... is needed for facilitating the prediction of BBB- agents as well as for reducing the false positive rate ofthe prediction of BBB+ agents It is therefore of interest to examine whether proper ... forthe training set The remaining compounds forthe training set were selected by maximizing the minimum distance between the compounds in the training set and the rest ofthe compounds in the ... particular, the model of ER agonists was the focus ofthe sutdy The capability ofthe most widely used SLMs for predicting ER agonists by using a significantly larger number and more diverse range of...
... compounds of interest in the prevention of colon cancer In the present study, we investigated the relationship of different structural factors of procyanidins, such as the mean degree of polymerization ... However, the development of effective and safe agents forthe prevention and treatment of cancer remains inefficient and costly, and falls short ofthe requirements for primary prevention among the ... assay The culture was incubated for 72 h in the absence or presence ofthe polyphenolic mixture at its respective IC50 values The cells were then trypsinized, pelleted by centrifugation [371 g for...
... disposition ofthe proximal His and Asp residues, affecting the imidazolate character ofthe His, but also by the formation of a LS species The latter indicating the probable binding of His42 to the ... consistent with the very subtle nature ofthe mutation, i.e the loss of a single methyl group, depicted in green in Fig In marked contrast, forthe reduced state comparison ofthe RR spectra ofthe Thr171Ser ... impact on thepropertiesof His170 The strength ofthe hydrogen bond between the proximal His and Asp residues, and thus the imidazolate character ofthe His is expected to modulate not only the strength...
... and chin, then stretch the bands over your head and secure them comfortably as shown; one band on the upper back of your head, the other below the ears at the base ofthe neck Adjust the mask ... a gown, first select the appropriate type forthe task and the right size for you The opening ofthe gown should be in the back; secure the gown at the neck and waist If the gown is too small ... away from the shoulders Slip the fingers of one hand under the cuff ofthe opposite arm Pull the hand into the sleeve, grasping the gown from inside Reach across and push the sleeve off the opposite...
... N-terminus ofthe H-protein In conclusion, the substrate propertiesofthe alternatively encoded Flaveria H-protein FtGLDHAA in the P-protein reaction of GDC differ significantly from those ofthe normal ... metabolism I Propertiesofthe system catalyzing the exchange of bicarbonate with the carboxyl-group of glycine in Peptococcus glycinophilus J Biol Chem 241, 197–205 21 Hiraga K & Kikuchi G (1980) The ... criteria of integrity Methods Enzymol 148, 403–420 32 Bradford MM (1976) A rapid and sensitive method forthe quantitation of microgram quantities of protein utilizing the principle of protein–dye...
... dilution in mL of 20 mm Tris ⁄ HCl buffer pH 7.8 The HNE molecules specifically interacting with the binding sites ofthe two OBP forms were then displaced by the addition of a large excess ofthe OBP ... Evaluation ofthe third hypothesis, the molecular basis of which is described above, is the aim of this study Here, we report the binding properties, chemical modification and chemical resistance of recombinant ... acidic residues) compared with the porcine form (8.3%) [12], and because of their spatial arrangement in the 3D structure ofthe proteins (see below) The functionality of these HNE chemically modified...
... is the angle between the projection ofthe tilt ofthe z axis on the xÂ, y plane (dened direction of tilt of z and the x axis), and j % a + c denes the location ofthe rhombic (x, y) axes The ... The two structures of WT metHb and rWT metHbH2O, exhibit signicant differences in the interaction ofthe FG loop with the heme and in the position ofthe B-helix, with Tyr32(B10) closer to the ... 10 in the direction ofthe 5-H position The rhombic axes are dened by j % 50 in Fig The difference in the overall shift dispersion pattern of Pe metHbCN relative to, for example, any ofthe mammalian...
... suggests that cathepsin K is a new member ofthe kininase family Both the kininogenase activity of cathepsin L and/or the kininase activity of cathepsin K may be favored by the generation of an acidic ... especially for cathepsin L, than for hK1, but were identical forthe four enzymes towards C-BK peptide ( lM) The similar affinity pattern for all peptides indicates that the differences in the variation ... 2A), was used for further analysis of kininogen processing by CP Forthe sake of homogeneity with N-BK and C-BK peptides, the donor/acceptor pair was kept at the N- and C-terminal part of BK-peptide...
... resulting from the technological process The scope ofthe research presented covers part ofthe research carried out under earlier works ofthe authors The scope ofthe research encompassed: • the development ... discussion The first stage ofthe research carried out was the determination ofthe factors that influence thepropertiesofthe aluminium phosphate binder The applied technological procedures for binder ... applied forthe protection of water walls of pulverized-fuel power boilers The developed variants ofthe production technology of coatings ofthe required utilitarian properties take into account the...
... infiltrated the CNS ofthe TLR3KO-B6 mice were similar to those ofthe B6 mice at dpi (Fig 1B) However, the levels of these cells in the CNS of TLR3KO-B6 mice were significantly higher than those of control ... mechanisms forthe increase are unknown, elevated levels of cytokines in the CNS of mice with high viral loads favoring the generation of FoxP3+ CD4+ T cells may contribute to the increase ofthe regulatory ... of H-2Ks-VP3159-166-tetramer reactive CD8+ T cells in the CNS of TLR3KO mice was also similar to that ofthe NLM mice at the early stage (7 dpi) of infection, indicating the similarities in the...
