mechanisms of their toxicity
Mixture toxicity of POPs dioxins, PCBs, PBDEs considerations from mechanisms of actions and for risk assessment
Ngày tải lên :
16/04/2015, 08:52
... Berg & R F Canton (2010) A Global Foodborne Burden of Disease? WHO-‐FERG In prep Es*ma*on of number of W-‐Europe children exceeding the TDI significantly (< ... Canton (2010) A Global Foodborne Burden of Disease? WHO-‐FERG In prep Breasded infants can exceed WHO TDI up to two orders of magnitude for 3-‐6 months M Van ... risk assessment of environmental matrices Aspects reduced bioavailability, environmental fate and transport not in present REP/TEF studies evaluated Mixtures of PCDDs, PCDFs...
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Pharmacokinetic and pharmacodynamic mechanisms for reduced toxicity of CPT 11 by thalidomide and st johns wort
Ngày tải lên :
14/09/2015, 13:44
... Pharmacokinetics of CPT-11 1.2.3 1.3 Anti-tumor activity and mechanism of action of CPT-115 Toxicities of CPT-11 .14 THALIDOMIDE .19 1.3.1 Clinical activity and mechanism of action of thalidomide ... .151 6.2 PHARMACODYNAMIC MECHANISMS OF THE PROTECTIVE EFFECTS OF THALIDOMIDE AND ST JOHN’S WORT 152 6.3 PHARMACOKINETIC MECHANISMS OF THE PROTECTIVE EFFECTS OF THALIDOMIDE AND ST JOHN’S ... incidence of resistance Secondly, there is often a greater than additive or synergistic effect of the drugs due to complementary mechanisms of action Finally, by using drugs with different types of...
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Mechanisms of polymer ca2+ interaction and their effects on the characteristics of alginate microspheres and films 3
Ngày tải lên :
14/09/2015, 17:43
... (Figure 22a).The Ca2+ enhanced gelation of κ-carrageenan by stabilization of the helical conformation of the polymer, through shielding of the charge of sulphate groups by Ca2+ (Watase and Nishinari, ... of double helices (Hermansson et al.,1991) However, in the presence of Ca2+, the aggregation of κ- carraggenan helices was limited, resulting in the formation of weaker gels The aggregation of ... Ca2+ contents of the films composed of a single polymer revealed that there might be varying affinity of the polymers for Ca2+ thus introducing the potential for varying degrees of cross-linking...
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Mechanisms of polymer ca2+ interaction and their effects on the characteristics of alginate microspheres and films 2
Ngày tải lên :
14/09/2015, 17:44
... the determination of amount of CaCO3 and volume of glacial acetic acid needed 103 CaCO3 was determined.The end point was marked by the first sign of complete disappearance of white CaCO3 particles ... cross-linking mechanisms and their effects on matrix integrity would assist in the control of the interaction between Ca2+ and alginate with the use of more appropriate cross-linking techniques C Mechanisms ... crosslinked using at least 0.15 g of CaCO3 Different amounts of CaCO3 were used in the study to evaluate the influence of various amounts of cross-linking agent on the gelation mechanisms C1.1.3 Medium...
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Mechanisms of polymer ca2+ interaction and their effects on the characteristics of alginate microspheres and films 1
Ngày tải lên :
14/09/2015, 17:45
... microspheres Yield of blank microspheres (g) Ca2+ content of blank microspheres (mg) Mean size of drug-containing microspheres (µm) Degree of agglomeration (%) Drug content (%) Drug content of S microspheres* ... restricted the movement of the polymer chains On the contrary, the polymer chains composed of a higher proportion of M and MG blocks were more flexible and exhibited a higher degree of mobility during ... weight of the polymer.Thus, from Equation 7, it can seen that the viscosity has a direct relationship with molecular weight In this part of the study, the influence of molecular size of the polymer...
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Báo cáo y học: "Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells"
Ngày tải lên :
31/10/2012, 15:12
... transfection of Bag-1 Morpho/AS to JAR cells did not alter the expression of PTEN after the exposure to hypoxia, which would mean that the expression of PTEN, and also that of Bcl-X, was independent of ... expression profiles of proteins involved in the mitochondrial (bcl-2, bax, and bcl-x, etc.) and stress reaction-related pathways of apoptosis (Fig 2) Table Altered protein expression of JAR cells ... calculated according to the formula: Changes in the level of phosphorylated JNK 1&2 (-fold of control) = absorbance of treated cells / absorbance of control cells All points were done duplicate X three...
