measuring the integrity of the human blood brain barrier using magnetic resonance imaging
Báo cáo y học: "The association between patellar alignment on magnetic resonance imaging and radiographic manifestations of knee osteoarthritis" ppsx
Ngày tải lên :
09/08/2014, 10:20
... Biomechanics of the patello-femoral joint Part II: A study of the effect of simulated femoro-tibial varus deformity on the congruity of the patellofemoral compartment and movement of the patella ... measurements of patellar alignment we found the axial slice that refers to the middle of the patella by using the three-dimensional cursor on the sagittal image LPTA is the angle between the posterior ... indicates the lateral displacement of the patella in relation to deepest part of the femoral sulcus LPTA shows the angle of patellar inclination, which indicates the tightness or looseness of the lateral...
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The application of electromagnetic theory in microwave therapy and magnetic resonance imaging
Ngày tải lên :
09/09/2015, 10:20
... is the gyromagnetic ratio of the nucleus and it expresses the relationship between the angular momentum and the magnetic moment of each MR active nucleus Therefore, the principle behind the ... among the coil elements in the array 1.3 Thesis Organization The work of this thesis covers two aspects One is on the application of microwave to cancer therapy, and the objective is to study the ... 31 In (2.17) the average of over each segment has been approximated by the value of at the centroid of the respective segment, that is, the center of the segment as it is even Therefore, we...
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báo cáo hóa học: " Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF" potx
Ngày tải lên :
19/06/2014, 22:20
... Permeability of blood- brain barrier to various sized molecules Am J Physiology 1985, 248:H712-H718 Chou S, Dix RD: Viral infections and the blood- brain barrier In Implications of the Blood- Brain Barrier ... turn, act at the luminal surface of the BMEC to enhance the transcellular transport of HIV-1 independently of actions on paracellular permeability Keywords: Blood- brain barrier; Human immunodeficiency ... Oosten M, de Boer AG, van Berkel TJC, Breimer DD, Kuiper J: The influence of cytokines on the integrity of the blood- brain barrier Journal of Neuroimmunology 1996, 64:37-43 Farkas G, Marton J, Nagy...
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Báo cáo y học: "Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis" ppt
Ngày tải lên :
13/08/2014, 15:21
... J: The influence of cytokines on the integrity of the blood- brain barrier in vitro J Neuroimmunol 1996, 64:37-43 55 Papadopoulos MC, Davies DC, Moss RF, Tighe D, Bennett ED: Pathophysiology of ... Under physiological conditions, the BBB maintains the cerebral micro-environment by tightly regulating the passage of molecules into and out of the brain to protect the brain from microorganisms and ... into the brain inflammatory response and jeopardising the functional integrity of the BBB [55-57] In the present study, we found that, during experimental sepsis, the antibody-mediated blockade of...
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Báo cáo y học: "Genomic linkage map of the human blood fluke Schistosoma mansoni" doc
Ngày tải lên :
14/08/2014, 21:20
... further assembly [13] Importantly, the largest 280 scaffolds comprise more than 70% of the 381 Mb in version 3.1 of the genome assembly; by placing markers in these scaffolds the majority of the ... cM) of the total genetic map length The genome assembly will benefit from the broad coverage of the map, high density of markers, and placement of previously unanchored and unordered scaffolds The ... accession numbers Blue lines show the scaffolds that match the DNA sequences of these genes in BLAST searches These six genes add further support to the anchoring of the LG3, LG4, and LG7 to chromosomes...
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Application of biologically active micelles in drug delivery across the blood brain barrier
Ngày tải lên :
11/09/2015, 09:10
... although 12% of all drugs are active in the CNS, only 8% of them are active in the brain for the treatment of diseases or disorders (Lipinski, 2000) The BBB lies between the blood flow and the brain ... in the central nervous system (CNS) is to overcome the barrier preventing the drugs moving from blood circulation into the brain parenchyma The limited penetration of drugs through the blood brain ... parenchyma The blood brain barrier (BBB) lies between the blood flow and the brain parenchyma The BBB prohibits most foreign molecules entering from the blood to brain, including CNS drugs The limited...
