mechanisms of drug action
Tài liệu Color Atlas of Pharmacology (Part 6): Quantification of Drug Action ppt
Ngày tải lên :
26/01/2014, 19:20
... affinity of ligands, the kinetics of interaction, and the characteristics of the binding site itself In studying the affinity and number of such binding sites, use is made of membrane suspensions of ... conditions of license 57 Quantification of Drug Action Addition of radiolabeled drug in different concentrations Organs Homogenization Membrane suspension Mixing and incubation Determination of radioactivity ... subject to terms and conditions of license 54 Quantification of Drug Action Concentration-Effect Relationship (A) The relationship between the concentration of a drug and its effect is determined...
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UPDATE ON MECHANISMS OF HORMONE ACTION – FOCUS ON METABOLISM, GROWTH AND REPRODUCTIONS pptx
Ngày tải lên :
27/06/2014, 19:20
... presence of glucose sensors in neurons of these brain areas Indeed, stimulation of glucoreceptors present in the neurons of the VMH, promotes the release of 40 Update on Mechanisms of Hormone Action ... (period of motor quiescence), phase II (period of preceding irregular contractions) and phase III (period of clustered potent contractions) It has been shown that plasma concentration of motilin ... alterations of white adipose tissue in obesity One of the consequences of the production and local release of cytokines and adipokines by adipocytes is the recruitment of large numbers of immune...
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Báo cáo khoa học: " Mechanisms of the action of povidone-iodine against human and avian influenza A viruses: its effects on hemagglutination and sialidase activities" doc
Ngày tải lên :
12/08/2014, 04:22
... of the virus titer by more than orders of magnitude in Madin-Darby canine http://www.virologyj.com/content/6/1/124 kidney (MDCK) cells [28] However, the target sites and mechanisms of PVP-I action ... directly, 100 mg/ml of PVP-I was added to a well of a 24-well flat-bottom plate to give a final concentration of 1.25, 2.50, 3.75 or 5.00 mg/ml, followed by addition of μl of virus (214 HAU) to ... acetate buffer (pH 6.0) at 37°C for 15 Enzymatic reaction was started by addition of μl of MUNA to a final concentration equivalent to a Km value of Page of 10 (page number not for citation purposes)...
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Mechanisms of hypoglycemic action of angiotensin peptides in diet induced diabetic mice
Ngày tải lên :
11/09/2015, 10:01
... events of the Ang-II and insulin signalling cross-talk 137 4.2 Putative mechanism of hypoglycaemic action of DAA-1 136 4.3 Putative mechanism of hypoglycaemic action of Ang-IV 141 LIST OF TABLES ... pathological actions of Ang-II which crosstalk with the insulin signalling pathway The hypoglycaemic action of DAA-1 may be prostaglandin-dependent as one of the downstream actions of prostaglandins ... blockers on hypoglycaemic actions of DAA-I and Ang-IV in C57BL/6J mice 118 3.6.2 Effect of losartan on the hypoglycemic action of DAA-I in C57BL/6J mice 119 3.7.1 Effects of Ang-IV and its metabolites...
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Tài liệu Women''''s attitudes towards mechanisms of action of family planning methods: survey in primary health centres in Pamplona, Spain doc
Ngày tải lên :
13/02/2014, 06:20
... of action of some FP methods We did not state the mechanism of action of any FP methods and thus asked women to express their beliefs independently of their actual choices and independently of ... hypothetical method of FP In further sections women were asked about their knowledge of the mechanism of action of specific FP methods and if doctors or providers should explain the details of how a method ... attitudes for postfertilization effects The purpose of our study was to assess the attitudes about the mechanisms of action of FP in terms of whether these may influence a woman's decision to...
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Báo cáo khoa học: Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138 pot
Ngày tải lên :
16/03/2014, 13:20
... availability of a range of structures of NNRTIresistant RTs drugs will provide greater understanding of the molecular basis of drug resistance mechanisms Such data will contribute to the design of novel ... between the subunits of the RT heterodimer [28] It is proposed that mutation of Glu138Lys causes loss of a key interaction of the glutamic acid carboxyl group to an amino group of TSAO inhibitors ... the side-chain of Lys101 [24] Consistent with the reports of the selection of Lys101Glu in clinical use of efavirenz, the crystal structure of RT with this NNRTI shows a contact of the inhibitor...
