matching as means to an end
a means to an end the biological basis of aging and death apr 1999
... changed dramatically during our history as a species, but maximum lifespan, as far as we can tell, has not As the twentieth century draws to a close, cardiovascular disease and stroke, cancer and ... range of laboratory organisms—from single-cell organisms through rats and mice—was found to increase maximal lifespan, in some cases up to double the normal maximum lifespan In warm-blooded animals, ... the study of cancer, and these may be instructive For most of its clinical history, cancer was viewed as a thousand or more different diseases, at least as many different cancers as there were...
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Báo cáo khoa học: The retinoid-X receptor ortholog, ultraspiracle, binds with nanomolar affinity to an endogenous morphogenetic ligand pptx
... products of the D melanogaster ring gland (JH III, bisepoxy JH III, and methyl farnesoate) are unknown, and hence on a kinetic basis JH III as an in vivo ligand for dUSP cannot be demanded or dismissed ... receptor In such cases, affinity was instead measured by a competition assay: JH III was used (30 lm) to suppress receptor fluorescence, and the test ligand then used over a progressive increase ... esterase has recently been cloned [9] Various such derivatives of the parent all-trans RA were found to bind to retinoic acid receptor (RAR), some as strongly as all-trans RA [10] In transfection...
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Báo cáo khoa học: " Echocardiography and electrocardiography as means to evaluate potential performance in horses" docx
... echocardiographic study was carried out by means of a Kontron equipment (model Sigma Iris 440), specifically equipped with a 3,5 MHz dual mechanicalsector transducer, and an Esaote Biomedica equipment ... short axis, at the chordae tendinae level (Fig 1).The Left Ventricular Diastolic Diameter (LVDD), the Diastolic Thickness of the Interventricular Septum (DTIS) and the Diastolic Thickness of the Left ... electrocardiograph model, was used The sensitivity was set at cm = mV and paper speed at 25 mm/sec “HS” was obtained by calculating the mean value of the QRS interval recorded by means of the three standard bipolar...
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Báo cáo sinh học: "A genetic epidemiological model to describe resistance to an endemic bacterial disease in livestock: application to footrot in sheep" potx
... includes a class of healthy animals, and one or more classes of affected animals In the case of endemic diseases the vast majority of animals at any one time may be classified as healthy, and this ... for an animal to become infected This means that there is no need for an exact definition of the infective dose Case 2: Infectious animals with and without clinical signs In many instances animals ... around 6% [9] Resistance to footrot has been shown to be heritable [10-12], and selection for increased resistance is feasible The aim of this study was to develop SELIRS and SELDCRS epidemic...
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HOW TO PASS AN IT AUDIT: As told by an enterprise end-user who deployed QualysGuard Policy Compliance pot
... clean and easy to read Compliance data was delivered on time and closed audits faster Moreover, the cost of the new solution was 90 percent cheaper than the previous platform and it worked as ... How to Pass an IT Audit As a lead security analyst at a large Fortune 500 financial institution, we’re subject to many audits of our IT security After trying several tools for Governance, Risk and ... to more than merely “pass” this audit Emphasized ease of use and value – QualysGuard PC offered a significantly easier way to achieve better results, so IT owners were much happier using it to...
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Báo cáo y học: " Bench-to-bedside review: The gut as an endocrine organ in the critically ill" pdf
... of gastric emptying and fasting cholecystokinin and peptide YY concentrations Relationship between the rate of gastric emptying (measured using an isotope breath test and calculated as the gastric ... predominantly from the colon and rectum, and, to a lesser extent, from the pancreas, distal small intestine and stomach [59] Fat is the most potent stimulant of PYY secretion [59,60] Plasma PYY ... increase rapidly following systemic infection [63] Like CCK, endogenous PYY secretion is increased; and if receptor sensitivity remains unchanged, both hormones are candidate mediators to slow gastric...