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Nanoparticles of biodegradable polymers for delivery of therapeutic agents and diagnostic sensitizers to cross the blood brain barrier (BBB) for chemotherapy and MRI of the brain
Ngày tải lên :
26/11/2015, 22:48
... History and Anatomy of the Blood Brain Barrier 1.1.2 Functions of the Blood Brain Barrier 1.1.3 Clinical Significance of the Blood Brain Barrier 1.2 METHODS TO OVERCOME THE BLOOD BRAIN BARRIER 1.3 NANOPARTICLES ... the presence of glutathione, likely via cotransport, is required [13] 1.1.2 Functions of the Blood Brain Barrier The main function of the blood brain barrier is to protect the brain The BBB serves ... presence of an intact blood brain barrier at the proliferating edge of the tumor has been suggested to be one of the major contributing factors to the failure of chemotherapy in the treatment of central...
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the blood – brain barrier
Ngày tải lên :
11/04/2014, 10:34
... through the diaphragm and the costal cartilages left of the sternum up to the level of the clavicle A transverse cut is made in the diaphragm The heart is then grasped using the index and thumb of the ... junctions of the blood- brain barrier Cell Mol Neurobiol 20, 57–74 68 Brightman, M W., and Tao-Cheng, J H (1993) Tight junctions of brain endothelium and epithelium In The Blood- Brain Barrier Cellular ... scale in the eyepiece of a light microscope and measure the length of the block using a 3.5X objective If division of the eyepiece scale is equal to 34.5 µm, then 8.5 divisions of the top of the block...
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Báo cáo y học: "Genetics and genomics converge on the human blood fluke" potx
Ngày tải lên :
14/08/2014, 21:20
... cercariae can then be used to infect a hamster, in which they develop into adult worms (Figure 1) The sex of the parasite is determined before the cercarial stage, so the sex of all the cercariae ... identification of the genes responsible will provide molecular insight into the biology of the parasite, the immune response it evokes, pathogenesis and mechanisms of drug resistance Particular examples of ... in order to span the whole length Data on the progeny genotypes were then assembled into linkage groups using the JOINMAP software [12], and gave eight major linkage groups (97% of markers) with...
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Cardiovascular magnetic resonance imaging in the assesment of myocardial blood flow, viability, and diffuse fibrosis in congenital and acquired heart disease
Ngày tải lên :
20/05/2016, 20:50
... Cardiovascular Magnetic Resonance Imaging (CMR) a) History of Magnetic Resonance Imaging and the Development of CMR In 1946, Felix Bloch and Edward Purcell discovered the nuclear magnetic resonance ... parameter: The race of change of the SI in LV cavity and myocardial tissue during the first pass of contrast agent b) Time to peak: The time from the onset of contrast enhancement (the foot of the SI ... for the fact that the R1 in blood changes due to the addition of contrast in the partial volume which excludes red blood cells The hematocrit values around weeks before or after the time of the...
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Báo cáo hóa học: " Adenoviruses with an avb integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastases" pdf
Ngày tải lên :
18/06/2014, 16:20
... is achieved with adenoviruses with RGD moieties in the HI loop of the fiber or in the KKTK domain of the fiber [30] Furthermore, mutation of the KKTK domain ablated binding to HSPGs and led to ... models and whether it can be applied in humans where the immune system makes the life of an adenovirus much tougher, requires further study RGD modification in the KKTK domain of the fiber shaft ... specificity of these viruses before testing these constructs in humans In this study, the feasibility of using MRI analysis for following tumor growth was evaluated From an ethical point of view,...
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báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
Ngày tải lên :
19/06/2014, 22:20
... whether the effect of AEA on the adhesion of leukocytes interferes on leukocyte transmigration through the BBB model As expected TMEV-infection of brain endothelial cells increased the number of ... phenol-red-free DMEM the top and the bottom of the filter, 400 μl of 10% FBS/phenolred-free DMEM and 200 μl of 0.45% albumin conjugated to Evan’s blue dye were added to the bottom and the top of the well, ... immunohistochemistry, in the brains of sham animals in both type of mice, Cnr1+/+ or Cnr1-/- The intracranial injection of TMEV induced the expression of VCAM-1 in the ipsilateral cerebral cortex surrounding blood...
