mechanisms of action of cytokines in the brain
Tài liệu Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in fish pdf
Ngày tải lên :
14/02/2014, 19:20
... at higher levels in testes than ovaries The deep interest in Dmrt1 in the field of sex determination in fish came with the discovery of a dmrt1 homologue on the Y chromosome of the fish medaka (Oryzias ... studied in the context of gonadal induction and maintenance, illuminating its important function But what about the other dmrt genes? Table summarizes the expression pattern of these genes in fish ... the ancestor of Dmrt1bY, is one of the downstream effectors of Sry in the male pathway In medaka, the duplicated copy of dmrt1 has acquired an upstream position in the sex-determining cascade...
- 10
- 860
- 0
Tài liệu Báo cáo khoa học: Roles of the human Rad51 L1 and L2 loops in DNA binding doc
Ngày tải lên :
19/02/2014, 06:20
... alanine If the aromatic side chain is involved in the interaction with DNA, then its replacement with alanine, a short side chain amino acid residue, should affect the DNA binding of the protein ... However, the fluorescence changes of these proteins were almost saturated at bases per monomer of poly(dT), showing that the changes were mainly due to the binding of the first DNA, while the binding of ... that of HsRad51 in the absence of DNA (Figs 2D,E) These results suggest that the Tyr232 residue is within neither the subunit–subunit interface nor the ATP-binding site In contrast to the salt-induced...
- 12
- 662
- 0
Báo cáo khoa học: In vitro analysis of the relationship between endonuclease and maturase activities in the bi-functional doc
Ngày tải lên :
17/03/2014, 10:20
... Each time the splicing reaction was minimally affected by prebinding the DNA to protein As the concentration of protein used, nM, yields a rate of splicing which is about 25% that of the maximal ... release of the cleavage products from the protein The amplitudes of the initial burst (2.78 and 2.83 nM) gave a ratio of DNA/protein of 0.94 : As will be discussed further, these data indicate ... inhibition of the endonuclease reaction [36] In the above experiments, the RNA was prebound to I-AniI before addition of the DNA substrate To determine whether the RNA substrate can inhibit the...
- 12
- 483
- 0
báo cáo hóa học: " Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: a clinical and experimental study in head-injured patients and in a murine model of closed head injury." pot
Ngày tải lên :
19/06/2014, 22:20
... effects of pro-inflammatory mediators, depending on the kinetic of their expression and posttraumatic regulation in the injured brain [3,12,13] However, the TNF-dependent regulation of IL18 in the injured ... corresponds to the time-point of maximal extent of intracerebral inflammation in the model of CHI used in this study [17] For assessment of intracerebral IL-18 levels, the murine brains were immediately ... wavelength of 405 nm The experimental part of the study was set-up on two different protocols with the aim to assess the TNF-dependent regulation of IL-18 in the murine brain: (1) The first part of the...
- 6
- 436
- 0
Báo cáo hóa học: " Research Article Analysis of the Tradeoff between Delay and Source Rate in Multiuser Wireless Systems" docx
Ngày tải lên :
21/06/2014, 11:20
... the computation of the variance of the blocks (the evaluation of the mean of the blocks is straightforward), which comes down to the computation of the expectation E[cu [n]cu [n + m]] The joint ... [m] (63) Like in the BC discipline, only the joint pdf of the last case is needed, as the other three options will result in zero in the expression of E[cu [n]cu [n + m]] This joint pdf is ∗ ∗ ... and the channel conditions (SNR, target BER) are captured in the mean and the variance mu and σu Thus, the evaluation of the user rates comes down to obtaining the mean and the variance of the...
- 13
- 530
- 0
Báo cáo khoa học: "Evaluation of the nuclear DNA content and GC percent in four varieties of Fagus sylvatica L" potx
Ngày tải lên :
08/08/2014, 14:21
... 3.5 %), indicatthat DNA content in the tortuosa variety is the same as in the common beech Furthermore, in replicated analyses of common beech with or without tortuosa, the coefficients of variation ... at the low end of the range of known 2C genome sizes, as for instance Musa acuminata (1.2 pg), Vitis vinifera (1.0 pg) or Phaseolus augustii (1.1pg) [4, 11] The GC content was then determined ... determined for the common beech and the tortuosa variety, after propidium iodide and mithramycin stainings Results are listed in table II In F sylvatica, the GC content was 40.0 ± 0.2 %; in the tortuosa...
