mechanisms of ger induced respiratory disease

... expression profiles of proteins involved in the mitochondrial (bcl-2, bax, and bcl-x, etc.) and stress reaction-related pathways of apoptosis (Fig 2) Table Altered protein expression of JAR cells induced ... importance of Fas and FasL [15], and that of TNF-R1 and TNF-α[16], in preeclampsia Thus, hypoxia -induced changes in the expression of both proapoptotic and antiapoptotic proteins, and 43 the balance of ... transfection of Bag-1 Morpho/AS to JAR cells did not alter the expression of PTEN after the exposure to hypoxia, which would mean that the expression of PTEN, and also that of Bcl-X, was independent of...

Ngày tải lên: 31/10/2012, 15:12

... with classical markers of autophagy, such as induction of LC3 and conversion of LC3-I to LC3-II [48,49,118], induction of beclin [48], induction of BNIP-3 [66] and activation of G-interacting protein ... establishment of senescence induced by a constitutively active form of Ras or MEK [121] process is often prevented by use of MEK inhibitors (See Table 2) The Ras ⁄ Raf ⁄ ERK pathway and senescence Mechanisms ... mesenchyme by FGF8 -induced DUSP6 activity When activated by the expression of constitutively active MEK1, downregulation of DUSP6 or by the expression of a phosphataseinactive mutant of DUSP6 (C294S),...

Ngày tải lên: 29/03/2014, 08:20

... a series of experiments which was designed to characterize the expression of CC chemokine receptors CCR1, CCR2 and CCR5 in the spinal cord of rats with experimentally induced MS-like disease, ... immunoneutralization of CCL3 [44], DNA vaccination [45], or genomic deletion of the CCR1 gene [22], reduces clinical disease Taken together, the results of the present study and from previous ones on the role of ... and the abundant expression of a variety of chemokine receptors by cells of monocyte/macrophage lineage is suggestive of a redundancy in the chemokine-mediated control of macrophage function [62]...

Ngày tải lên: 19/06/2014, 22:20

... Origin of the SARS virus Soon after the identification of a new coronavirus as the causative agent of SARS and of a southern Chinese province as the first area of occurrence, animal species of this ... and gastrointestinal diseases of humans and domestic animals [12,13] The group of coronaviruses is classified as a member of the order nidovirales, which represents a group of enveloped positive-sense ... to the development of therapeutic regimes based on molecular mechanisms of the disease, the causative agent had to be isolated and analysed Soon after the fast establishment of the international...

Ngày tải lên: 12/08/2014, 18:21

... circulation in a rat model of acid aspiration -induced lung injury Ventilation of lungs isolated from rats exposed to cecal ligation -induced sepsis with a tidal volume of 20 ml/kg, without PEEP, ... levels of TNF-α, IL-1β, and IL-6 compared with unventilated controls and lungs ventilated with a tidal volume of 10 ml/kg and a PEEP level of cmH2O [20] In a rat model of ml/kg PEEP 10 Acid -induced ... severity of ventilator -induced pulmonary edema and protein permeability [32] The same group also reported that inhibition of tyrosine kinase, calcium/calmodulin, or inhibition of phosphorylation of...

Ngày tải lên: 12/08/2014, 19:21

... survival benefits The authors of the report observed that plateau pressures in the control groups of the two beneficial trials were larger than those used in the control groups of the nonbeneficial trials ... Science review: Mechanisms of ventilator -induced injury Crit Care 2003, 7:233-241 Ranieri VM, Suter PM, Tortorella C, De Tullio R, Dayer JM, Brienza A, Bruno F, Slutsky AS: Effect of mechanical ... in patients with acute respiratory distress syndrome Am J Respir Crit Care Med 2002, 165:12711274 Eichacker P, Gerstenberger E, Banks S, Cui X, et al.: A metaanalysis of ALI and ARDS trials testing...

