massarray™+highly+accurate+andversatile+high+throughput+analysis+ofgenetic+variations

... modeling enables high- throughput analysis of complex nonlinear systems in various applications [1-2] In particular it was shown that generalized models can be used to obtain statistically highly- significant ... Abstract Purpose — Describe a high- throughput method for the analysis of uncertain models, e.g in biological research Methods — Generalized modeling for conceptual analysis of large classes of ... Generalized Models for high- throughput analysis of uncertain nonlinear systems Thilo Gross1,2 , Stefan Siegmund∗2 Max-Planck Technical...

Ngày tải lên: 18/06/2014, 18:20

... modeling enables high- throughput analysis of complex nonlinear systems in various applications [1-2] In particular it was shown that generalized models can be used to obtain statistically highly- significant ... Abstract Purpose — Describe a high- throughput method for the analysis of uncertain models, e.g in biological research Methods — Generalized modeling for conceptual analysis of large classes of ... Generalized Models for high- throughput analysis of uncertain nonlinear systems Thilo Gross1,2 , Stefan Siegmund∗2 Max-Planck Technical...

Ngày tải lên: 20/06/2014, 01:20

... modeling enables high- throughput analysis of complex nonlinear systems in various applications [1-2] In particular it was shown that generalized models can be used to obtain statistically highly- significant ... Abstract Purpose — Describe a high- throughput method for the analysis of uncertain models, e.g in biological research Methods — Generalized modeling for conceptual analysis of large classes of ... Generalized Models for high- throughput analysis of uncertain nonlinear systems Thilo Gross1,2 , Stefan Siegmund∗2 Max-Planck Technical...

Ngày tải lên: 20/06/2014, 21:20

... Transl Med 2010, 2:20ra14 doi:10.1186/gm140 Cite this article as: Newman S, Edwards PAW: High- throughput analysis of chromosome translocations and other genome rearrangements in epithelial cancers ... tumor, most of which can be confirmed by PCR Stephens et al [5] estimate that 50% of structural variations were detected in their study This may seem Page of like a low figure but, as the authors ... the future as more sequencing reads are generated, the reads used are longer, and bioinformatic analysis is refined Rearrangements in breast cancers are more numerous than expected There were...

Ngày tải lên: 11/08/2014, 12:20

... Genome-wide high- throughput screens in functional genomics Curr Opin Genet Dev 2004, 14:470-476 Hartman JLt, Tippery NP: Systematic quantification of gene interactions by phenotypic array analysis ... 2004, 5:R49 Weiss A, Delproposto J, Giroux CN: High- throughput phenotypic profiling of gene-environment interactions by quantitative growth curve analysis in Saccharomyces cerevisiae Anal Biochem ... bodies (Figure 1c, 40 hours) The entire video clip from the first stage of our analysis can be summarized by wavelet analysis, where wave frequency and power spectrum are plotted as a function of...

Ngày tải lên: 14/08/2014, 07:22

... related to gene duplication [37] Highly connected proteins are more likely to interact with a protein that is duplicated than with one that has few links Thus, these highly connected proteins gain ... two-hybrid methods and that yielded data sets whose analysis required a FEBS Journal 272 (2005) 5391–5399 ª 2005 FEBS S Fields High- throughput two-hybrid analysis significant investment in computational ... analysis of 100 trials revealed that  7% of the interactions were of the highest confidence and always grouped with the positive set, 11% were of next highest confidence, and 24% of the next highest...

Ngày tải lên: 23/03/2014, 15:21

... 410:57-73 doi:10.1186/1471-2229-11-65 Cite this article as: Grattapaglia et al.: High- throughput SNP genotyping in the highly heterozygous genome of Eucalyptus: assay success, polymorphism and transferability ... nucleotide diversity (0.2% to 0.5%) [3,27-29] and outbred species with much higher sequence diversity typically ≥2% [9-13] In highly heterozygous genomes, the development of GGGT SNP assays has been ... scored with high call rate, a more stringent in silico selection on the flanking sequences yields more SNPs with higher call rates and GeneTrain scores as well as SNPs with average higher GeneCall50...

Ngày tải lên: 11/08/2014, 11:22

... fully automated high- throughput screening system offers a number of advantages: Besides saving labor, the subjective component of the human observer is replaced by deterministic image analysis algorithms ... affecting the barley/powdery mildew interaction Conclusion The described high- throughput screening system enables a large-scale analysis of candidate genes regarding the resistance of crop plants ... two dimensions via LDA is depicted Both dimensions show a high correlation Incorporating a third discriminant axis would show a similar highly- correlated scenario in 3-D As a result, classification...

Ngày tải lên: 12/08/2014, 05:20

... it can be considered as a highly specific CXCR4 antagonist [26-28] It was demonstrated that two aspartate residues at positions 171 and 262 of CXCR4 are crucial for the high- affinity binding of ... and the 'macrophage inflammatory proteins' MIP-1α and MIP-1β The chemokine MIP-1α occurs in two highly related isoforms, designated LD78α and LD78β, and although they only differ in three amino ... CCR5 or CXCR4 expression, we used the U87.CD4 cell line as a starting point to create a cell line highly suitable for the evaluation of the anti-HIV activity of potential CCR5 and CXCR4 antagonists...

