... to the loss of the overlying retina If the edge of the dialysis remains close to the RPE, then the tear may not be discovered unless scleral depression is performed As the vitreous contracts, the ... observable withthe fundus camera, for future reference cooperative.81 The optometrist should tell thepatient that the risk associated withthe treatment of a problematic retinal tear is less than the ... greater the possible loss of vision after reattachment of the retina The prognosis is very poor when the detachment involves the macula The longer the macula is detached, the poorer the resultant...
... differential diagnosis (Table 52-4) For instance, the finding of scaling papules (present in patients with psoriasis or atopic dermatitis) places thepatient in a different diagnostic category than ... skin lesions If the examiner focuses on linear erosions overlying an area of erythema and scaling, he or she may incorrectly assume that the erosion is the primary lesion and the redness and ... secondary, while the correct interpretation would be that thepatient has a pruritic eczematous dermatitis with erosions caused by scratching Figure 52-1 Superficial spreading melanoma This is the most...
... epidermal atrophy) Scar: A change in the skin secondary to trauma or inflammation Sites may be erythematous, hypopigmented, or hyperpigmented depending on their age or character Sites on hair-bearing ... elicits the desire to scratch Pruritus is often the predominant symptom of inflammatory skin diseases (e.g., atopic dermatitis, allergic contact dermatitis); it is also commonly associated with ... Erosion: Loss of epidermis without an associated loss of dermis Ulcer: Loss of epidermis and at least a portion of the underlying dermis Excoriation: Linear, angular erosions...
... possible to assess the distribution of the eruption accurately Thepatient should first be viewed from a distance of about 1.5–2 m (4–6 ft) so that the general character of the skin and the distribution ... correlates highly with diagnosis (Fig 52-6) For example, a hospitalized patientwith a generalized erythematous exanthem is more likely to have a drug eruption than is a patientwith a similar rash ... during a physical examination: the distribution of the eruption, the types of primary and secondary lesions, the shape of individual lesions, and the arrangement of the lesions An ideal skin examination...
... The distribution of some common dermatologic diseases and lesions Figure 52-7 Psoriasis This papulosquamous skin disease is characterized by small and large erythematous papules and plaques with...
... contrast, lesions with a generalized arrangement are common and suggest a systemic etiology Figure 52-9 Erythema multiforme This eruption is characterized by multiple erythematous plaques with a target ... reaction to drugs (e.g., sulfonylamides) or infections (e.g., HSV) (Courtesy of the Yale Resident's Slide Collection; with permission.) Figure 52-10 ...
... the latter technique, a punch is pressed against the surface of the skin and rotated with downward pressure until it penetrates to the subcutaneous tissue The circular biopsy is then lifted with ... selected areas of the body In this procedure, a small area of skin is anesthetized with 1% lidocaine with or without epinephrine The skin lesion in question can be excised or saucerized with a scalpel ... of the slide accelerates dissolution of keratin When the preparation is viewed under the microscope, the refractile hyphae will be seen more easily when the light intensity is reduced and the...
... suspected allergens is applied to thepatient' s back under occlusive dressings and allowed to remain in contact withthe skin for 48 h The dressings are removed, and the area is examined for evidence ... reactions (e.g., erythema, edema, or papulovesicles) This test is best performed by physicians with special expertise in patch testing and is often helpful in the evaluation of patients with chronic ... assess whether a skin lesion will blanch with pressure as, for example, in determining whether a red lesion is hemorrhagic or simply blood-filled Urticaria (Fig 52-11) will blanch with pressure,...
... same as the prognosis of the person with aortic stenosis who develops the first symptoms of congestive heart failure (median survival, ~8 months) However, thepatientwith heart disease ... the traitorous behavior of cancer cells is that thepatient feels betrayed by his or her body The cancer patient feels that he or she, and not just a body part, is diseased The Magnitude of the ... various populations in Table 77-2 Along withthe decrease in incidence has come an increase in survival for cancer patients The 5-year survival for white patients was 39% in 1960–1963 and 68% in...
... The past medical history may alert the physician to the presence of underlying diseases that may affect the choice of therapy or the side effects of treatment The social history may reveal occupational ... lymphoma Increasing evidence links the expression of certain genes withthe prognosis and response to therapy (Chaps 79, 80) Occasionally a patient will present with a metastatic disease process ... workers, rehabilitation medicine specialists, and a number of other consulting professionals working closely with each other and withthepatient and family ...
