maturation for the protective properties of the pellicle

... is needed for facilitating the prediction of BBB- agents as well as for reducing the false positive rate of the prediction of BBB+ agents It is therefore of interest to examine whether proper ... for the training set The remaining compounds for the training set were selected by maximizing the minimum distance between the compounds in the training set and the rest of the compounds in the ... particular, the model of ER agonists was the focus of the sutdy The capability of the most widely used SLMs for predicting ER agonists by using a significantly larger number and more diverse range of...

Ngày tải lên: 14/09/2015, 12:43

... compounds of interest in the prevention of colon cancer In the present study, we investigated the relationship of different structural factors of procyanidins, such as the mean degree of polymerization ... However, the development of effective and safe agents for the prevention and treatment of cancer remains inefficient and costly, and falls short of the requirements for primary prevention among the ... assay The culture was incubated for 72 h in the absence or presence of the polyphenolic mixture at its respective IC50 values The cells were then trypsinized, pelleted by centrifugation [371 g for...

Ngày tải lên: 07/03/2014, 05:20

... disposition of the proximal His and Asp residues, affecting the imidazolate character of the His, but also by the formation of a LS species The latter indicating the probable binding of His42 to the ... consistent with the very subtle nature of the mutation, i.e the loss of a single methyl group, depicted in green in Fig In marked contrast, for the reduced state comparison of the RR spectra of the Thr171Ser ... impact on the properties of His170 The strength of the hydrogen bond between the proximal His and Asp residues, and thus the imidazolate character of the His is expected to modulate not only the strength...

Ngày tải lên: 07/03/2014, 21:20

... and chin, then stretch the bands over your head and secure them comfortably as shown; one band on the upper back of your head, the other below the ears at the base of the neck Adjust the mask ... a gown, first select the appropriate type for the task and the right size for you The opening of the gown should be in the back; secure the gown at the neck and waist If the gown is too small ... away from the shoulders Slip the fingers of one hand under the cuff of the opposite arm Pull the hand into the sleeve, grasping the gown from inside Reach across and push the sleeve off the opposite...

Ngày tải lên: 08/03/2014, 13:20

... N-terminus of the H-protein In conclusion, the substrate properties of the alternatively encoded Flaveria H-protein FtGLDHAA in the P-protein reaction of GDC differ significantly from those of the normal ... metabolism I Properties of the system catalyzing the exchange of bicarbonate with the carboxyl-group of glycine in Peptococcus glycinophilus J Biol Chem 241, 197–205 21 Hiraga K & Kikuchi G (1980) The ... criteria of integrity Methods Enzymol 148, 403–420 32 Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein–dye...

Ngày tải lên: 23/03/2014, 04:20

... dilution in mL of 20 mm Tris ⁄ HCl buffer pH 7.8 The HNE molecules specifically interacting with the binding sites of the two OBP forms were then displaced by the addition of a large excess of the OBP ... Evaluation of the third hypothesis, the molecular basis of which is described above, is the aim of this study Here, we report the binding properties, chemical modification and chemical resistance of recombinant ... acidic residues) compared with the porcine form (8.3%) [12], and because of their spatial arrangement in the 3D structure of the proteins (see below) The functionality of these HNE chemically modified...

Ngày tải lên: 23/03/2014, 10:20

... is the angle between the projection of the tilt of the z axis on the xÂ, y plane (dened direction of tilt of z and the x axis), and j % a + c denes the location of the rhombic (x, y) axes The ... The two structures of WT metHb and rWT metHbH2O, exhibit signicant differences in the interaction of the FG loop with the heme and in the position of the B-helix, with Tyr32(B10) closer to the ... 10 in the direction of the 5-H position The rhombic axes are dened by j % 50 in Fig The difference in the overall shift dispersion pattern of Pe metHbCN relative to, for example, any of the mammalian...

Ngày tải lên: 23/03/2014, 17:22

... suggests that cathepsin K is a new member of the kininase family Both the kininogenase activity of cathepsin L and/or the kininase activity of cathepsin K may be favored by the generation of an acidic ... especially for cathepsin L, than for hK1, but were identical for the four enzymes towards C-BK peptide ( lM) The similar affinity pattern for all peptides indicates that the differences in the variation ... 2A), was used for further analysis of kininogen processing by CP For the sake of homogeneity with N-BK and C-BK peptides, the donor/acceptor pair was kept at the N- and C-terminal part of BK-peptide...

Ngày tải lên: 31/03/2014, 07:20

... resulting from the technological process The scope of the research presented covers part of the research carried out under earlier works of the authors The scope of the research encompassed: • the development ... discussion The first stage of the research carried out was the determination of the factors that influence the properties of the aluminium phosphate binder The applied technological procedures for binder ... applied for the protection of water walls of pulverized-fuel power boilers The developed variants of the production technology of coatings of the required utilitarian properties take into account the...

Ngày tải lên: 30/05/2014, 12:08

... infiltrated the CNS of the TLR3KO-B6 mice were similar to those of the B6 mice at dpi (Fig 1B) However, the levels of these cells in the CNS of TLR3KO-B6 mice were significantly higher than those of control ... mechanisms for the increase are unknown, elevated levels of cytokines in the CNS of mice with high viral loads favoring the generation of FoxP3+ CD4+ T cells may contribute to the increase of the regulatory ... of H-2Ks-VP3159-166-tetramer reactive CD8+ T cells in the CNS of TLR3KO mice was also similar to that of the NLM mice at the early stage (7 dpi) of infection, indicating the similarities in the...

