mechanism based approaches to the evaluation of drug drug interactions

... matching of protein spots first to reference gels of the same condition and thereafter to reference gels common to both conditions The stepwise annotation of protein spots to two independent levels of ... (Fig 1) The four level match-sets are the reference gels of the respective quadrants from the 2D gel sections of each condition and the four higher-level match-sets are the reference gels of the ... the major role of the MMP family is the control of cellular responses critical to homeostatic regulation of the extracellular environment and the immune response [19,20] We decided to apply protease...

Ngày tải lên: 07/03/2014, 06:20

... SVCs: the series of V1 to V3 and the series of V4 to V5 , because they not share their tenses The directional verb p©j ‘go’ performs as an adverb identi— fying the outward direction of the action ... into the following productions (34) → Whereby restricting the power of the gapresolution connective, the two stacks of the daughters are shared but not with their mother An interesting trait of ... (subject or object) of arbitrary np’s in (13) from the directionality (the subject on the left and the object on the right) With these reasons, I therefore adapted the notions of MICG’s memory modalities...

Ngày tải lên: 08/03/2014, 21:20

... R5 to 2.5 V on the input of the ADC (the maximum input voltage of ADC4 of the MSP430) 5.2 Environment Emulator: Software We already know that the capacitance (stated in terms of the amount of ... emulator We measure the current consumed by the DUT, and we set the output voltage The characteristics of the energy harvester and the storage element are implemented in software Figure is the ... part of the EE On the EE we connected VDD (voltage drain drain) to the USB power of the board The ADC (analog -to- digital converter) and DAC (digital -to- analog converter) lines are connected to...

Ngày tải lên: 21/06/2014, 11:20

... sensitivity to Ca2+ [29, 30] The initial release occurs in the vicinity of the plasma membrane It spreads into the cell through the regenerative release of Ca2+ by the RyR and /or the IP3R in the form of ... RyR to produce sparks, but provides the necessary amount of Ca2+ to charge up the ER and sensitize the RyR [52] Another way of internal store reloading is achieved by the various isoforms of the ... representing the position of the particle, were also taken to represent the position of the myosin head The position of the myosin head, determined by the above method, was compared between the two...

Ngày tải lên: 28/06/2014, 15:20

... further evidence of the potential beneficial effects of these type of compounds in the treatment of inflammatory diseases of the airways Anticholinergics In two poster presentations Dr A Anzueto ... extracellular proteolysis These effects also support the use of the compound in the treatment of COPD Kinase inhibitors A new addition to the PDE4 inhibitor field is Roflumilast, a potent and ... characterisation of a model of elastase-induced emphysema in the mouse This model may be of great use to the many groups now seeking to study and develop drugs for the treatment of COPD Dr DC Underwood...

Ngày tải lên: 12/08/2014, 18:20

Ngày tải lên: 13/11/2014, 10:08

... Section 2.2.2 NATIONAL UNIVERSITY OF SINGAPORE SINGAPORE 1.5 Organization of the Thesis 24 1.5 Organization of the Thesis The following highlights the contents of each of the remaining chapters Chapter ... by (1.6) has to be reformulated to take into account: (i) the effect of w(t) and (ii) the interpretations of constraints (1.6d) and (1.6e) in the presence of w(t) For the control of system (1.10), ... priori in the parametrization, one method of designing this feedback gain is introduced to control the asymptotic behavior of the closed-loop system The underlying idea of the method is that the support...

Ngày tải lên: 11/09/2015, 14:29

... and the condition of the accuracy of the approximation is given 1.3 Objectives and Scope of the Thesis This thesis attempts to improve and characterize several issues of MPC control law: the ... chosen to provide a large XN via the use of a short N The size of X f depends on the choice of K Similarly, K affects the size of F∞ from (2.32) for a fixed W Hence, the choice of K is a trade-off ... be computed off-line, the on-line work at time t is simplified to the identification of the polytope CR j which x(t) belongs to and then the computation of c∗ (t) from (3.21) Note that the on-line...

Ngày tải lên: 11/09/2015, 14:29

... mechanism may exist to facilitate the viral replication These findings would stimulate further investigation to unveil the regulatory mechanisms that honey bees use to control the pattern of replication ... to RT-PCR to assess the sensitivity of the assay A) Amplification plots were generated by using seven serial dilutions of the RNA, ranging from 103 pg to fg per reaction as the template for the ... transmission of DWV and suggested that the lining of the digestive tract was likely the primary site of the DWV infection via food-borne transmission, with the virus spreading to secondary sites from the...

Ngày tải lên: 20/12/2015, 08:30

... provider’s topology from the customer’s perspective The customer is aware of the core due to the information he received regarding the VCs, but has no other knowledge The same ideals apply to customer ... with the CE routers there are mechanisms in place to limit the impact of DoS attacks to the VPN where they originated Which equates to the way these attacks are handled in Frame-Relay and ATM based ... able to handle this by some of the methods already addressed in previous sections As the provider only tells the customer about VCs there is a lack of places to attack Also due to the fact they...

Ngày tải lên: 21/12/2013, 19:15

... with the nt sequence of the open reading frame (ORF) of their cDNAs and the corresponding aa sequences, in Table Summary of the purification of DNases I from the pancreases of three species of snake ... corresponding to the nt sequences of the cDNA from positions 28–48 and 867–885, respectively The amplified fragment was ligated into the pcDNA3.1 (+) vector (Invitrogen) to construct the expression vector ... cloned the cDNA of each A single amino acid (aa) substitution was confirmed to affect the thermal stabilities of vertebrate DNases I and, furthermore, one of the postulated mechanisms whereby thermal...