Ngày tải lên: 12/08/2014, 19:22

... present review discusses the biochemical characteristics of GAGs, their biological roles and mechanisms of action in several respiratory diseases, and their potential therapeutic effects Figure ... [19] Stabilization of some mast cell tryptases [22] Modulation of the activity of various mast cell chymases [59] Regulation of the inflammatory response [57] Remodelling of the airway wall in ... proliferation of cells and that require a vast array of paracrine mechanisms) require an environment with a water concentration considerably higher than that of many mature organs From this point of view,...

Ngày tải lên: 13/08/2014, 03:20

... surrogate marker of methadone -induced respiratory depression However, because the elimination rate of naloxone varies with a half-life of 45 to 90 minutes, a continuous infusion runs the risk of naloxone ... had a history of heroin addiction with a maintenance treatment of 70 mg/day of methadone (confirmed by a prescription from his maintenance program centre) and occasional use of mg of flunitrazepam ... reported [7], the half-life of R-methadone was longer than that of S-methadone TK/TD relationships allow the descriptive and quantitative characterisation of the time course of the in vivo drug effect...

Ngày tải lên: 13/08/2014, 03:20

... to the presence of a E-to-K mutation at codon 303 of the Tax protein [83,184,186] In cell culture, transfection of provirus 395 yields reduced levels of Tax activity (~ 10 % of wild-type) although ... population of cells having undergone different numbers of mitotic cycles (i.e a "ladder pattern") instead of a classical pyramid shape of the progeny population The heterogeneity of the telomere ... of a strategy based on the induction of viral and cellular gene expression Among a number of methodological approaches, modulation of chromatin condensation, which is an essential component of...

Ngày tải lên: 13/08/2014, 09:20

... and Nutrition Board of the Institute of Medicine of the National Academy of Sciences, 34 the adequate intake of chromium is set to 30 µg/d (243) Given the known absorption of chromium at approximately ... the National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute of Aging for providing financial needs to defray the cost of attending professional conferences ... Accepted by the Faculty of Indiana University, in partial fulfillment of the requirements for the degree of Doctor of Philosophy Jeffrey S Elmendorf,...

Ngày tải lên: 24/08/2014, 10:54

... detected; however, varying levels of prevalence of anti-CII antibodies in RA that are dependent on the nature and source of CII used for assay and the phase of the clinical disease have been observed ... also demonstrate the impact of differential Fc sialylation on pro- or anti-inflammatory activities of IgG [28] Need for animal models A basic understanding of disease mechanisms is a prerequisite ... stages of the development of human arthritis, although they will not be identical to those of RA On the other hand, RA itself is not a single disease but a syndrome that includes different disease...

Ngày tải lên: 09/08/2014, 08:23

... cell culture system of SARS-CoV, bananin inhibited viral replication at a half maximal effective concentration of less than 10 lm and a concentration causing 50% of cell death of over 300 lm, suggesting ... possible mechanisms of bananin activity, and are also used to drive restrained docking simulations of the bananin–SARSCoV helicase interaction, aiming to define the sterical requirements of new ... although no evidence of helicase–membrane protein interaction could be obtained (Doc S1 and Fig S1) Thus, the mechanisms of bananin activity have been ascribed to the binding of the small molecule...

Ngày tải lên: 28/03/2014, 23:20

... coefficient of the laser -induced plasma Analysis of the absorption coefficient of the laser -induced plasma requires thermodynamic properties of the laserinduced plasma Based on the measured velocity of ... assumptions concerning the mechanisms of highpower laser evaporation processes Fig Onset of the laser -induced plasma Fig Transient transmissivity of the laser -induced plasma 3.2 Results of the transmissivity ... intensity of the excimer laser beam at the target surface The width of the nickel specimen is about 100 µm This is to ensure that the width of the specimen is shorter than the depth of focus of the...