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Exergoeconomic performance optimization of an endoreversible intercooled regenerative Brayton combined heat and power plant coupled to variable-temperature heat reservoirs
... performance of an endoreversible intercooled regenerative Brayton CHP plant coupled to constant-temperature heat reservoirs A thermodynamic model of an endoreversible intercooled regenerative Brayton ... economic optimization to evaluate and optimize the design and performance of energy systems Salamon and Nitzan [31] combined the endoreversible model with exergoeconomic analysis for endoreversible ... heat resistance It was termed as finite time exergoeconomic analysis [32-38] to distinguish it from the endoreversible analysis with pure thermodynamic objectives and the exergoeconomic analysis...
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Tài liệu Báo cáo khoa học: The PA-TM-RING protein RING finger protein 13 is an endosomal integral membrane E3 ubiquitin ligase whose RING finger domain is released to the cytoplasm by proteolysis ppt
... responsible for sorting the bean storage protein phaseolin to the protein storage vacuole [13] and was shown to bind to C-terminal vacuolar sorting determinants on tobacco chitinase and barley lectin [14], ... anergic CD4+ T-cells, which are unresponsive to antigen rechallenge [15] It was further characterized as an E3 ubiquitin ligase that localizes to recycling endosomes, and was later confirmed to ... possess an E3 ubiquitin ligase that can be released into the cytoplasm by proteolysis The PA-TM-RING protein RNF13 is synthesized as an integral endosomal membrane protein, but post-translational...
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Báo cáo khoa học: Unconventional translation initiation of human trypsinogen 4 at a CUG codon with an N-terminal leucine A possible means to regulate gene expression pdf
... al Transient transfection of human U87 glioblastoma cells with trypsinogen GFP-fused constructs We expressed human trypsinogen 4, fused with GFP reporter protein, in the U87 human glioblastoma ... functional roles in human cancer and metastasis [2022], amyloid fragment production in aged astrocytes [23], or in epithelial tissues modulating proteaseactivated receptor-2 and -4 activity [16,24] ... L, Lang K, Zanker KS, Metzger R, Schneider PM, Gerke V et al (2004) S100 family members and trypsinogens are predictors of distant metastasis and survival in early-stage non-small cell lung cancer...
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Báo cáo " Self-regulated strategy development as a means to foster learner autonomy in a writing course " pdf
... for two main reasons First, many autonomy experts suggest it as an option to approach the problem According to Little [15], students are not automatically autonomous in the formal classroom The ... (eds), Learner Autonomy in Language Learning: Defining the Field and Effecting Change, Franfurt: Peter Lang, 1999 [5] P Benson, Autonomy in language teaching and learning, Language Teaching 40 ... to be learnt The teacher and students establish the significance of the writing and self-regulation strategies How and when these strategies can be used for the present task and future ones and...
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columbia university press an end to poverty 2004
... deeply rooted in Christian assumptions about original sin, was translated into the terms made available by the Newtonian language of natural theology and was extended into the sphere of sexual ... arose was very different from our own It was dominated by the revolutions of in America and in France, as well as by the first movements to overcome slavery An End to Poverty? and empire ... it was nevertheless to be cherished – because it explained why mankind was induced to ‘found cities and commonwealths, and to invent and improve all the sciences and arts, which ennoble and embellish...
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Báo cáo khoa học: "Liposarcoma of the colon presenting as an endoluminal mass" docx
... decreased density and dismorphism of glands, inflammatory infiltrate in corion, necrotic material and granulation tissue Laparotomy revealed an intraluminal mass at the right colic angle and a ... Scand 1986, 152:389-391 Mohandas D, Chandra RS, Srinivasan V, Bhaskar AG: Liposarcoma of the ileum with secondaries in the liver Am J Gastroenterol 1972, 58:172-176 Dei Tos AP: Atypical lipomatous ... secondary to metastasis from a low-grade retroperitoneal liposarcoma Am Surg 2004, 70:775-778 Boggi U, Viacava P, Naccarato AG, Giulianotti PC, di Candio G, Battolla L, Mosca F: Giant pedunculated...