Ngày tải lên: 19/06/2014, 22:20

... failure) minimum of 0.70 and three exceeded the preferred value of 0.80 (Table 2) Multi-trait scaling analyses supported the grouping of items into dimensions for 26 of the 36 items as their corrected ... quality as well as general support for the psychometric properties of the DCGM-37 when used in children undergoing treatment for cancer However the dimensionality of the instrument is uncertain which ... doubtful about the future However, after completing the questionnaire together, some parents expressed appreciation over the way the instrument opened up for deeper conversation with their offspring...

Ngày tải lên: 20/06/2014, 16:20

... gain insight into the mechanisms of these drugs on the OA subchondral bone osteoblasts, we further studied the effect of the therapeutic concentration of these drugs, 20 μg/mL, on the major intracellular ... different levels, by limiting the extent of the type I collagen degradation as well as the resorptive activity of the subchondral bone The role of cathepsin K in the remodelling of this tissue has been ... reached for rhein IL-1β also markedly increased the SAPK/JNK (p46 and p54), particularly the level of the p46 isoforms Diacerein and rhein, however, had no effect on the activation level of either...

Ngày tải lên: 09/08/2014, 10:23

... to other ethnic groups and in other countries Nonetheless, the sample used for the study and the attendant analyses of the CCBQ data should provide a good launching point for future tests of the ... supported by the National Bureau of Controlled Drugs, Department of Health, Taiwan (grant number: DOH97-NNB-1044) The authors thank the participants and the staffs of the methadone clinics for their ... (approximately 3USD) for their participation Page of In order to prevent contamination of the original study sample, the test-retest reliability of the CCBQ, additional sample of 51 methadone patients...

Ngày tải lên: 11/08/2014, 16:23

... their content to the ICF and to appraise the currently available evidence of the quality of their measurement properties in order to offer recommendations for the use of PF scales for various purposes ... assessing the functioning of specific limbs or joints The 51 studies identified by the main search that examined the measurement properties of the original language version of one of the 26 retained ... subscales consist of only items or because the response format is often yes/no Therefore we would not recommend it for use or for further testing The CSHQ-RA and ROAD are among the most recently...

Ngày tải lên: 12/08/2014, 00:20

... that each set of items formed only one factor; therefore only a single score was generated for each of these domains Items from the Perceptions of Insulin Therapy domain formed two distinct factors, ... and the other negatively worded items Because of the lack of substantive meaning for the separate factors, only a single composite scale was generated Items from the Inhaler Performance domain formed ... administrations Three of the eight tests of change in means were significant (Perceptions of Insulin Therapy and Treatment Preference for type and Diabetes Worries for type 2), but the size of the change...

Ngày tải lên: 12/08/2014, 01:21

... and SIV mutants containing the corresponding residues of the opposite virus Obvious differences were the identities of the residues at the P2 and P1 positions; we therefore created an HIV-1 mutant ... assayed for infection of P4-CCR5 indicator cells Infectivity was calculated after normalizing for the RT content of the SIV inocula Values shown are normalized against the infectivity of the vehicle-treated ... the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to DSB The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to DSB Viruses...

Ngày tải lên: 13/08/2014, 13:20

... diagnosis of depression was computed as the quotient of the cases classified as depression by both of the measures applied and the number of cases classified as depression by either of the measure ... On the validity of the Beck Depression Inventory A review Psychopathology 1998, 31:160-168 Hojat M, Shapurian R, Mehryar AH: Psychometric properties of a Persian version of the short form of the ... were included in the study if they were in the 11 grade (to avoid the symptoms of depression due to educational stress of appearing for board examination in the 10th as well as the 12th grades),...

Ngày tải lên: 13/08/2014, 18:21

... when the adult version of the SPSQ was developed [32] The cut-off used is the closest to adhere to the DSMIV definition of social phobia A paper and pencil format of the SPSQ-C was used The instrument ... discussion of the design and in the preparation of the ms CGS supervised the design and execution of the study and made contributions to the ms.GA supervised the design and execution of the study ... adopted for the evaluation of validity The procedure of a case-control study starts with the selection of known cases and then an appropriate number of controls are selected [41] One week after the...

Ngày tải lên: 13/08/2014, 18:21

... porous or nonporous, the gas transport mechanisms vary from one to another The former is for the separation of gases on the basis of their molecular size through the small pores in the membrane matrix, ... accurately estimate the outer-layer thickness and demonstrate the existence of the multilayered structure of the dual-layer hollow fiber membranes The success in the formation of defect-free hollow ... TAILORING THE PROPERTIES OF GLASSY POLYMERIC MEMBRANES FOR ENERGY DEVELOPMENT LI FUYUN B Tech (Hons.), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CHEMICAL AND...

Ngày tải lên: 09/09/2015, 17:56

... Introduction the cause of this loss of photocurrent was the one of the motivations for the present study Regarding the advantage of Au nanoparticles improving the photocatalytic performance of TiO222,25,26 ... dependent on the intensity and spectrum of the illuminating sunlight, the redox properties of the dye and the efficiencies of the charge injection process and collection of the electron in the semiconductor ... above, the LUMO of the dye needs to be higher than the conduction band of the semiconductor and the HOMO of the dye lower than the Fermi level of the redox mediator as shown in Figure2-1 Thirdly, the...

Ngày tải lên: 10/09/2015, 15:47