N-terminal domain in PM8E103C Results of SDS ⁄ PAGE analysis, under reducing conditions of the divinyl sulfone (DVS) cross-linking reaction of PM8E103C, at different time-points of incubation (indicated...
Ngày tải lên: 16/03/2014, 13:20
Báo cáo khoa học: A novel mass spectrometric approach to the analysis of hormonal peptides in extracts of mouse pancreatic islets ppt
... of the many compounds of the pancreatic islet extract (Fig 1a) The prominent signals in the spectrum originated from products of proinsulin Two insulin variants are expressed in mouse, insulin ... spectrometry of insulin J Am Chem Soc 104, 2948 36 Furuta, M., Carroll, R., Martin, S., Swift, H.H., Ravazzola, M., Orci, L & Steiner, D.F (1997) Incomplete processing of proinsulin to insulin accompanied ... affects the intracellular level of calcium and specific binding of C-peptide to plasma membrane has been observed During proinsulin conversion, insulin and C-peptides are produced in equimolar...
Ngày tải lên: 17/03/2014, 10:20