Ngày tải lên: 20/02/2014, 23:20

... In the absence of a clinical evaluation, a simulator was developed to simulate 70 days of data and test the ability of the system to store large amounts of data and to manipulate these data to ... including the requirement to identify the monitored subject from others in the home (Biometrics signature), IR conflicts and the inability to monitor the subject outside of the home environment Monitoring ... have the ability to identify the monitored subject, and distinguish between their location and the location of others if the monitored person is living with others or regularly receives visitors...

Ngày tải lên: 05/03/2014, 21:20

... various steps in the cytotoxic activity of the drug, from a decrease of drug accumulation in the cell to abrogation of apoptosis induced by the chemical substance Often several different mechanisms ... release of these drugs (ADR and VCR) [5] PrPC-mediated multidrug resistance (MDR) was thought to be related to upregulation of P-glycoprotein (P-gp) [6] and inhibition of apoptosis [6–9]; these ... 25% of the tumor cells exhibiting IR; 2, 25–50% of the tumor cells exhibiting IR; 3, 50–75% of the tumor cells exhibiting IR; 4, > 75% of the tumor cells exhibiting IR The overall score was the...

Ngày tải lên: 07/03/2014, 03:20

... boundaries, off to the syntactic parser The f'n'st task is to find the prosodic constituents, i.e to find where the syllables are, where the feet ~ are, and where the prosodic words are The particular ... number of clitics which are suffixes as far as the phonology is concerned (i.e., they undergo Vowel Harmony with the word to which they attach) are separate words from the point of view of the syntax ... suffixation of an affix to a prescribed prosodic subconstitucnt of a word rather than to the whole word 2.2 The Non.Isomorphism of Morphophonology and Morphosyntax Another fundamental property of morphology...

Ngày tải lên: 08/03/2014, 18:20

... 3, cf Luhn (1958)) Then, the weight of each cluster is calculated by dividing the square of the number of significant words in the cluster by the total number of words in the cluster Sentences ... a Satellite (Marcu (2000)) The Nucleus is the equivalent of the arc destination, and the Satellite is the equivalent of the arc origin in the non-treebased approach The symmetrical or undirected ... other sentences relate to them (Sparck-Jones (1993)) The first method consists of simply determining the in-degree of each node in the graph A node represents a sentence, and the in-degree of...

Ngày tải lên: 17/03/2014, 06:20

... as DFMO retards the growth of the pancreas [101], but does not inhibit the secretory function of the exocrine part of the organ [102] The cellular functions of the polyamines in the pancreas were ... protocol A plausible explanation for the failure to inhibit tumorigenesis is the competition of the mutant ODC for the binding of the antizyme and releasing the wild-type enzyme [52] The mechanisms ... SSAT The apparent synergism between the polymorphism of the ODC gene and the use of aspirin was proposed to be a combined result of an inhibition of polyamine biosynthesis and an activation of their...

Ngày tải lên: 30/03/2014, 13:20

... whereas in the sentence “They arrived to the town” the preposition to is a confusion error (cf arrived in the town) Most work on automated correction of preposition errors, with the exception of Gamon ... sentences and removed them 510 N Mw = i N FPw = i In the above equations, N is the total number of instances, ci is the class (1 or 0) , and pi sys crowd indicates the proportion of the crowd that classified ... English speakers They were asked to annotate the preposition usage instance as one of the following: extraneous (Error), not extraneous (OK) or too hard to decide (Unknown); the last category...

Ngày tải lên: 30/03/2014, 21:20

... not easy to conceive of Ireland, Denmark, and Russia without potatoes However, both tomatoes and potatoes are of New World origin (figure 1.1) At the time of their introduction into the Old World, ... lineages to be placed sister to the wild progenitor populations Evolutionary History of the Domesticated Sunflower 37 from which they were derived, and this is not the case On the other hand, given the ... accept these crops because they were similar to local poisonous plants (deadly nightshades), they were thought to cause disease (under the Doctrine of Signatures the swollen tubers of potato were...

Ngày tải lên: 03/04/2014, 12:10

... shown to be the reason for up to 75% of drug switches for toxicity within the first three years of first-line HAART [21] In South Africa, there is an ongoing debate about whether or not the side-effect ... shown to impact negatively on both physical and mental HRQoL [10,31] However, the nature of the symptoms and whether they were attributed to the disease process or to HAART was not clear In the ... Limitations to the study included possible selection bias and information bias related to the use of the MOS-SF36 instrument The loss of up to 50% of patients, who had incomplete HRQoL data, from the...

Ngày tải lên: 20/06/2014, 08:20

... and the warm familiarity of history -of the Jazz Age, of the Great Depression, of Reaganomics, and so on Third, I would like to extend the good luck of past generations to those of the present The ... nobles, and tithes, a strict tenth of the gross produce of the peasants down to the potherbs in their gardens and two shillings in the pound from the personal earnings of the expanding class of shopkeepers ... unable to know the place of economics within the broader community of INTRODUCTION ideas, much less be able to explain it to the uninitiated We will be unable to engage in the rhetoric of the intellect...

Ngày tải lên: 28/06/2014, 09:20