media uptake and cytotoxicity of gold drugs

... dysregulation of adipocyte functions, including oversecretion of TNF-a, PAI-1 and heparin HBEGF and hyposecretion of adiponectin, which results in the development of a variety of metabolic and circulatory ... phosphodiesterase (TDP1), aprataxin and senataxin, respectively While the functions of ATM and MRE11 in DNA double strand break repair and of TDP1 immediately upstream of nucleotide excision repair ... Obesity and Metabolic Syndrome S3.4-1 Integration of inflammatory and metabolic signals in obesity and diabetes G Hotamisligil Department of Genetics and Complex Diseases, Harvard School of Public...

Ngày tải lên: 19/02/2014, 07:20

... the rapid uptake of [3H]anandamide by Ó FEBS 2003 Uptake and metabolism of anandamide by rabbit platelets (Eur J Biochem 270) 3501 Fig Effect of caffeic acid and indomethacin on [3H]anandamide metabolism ... involvement of FAAH on [3H]anandamide uptake and metabolism by rabbit platelets, the effect of phenylmethylsulfonyl fluoride on [3H]anandamide uptake was determined (Fig 5) Preincubation of the platelet ... in Fig 7, the profile of [3H]anandamide uptake was identical at 37 °C and 25 °C At these two temperatures, the metabolism of [3H]anandamide took place to the same extent and resulted in the same...

Ngày tải lên: 08/03/2014, 08:20

Ngày tải lên: 15/03/2014, 23:22

... at 13 h (P < 0.01) and 24 h (P < 0.01) Corn and fish CRLPs were taken up at very similar rates, and there were also no significant differences in the rates of uptake of palm and olive CRLPs Fig ... enriched in SFAs, MUFAs, n)6 PUFAs and n)3 PUFAs [23], as well as containing a range of other fatty acids, and these enrichments influence the uptake and metabolism of the particles by the liver [24–26,31] ... differential rates of uptake of CRLPs of different fatty acid compositions by macrophages observed in the present study is due to differences in the oxidative state of the particles Evaluation of the lipid...

Ngày tải lên: 16/03/2014, 12:20

... rate to be orders of magnitude higher in one direction than in the others In the case of Si and Ge SCs, gold is often used as an efficient catalyst The physical properties of Si and Ge make it possible ... analysis and interpretation of the data and drafted the manuscript TB conceived the study and carried out its coordination,the analysis and interpretation of the data, participated to the growth of ... NW, and revised the manuscript FD carried out the growth of Si NW, SEM characterization, analysis and interpretation of the results PG, FO, participated to the growth of Si and SiGe NW BS and...

Ngày tải lên: 21/06/2014, 05:20

... size, amount of ligand present per weight of sample, and degree of ligand coverage Once the characteristics of the nanoparticle samples were studied, samples were then tested for cytotoxicity ... cause of the observed cytotoxicity Conclusions In conclusion, we have synthesized and characterized yttrium oxide nanoparticles of spherical, platelet, and rodlike morphology, and explored the cytotoxicity ... cells, with the goal of assessing the nanoparticle characteristics that affect cytotoxicity Cytotoxicity and ROS Generation of Nanoparticles Nanoparticles were tested for in vitro cytotoxicity by...

Ngày tải lên: 22/06/2014, 00:20

Ngày tải lên: 28/06/2014, 11:20

... Materials and Methods Mac-1-mediated Uptake and Killing of Bordetella bronchiseptica by Porcine Alveolar Macrophages 47 Ta ble Anti-Mac-1 blocking of AM binding and uptake of B bronchiseptica Ab treatment ... the uptake of B bronchiseptica (Fig 3B) Even at relatively high concentrations (10%) of serum, the uptake of B bronchiseptica was elevated 5-fold compared to medium (Fig and 3) Fig Serum-mediated ... increased binding and uptake of B bronchiseptica by addition of serum was not inhibited by anti-Mac-1 antibodies, indicating that the dramatic increase of B bronchiseptica uptake by serum is mediated...