... failure) minimum of 0.70 and three exceeded the preferred value of 0.80 (Table 2) Multi-trait scaling analyses supported the grouping of items into dimensions for 26 ofthe 36 items as their corrected ... quality as well as general support forthe psychometric propertiesofthe DCGM-37 when used in children undergoing treatment for cancer However the dimensionality ofthe instrument is uncertain which ... doubtful about the future However, after completing the questionnaire together, some parents expressed appreciation over the way the instrument opened up for deeper conversation with their offspring...
... gain insight into the mechanisms of these drugs on the OA subchondral bone osteoblasts, we further studied the effect ofthe therapeutic concentration of these drugs, 20 μg/mL, on the major intracellular ... different levels, by limiting the extent ofthe type I collagen degradation as well as the resorptive activity ofthe subchondral bone The role of cathepsin K in the remodelling of this tissue has been ... reached for rhein IL-1β also markedly increased the SAPK/JNK (p46 and p54), particularly the level ofthe p46 isoforms Diacerein and rhein, however, had no effect on the activation level of either...
... to other ethnic groups and in other countries Nonetheless, the sample used forthe study and the attendant analyses ofthe CCBQ data should provide a good launching point for future tests ofthe ... supported by the National Bureau of Controlled Drugs, Department of Health, Taiwan (grant number: DOH97-NNB-1044) The authors thank the participants and the staffs ofthe methadone clinics for their ... (approximately 3USD) for their participation Page of In order to prevent contamination ofthe original study sample, the test-retest reliability ofthe CCBQ, additional sample of 51 methadone patients...
... their content to the ICF and to appraise the currently available evidence ofthe quality of their measurement properties in order to offer recommendations forthe use of PF scales for various purposes ... assessing the functioning of specific limbs or joints The 51 studies identified by the main search that examined the measurement propertiesofthe original language version of one ofthe 26 retained ... subscales consist of only items or because the response format is often yes/no Therefore we would not recommend it for use or for further testing The CSHQ-RA and ROAD are among the most recently...
... that each set of items formed only one factor; therefore only a single score was generated for each of these domains Items from the Perceptions of Insulin Therapy domain formed two distinct factors, ... and the other negatively worded items Because ofthe lack of substantive meaning forthe separate factors, only a single composite scale was generated Items from the Inhaler Performance domain formed ... administrations Three ofthe eight tests of change in means were significant (Perceptions of Insulin Therapy and Treatment Preference for type and Diabetes Worries for type 2), but the size ofthe change...
... and SIV mutants containing the corresponding residues ofthe opposite virus Obvious differences were the identities ofthe residues at the P2 and P1 positions; we therefore created an HIV-1 mutant ... assayed for infection of P4-CCR5 indicator cells Infectivity was calculated after normalizing forthe RT content ofthe SIV inocula Values shown are normalized against the infectivity ofthe vehicle-treated ... the CA-SP1 junction accounts forthe differential sensitivity of HIV-1 and SIV to DSB The sequence ofthe CA-SP1 junction accounts forthe differential sensitivity of HIV-1 and SIV to DSB Viruses...
... diagnosis of depression was computed as the quotient ofthe cases classified as depression by both ofthe measures applied and the number of cases classified as depression by either ofthe measure ... On the validity ofthe Beck Depression Inventory A review Psychopathology 1998, 31:160-168 Hojat M, Shapurian R, Mehryar AH: Psychometric propertiesof a Persian version ofthe short form ofthe ... were included in the study if they were in the 11 grade (to avoid the symptoms of depression due to educational stress of appearing for board examination in the 10th as well as the 12th grades),...
... when the adult version ofthe SPSQ was developed [32] The cut-off used is the closest to adhere to the DSMIV definition of social phobia A paper and pencil format ofthe SPSQ-C was used The instrument ... discussion ofthe design and in the preparation ofthe ms CGS supervised the design and execution ofthe study and made contributions to the ms.GA supervised the design and execution ofthe study ... adopted forthe evaluation of validity The procedure of a case-control study starts with the selection of known cases and then an appropriate number of controls are selected [41] One week after the...
... porous or nonporous, the gas transport mechanisms vary from one to another The former is forthe separation of gases on the basis of their molecular size through the small pores in the membrane matrix, ... accurately estimate the outer-layer thickness and demonstrate the existence ofthe multilayered structure ofthe dual-layer hollow fiber membranes The success in the formation of defect-free hollow ... TAILORING THEPROPERTIESOF GLASSY POLYMERIC MEMBRANES FOR ENERGY DEVELOPMENT LI FUYUN B Tech (Hons.), NUS A THESIS SUBMITTED FORTHE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CHEMICAL AND...
... Introduction the cause of this loss of photocurrent was the one ofthe motivations forthe present study Regarding the advantage of Au nanoparticles improving the photocatalytic performance of TiO222,25,26 ... dependent on the intensity and spectrum ofthe illuminating sunlight, the redox propertiesofthe dye and the efficiencies ofthe charge injection process and collection ofthe electron in the semiconductor ... above, the LUMO ofthe dye needs to be higher than the conduction band ofthe semiconductor and the HOMO ofthe dye lower than the Fermi level ofthe redox mediator as shown in Figure2-1 Thirdly, the...