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Báo cáo y học: "Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic change" pps
Ngày tải lên :
09/08/2014, 07:20
... radiological evidence of OA of the affected knee on a radiograph obtained within six months of the outset of the study Finally, patients had to have a minimum JSW of the medial compartment of between and ... seen, either between the level of the biomarker and the loss of cartilage volume assessed by qMRI (global, medial, and lateral compartments), or between the level of the biomarker and the changes ... to the JSW measurement obtained from each radiograph Each of the radiographs measured the minimum JSW in the medial compartment using the automated computerized method of measurement [21] In the...
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Báo cáo y học: "Magnetic resonance imaging in psoriatic arthritis: a review of the literature" pdf
Ngày tải lên :
09/08/2014, 07:20
... example of bone oedema from a patient with the mutilans form of PsA There is extensive bone oedema involving the head of the proximal phalanx and extending down the shaft of the bone On the distal ... coworkers [41] described the MRI features of enthesitis as being characterized by ‘swelling [of the entheseal region] and deviation from the normally uniform low signal intensity of tendons and ligaments, ... arrow) There is also diffuse bone oedema (short thin arrows) involving the head of the proximal phalanx and extending distally down the shaft capsular fluid/oedema’ in entheseal portions of the...
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Báo cáo y học: "Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis" potx
Ngày tải lên :
09/08/2014, 08:22
... In two of the patients in whom zygapophyseal joints were MRI-negative, signs of osteitis were seen at other sites of the spine: in the vertebral bodies of thoracic vertebrae 11 and 12 of patient ... vertebra of the lumbar spine; Th, vertebra of the thoracic spine Results Mononuclear cell infiltration We summarize the results of a semi-quantitative analysis of mononuclear cell infiltration in the ... cytoreductive therapy in chronic idiopathic myelofibrosis [14] (Figure 1b; red arrows, edema; black arrow, vacuoles of fat cells) The relative amount of edema, calculated as the percentage of the total...
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Báo cáo y học: "Risk factors associated with the loss of cartilage volume on weight-bearing areas in knee osteoarthritis patients assessed by quantitative magnetic resonance imaging: a longitudinal study" pot
Ngày tải lên :
09/08/2014, 10:20
... width data The analyses focused first on MRI data from the central areas of the medial compartment as they presented the greatest loss of cartilage volume and were therefore the areas of the most ... topographical loss of cartilage in the different subregions of the knee and the associated risk factors Moreover, the impact of the location and rate of cartilage loss on the evolution of OA symptoms ... time as the disease progressed The relationship between the worsening in the WOMAC scores with the loss of cartilage on the central portion of the tibial plateau is intriguing The level of significance...
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Báo cáo y học: "What magnetic resonance imaging has told us about the pathogenesis of rheumatoid arthritis - the first 50 years" doc
Ngày tải lên :
09/08/2014, 13:22
... events leading to bone erosion The advent of magnetic resonance imaging (MRI) in early rheumatoid arthritis (RA) allows the demonstration of the early appearance of MRI bone oedema, histologically ... undertaking molecular imaging in vivo in humans The power of imaging to probe beyond the anatomical basis for RA and progressively delve The Scientific Basis of Rheumatology: A Decade of Progress This ... prevented used, including the quantitative measurement of synovitis by the evaluation of its thickness in millimetres, calculation of the volume of a given slice, or estimating the entire joint volume...
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báo cáo khoa học: "Contribution of magnetic resonance imaging in the diagnosis of talus skip metastases of Ewing’s sarcoma of the calcaneus in a child: a case report" pdf
Ngày tải lên :
10/08/2014, 23:20
... Jalal et al.: Contribution of magnetic resonance imaging in the diagnosis of talus skip metastases of Ewing’s sarcoma of the calcaneus in a child: a case report Journal of Medical Case Reports 2011 ... from the father of our patient for publication of this case report and any accompanying images A copy of the written consent is available for review by the Editor-in-Chief of this journal Page of ... osteosarcoma, and the distinction often requires extensive evaluation using varied imaging modalities [7] CT can reveal a soft-tissue mass of the foot, such as permeative lytic lesions of the bone with...
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