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Study on the Photolytic Mechanisms of Red 141 Dye Wastewaters with an 185nm Vacuum-UV lamp
Ngày tải lên :
05/09/2013, 09:08
... vacuum-UV photolysis of water (H2O-VUV) is still a field of active research compared to other AOPs (Oppenlander and Gliese, 2000) The special requirements of the VUV photolysis of water according ... related to the formation of high local concentration of hydroxyl radicals (OH.) and a series of other species (Gonzalez and Braun, 1995) within a photochemical reaction zone of less than 0.1 mm (Heit ... differentiation of the contributions on the decomposition of Re 141 in aqueous solutions by UV direct photolysis, OH generated from the excitement of water, oxygen, and H2O2, respectively Development of the...
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ISOTOPE HYDROGRAPH SEPARATION FOR MODELING OF RUNOFF MECHANISMS OF ATMOSPHERICALLY DERIVED CHEMICAL AND RADIOACTIVE POLLUTANTS
Ngày tải lên :
05/09/2013, 09:08
... measurement, considering of their respective analytical errors A concept of two-component mixing was employed, in which it was assumed that runoff is composed of a mix of two components: one originating ... content with that of aluminum Aluminum was chosen as a reference because of its naturally high content in soil In principle, the ratio of their content of the depositions to that of the surface ... and by setting C1 and C2 as mentioned above, the fraction of new water evaluated for the main part of the runoff (0000 of Oct 22 to 1600 of Oct 23, 40 h in total) was found to be as shown in Fig...
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Mechanisms of Unstable Nitrite Inhibition of Aerobic Phosphate Uptake
Ngày tải lên :
05/09/2013, 09:38
... some of PAOs can that, the inhibitory effect of nitrite will be reduced Hence, the purpose of this study is to examine the effect of anoxic activity of PAOs on reduction of inhibitory effect of ... Cycle Operations of SBRs for Cultivation of the Enriched PAOs - 66 - Journal of Water and Environment Technology, Vol 6, No.1, 2008 Table - Composition of Synthetic Wastewater Methods of nitrite inhibition ... presence of nitrite was 13 mgP.gVSS-1.h-1 and the % activity of phosphate uptake was 39% On the other hands, in the case of AA with 1.9 mgN/gVSS of initial nitrite concentration, the size of inhibition...
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Transmission mechanisms of monetary policy the evidence
Ngày tải lên :
05/01/2014, 17:01
... cycle soon followed Transmission Mechanisms of Monetary Policy Traditional Interest-Rate Channels: expansionary monetary policy ir ↓, I ↑, Y↑ The interest rate channel of monetary transmission applies ... price for it relative to the cost of the facilities and equipment they are buying I ↑ because firms can buy a lot of new investment goods with only a small issue of stock The transmission mechanism ... Pe ↑, W ↑, C ↑, Y ↑ Tobin’s q and wealth mechanisms allow for a general definition of equity that includes housing and land An ↑ in house prices, which ↑ their value relative to replacement cost,...
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Tài liệu Women''''s attitudes towards mechanisms of action of family planning methods: survey in primary health centres in Pamplona, Spain doc
Ngày tải lên :
13/02/2014, 06:20
... of action of some FP methods We did not state the mechanism of action of any FP methods and thus asked women to express their beliefs independently of their actual choices and independently of ... hypothetical method of FP In further sections women were asked about their knowledge of the mechanism of action of specific FP methods and if doctors or providers should explain the details of how a method ... argument for the acceptance of this method was the minimization of any losses (regardless of their cause) [34,35] Our interpretation at this point is that a substantial fraction of women consider the...
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Tài liệu Báo cáo khoa học: Mechanisms of amyloid fibril formation – focus on domain-swapping doc
Ngày tải lên :
14/02/2014, 18:20
... understanding of the importance of different parts of the molecule and their flexibility in the process of amyloid fibril formation often results more from a structural analysis of the amyloid ... blocks only after partial unfolding of the a-helix from the body of the b-sheet (Fig 2C) Possible role of domain-swapping in the ‘off-pathway folding’ (OFF) model The OFF model for amyloid formation ... variants of amyloid fibrils differing in the number of filaments and the helicity of their intertwining [22–24] The structure of the mature fibrils has been determined in a limited number of cases...
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Tài liệu Báo cáo khoa học: Survival mechanisms of pathogenic Mycobacterium tuberculosis H37Rv ppt
Ngày tải lên :
16/02/2014, 15:20
... Proton ATPasePump Inhibition of acidification of phagosome harbouring Mycobacteria Expression of virulence proteins of PE-PGRS family C O2– Fig Key factors of the survival mechanisms involved in the ... of digested material by exocytosis Fig Detailed structure of a macrophage showing a typical process of phagocytosis Engulfed material A D Phagosome TACO Fusion Lysosome Inhibition of fusion of ... proteins of mycobacteria have a profound influence on its pathogenicity It was found that the disruption of an erp gene of M tuberculosis encoding a secretory protein effects the survival of M tuberculosis...