Ngày tải lên: 13/08/2014, 13:20

... shown) Taken together, these data indicate that LMF represents a highly accurate signature analysis method that is suitable for high- throughput applications reviews Peck et al R61.3 comment Fraction ... range of differential expression likely to be encountered in a typical signature analysis experiment ments were highly correlated, with 97.9% of data points falling within twofold of their corresponding ... expression-based high- throughput screening (GEHTS) and application to leukemia differentiation Nat Genet 2004, 36:257-263 Yang L, Tran DK, Wang X: BADGE, Beads Array for the Detection of Gene Expression, a high- throughput...

Ngày tải lên: 14/08/2014, 16:21

... signalling pathways 10 1.3 Introduction to high- throughput biomarker selection 13 1.3 Introduction to microarray experiments 13 1.3.2 Statistical analysis of microarray data 15 1.3.3 ... initiation Current microarray data analysis tools provided good predictive performance However, the signatures produced by those tools have VIII SUMMARY been found to be highly unstable with the variation ... Unsupervised hierarchical clustering analysis provides additional indication of the predictive ability of selected signatures Then the other type of high- throughput dataset used for signature...

Ngày tải lên: 09/09/2015, 10:14

... hydrolysis Significantly higher copy number of AMY1 gene was found in populations with high- starch diets than those with traditional low-starch diets (Perry et al., 2007) The high copy number of AMY1 ... used in high- throughput identification of SNPs On a SNP genotyping array, each SNP allele is represented by matched and mismatched groups of probes approximately 25 bp long Due to the high density ... (Notini et al., 2008) Genomic variations have different forms, such as Single Nucleotide Polymorphism (SNP) and short insertion or deletion (indel) (Shastry, 2009) Variations with size greater...

Ngày tải lên: 11/09/2015, 10:01

... therefore, modeling the interactions between these requires the use of highly nonlinear rate laws Furthermore, all of these processes are highly dependent on each other in nonlinear ways [4] As a result ... result of the very nonlinearities that cause these problems, the modeling and analysis of these systems in simple yet accurate ways become absolutely necessary for understanding the functions that ... family of methods that act as accurate extensions of the technique used to derive enzyme kinetics from mass action kinetics, and we demonstrate their use in obtaining accurate simplied models During...

Ngày tải lên: 18/02/2014, 06:20

Ngày tải lên: 21/02/2014, 05:20

... [15N]-HSQC spectra We anticipate that high yield cell-free protein synthesis and combinatorial isotope labelling will become routine techniques in high- throughput NMR studies of proteins Acknowledgements ... Guignard L, Ozawa K, Pursglove SE, Otting G & Dixon NE (2002) NMR analysis of in vitro-synthesized proteins without purification: a high- throughput approach FEBS Lett 524, 159–162 22 Keppetipola S, ... for two crosspeaks from flexible residues Signals near 112 p.p.m in the 15N dimension arise from highly mobile NH2 groups of c at natural isotopic abundance The spectrum demonstrates that the w–v...

Ngày tải lên: 07/03/2014, 12:20

... KEGGanim: pathway animations for high- throughput data Bioinformatics 24, 588–590 Antonov AV & Mewes HW (2006) Complex functionality of gene groups identified from high- throughput data J Mol Biol 363, ... protein lists in order to address this challenge High- throughput metabolomics has recently started to be instrumental in exploring metabolic variations on a genomic scale [7–10,35,36] The output ... cases, TICL provides new biological insights into variations 2090 In addition to the ability to generate a large amount of data per experiment, high- throughput technologies also brought the challenge...

Ngày tải lên: 16/03/2014, 01:20

... Figure 1- Text Analysis Process Flow For deployment of text analysis engines we tested two configurations During the development phase ... servers with 4Gb RAM Each WAS instance had two MDBs with text analysis engines Work was distributed using message queues Each text analysis engine was deployed to function independent of other ... servers were configured for text processing The average document throughput for each blade was 20 documents per minute The text analysis engine was designed by conceptually breaking up the task...

Ngày tải lên: 31/03/2014, 03:20

... Neagle, B D (1996) FLIPR: a new instrument for accurate, high throughput optical screening J Biomol Screen 1, 75 – Hertzberg, R P., and Pope, A J (2000) High throughput screening: new technology for ... High Throughput Screening Assays 1 Design and Implementation of High Throughput Screening Assays Ricardo Macarrón and Robert P Hertzberg ... and Saussy, D L (1996) Experimental design for high- throughput screening Drug Discovery Today 1(7), 277–286 Major, J S (1995) Challenges of high throughput screening against cell surface receptors...

Ngày tải lên: 11/04/2014, 09:46

... for High Throughput Sequencing Naiara Rodríguez-Ezpeleta Ana M Aransay ● Michael Hackenberg Editors Bioinformatics for High Throughput Sequencing Editors Naiara Rodríguez-Ezpeleta Genome Analysis ... involved in the different steps of a high throughput sequencing project The “newbies” eager to learn the basics of high throughput sequencing technologies and data analysis will find what they yearn ... Ji 11 Applications of High- Throughput Sequencing Rodrigo Goya, Irmtraud M Meyer, and Marco A Marra 27 Computational Infrastructure and Basic Data Analysis for High- Throughput Sequencing ...

Ngày tải lên: 29/05/2014, 14:33