Ngày tải lên: 07/08/2014, 17:22

... laser and detected in the range of 570 - 650 nm Visualisation of nuclei (DAPI and Hoechst staining) was achieved with an excitation wavelength of 350 nm and a detection wavelength range of 450 ... http://www.jnanobiotechnology.com/content/9/1/32 Page of 14 Figure Time dependent uptake of Ru@SiO2-NH2 nanoparticles Ru@SiO2-NH2 nanoparticles uptake over h (A and B) and 24 h (C and D) in UMB-SCC 745 A, C: confocal ... http://www.jnanobiotechnology.com/content/9/1/32 Page of 14 Figure Time dependent uptake of Ru@SiO2-PEG nanoparticles Ru@SiO2-PEG nanoparticle uptake after h (A and B) and 24 h (C and D) in UMB-SCC 745 A, C: confocal...

Ngày tải lên: 11/08/2014, 00:23

... combination of fecal occult blood test and sigmoidoscopy, and colonoscopy Each test was described in terms of how the test is completed, how often it needs to be completed, the amount of time needed ... outcomes were completion of colon cancer screening tests and cost of each additional patient screened Methods We conducted a controlled trial assessing the main outcome of colon cancer screening ... patients of attending physicians listed alphabetically in the intervention pool for the intervention group and the first 100 patients of attending physicians in the control group Description of Intervention...

Ngày tải lên: 11/08/2014, 05:21

... combination of fecal occult blood test and sigmoidoscopy, and colonoscopy Each test was described in terms of how the test is completed, how often it needs to be completed, the amount of time needed ... outcomes were completion of colon cancer screening tests and cost of each additional patient screened Methods We conducted a controlled trial assessing the main outcome of colon cancer screening ... patients of attending physicians listed alphabetically in the intervention pool for the intervention group and the first 100 patients of attending physicians in the control group Description of Intervention...

Ngày tải lên: 11/08/2014, 16:21

... phase and the peak of the fluctuation are influenced by the progressive mixing of the bolus with the inspired gas, and depend on the location of the sampling site in relation to the position of ... alternative to the present systems of administration into the upstream of the ventilator It would also offer the advantage of not generating high concentrations of NO2 and obviate the need for sodalime ... perfused part of the ventilated lung parenchyma takes part in the pulmonary uptake of NO [13] It follows that the fluctuation of tracheal NO concentration can serve as an index of the extent of alveolar...

Ngày tải lên: 12/08/2014, 18:20

... (a and b) 26 mL of toluene + mL of ethanolwashed AuNPs at 180 oC for 4h, (c and d) 28 mL of toluene + mL of assynthesized AuNPs + 0.5 mL of 2-propanol at 180 oC for h, and (e and f) 28 mL of ... decomposition and they can be easily handled and functionalized as stable organic and molecular compounds By virtue of these striking features of gold nanoparticles and assistance of organics surfactants, ... believed that synthesis and self-assembly of gold nanoparticles could induce novel properties and applications This project focuses on the study of synthesis and organization of gold nanoparticles...

Ngày tải lên: 11/09/2015, 16:06

... (submitted) The effect of mucin of LS174T cells on the uptake of WGA-conjugated PLGA nanoparticles Wang CX, Ho PC, LY Lim (in preparation) The cytotoxicity and uptake of wheat germ agglutinin ... n=6 70 3.3 Uptake of fWGA by (A) Caco-2, (B) HT-29 and (C) CCD-18Co cells as a function of incubation time (Data represent mean ± SD, n=4) 72 3.4 Uptake of fWGA by the Caco-2, HT-29 and CCD-18Co ... 100,000x) and (B) SEM (magnification of 35,000x) micrographs of WNP 109 4.3 In vitro release profiles of paclitaxel from WNP into PBS, pH 7.4, 37°C (Mean ± SD, n=3) 110 4.4 In vitro cytotoxicity profile...