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Tài liệu Báo cáo khoa học: Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction pptx
Ngày tải lên :
18/02/2014, 06:20
... with an increased risk of T2DM, hypertension and CVD; however, the exact underlying pathophysiological mechanisms by which obesity increases the risk of VD remains the subject of intensive investigation ... hypertension They also found that 55–58% of their diabetic patients with ED had low TT levels In another study, Hofstra et al [57] assessed the prevalence of isolated hypogonadotrophic hypogonadism ... pathophysiological mechanisms of obesity-induced androgen deficiency and hypogonadism-induced obesity remain the subject of intense investigation Several hypotheses have discussed the relationship of androgen...
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Tài liệu Báo cáo khoa học: Reaction mechanisms of thiamin diphosphate enzymes: redox reactions pdf
Ngày tải lên :
18/02/2014, 08:20
... deprotonation of C2a-OH of HEThDP and protonation of FAD at N5 and N1) The tight and rigid binding of both cofactors excludes a direct carbanion mechanism with covalent linkage between C2a of the HEThDP ... cluster [28] Rapid depletion of the thiamin radical and reduction of all clusters is only achieved after addition of CoA What is the special role of CoA for propagation of the second electron and ... radical An additional intricacy of this mechanism is the necessity of a structural rearrangement of CoA in the course of catalysis: initially, the reactive thiol group of CoA must be positioned proximal...
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Tài liệu Báo cáo khoa học: Marine toxins and the cytoskeleton: a new view of palytoxin toxicity ppt
Ngày tải lên :
18/02/2014, 14:20
... shape Nevertheless, they were not observed here Instead of this, enterocytes retained their typical columnar morphology after losing many of their microfilaments Similar cases using cultured cells ... one-third of their total actin content (reduction by 33 ± 6.7%) and underwent rounding (Fig 2) This fact helps to confirm that maintenance of cells in suspension was not responsible for the absence of ... a natural blocker of the Na+ pump and an inhibitor of palytoxin action, have provided interesting findings Through the partial inhibition of Na+ ⁄ K+-ATPase, and regardless of changes in intracellular...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
Ngày tải lên :
19/02/2014, 16:20
... of the active species [76] Further support in favour of the idea of the involvement of a high-valent iron-oxene in P450 catalysis came from experiments with metalloporphyrin models [5,6,77] Of ... of the crystal structure of NDO as well as spectroscopic data provide a rationale for the catalytic mechanism of this class of enzymes Naphthalene 1,2dioxygenase is a heterohexamer composed of ... reect ring opening of an epoxide intermediate at either of its two C-O bonds [219,220] The sum of these ndings strongly invokes the notion of oxygen activation during redox cycling of the diverse...
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Motivating Better Hygiene Behaviour: Importance for Public Health Mechanisms of Change doc
Ngày tải lên :
05/03/2014, 21:20
... lighter forms ofwater contamination of their own water sources Lack ofwater and soap for handwashing plays a bigger role in the transmission of diarrhoeal diseases than the drinking of unboiled ... communication and level of power/influence Culture refers to the common ways ofthinking and acting ofmembers of a particular society, their concepts on health and hygiene, their beliefs on how particular ... move from the increase of knowledge to the demonstrated improvement of hygiene conditions and practices professionalism of hygiene educators and adaption of a team approach ofengineers, health staff...
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Báo cáo khoa học: Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death ppt
Ngày tải lên :
07/03/2014, 03:20
... amounts of nitric oxide (NO) generated by pathological expression of NO synthase isoforms are certainly neurotoxic, whereas homeostatic levels of NO produced by the endothelial isoform of this ... Protection Toxicity Protection [28] [30] [31] [37] [48] [38] Protection NT Protection Protection Protection NT Protection Toxicity Toxicity Toxicity Toxicity Protection NT Protection (CB2) Toxicity ... stroke and in the mechanisms of post-ischemic neuronal death (Table 1) To this end, models of focal and global ischemia in vivo, with or without reperfusion, as well as models of oxygen glucose...
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Báo cáo khoa học: Molecular mechanisms of the phospho-dependent prolyl cis ⁄ trans isomerase Pin1 docx
Ngày tải lên :
07/03/2014, 05:20
... Molecular mechanisms of Pin1 tPro213 Fig NOESY spectrum of the triply phosphorylated SRSRpT212PpS214LPpT217PPTR peptide of Tau The cis conformation for the Pro219 is below the limit of detection ... FEBS 5215 Molecular mechanisms of Pin1 G Lippens et al populations, as one of the forms would continuously disappear from the pool of free peptides Structural characterization of the MPM-2 antibody ... examined in great detail the structure of both cis and trans conformers of the same peptide by NMR spectroscopy [31] The local structure of the cis conformer of this peptide is characterized by...
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