- 4
- 330
- 0
Báo cáo lâm nghiệp: " A flow cytometric evaluation of the nuclear DNA content and GC percent in genomes of European oak species" pptx
Ngày tải lên :
08/08/2014, 18:21
... calculation is based on only the first subpopulation of nuclei, the 2C peak, avoiding the higher levels Yet another source of variation can be the in vitro procedure However, the propagation procedure ... selected as an internal standard The Q petraea and Q robur clones originated from donor trees in northeastern France (Lorraine) The Q pubescens donor tree was from the French southern Alps (Provence) ... both intercalating and base specific dyes are used to enable calculation of the AT/GC base composition (= GC%) in a genome The simple technique developed herein could be extended to estimate the...
- 3
- 243
- 0
Báo cáo y học: "Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice" doc
Ngày tải lên :
09/08/2014, 01:24
... important at the induction of MIRP In order to define the infiltrating inflammatory cells in the acute and chronic phases of murine MIRP, we stained tissue sections dissected from cartilage of nasal, ... and the present findings of antibody titers could possibly be explained by the fact that titers at day 35 not reflect the factors that are crucial for the initial triggering of the matrilin-1-induced ... distress in the acute phase, which in two mice had high scores However, the symptoms in these strains did not proceed in relapses as they did in the QD and B10.Q mice, and therefore resulted in a...
- 8
- 540
- 0
Báo cáo y học: " T4 genes in the marine ecosystem: studies of the T4-like cyanophages and their role in marine ecology" doc
Ngày tải lên :
12/08/2014, 02:20
... product of trx is thioredoxin, an important regulatory protein that is essential in the co-ordination of the light-dark reactions of photosynthesis by the activation of a number of enzymes, one of the ... synthesis of the polyamines spermidine and spermine With polyamines implicated in the stabilising the psbA mRNA in the cyanobacterium Synechocystis [64], altering structure of PSII [65] and restoring ... noticeable by their absence is denA, ndd and denB, the products of these genes are all involved in the degradation of host DNA at the start of infection [45] The lack of homologues of these genes...
- 19
- 524
- 0
Báo cáo khoa học: "The influence of the PRKAG3 mutation on glycogen, enzyme activities and fibre types in different skeletal muscles of exercise trained pigs" pot
Ngày tải lên :
12/08/2014, 18:22
... from the intensity of the blue staining (30-50 fibres of each type) into high- if the whole fibre was stained, mediumif some staining was apparent, mostly at the cells borders, or low if there ... semitendinosus in the carriers and the non-carriers of the PRKAG3 mutation are presented in Table The CS activity was higher (P < 0.05) in the carriers of the PRKAG3 mutation than in the non-carriers ... 0.05) in m biceps femoris and m longissimus dorsi in the carriers than in the noncarriers Discussion The main new finding of this study is, that after exercise training the PRKAG3 mutation influences...
- 8
- 263
- 0
Báo cáo y học: " The role of the humoral immune response in the molecular evolution of the envelope C2, V3 and C3 regions in chronically HIV-2 infected patients" pdf
Ngày tải lên :
13/08/2014, 05:21
... is the main driver of the rapid intra-host evolution of the C2 and C3 regions in HIV-2 [15,25,58,60,64-66] Indeed, we found that most of the amino acids under selection are located in C2, including ... below), in the envelope complex of HIV-2 differs substantially from that of HIV-1 Glycans on HIV-1 envelope protein play an important role in the folding of the glycoproteins, in infection and in ... common in HIV-2 than in HIV-1 infection Still, little is known about the role of humoral immunity in the evolution of the HIV-2 env gene In the present study we analyze, for the first time, the...
- 12
- 308
- 0
Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt
Ngày tải lên :
13/08/2014, 15:21
... surrounding brain cells, relaying into the brain inflammatory response and jeopardising the functional integrity of the BBB [55-57] In the present study, we found that, during experimental sepsis, the ... assessment of Evans Blue (EB) extravasation in four animals per experimental condition Briefly, 20 μl of a 2% solution of EB in saline was injected into the tail vein one hour before harvesting of brains ... tightly regulating the passage of molecules into and out of the brain to protect the brain from microorganisms and neurotoxic substances During sepsis, however, blood-borne proinflammatory mediators...