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Báo cáo y học: "Screening of an endothelial cDNA library identifies the C-terminal region of Nedd5 as a novel autoantigen in systemic lupus erythematosus with psychiatric manifestations" ppt
... after apoptotic stimuli, suggesting a possible mechanism by which Nedd5 may be autoantigenic Indeed, apoptosis may play an important role in bypassing tolerance to intracellular autoantigens The ... dihydrochloride (Sigma) was used as a substrate and absorbance was measured at 490 nm Means + standard deviations (SD) of the absorbance reading of the healthy controls were considered the cutoff levels for ... et al manifestations and serum antibodies against neuronal antigens, ribosomes, and phospholipids [4] Recently, we demonstrated an association between the presence of antiendothelial-cell antibodies...
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Báo cáo y học: "Using single nucleotide polymorphisms as a means to understanding the pathophysiology of asthma" pps
... for diseases with simple Mendelian inheritance, such as cystic fibrosis [20] The application of linkage analysis to complex disorders without obvious Mendelian inheritance such as asthma has been ... linkage analysis in complex human diseases has seen a shift in emphasis away from linkage analysis and microsatellite markers towards SNP genotyping and different analytical strategies based on association ... might also be an issue [51] SNP analysis and complex human disease There are several potential advantages to using SNPs to investigate the genetic determinants of complex human diseases in comparison...
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Báo cáo khoa học: " Efficacy of and tolerance to mild induced hypothermia after out-of-hospital cardiac arrest using an endovascular cooling system" pptx
... induced to manage severe head trauma with associated brain oedema Importantly, this rebound hyperthermia was associated with an increase in intracranial pressure Brain oedema secondary to postanoxic ... was left to the discretion of the cardiologist and intensivist in charge of the patient When angioplasty was performed, routine anti-aggregant treatment associated with unfractioned heparin was ... infusion, and pancuronium bromide was administered when necessary to avoid shivering during MIH End- points The primary end- point was the ability of the endovascular cooling system to achive a...
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Báo cáo y học: "Cost-effectiveness analysis of clinical specialist outreach as compared to referral system in Ethiopia: an economic evaluation" pot
... graphs and narrative descriptions Sensitivity analysis was done to assess how the result of the analysis could change based on the values of some selected independent variables with a potential to ... analysis Analysis of the cleaned data set was done by using SPSS 16.0 Data from different sources get linked during analysis and Microsoft Excel was used to calculate the final summary values and ... University to ensure the propriety standards of the evaluation Informed consent was obtained from all participant patients in the data collection process prior to any attempt to collect data Data analysis...
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Báo cáo y học: " Exogenous nitric oxide requires an endothelial glycocalyx to prevent postischemic coronary vascular leak in guinea pig hearts" docx
... microscopy, and immunohistochemistry PC analysed and interpreted the data BFB was responsible for the study design and the analysis and interpretation of data and helped to draft the manuscript ... Preparing and applying NO stock solution To prepare an aqueous saturated solution of NO, mL of deionized water was sealed into a small glass vial with a stopper and a long syringe needle was inserted, ... hypoxanthine, xanthine, guanosine, and urate together (products of adenine nucleotide catabolism) as well as that of uric acid alone were quantified by reverse-phase HPLC [19] In each case, the...
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Báo cáo y học: " Landmark survival as an end-point for trials in critically ill patients – comparison of alternative durations of follow-up: an exploratory analysis" doc
... databases Access to the data was granted by the ANZICS CORE Management Committee in accordance with standing protocols Data are collected primarily for ICU Outcome Peer Review under Quality Assurance ... statistical analysis and drafted the manuscript KMH performed data analysis and helped to draft the manuscript CG, RB, GH, and SW participated in its design and analysis of the study, and coordinated ... ICU Director and results are reported back to the Director Each hospital allows subsequent data use as appropriate under the ANZICS CORE standing procedures and in compliance with the ANZICS CORE...
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developing an end to end windows store app using c and xaml
... 218 12 Developing an end -to- end Windows Store app using C++ and XAML: Hilo The Hilo end -to- end photo sample provides guidance to C++ developers that want to create a Windows app using ... Here's an example: C++: FileAllPhotosQuery.cpp auto photos = ref new Vector(); for (auto file : files) { auto photo = ref new Photo(file, ref new NullPhotoGroup(), policy); photos->Append(photo); ... and std::random_shuffle to choose random photos (more precisely, indices to an array of photos) This example uses std::iota to create a sequence of array indices and std::random_shuffle to randomly...
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