... categorizes the tumor on the basis of the size of the primary tumor lesion (T1–4, where a higher number indicates a tumor of larger size), the presence of nodal involvement (usually N0 and N1 for the ... other prognostic factors have been identified (Chaps 104, 105, and 106) In addition to tumor burden, a second major determinant of treatment outcome is the physiologic reserve of thepatient Patients ... stage for stage, than fully active patients Physiologic reserve is a determinant of how a patient is likely to cope withthe physiologic stresses imposed by the cancer and its treatment This factor...
... to cure thepatient and the pressure of a busy schedule greatly limit the time a physician spends with a patient who is receiving only palliative care Resist these forces In addition to the medicines ... complications of both the disease and its treatment as well as the complex psychosocial problems associated with cancer In the short term during a course of curative therapy, thepatient' s functional ... interface withthe Internet.2 The skilled physician also has much to offer thepatient for whom curative therapy is no longer an option Often a combination of guilt and frustration over the inability...
... nonjudgmental, so that patients are more likely to discuss withthe physician what they are actually doing The appearance of unexpected toxicity may be an indication that a supplemental therapy is being ... biopsied If disease persists, the multidisciplinary team discusses a new salvage treatment plan If thepatient has been rendered disease-free by the original treatment, thepatient is followed regularly ... consequence of the disease and some as a consequence of the treatment An understanding of these disease- and treatment-related problems may help in their detection and management Despite these concerns,...
... which to indicate the severity of the pain The clinical condition is often dynamic, making it necessary to reassess thepatient frequently Pain therapy should not be withheld while the cause of pain ... caused by chemotherapy (Chap 81) Its severity can be predicted from the drugs used to treat the cancer Three forms of emesis are recognized on the basis of their timing with regard to the noxious ... signals in the chemoreceptor trigger zone in the medulla, the cerebral cortex, and peripherally in the intestinal tract lead to stimulation of the vomiting center in the medulla, the motor center...
... discussed openly withthepatient An empathetic health care team is sensitive to the individual patient' s needs and permits negotiation where such flexibility will not adversely affect the course of ... course of treatment Cancer survivors have other sets of difficulties Patients may have fears associated withthe termination of a treatment they associate with their continued survival Adjustments ... handicaps, real and perceived Patients may be preoccupied with minor physical problems They perceive a decline in their job mobility and view themselves as less desirable workers They may be victims of...
... affected by the diagnosis and is coping with it is an important goal of patient management It is best to speak frankly withthepatient and the family regarding the likely course of disease These discussions ... hope Of course, patients not all progress through all the stages or proceed through them in the same order or at the same rate Nevertheless, developing an understanding of how thepatient has been ... and the goal of palliative therapy is embraced in the hope of being able to live with disease; finally, at the disclosure of imminent death, another adjustment in outlook takes place The patient...
... decreased the absolute number of WT1/MHC tetramer+CD8+ cells and the decrease was maintained for two to three weeks On the other hand, in MLPC cells without the addition of WT1 peptides, the absolute ... imatinib therapy, we started WT1 peptide vaccination therapy in combination with imatinib in a CML patient who could not acquire a major molecular response through the administration with a single ... speculated to be the late effects of imatinib therapy at the dose of 600 mg a day However, bcr-abl transcripts gradually increased to more than 1,000 copies thereafter Since thepatient was HLA-A*2402+...
... of the art MAGNITUDE OF THE USER FACILITY ENTERPRISE The user facility enterprise is large, whether measured by the numbers of scientists involved, the cost of the facilities, or the size of the ... research, was driven by the high cost of the core of the facility and the diverse instrumentation needed to equip the dozens of beamlines The funding of the core, the hardware, and the highly skilled ... from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine The members of the committee responsible for the report were chosen for their...
... approaches for managing both the MS disease p rocess and ssociated conditions, and to discuss these a approaches in the context of the aging MS patient An Overview of MS in Aging The hallmarks ... genitourinary dysfunction As thepatientwith MS ages, morbidities and p hysiological changes associated withthe normal aging process interact with MS-related pathology to influence the severity of impairment ... as the disease progresses, there may be residual deficits that accumulate over time Exacerbations can last days to weeks to months The longer a patient has MS, the greater the chance that the...