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meskin - phytochemicals - mechanisms of action (taylor, 2005)
Ngày tải lên :
03/04/2014, 12:04
... humans of antioxidant effects following consumption of anthocyanins are less definitive Much of the early work on anthocyanins has resulted from studies 14 PHYTOCHEMICALS: MECHANISMS OF ACTION of ... Table 1.1 Distribution of anthocyanins in common foods.a PHYTOCHEMICALS: MECHANISMS OF ACTION ABSORPTION AND METABOLISM OF ANTHOCYANINS ANTIOXIDANT AND OTHER BIOLOGICAL EFFECTS OF ANTHOCYANINS IN ... segments of the gut h after consumption of black raspberry More than 50% of all anthocyanins seem to be degraded within h of consumption of a meal Thus, it seems clear that more than 50% of the...
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Báo cáo y học: "Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action" pps
Ngày tải lên :
09/08/2014, 01:21
... of 2.02 × 106 than HA with a MW of 9.5 × 105 [102] Similarly, the histology of articular cartilage and synovial tissue was significantly better with an HA of MW = 2.02 × 106 than with an HA of ... hyaluronic acid in osteoarthritis of the knee: an investigation into mechanisms of action Osteoarthritis Cartilage 1994, 2:133-140 55 Kikuchi T, Yamada H, Shimmei M: Effect of high molecular weight hyaluronan ... prevent invasion of inflammatory cells into the joint space In acute and chronic inflammatory processes of the joint, the size of HA molecules decreases at the same time as the number of cells in...
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Báo cáo y học: "Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action" pot
Ngày tải lên :
09/08/2014, 20:21
... gene-deletion fitness profiling, where the growth profiles of haploid deletion strains in the presence of drug are compared to growth profiles obtained in the presence of a second deletion [5] ... While experimental Page of 17 testing of direct binding of predicted targets to drugs is beyond the scope of this paper, we accurately predicted known drug target interactions in cross-validation, ... because of scaling issues and because they not, in the majority of cases, interrogate essential genes, most of which encode drug targets Finally, overexpression profiling is an approach to drug...
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Báo cáo khoa học: " Science review: Mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids" pdf
Ngày tải lên :
12/08/2014, 20:20
... of all trials identified using these methods Reports were selected on the basis of relevance to the specific topics covered Mechanisms of glucocorticoid insufficiency 244 Dysfunction at any of ... activities of other classes of transcription factors by transrepression Regulation of gene trascription by nuclear receptors requires the recruitment of coregulators Their number not allow direct ineraction, ... restoration of the sympathetic modulation of heart rate and vasomotor tone [93], as well as the potentiation of exogenous catecholamine action that can be seen within minutes after a 50 mg bolus of hydrocortisone...
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Báo cáo y học: " Perinatal acquisition of drug-resistant HIV-1 infection: mechanisms and long-term outcome" potx
Ngày tải lên :
12/08/2014, 23:22
... available in the latter studies The comparison of the maternal and neonatal drug resistance profiles pointed to two different mechanisms of acquisition of resistant variants by infants in the perinatal ... increased risk of infection by drugresistant HIV-1 strains when the mother harbors such viruses or when drug pressure during MTCT prophylaxis is suboptimal Vertical transmission of drug- resistant ... plasma DNA plasma DNA Re-emergence of wild-type virus In the absence of zidovudine Transmission of wild-type virus and selection of resistant variants with PTME Figure of antiretroviral resistance...
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MECHANISMS OF HEXOSAMINE-INDUCED CHOLESTEROL ACCUMULATION AND THERAPEUTIC ACTIONS OF CHROMIUM
Ngày tải lên :
24/08/2014, 10:54
... and Nutrition Board of the Institute of Medicine of the National Academy of Sciences, 34 the adequate intake of chromium is set to 30 µg/d (243) Given the known absorption of chromium at approximately ... role of the HBP in promotion of this phenotype I will then detail mechanisms by which increased HBP activity may impair lipoprotein metabolism, and finally discuss the beneficial actions of Cr3+ ... of the current body of knowledge in the field of diabetes and cardiovascular health I will also identify future questions and studies which could serve to enhance the understanding of these mechanisms...
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Mixture toxicity of POPs dioxins, PCBs, PBDEs considerations from mechanisms of actions and for risk assessment
Ngày tải lên :
16/04/2015, 08:52
... Berg & R F Canton (2010) A Global Foodborne Burden of Disease? WHO-‐FERG In prep Es*ma*on of number of W-‐Europe children exceeding the TDI significantly (< ... Canton (2010) A Global Foodborne Burden of Disease? WHO-‐FERG In prep Breasded infants can exceed WHO TDI up to two orders of magnitude for 3-‐6 months M Van ... risk assessment of environmental matrices Aspects reduced bioavailability, environmental fate and transport not in present REP/TEF studies evaluated Mixtures of PCDDs, PCDFs...