- 9
- 312
- 0
Báo cáo y học: "Endothelial Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients" potx
Ngày tải lên :
14/08/2014, 07:21
... tissue invasion in malignant diseases by converting plasminogen into plasmin, resulting in degradation of extracellular matrix [1-4] Migration of inflammatory cells from the blood stream into tissues ... http://ccforum.com/content/15/1/R63 Page of 14 (Figure 3a,b) These data indicated that the elevation of suPAR levels in ICU patients remain rather stable within the first week of intensive care treatment measures ... analyses, including markers of inflammation/infection (CRP, PCT), hepatic (albumin, international normalized ratio (INR)) and renal (creatinine) function at admission, suPAR remained an independent...
- 14
- 292
- 0
In this paper, we investigate the relationship between migration and species distribution in multizone environment. We present a discrete model for migration of three competing species over three zones. We prove that the migration tactics of species leads
Ngày tải lên :
16/10/2015, 09:09
... cases, the simulation is performed on processors and the initial paths are in black while the correction step is in dotted red lines of the simulation For instance in the left part of Fig 1, the ... We compute S the sum of the probability of the events occurring in the subtrees Now, we change the initial step of the simulation When we draw the random number, we check if un < S In that case ... set of parallel simulations for the inconsistent parts using the new point as a starting point of the next run on logical process LPi+1 These new runs are performed with the same sequence of...
- 8
- 292
- 0
The u s presidency and executive power in the works of thomas pynchon, philip roth and cormac mccarthy
Ngày tải lên :
08/11/2015, 00:06
... and binding it together in grief and inspiration after their death This ideal of the presidency arose, as McCann outlines, from the general weakness of the office in the latter half of the nineteenth ... unreliable The last section of The Counterforce’, the final part of Gravity’s Rainbow, collapses the preceding narrative of the novel as the text disintegrates Bleeding Edge plays with conspiracy theories ... discussed the presence of the Cold War in the Border Trilogy and The Road, and the influences of both the Reagan and Clinton administrations on McCarthy’s fiction Other critics have interrogated the...
- 245
- 438
- 0
Sumary: The difference of the culture between Vietnam and US (lesson in the university)
Ngày tải lên :
29/02/2016, 14:27
... time to introduce the neighbor many things, many places (going shopping, doing everything together) Then they less contact because they think you need independence Sometime the friend send the email ... presents from the wedding or anniversaries like cake or fruit as the thanks of yours - Acquaintances When acquaintances meet together in the street, they often smile together if they are at the same ... days, the family stops bringing rice for the dead to the altar And finally, after 100 days, the family celebrates, or the end of the tears After one year is the ceremony of the first anniversary of...
- 11
- 396
- 4
Construing the world: conceptual metaphors and event-construal in news stories potx
Ngày tải lên :
07/03/2014, 17:20
... focus on the metaphorical style of literary texts) as well as with Lakoff (1992), while differing from these studies in broadening the focus to an examination of the interaction of linguistic ... with the mission of finding whether the government's treatment of Dr Kelly contributed to his death The hearings, now beginning their fourth week, have broadened their focus to examine the whole ... heart As in the other texts, the headline here works as an encapsulation of the event-construal of the news story.23 The news story’s focus on the participants’ emotions is indicated in the text...
- 27
- 558
- 0
Báo cáo khoa học: The calpain 1–a-actinin interaction Resting complex between the calcium-dependant protease and its target in cytoskeleton doc
Ngày tải lên :
07/03/2014, 21:20
... to interact with Calp1 This indicates the presence of a calpain binding site in the C-terminal domain of smooth muscle a-actinin Involvement of the C-terminal domain of ask in Calp1 binding In ... binding site is included in the C-terminal domain of the ask molecule, and this binding is independent of the susceptibility of the a-actinin isoform to calpain proteolysis Identification of the ... to the origin of interactions [9,10,12,27] with the targets, the stability of complexes in the resting stage [3,48] and the activation state [7,33] of the binding calpain The topology of the interface...
- 9
- 334
- 0
Báo cáo khoa học: "INTEGRATING TEACHING THE ENGLISH TENSE: NAIVE AND FORMAL GRAMMARS IN AN INTELLIGENT TUTOR FOR FOREIGN LANGUAGE TEACHING" pdf
Ngày tải lên :
18/03/2014, 02:20
... underlying the choice and conjugation of an English verb tense One of the main concerns in designing the knowledge base for this module has been that of maintaining the wealth of ideas and intuitions ... adoption of the naive 151 , finally (ternary tense) the past The name for a tense combination in the systemic approach is determined by considering the inverted order of the choices: in our case the ... completed)) By the end of next month I shall have finished my thesis the speaking time is now, the event time is given by the time interval associated with the action to finish the thesis and the reference...
- 6
- 406
- 2