Ngày tải lên: 14/09/2015, 08:37

... (b) the composite of C1 and PLA and (c) the composite after immersed in DCM for 30 Figure 4-4 SEM images of (a) B1+S and (b) the composite of B1+S and PLA Figure 4-5 SEM images of (a) B2, (b) B2/PLA, ... McKeown, and A D'Emanuele, Int J Pharm 252, 263 (2003) 53 Code of Federal Regulations - Title 21 - Food and Drugs Title 21—Food and Drug Chapter I—Food and Drug Administration Department of Health and ... Research work of this thesis 1.2.1 Synthesis and characterization of nickel ferrite nanoparticles 1.2.2 Composite of nickel ferrite nanoparticles and polymer 1.2.3 Cytotoxicity of nickel ferrite...

Ngày tải lên: 14/09/2015, 17:50

... layer and in completely defined culture media2 9 2.2 Use of hESCs in dental implant materials research There are presently no known research on testing of the cytotoxicity and osteogenesis of dental ... knowledge and understanding of stem cells is so enormous and being so helpful Ms Li Lu Lu for her help with the draft and invaluable suggestions Last but not least, Mr Chan Swee Heng and Ms Angelin ... differentiation of hESCs Chapter II Human Embryonic Stem Cells and their Uses ………………… 2.1 Origin and characteristics of hESCs 2.2 Use of stem cells in dental implant material research 12 2.3 Processing and...

Ngày tải lên: 30/09/2015, 14:23

... Experimental animals and drug administration This study was conducted with the consent of the Committee on the Use of Live Animals in Teaching and Research of the University of Hong Kong Male ICR ... administration of CY resulted in a significant drop in WBC number on day and 11 (80% and 88% respectively) in mice Recovery of WBC count started on day and day 11 in all treatment groups and returned ... (Reichert, U.S.A.) Assessment of angiogenesis Immunohistochemical staining of microvessels in the tissues of stomach and duodenum was performed by using von Willebrand factor antibody [18] The...

Ngày tải lên: 02/11/2012, 10:19

... influenza pandemic and drastic increase in antiviral drugs consumption It is therefore worthy to monitor the drugs in surface waters in the winter season to get more insight of whether the drugs really ... development of oseltamivir-resistant influenza viruses Furthermore, Japan is at the top of the list of countries for per capita consumption of Oseltamivir (Soderstrom et al., 2009), and it has ... seasonal use and high pandemic use of the drug (≤ 98.1 μg/L) One concern raised today is the environmental risk of the drug in water environment It is suspected that the presence of the drug in...

Ngày tải lên: 05/09/2013, 10:15

... analyses of the other parameters were measured according to JIS K0102 RESULTS AND DISCUSSION Summary of Experimental Results The mean and standard deviation of MLSS, SRT, effluent SS, D-BOD and T-N ... removal of excess sludge after the cease of coagulant addition (Mishima and Nakajima, 2003c) On the other hand, the relationship between CFe and vrel, Cmax is shown in Fig and a clear tendency of ... were carried out and the stabilization of phosphorus removal efficiency was investigated The objective of this study is to clarify the effect of coagulant on phosphorus uptake and release as well...

Ngày tải lên: 05/09/2013, 10:15

... amounts of ODT were used, and smaller AuNPs were produced in the presence of Table Comparison of Reaction Time, LSPR λmax, and Size of Gold Nanoparticles Synthesized Using Different Amounts of ODTa ... similar reaction conditions and identical molar ratios of gold salt, thiol, and 9-BBN, a catalytic amount, 0.005 mL (0.01 mmol), of TOA was immediately injected after addition of 9-BBN (see Scheme 1) ... addition of 9-BBN to the reaction mixture, an immediate reduction of Au(I) ions took place, and the solution contained a high concentration of active nuclei Due to presence of a large number of active...

Ngày tải lên: 18/09/2013, 21:27