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Characterization of CMX 13 and evaluation of efficacy and mechanisms of action in animal model of autoimmunity
Ngày tải lên :
12/09/2015, 09:55
... bioassay-guided fractionation of CMX-13’ RP-HPLC Chromatogram of CMX-13’ RP-HPLC Chromatogram of CMX-13 Immunosuppression of PHA+PBMCs by subfractions of CMX-13 after RP-HPLC RP-HPLC Chromatogram of CMX-13-1 ... severity of the autoimmune disease increased with the age of the mice, with the majority of the untreated and DMSO control mice dying of renal failure at 16-24 weeks of age Treatment of the MRL-lpr/lpr ... Immunosupression of PHA+PBMCs by EtOAc EXT Suppression of PHA+PBMCs by Solvent Extracts Bioassay-guided fractionation of CMX-13’ RP- TLC of CMX-13, CMX-13-5 and CMX-13’ Retention times of RP-HPLC isolates...
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Báo cáo y học: "Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells"
Ngày tải lên :
31/10/2012, 15:12
... expression profiles of proteins involved in the mitochondrial (bcl-2, bax, and bcl-x, etc.) and stress reaction-related pathways of apoptosis (Fig 2) Table Altered protein expression of JAR cells ... transfection of Bag-1 Morpho/AS to JAR cells did not alter the expression of PTEN after the exposure to hypoxia, which would mean that the expression of PTEN, and also that of Bcl-X, was independent of ... was calculated according to the formula: DNA fragmentation (-fold of control) = absorbance of drug- treated cells/absorbance of control cells Becton Dickinson PowerBlot In this study, we analyzed...
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Báo cáo y học: "Risk and Benefit of Drug Use During Pregnancy"
Ngày tải lên :
02/11/2012, 11:12
... higher occurrence of one or some CA-groups after the use of the given drug due to the specificity of teratogens Recall bias may act for all CAs similarly Secondly, the use of the drug under study ... factors in the origin of isolated CAs based on polygenic-environmental interaction, i.e multifactorial etiology III Teratogenic risk of drugs is exaggerated The exaggeration of drug teratogenicity ... use of the combination of these two drugs increased the risk for poly/syndactyly six fold [33] Our analyses also demonstrated that it is necessary to differentiate the administrative route of drugs...
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Another Piece of the Action
Ngày tải lên :
06/11/2012, 16:13
... and ADD were just two of the side of effects of the procedures that were performed on him to impress the Kelvan mental map over his developing human brain Great intelligence often came with a price ... time one of them would reproduce the works of Shakespeare Shakespeare was one thing, but two groups of monkeys knocking out a Preamble to the Constitution? Even on Earth the Constitution of the ... high number of humanoid species encountered in such a relatively small part of our galaxy.” He was simultaneously praised by some and denounced by others As one of his examples, he offered the...
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Study on the Photolytic Mechanisms of Red 141 Dye Wastewaters with an 185nm Vacuum-UV lamp
Ngày tải lên :
05/09/2013, 09:08
... related to the formation of high local concentration of hydroxyl radicals (OH.) and a series of other species (Gonzalez and Braun, 1995) within a photochemical reaction zone of less than 0.1 mm (Heit ... vacuum-UV photolysis of water (H2O-VUV) is still a field of active research compared to other AOPs (Oppenlander and Gliese, 2000) The special requirements of the VUV photolysis of water according ... water The solution of Red 141 was added to the reactor with a predetermined amount of H2O2 solution Typical reaction runs lasted 60 minutes At desired time intervals, aliquots of solution were...
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ISOTOPE HYDROGRAPH SEPARATION FOR MODELING OF RUNOFF MECHANISMS OF ATMOSPHERICALLY DERIVED CHEMICAL AND RADIOACTIVE POLLUTANTS
Ngày tải lên :
05/09/2013, 09:08
... mentioned above, the fraction of new water evaluated for the main part of the runoff (0000 of Oct 22 to 1600 of Oct 23, 40 h in total) was found to be as shown in Fig 2c The fraction reached its ... areas It has been reported that the statistical mean of the fraction of new water is 0.23 (i.e 0.77 is the fraction of peak discharge consisting of old water) for 32 forested areas in precipitation ... 22-23 of 2003 The amount of precipitation was 30 mm in total Figure shows the precipitation record of the studied event (Fig 2a) and the record of the river flow rate (solid line, Fig 2b) of the...
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