Ngày tải lên: 06/05/2014, 08:55

... cell surface of epithelial cells Confocal laser scanning image of the distribution of viral glycConfocal laser scanning image of the distribution of viral glycoproteins on cell surface of epithelial ... responses and Disease Enhancement during respiratory Syncytial Virus Infection Clinical microbiology Reviews 2005, 18:541-555 Hoffman SJ, Laham FR, Polack FP: Mechanisms of illness during respiratory ... important viral pathogen of serious lower -respiratory tract illness in infants and young children RSV infects nearly 70% of infants in their first year of life; by the age of 24 months old virtually...

Ngày tải lên: 18/06/2014, 18:20

... experimental evidence regarding the role of Type D personality in potential mechanisms of disease as well as work-related Type D personality and mechanisms of disease Type D personality and work-related ... review of health status, mechanisms of disease, and work-related problems Health and Quality of Life Outcomes 2010 8:9 Publish with Bio Med Central and every scientist can read your work free of ... examined behavioral and biological mechanisms of disease as a function of Type D personality in apparently health individuals (Table - section a) Regarding behavioral mechanisms, two studies showed...

Ngày tải lên: 18/06/2014, 19:20

... pathogenesis of demyelinating disease; however, such activation after viral infection does not alter the development of disease To further understand the immunological mechanisms of the acceleration of ... underlying mechanisms of exacerbated susceptibility to TMEVinduced demyelinating disease in TLR3KO-SJL mice, we compared the expression levels of TMEV RNA and cytokine genes in the CNS of virus-infected ... development of TMEV -induced demyelinating disease, which bears both viral and autoimmunity components To investigate the role of TLR3-mediated innate immune responses on the pathogenesis of TMEV-induced...

Ngày tải lên: 19/06/2014, 22:20

... cell surface of epithelial cells Confocal laser scanning image of the distribution of viral glycConfocal laser scanning image of the distribution of viral glycoproteins on cell surface of epithelial ... responses and Disease Enhancement during respiratory Syncytial Virus Infection Clinical microbiology Reviews 2005, 18:541-555 Hoffman SJ, Laham FR, Polack FP: Mechanisms of illness during respiratory ... important viral pathogen of serious lower -respiratory tract illness in infants and young children RSV infects nearly 70% of infants in their first year of life; by the age of 24 months old virtually...

Ngày tải lên: 20/06/2014, 01:20

... na l of m e dic i n e review article Mechanisms of Disease Myocardial Reperfusion Injury Derek M Yellon, D.Sc., and Derek J Hausenloy, Ph.D C oronary heart disease is the leading cause of death ... description of the histologic features of reperfused ischemic canine myocar­ dium They reported cell swelling, contracture of myofibrils, disruption of the sarco­ lemma, and the appearance of intramitochondrial ... Much longer periods of reperfusion occur in patients, permitting time for the effects of infarct healing and left ventricular remodeling to take place Encourage the use of a longer period of reperfusion...

Ngày tải lên: 27/06/2014, 00:20

... 80 percent of men and 85 percent of women Varicose veins were present in 40 percent of men and 16 percent of women, whereas ankle edema was present in percent of men and 16 percent of women.3 ... d j o u r na l of m e dic i n e Table Revised Clinical Classification of Chronic Venous Disease of the Leg.* Class Definition Comments C0 No visible or palpable signs of venous disease C1 Telangiectases, ... permission of the publisher.) SK IN CH A NGES Venous hypertension seems central to the skin changes in chronic venous disease In a sample of 360 lower limbs of patients with a wide spectrum of venous disease, ...

Ngày tải lên: 27/06/2014, 00:20

... mean ± standard error of the mean Asterisks denote values that differ at p < 0.05 (Student's t test) disease was induced by intra-articular injection of OVA into the knees of OVA immunized rabbits ... similar levels of expression of hIL-10, vIL-10, and mut.hIL-10 (Figure 1) IL-10 was not detected in sera (data not shown) of any of the treated animals or in the lavage fluids of knees that received ... progression of antigen induced arthritis In particular, the three forms of IL-10 were all successful in reducing intra-articular leukocytosis and the degree of synovitis, as well as normalizing Page of...

Ngày tải lên: 09/08/2014, 08:22